GREMLIN Database
RL5 - 50S ribosomal protein L5
UniProt: P50558 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 175 (140)
Sequences: 2392 (996)
Seq/√Len: 84.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_V44_T3.7821.00
104_S130_T3.5061.00
5_D143_R2.9531.00
21_V132_N2.6861.00
8_D140_V2.5841.00
20_V83_L2.5631.00
107_I112_D2.5431.00
99_N138_Y2.4291.00
84_E88_P2.2991.00
24_M36_A2.2881.00
17_I131_V2.2871.00
51_T71_K2.2631.00
41_E47_Q2.2381.00
117_E120_P2.1631.00
83_L87_L2.0401.00
86_A105_F2.0261.00
81_D85_R1.9271.00
41_E48_T1.9151.00
94_R142_K1.8981.00
8_D137_G1.8931.00
24_M40_L1.8481.00
53_A56_P1.8161.00
83_L131_V1.7951.00
52_K67_P1.7721.00
30_G68_I1.7231.00
13_R136_P1.7081.00
37_E50_R1.6901.00
50_R67_P1.6561.00
139_R142_K1.6461.00
62_L68_I1.6061.00
53_A65_G1.5641.00
137_G140_V1.5481.00
20_V87_L1.5291.00
33_L70_A1.5191.00
18_E134_T1.5100.99
110_H125_Y1.4640.99
22_V127_M1.4510.99
40_L70_A1.4160.99
51_T69_G1.3870.99
26_V36_A1.3840.99
111_T118_Y1.3670.99
93_D96_Q1.3350.99
37_E41_E1.3330.99
39_I125_Y1.3110.99
92_L96_Q1.3040.98
71_K128_D1.2930.98
96_Q128_D1.2810.98
5_D139_R1.2650.98
98_D102_N1.2590.98
109_E124_I1.2570.98
38_T41_E1.2450.98
122_I125_Y1.2370.98
35_N39_I1.2180.98
74_L82_F1.2100.98
92_L105_F1.2060.97
26_V33_L1.1890.97
24_M125_Y1.1690.97
34_Q38_T1.1690.97
17_I83_L1.1590.97
18_E21_V1.1480.97
81_D84_E1.1460.97
56_P64_Q1.1430.96
49_V71_K1.1410.96
111_T124_I1.1270.96
11_E14_E1.0930.95
23_H128_D1.0670.95
35_N122_I1.0520.94
22_V40_L1.0510.94
38_T42_A1.0190.93
6_S140_V1.0190.93
28_Q123_G1.0110.93
37_E70_A1.0070.93
4_T7_T1.0030.93
24_M70_A0.9830.92
36_A70_A0.9710.92
100_T138_Y0.9610.91
8_D13_R0.9560.91
30_G33_L0.9470.91
30_G62_L0.9310.90
96_Q105_F0.9280.90
6_S143_R0.9210.89
26_V41_E0.9160.89
35_N118_Y0.8880.88
20_V131_V0.8810.87
10_H107_I0.8780.87
90_A112_D0.8690.86
46_Q78_T0.8640.86
41_E44_T0.8600.86
118_Y122_I0.8570.86
107_I128_D0.8550.86
23_H108_E0.8530.85
120_P123_G0.8510.85
5_D8_D0.8490.85
118_Y125_Y0.8410.85
22_V86_A0.8310.84
13_R135_R0.8130.83
135_R140_V0.7940.81
28_Q125_Y0.7880.81
136_P140_V0.7850.80
62_L66_D0.7780.80
42_A120_P0.7740.79
96_Q103_V0.7710.79
95_R139_R0.7650.79
125_Y128_D0.7600.78
92_L103_V0.7500.77
56_P65_G0.7410.76
39_I110_H0.7370.76
40_L44_T0.7360.76
37_E48_T0.7360.76
15_P133_L0.7330.76
119_D128_D0.7330.76
109_E119_D0.7280.75
24_M128_D0.7270.75
90_A107_I0.7220.74
104_S128_D0.7190.74
134_T142_K0.7170.74
25_G69_G0.7160.74
51_T57_E0.7090.73
16_R80_V0.7060.73
24_M39_I0.7050.73
110_H131_V0.7040.73
82_F113_F0.7030.72
57_E104_S0.6970.72
28_Q32_E0.6940.72
100_T139_R0.6900.71
51_T119_D0.6860.71
18_E132_N0.6790.70
30_G66_D0.6780.70
99_N133_L0.6770.70
40_L72_V0.6750.69
30_G104_S0.6690.69
77_D81_D0.6690.69
44_T48_T0.6620.68
60_F82_F0.6590.68
92_L95_R0.6590.68
15_P90_A0.6530.67
31_V59_E0.6480.66
12_M24_M0.6480.66
139_R143_R0.6450.66
11_E43_I0.6450.66
77_D80_V0.6450.66
17_I20_V0.6350.65
21_V71_K0.6310.64
97_F102_N0.6270.64
31_V107_I0.6260.64
26_V29_G0.6190.63
103_V110_H0.6180.63
23_H104_S0.6130.62
97_F103_V0.6120.62
12_M111_T0.6110.62
27_G63_R0.6100.62
26_V68_I0.5990.60
59_E62_L0.5970.60
94_R139_R0.5930.59
93_D97_F0.5930.59
133_L141_A0.5890.59
10_H14_E0.5870.59
42_A76_D0.5870.59
53_A66_D0.5870.59
123_G143_R0.5860.59
17_I132_N0.5770.57
29_G33_L0.5760.57
44_T110_H0.5750.57
18_E71_K0.5750.57
33_L110_H0.5730.57
39_I122_I0.5720.57
32_E81_D0.5710.57
24_M53_A0.5700.56
26_V51_T0.5690.56
5_D9_F0.5670.56
76_D83_L0.5670.56
59_E118_Y0.5640.56
76_D105_F0.5630.56
22_V66_D0.5570.55
104_S132_N0.5550.55
49_V80_V0.5550.55
104_S112_D0.5540.54
20_V79_A0.5480.54
76_D92_L0.5460.53
64_Q87_L0.5460.53
107_I127_M0.5430.53
12_M77_D0.5400.53
26_V77_D0.5390.52
108_E118_Y0.5380.52
83_L136_P0.5380.52
9_F13_R0.5370.52
110_H121_N0.5370.52
26_V70_A0.5350.52
104_S118_Y0.5340.52
29_G32_E0.5320.51
22_V107_I0.5300.51
118_Y123_G0.5270.51
36_A125_Y0.5250.51
76_D101_G0.5200.50
26_V71_K0.5190.50
57_E62_L0.5190.50
20_V82_F0.5190.50
95_R111_T0.5170.49
57_E60_F0.5170.49
15_P82_F0.5120.49
105_F114_P0.5110.49
23_H96_Q0.5100.49
15_P98_D0.5090.48
29_G68_I0.5080.48
10_H88_P0.5050.48
56_P66_D0.5040.48
36_A40_L0.5030.48
30_G34_Q0.5020.47
30_G111_T0.5000.47
135_R141_A0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8D 1 0.8 100 0.115 Contact Map
3j21E 1 0.9943 100 0.124 Contact Map
3zf7L 1 0.9486 100 0.127 Contact Map
4a17D 1 0.9543 100 0.133 Contact Map
1vx7G 1 0.7086 100 0.135 Contact Map
4ujqM 1 0.9486 100 0.141 Contact Map
1iq4A 1 0.88 100 0.239 Contact Map
4tp9F 1 0.8743 100 0.239 Contact Map
4rb6G 1 0.88 100 0.24 Contact Map
3bboH 1 0.8686 100 0.247 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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