GREMLIN Database
RL18 - 50S ribosomal protein L18
UniProt: P50562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (181)
Sequences: 485 (244)
Seq/√Len: 18.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_S45_T7.2831.00
90_G126_A4.5201.00
46_A119_I4.4311.00
49_V58_T3.7161.00
36_V49_V3.3831.00
72_W176_T3.2320.99
12_R16_E2.9710.99
43_H65_S2.7910.98
46_A89_A2.7550.98
44_V82_A2.5580.97
101_A134_D2.4940.96
110_A117_F2.4840.96
159_L163_D2.4530.96
172_H176_T2.2990.94
175_E179_A2.2730.94
22_H25_L2.2650.94
103_L120_Q2.1770.92
43_H63_H2.1620.92
35_L123_A2.1320.91
85_T88_L2.0790.90
35_L89_A2.0520.90
64_S85_T2.0400.89
171_A175_E1.9790.88
171_A182_E1.9410.87
123_A128_L1.8510.84
80_P148_I1.8390.84
62_A66_D1.8150.83
74_A172_H1.7560.81
142_R146_E1.7550.81
107_L117_F1.7550.81
100_E129_D1.7130.79
48_L128_L1.6750.77
20_D23_Q1.6590.77
37_A138_A1.5230.70
120_Q132_H1.5160.70
111_T114_S1.5050.69
177_R181_M1.4990.69
3_T8_K1.4960.69
43_H64_S1.4900.68
75_P78_N1.4750.68
66_D88_L1.4550.67
13_R24_R1.4280.65
35_L119_I1.3800.62
32_K100_E1.3540.61
39_K108_N1.3310.59
174_D178_E1.3070.58
148_I151_Y1.2970.57
72_W84_L1.2960.57
112_P136_V1.2490.54
14_R38_R1.2480.54
105_I110_A1.2410.54
62_A92_R1.2390.54
60_A93_A1.2260.53
81_A92_R1.2210.53
88_L92_R1.2050.52
70_Y176_T1.1850.51
48_L89_A1.1460.48
24_R38_R1.1330.47
47_Q62_A1.1210.47
52_G57_E1.1160.46
123_A130_V1.1100.46
25_L28_L1.0990.45
28_L100_E1.0830.44
59_V97_G1.0820.44
11_M120_Q1.0720.44
87_L91_Q1.0700.43
150_E153_E1.0590.43
103_L132_H1.0390.42
66_D92_R1.0390.42
81_A85_T1.0350.41
120_Q124_I1.0340.41
118_A138_A1.0270.41
125_D164_F1.0260.41
80_P101_A1.0240.41
140_W143_T1.0220.41
72_W172_H1.0210.41
13_R19_T1.0210.41
175_E182_E1.0200.40
167_T174_D0.9980.39
170_P173_F0.9860.38
18_R62_A0.9820.38
19_T24_R0.9810.38
37_A119_I0.9730.38
155_L163_D0.9720.38
35_L46_A0.9550.37
155_L164_F0.9490.36
152_A164_F0.9460.36
80_P145_G0.9350.36
44_V109_T0.9320.35
154_S161_S0.9220.35
22_H26_R0.9200.35
106_G125_D0.9140.34
87_L90_G0.9130.34
28_L51_T0.9090.34
31_G136_V0.9080.34
142_R147_H0.9020.34
79_L128_L0.9010.34
148_I159_L0.8950.33
25_L29_K0.8760.32
102_V176_T0.8750.32
84_L102_V0.8720.32
33_P50_T0.8670.32
43_H58_T0.8650.32
2_A95_D0.8620.32
60_A92_R0.8480.31
28_L178_E0.8400.30
30_S59_V0.8390.30
145_G148_I0.8320.30
39_K57_E0.8290.30
121_E125_D0.8270.30
156_D159_L0.8240.30
146_E150_E0.8200.29
116_V119_I0.8190.29
166_A182_E0.8180.29
74_A79_L0.8180.29
103_L122_G0.8120.29
74_A84_L0.8110.29
85_T119_I0.8110.29
20_D27_L0.8110.29
79_L93_A0.8100.29
43_H77_G0.8100.29
40_S77_G0.8060.29
33_P136_V0.7950.28
72_W110_A0.7940.28
36_V58_T0.7880.28
117_F133_N0.7830.27
44_V116_V0.7760.27
100_E115_K0.7680.27
153_E167_T0.7640.27
14_R24_R0.7640.27
89_A124_I0.7620.26
18_R66_D0.7610.26
65_S77_G0.7600.26
50_T69_A0.7600.26
37_A46_A0.7590.26
115_K138_A0.7590.26
162_G165_D0.7570.26
74_A93_A0.7570.26
46_A130_V0.7550.26
179_A182_E0.7530.26
169_L172_H0.7470.26
104_D107_L0.7440.26
2_A9_V0.7410.25
168_A171_A0.7360.25
165_D171_A0.7340.25
35_L90_G0.7330.25
23_Q37_A0.7330.25
162_G166_A0.7310.25
3_T20_D0.7250.25
113_G132_H0.7230.25
34_R104_D0.7230.25
110_A126_A0.7160.24
62_A152_A0.7130.24
51_T78_N0.7110.24
27_L102_V0.7090.24
93_A97_G0.7060.24
70_Y128_L0.7050.24
36_V104_D0.7000.24
160_Y166_A0.6990.24
129_D161_S0.6950.23
14_R19_T0.6940.23
62_A67_L0.6930.23
144_R174_D0.6910.23
24_R56_D0.6900.23
20_D24_R0.6900.23
38_R56_D0.6890.23
21_Y104_D0.6890.23
85_T92_R0.6880.23
144_R152_A0.6880.23
142_R175_E0.6860.23
38_R104_D0.6820.23
41_N51_T0.6780.23
34_R38_R0.6740.22
107_L114_S0.6690.22
35_L48_L0.6680.22
56_D86_G0.6680.22
20_D26_R0.6660.22
67_L70_Y0.6630.22
50_T59_V0.6600.22
22_H149_A0.6590.22
60_A101_A0.6590.22
154_S168_A0.6510.21
102_V147_H0.6500.21
156_D163_D0.6460.21
68_D112_P0.6460.21
39_K44_V0.6400.21
62_A88_L0.6370.21
141_S157_E0.6350.21
51_T81_A0.6300.21
37_A81_A0.6300.21
7_Y12_R0.6290.21
64_S88_L0.6290.21
75_P115_K0.6220.20
40_S60_A0.6220.20
58_T115_K0.6210.20
79_L84_L0.6190.20
21_Y24_R0.6190.20
170_P177_R0.6140.20
52_G102_V0.6130.20
97_G147_H0.6120.20
165_D182_E0.6110.20
159_L174_D0.6100.20
54_D146_E0.6100.20
27_L75_P0.6100.20
89_A119_I0.6090.20
4_G8_K0.6080.20
97_G142_R0.6060.20
70_Y141_S0.6060.20
153_E171_A0.6030.20
44_V64_S0.6000.19
175_E178_E0.5940.19
137_L143_T0.5940.19
173_F176_T0.5930.19
5_P108_N0.5930.19
59_V69_A0.5890.19
106_G122_G0.5870.19
39_K150_E0.5850.19
167_T170_P0.5850.19
122_G125_D0.5820.19
178_E181_M0.5810.19
90_G94_V0.5800.19
56_D83_Y0.5780.19
106_G121_E0.5760.19
72_W120_Q0.5740.18
83_Y86_G0.5740.18
59_V129_D0.5730.18
21_Y86_G0.5700.18
132_H137_L0.5660.18
170_P181_M0.5610.18
129_D134_D0.5600.18
114_S120_Q0.5580.18
19_T78_N0.5570.18
144_R154_S0.5570.18
34_R117_F0.5540.18
58_T151_Y0.5530.18
12_R162_G0.5520.18
107_L116_V0.5510.18
6_R27_L0.5500.18
138_A142_R0.5480.18
18_R73_A0.5480.18
54_D120_Q0.5440.17
48_L114_S0.5440.17
44_V87_L0.5430.17
96_A114_S0.5430.17
25_L138_A0.5420.17
17_V20_D0.5400.17
3_T31_G0.5380.17
137_L152_A0.5370.17
42_K95_D0.5340.17
106_G131_P0.5330.17
72_W93_A0.5320.17
108_N116_V0.5310.17
11_M148_I0.5300.17
38_R67_L0.5260.17
61_S96_A0.5250.17
75_P92_R0.5240.17
155_L162_G0.5220.17
111_T132_H0.5170.16
5_P80_P0.5160.16
28_L40_S0.5160.16
11_M103_L0.5130.16
14_R36_V0.5130.16
81_A88_L0.5130.16
65_S68_D0.5080.16
87_L177_R0.5080.16
124_I176_T0.5080.16
49_V175_E0.5040.16
57_E142_R0.5030.16
99_E112_P0.5020.16
38_R127_G0.5020.16
60_A98_V0.5010.16
9_V87_L0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zf7u 1 1 100 0.215 Contact Map
4ujqG 1 1 100 0.217 Contact Map
1vq8N 1 0.9945 100 0.221 Contact Map
3j61D 1 0.9836 100 0.225 Contact Map
4a17M 1 1 100 0.229 Contact Map
3j39D 1 1 100 0.231 Contact Map
3j21O 1 1 100 0.234 Contact Map
4w20D 1 1 100 0.237 Contact Map
1vx7R 1 1 100 0.239 Contact Map
1ovyA 1 0.5137 100 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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