GREMLIN Database
GVPF2 - Protein GvpF 2
UniProt: P33959 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (197)
Sequences: 952 (753)
Seq/√Len: 53.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_T174_A5.4431.00
42_V68_V4.8991.00
165_Y175_F4.1281.00
113_T147_V3.4811.00
113_T168_E3.3661.00
6_L89_A2.8641.00
10_G65_L2.7251.00
99_A102_A2.7061.00
114_V169_H2.5041.00
119_K162_N2.4631.00
38_S100_R2.3991.00
41_A92_L2.3251.00
32_Y45_D2.3151.00
90_R93_K2.2991.00
109_E148_G2.2991.00
32_Y89_A2.2431.00
139_T165_Y2.1821.00
117_G197_W2.1591.00
13_D108_T2.0921.00
5_H48_T2.0441.00
9_Y44_S1.8950.99
159_L162_N1.8690.99
176_D193_Y1.8350.99
7_Y61_H1.8140.99
194_T197_W1.8000.99
120_V191_V1.7860.99
37_R100_R1.7810.99
78_V106_T1.7730.99
147_V168_E1.7600.99
13_D111_A1.7230.99
105_S109_E1.6940.99
152_N201_N1.6760.99
26_A44_S1.6670.99
33_T40_S1.6520.99
36_Y100_R1.6370.98
168_E171_T1.6180.98
29_T44_S1.5950.98
55_D58_V1.5330.98
6_L45_D1.5270.98
118_V191_V1.5200.97
114_V172_R1.5090.97
117_G201_N1.5090.97
46_I51_P1.4660.97
45_D89_A1.4500.97
25_V60_A1.3980.96
100_R104_R1.3820.96
139_T194_T1.3810.96
92_L112_G1.3710.95
139_T143_S1.3620.95
9_Y81_S1.3600.95
119_K155_F1.3470.95
62_N66_Q1.3440.95
117_G162_N1.3370.95
8_T80_M1.3270.94
10_G68_V1.3200.94
55_D59_E1.3090.94
76_A110_I1.3020.94
139_T149_E1.2650.93
146_S179_I1.2640.93
173_D177_A1.2460.92
137_D185_A1.2390.92
10_G42_V1.2360.92
58_V82_F1.2300.92
12_I42_V1.2210.92
152_N164_S1.2200.91
57_A82_F1.2180.91
112_G170_D1.2060.91
116_L172_R1.2050.91
82_F198_P1.2010.91
106_T109_E1.1950.91
7_Y198_P1.1490.89
31_A68_V1.1380.88
31_A64_V1.1370.88
34_V107_L1.1240.88
117_G194_T1.1050.87
14_D40_S1.1050.87
115_E197_W1.0970.86
120_V161_I1.0870.86
58_V62_N1.0820.86
78_V82_F1.0760.85
142_L175_F1.0640.85
121_L159_L1.0620.85
128_A132_A1.0580.84
141_R185_A1.0550.84
34_V93_K1.0540.84
89_A93_K1.0440.84
62_N201_N1.0430.83
136_S141_R1.0400.83
139_T151_E1.0380.83
122_A160_I1.0340.83
34_V43_V1.0320.83
118_V189_L1.0310.83
55_D62_N1.0280.83
180_D184_A1.0190.82
34_V96_L1.0180.82
97_R177_A1.0150.82
44_S57_A1.0130.82
66_Q198_P1.0130.82
11_I39_L1.0040.81
180_D183_D0.9980.81
14_D38_S0.9900.80
41_A112_G0.9890.80
80_M84_M0.9880.80
129_V184_A0.9830.80
92_L95_V0.9820.80
91_T94_G0.9770.79
84_M156_T0.9760.79
188_D197_W0.9760.79
172_R176_D0.9680.79
141_R182_I0.9640.78
155_F159_L0.9570.78
162_N201_N0.9440.77
41_A107_L0.9240.75
102_A140_A0.9190.75
60_A119_K0.9170.75
61_H119_K0.8980.73
6_L199_P0.8980.73
136_S140_A0.8940.73
139_T144_A0.8880.72
123_P190_T0.8790.72
137_D140_A0.8760.71
8_T21_N0.8680.71
86_F119_K0.8680.71
38_S171_T0.8610.70
111_A168_E0.8560.70
7_Y200_Y0.8540.69
14_D35_S0.8530.69
26_A107_L0.8530.69
12_I40_S0.8420.68
11_I103_L0.8410.68
34_V111_A0.8410.68
141_R181_E0.8390.68
138_V180_D0.8360.68
152_N155_F0.8330.67
112_G169_H0.8170.66
66_Q69_L0.8130.66
9_Y24_G0.8120.65
76_A108_T0.8110.65
51_P83_G0.8010.64
105_S125_D0.8000.64
11_I31_A0.7980.64
116_L167_V0.7960.64
6_L77_V0.7950.64
179_I193_Y0.7940.64
35_S38_S0.7930.64
167_V175_F0.7930.64
24_G31_A0.7920.64
117_G160_I0.7910.63
86_F192_R0.7890.63
96_L107_L0.7800.62
82_F131_T0.7800.62
121_L192_R0.7780.62
17_S70_E0.7750.62
159_L198_P0.7720.62
186_H198_P0.7680.61
145_L182_I0.7650.61
55_D82_F0.7640.61
10_G31_A0.7620.61
129_V133_A0.7530.60
151_E163_K0.7510.59
33_T42_V0.7480.59
8_T92_L0.7460.59
140_A143_S0.7450.59
133_A170_D0.7440.59
116_L193_Y0.7440.59
58_V192_R0.7430.59
86_F95_V0.7350.58
136_S139_T0.7240.57
81_S85_A0.7220.56
181_E185_A0.7200.56
5_H50_D0.7170.56
9_Y25_V0.7150.56
146_S165_Y0.7110.55
41_A96_L0.7050.55
118_V168_E0.7030.54
76_A111_A0.6970.54
81_S88_N0.6970.54
81_S84_M0.6960.54
43_V92_L0.6960.54
174_A177_A0.6950.54
36_Y97_R0.6950.54
52_E58_V0.6930.53
78_V81_S0.6930.53
68_V161_I0.6930.53
100_R174_A0.6920.53
60_A154_C0.6910.53
75_R198_P0.6830.52
51_P54_T0.6830.52
27_G30_R0.6790.52
175_F179_I0.6740.51
136_S154_C0.6720.51
69_L201_N0.6700.51
58_V197_W0.6690.51
22_V68_V0.6680.51
164_S201_N0.6670.51
75_R164_S0.6600.50
15_N19_A0.6590.50
15_N35_S0.6580.50
65_L83_G0.6560.49
10_G77_V0.6560.49
111_A174_A0.6530.49
118_V165_Y0.6520.49
68_V75_R0.6500.49
11_I87_K0.6440.48
57_A83_G0.6420.48
165_Y197_W0.6420.48
80_M190_T0.6380.48
149_E165_Y0.6370.47
139_T163_K0.6350.47
139_T161_I0.6290.47
65_L197_W0.6240.46
106_T110_I0.6230.46
37_R110_I0.6230.46
21_N177_A0.6220.46
27_G56_A0.6180.45
34_V65_L0.6140.45
118_V180_D0.6120.45
31_A188_D0.6120.45
122_A189_L0.6120.45
51_P116_L0.6110.45
8_T41_A0.6070.44
125_D132_A0.6070.44
65_L84_M0.6050.44
44_S83_G0.6030.44
42_V161_I0.6030.44
10_G58_V0.6000.44
87_K91_T0.5930.43
63_T137_D0.5920.43
79_P202_F0.5900.42
64_V199_P0.5880.42
21_N134_V0.5860.42
169_H189_L0.5860.42
26_A57_A0.5840.42
118_V146_S0.5800.41
126_D200_Y0.5800.41
38_S104_R0.5780.41
117_G165_Y0.5730.41
80_M88_N0.5730.41
53_R201_N0.5710.41
39_L107_L0.5710.41
142_L150_T0.5700.40
57_A117_G0.5700.40
117_G158_R0.5700.40
23_D27_G0.5700.40
54_T162_N0.5680.40
115_E198_P0.5670.40
31_A44_S0.5670.40
39_L135_R0.5640.40
38_S41_A0.5640.40
9_Y78_V0.5640.40
142_L189_L0.5640.40
101_R178_A0.5620.40
111_A169_H0.5600.39
38_S120_V0.5600.39
6_L92_L0.5590.39
76_A169_H0.5580.39
115_E201_N0.5540.39
79_P166_L0.5540.39
99_A123_P0.5520.39
68_V105_S0.5510.38
154_C189_L0.5500.38
116_L176_D0.5500.38
173_D178_A0.5490.38
21_N50_D0.5480.38
48_T102_A0.5460.38
46_I165_Y0.5460.38
6_L32_Y0.5410.37
125_D129_V0.5410.37
62_N69_L0.5390.37
118_V160_I0.5380.37
88_N187_D0.5380.37
20_L205_I0.5380.37
178_A181_E0.5370.37
63_T123_P0.5340.37
103_L198_P0.5290.36
10_G69_L0.5280.36
22_V58_V0.5280.36
119_K159_L0.5260.36
120_V197_W0.5240.36
123_P173_D0.5220.36
96_L114_V0.5210.36
127_T131_T0.5200.35
186_H189_L0.5190.35
103_L108_T0.5190.35
57_A201_N0.5170.35
5_H53_R0.5170.35
120_V189_L0.5160.35
137_D141_R0.5120.35
41_A80_M0.5110.35
151_E154_C0.5080.34
69_L198_P0.5050.34
26_A70_E0.5050.34
146_S163_K0.5040.34
62_N152_N0.5030.34
125_D177_A0.5020.34
9_Y31_A0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qsgA 1 0.9263 100 0.125 Contact Map
2hn1A 2 0.7281 9.7 0.957 Contact Map
3v4gA 5 0.4147 9 0.957 Contact Map
3u0kA 1 0.3502 7.7 0.959 Contact Map
3lapA 6 0.4286 6.9 0.96 Contact Map
3vv5A 1 0.2028 6.7 0.96 Contact Map
2bbhA 2 0.6221 5.3 0.962 Contact Map
2cveA 1 0.6267 5.2 0.962 Contact Map
3fkuX 1 0.1382 4.9 0.962 Contact Map
1vi7A 1 0.6544 4.8 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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