COX1 - HALSA - GREMLIN Contacts

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COX1 - Cytochrome c oxidase polypeptide 1

UniProt:	P33518	Sequences: MATAASSITLTVLMGVLLVGVVAVLARLEDWRSYTPLSDVGGGLGERTGYTHEEKPGGIIRWFTTVDHKDIGILYGVYGTIAFAWGGVSVLLMRTELATSSETLISPSLYNGLLTSHGITMLFLFGTPMIAAFGNYFIPLLIDADDMAFPRINAIAFWLLPPGAILIWSGFLIPGIATAQTSWTMYTPLSLQMSSPAVDMMMLGLHLTGVSATMGAINFIATIFTERGEDVGWPDLDIFSWTMLTQSGLILFAFPLFGSALIMLLLDRNFGTTFFTVAGGDPIFWQHLFWFFGHPEVYVLVLPPMGIVSLILPKFSGRKLFGFKFVVYSTLAIGVLSFGVWAHHMFTTGIDPRIRSSFMAVSLAISIPSAVKVFNWITTMWNGKLRLTAPMLFCIGFVQNFIIGGVTGVFLAVIPIDLILHDTYYVVGHFHFIVYGAIGFALFAASYYWFPMVTGRMYQKRLAHAHFWTALVGSNATFLAMLWLGYGGMPRRYATYIPQFATAHRLATVGAFLIGVSTLIWLFNMATSWREGPRVDSTDPWDLEETDQFTNDWAWFRAKEETTVLPDGGDEAQSEADAVTDGGQPAADSDTES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	593 (505)
Sequences:	4166 (1434)
Seq/√Len:	63.8

ECOLI - CYOB
BACSU - QOX1 COX1
HALSA - COX1 Q9HN95
SULSO - Q97UN0 Q981A5 Q97VG9 Q97XY4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
481_M	507_A	5.202	1.00
78_Y	157_F	5.068	1.00
311_I	444_A	4.520	1.00
389_A	463_A	4.325	1.00
450_F	528_S	4.139	1.00
82_A	164_A	3.975	1.00
411_L	426_V	3.791	1.00
304_P	441_A	3.759	1.00
469_T	517_S	3.603	1.00
242_T	330_T	3.581	1.00
316_S	380_M	3.566	1.00
232_G	235_D	3.495	1.00
389_A	460_K	3.454	1.00
245_T	334_G	3.316	1.00
323_F	327_V	3.186	1.00
89_S	113_L	3.068	1.00
223_I	244_L	2.957	1.00
138_I	223_I	2.931	1.00
476_A	510_G	2.895	1.00
238_I	320_L	2.834	1.00
307_I	445_A	2.830	1.00
447_Y	466_H	2.763	1.00
233_W	236_L	2.686	1.00
73_I	136_Y	2.666	1.00
432_F	475_N	2.659	1.00
105_I	113_L	2.627	1.00
312_L	398_V	2.597	1.00
181_T	198_V	2.563	1.00
224_F	233_W	2.496	1.00
185_M	285_W	2.458	1.00
61_R	70_D	2.429	1.00
380_M	391_M	2.401	1.00
347_T	421_H	2.370	1.00
101_S	495_T	2.306	1.00
459_Q	527_T	2.274	1.00
336_L	365_I	2.263	1.00
119_I	185_M	2.250	1.00
315_F	448_Y	2.243	1.00
125_F	439_G	2.234	1.00
396_G	471_L	2.226	1.00
469_T	520_I	2.218	1.00
314_K	448_Y	2.201	1.00
473_G	513_L	2.179	1.00
366_S	409_V	2.154	1.00
393_F	466_H	2.136	1.00
461_R	465_A	2.129	1.00
501_A	505_R	2.109	1.00
205_L	261_L	2.075	1.00
95_T	512_F	2.033	1.00
100_S	501_A	2.022	1.00
119_I	201_M	2.007	1.00
460_K	464_H	1.971	1.00
462_L	465_A	1.936	1.00
443_F	521_W	1.932	1.00
380_M	395_I	1.893	1.00
107_P	494_A	1.862	1.00
462_L	523_F	1.860	1.00
317_G	386_R	1.858	1.00
108_S	112_G	1.850	1.00
245_T	331_L	1.835	1.00
509_V	513_L	1.829	1.00
462_L	520_I	1.829	1.00
292_F	296_E	1.823	1.00
92_L	105_I	1.805	1.00
410_F	425_Y	1.792	1.00
446_S	521_W	1.778	1.00
527_T	531_E	1.773	1.00
253_A	338_F	1.769	1.00
466_H	470_A	1.760	1.00
199_D	268_R	1.755	1.00
466_H	521_W	1.711	0.99
92_L	113_L	1.675	0.99
286_Q	422_D	1.653	0.99
527_T	533_P	1.644	0.99
267_D	272_T	1.637	0.99
385_L	391_M	1.616	0.99
452_M	552_D	1.616	0.99
250_I	254_F	1.615	0.99
523_F	527_T	1.615	0.99
416_I	420_L	1.607	0.99
59_I	63_F	1.604	0.99
78_Y	161_P	1.604	0.99
86_G	120_T	1.595	0.99
293_G	296_E	1.587	0.99
311_I	445_A	1.578	0.99
305_M	369_S	1.577	0.99
428_G	482_L	1.571	0.99
315_F	390_P	1.568	0.99
466_H	517_S	1.563	0.99
476_A	506_L	1.556	0.99
253_A	299_V	1.554	0.99
223_I	240_S	1.538	0.99
301_V	305_M	1.534	0.99
152_I	214_M	1.528	0.99
456_R	532_G	1.526	0.99
309_S	376_W	1.525	0.99
394_C	444_A	1.512	0.99
184_T	289_F	1.508	0.99
307_I	311_I	1.495	0.98
484_L	503_A	1.493	0.98
231_V	237_D	1.489	0.98
479_L	483_W	1.487	0.98
393_F	443_F	1.485	0.98
78_Y	160_L	1.476	0.98
72_G	132_A	1.469	0.98
457_M	535_V	1.464	0.98
512_F	516_V	1.454	0.98
124_L	208_T	1.454	0.98
157_F	161_P	1.452	0.98
396_G	467_F	1.450	0.98
84_A	522_L	1.440	0.98
473_G	510_G	1.435	0.98
313_P	320_L	1.435	0.98
447_Y	463_A	1.435	0.98
469_T	516_V	1.431	0.98
88_V	92_L	1.431	0.98
179_A	201_M	1.431	0.98
400_N	475_N	1.426	0.98
443_F	466_H	1.423	0.98
223_I	236_L	1.421	0.98
456_R	528_S	1.417	0.98
326_V	330_T	1.415	0.98
220_I	244_L	1.415	0.98
91_L	511_A	1.412	0.98
227_R	230_D	1.411	0.98
550_T	558_A	1.409	0.98
557_R	560_E	1.404	0.98
307_I	449_W	1.403	0.98
523_F	526_A	1.403	0.98
477_T	511_A	1.398	0.98
98_A	505_R	1.394	0.97
76_G	132_A	1.389	0.97
95_T	104_L	1.378	0.97
141_L	240_S	1.375	0.97
266_L	272_T	1.357	0.97
256_L	291_F	1.355	0.97
224_F	244_L	1.352	0.97
550_T	554_A	1.350	0.97
96_E	101_S	1.346	0.97
477_T	514_I	1.343	0.97
137_F	448_Y	1.337	0.97
167_I	204_G	1.334	0.97
273_T	276_T	1.332	0.97
263_M	275_F	1.327	0.97
85_W	120_T	1.327	0.97
181_T	190_S	1.323	0.97
466_H	518_T	1.323	0.97
300_L	434_V	1.308	0.96
135_N	218_N	1.306	0.96
187_T	285_W	1.304	0.96
206_H	262_I	1.300	0.96
551_N	554_A	1.294	0.96
184_T	421_H	1.291	0.96
532_G	535_V	1.291	0.96
551_N	555_W	1.287	0.96
502_T	506_L	1.287	0.96
509_V	512_F	1.283	0.96
432_F	479_L	1.281	0.96
470_A	517_S	1.280	0.96
245_T	330_T	1.277	0.96
312_L	380_M	1.277	0.96
93_M	113_L	1.276	0.96
65_T	70_D	1.267	0.96
185_M	201_M	1.267	0.96
134_G	243_M	1.266	0.96
441_A	444_A	1.261	0.95
138_I	240_S	1.257	0.95
466_H	520_I	1.255	0.95
475_N	479_L	1.254	0.95
333_I	372_K	1.252	0.95
216_A	251_L	1.251	0.95
185_M	198_V	1.245	0.95
519_L	523_F	1.242	0.95
392_L	467_F	1.240	0.95
417_D	426_V	1.239	0.95
138_I	142_I	1.228	0.95
216_A	247_S	1.225	0.95
260_A	285_W	1.220	0.95
91_L	515_G	1.218	0.95
85_W	89_S	1.218	0.95
124_L	164_A	1.214	0.94
246_Q	299_V	1.200	0.94
466_H	524_N	1.198	0.94
327_V	330_T	1.185	0.94
362_S	412_A	1.183	0.94
224_F	248_G	1.176	0.93
137_F	453_V	1.176	0.93
550_T	559_K	1.174	0.93
539_D	543_L	1.172	0.93
380_M	385_L	1.170	0.93
483_W	503_A	1.169	0.93
135_N	153_N	1.169	0.93
481_M	484_L	1.163	0.93
154_A	158_W	1.161	0.93
389_A	464_H	1.159	0.93
67_D	70_D	1.158	0.93
199_D	269_N	1.157	0.93
347_T	418_L	1.142	0.92
230_D	235_D	1.140	0.92
83_F	90_V	1.139	0.92
187_T	264_L	1.131	0.92
461_R	464_H	1.128	0.92
326_V	329_S	1.123	0.92
393_F	447_Y	1.121	0.92
436_G	474_S	1.117	0.92
315_F	391_M	1.114	0.91
359_M	414_I	1.112	0.91
465_A	520_I	1.105	0.91
231_V	236_L	1.103	0.91
62_W	74_L	1.102	0.91
60_I	64_T	1.100	0.91
463_A	524_N	1.096	0.91
83_F	86_G	1.095	0.91
298_Y	303_P	1.092	0.91
522_L	526_A	1.092	0.91
362_S	411_L	1.084	0.90
411_L	420_L	1.072	0.90
554_A	559_K	1.063	0.89
78_Y	82_A	1.062	0.89
130_I	216_A	1.062	0.89
363_L	412_A	1.061	0.89
311_I	390_P	1.060	0.89
239_F	243_M	1.057	0.89
552_D	555_W	1.056	0.89
80_T	84_A	1.053	0.89
290_W	293_G	1.053	0.89
76_G	453_V	1.047	0.89
245_T	248_G	1.047	0.89
109_L	113_L	1.046	0.89
116_S	171_F	1.045	0.89
470_A	514_I	1.029	0.88
181_T	185_M	1.028	0.88
263_M	274_F	1.028	0.88
526_A	530_R	1.026	0.88
308_V	397_F	1.023	0.87
428_G	481_M	1.022	0.87
119_I	285_W	1.021	0.87
62_W	70_D	1.020	0.87
91_L	508_T	1.018	0.87
133_F	307_I	1.016	0.87
77_V	81_I	1.016	0.87
424_Y	489_M	1.015	0.87
206_H	261_L	1.014	0.87
163_G	204_G	1.012	0.87
58_G	61_R	1.002	0.86
311_I	394_C	0.997	0.86
131_A	211_S	0.996	0.86
220_I	251_L	0.996	0.86
372_K	376_W	0.993	0.86
126_G	300_L	0.991	0.86
96_E	103_T	0.990	0.86
228_G	562_T	0.989	0.86
65_T	154_A	0.986	0.85
305_M	376_W	0.986	0.85
219_F	223_I	0.984	0.85
187_T	190_S	0.980	0.85
156_A	214_M	0.978	0.85
99_T	102_E	0.975	0.85
73_I	453_V	0.974	0.85
505_R	509_V	0.970	0.85
311_I	441_A	0.969	0.84
83_F	125_F	0.965	0.84
308_V	312_L	0.965	0.84
309_S	372_K	0.963	0.84
79_G	129_M	0.960	0.84
539_D	542_D	0.958	0.84
490_P	493_Y	0.955	0.84
120_T	168_W	0.952	0.83
392_L	464_H	0.952	0.83
96_E	495_T	0.951	0.83
155_I	159_L	0.951	0.83
301_V	437_A	0.948	0.83
171_F	174_P	0.947	0.83
313_P	319_K	0.942	0.83
348_T	422_D	0.941	0.83
489_M	504_H	0.940	0.83
266_L	270_F	0.939	0.83
218_N	222_T	0.939	0.83
480_A	503_A	0.938	0.82
120_T	164_A	0.936	0.82
233_W	244_L	0.933	0.82
74_L	157_F	0.933	0.82
84_A	88_V	0.933	0.82
315_F	541_W	0.920	0.81
80_T	522_L	0.916	0.81
446_S	525_M	0.913	0.81
380_M	383_G	0.913	0.81
134_G	219_F	0.912	0.81
301_V	438_I	0.911	0.81
212_A	250_I	0.910	0.81
190_S	264_L	0.906	0.80
138_I	243_M	0.905	0.80
220_I	248_G	0.904	0.80
404_G	433_I	0.903	0.80
389_A	392_L	0.902	0.80
234_P	328_Y	0.902	0.80
59_I	74_L	0.899	0.80
126_G	438_I	0.896	0.79
470_A	518_T	0.895	0.79
123_F	292_F	0.890	0.79
169_S	200_M	0.890	0.79
97_L	424_Y	0.889	0.79
235_D	565_L	0.889	0.79
529_W	532_G	0.885	0.79
90_V	436_G	0.885	0.79
387_L	391_M	0.885	0.79
409_V	412_A	0.883	0.78
170_G	179_A	0.882	0.78
209_G	258_G	0.880	0.78
126_G	434_V	0.879	0.78
305_M	372_K	0.876	0.78
550_T	555_W	0.875	0.78
126_G	439_G	0.875	0.78
142_I	240_S	0.873	0.78
185_M	190_S	0.871	0.78
238_I	326_V	0.869	0.77
460_K	463_A	0.865	0.77
443_F	518_T	0.865	0.77
296_E	300_L	0.863	0.77
71_I	153_N	0.863	0.77
432_F	482_L	0.859	0.77
78_Y	164_A	0.857	0.76
407_T	482_L	0.852	0.76
469_T	513_L	0.852	0.76
163_G	208_T	0.852	0.76
308_V	441_A	0.850	0.76
229_E	562_T	0.849	0.76
315_F	388_T	0.848	0.76
520_I	523_F	0.847	0.76
472_V	519_L	0.847	0.76
367_I	371_V	0.845	0.75
443_F	470_A	0.843	0.75
179_A	185_M	0.843	0.75
317_G	542_D	0.843	0.75
295_P	298_Y	0.838	0.75
337_S	422_D	0.835	0.75
335_V	339_G	0.834	0.74
450_F	529_W	0.834	0.74
320_L	323_F	0.833	0.74
390_P	458_Y	0.832	0.74
366_S	372_K	0.831	0.74
236_L	240_S	0.829	0.74
308_V	394_C	0.828	0.74
538_T	551_N	0.826	0.74
319_K	324_K	0.825	0.74
281_D	492_R	0.823	0.73
125_F	129_M	0.821	0.73
180_Q	193_M	0.818	0.73
369_S	372_K	0.818	0.73
85_W	168_W	0.817	0.73
206_H	258_G	0.816	0.73
159_L	207_L	0.815	0.73
130_I	243_M	0.814	0.73
261_L	265_L	0.810	0.72
535_V	552_D	0.809	0.72
451_P	457_M	0.807	0.72
456_R	529_W	0.807	0.72
92_L	104_L	0.806	0.72
329_S	332_A	0.802	0.71
204_G	262_I	0.802	0.71
473_G	517_S	0.800	0.71
254_F	258_G	0.798	0.71
515_G	519_L	0.796	0.71
97_L	504_H	0.796	0.71
388_T	464_H	0.794	0.71
227_R	235_D	0.793	0.71
179_A	285_W	0.793	0.71
399_Q	403_I	0.793	0.71
110_Y	114_L	0.792	0.71
202_M	265_L	0.791	0.70
127_T	293_G	0.790	0.70
292_F	300_L	0.787	0.70
265_L	269_N	0.785	0.70
434_V	438_I	0.783	0.70
406_V	409_V	0.782	0.70
119_I	167_I	0.782	0.70
93_M	118_G	0.781	0.69
396_G	440_F	0.781	0.69
70_D	74_L	0.779	0.69
238_I	490_P	0.779	0.69
179_A	198_V	0.775	0.69
252_F	338_F	0.775	0.69
193_M	196_P	0.774	0.69
305_M	370_A	0.773	0.69
450_F	458_Y	0.773	0.69
458_Y	463_A	0.772	0.69
131_A	250_I	0.772	0.69
215_G	260_A	0.771	0.68
342_A	350_I	0.770	0.68
443_F	447_Y	0.770	0.68
151_R	155_I	0.768	0.68
286_Q	348_T	0.768	0.68
459_Q	523_F	0.768	0.68
62_W	65_T	0.768	0.68
87_G	90_V	0.768	0.68
524_N	528_S	0.767	0.68
438_I	442_L	0.767	0.68
392_L	468_W	0.765	0.68
160_L	211_S	0.761	0.67
283_I	348_T	0.760	0.67
166_L	200_M	0.757	0.67
549_F	560_E	0.753	0.67
386_R	542_D	0.753	0.67
287_H	482_L	0.749	0.66
227_R	231_V	0.748	0.66
390_P	448_Y	0.748	0.66
372_K	375_N	0.748	0.66
87_G	518_T	0.747	0.66
165_I	169_S	0.745	0.66
95_T	508_T	0.741	0.65
426_V	430_F	0.740	0.65
428_G	480_A	0.740	0.65
402_I	406_V	0.737	0.65
410_F	416_I	0.735	0.65
293_G	300_L	0.735	0.65
103_T	495_T	0.732	0.64
129_M	155_I	0.732	0.64
106_S	109_L	0.731	0.64
326_V	371_V	0.729	0.64
376_W	397_F	0.729	0.64
242_T	302_L	0.729	0.64
132_A	454_T	0.723	0.63
326_V	375_N	0.720	0.63
393_F	467_F	0.720	0.63
456_R	531_E	0.719	0.63
450_F	454_T	0.719	0.63
234_P	323_F	0.717	0.63
424_Y	504_H	0.717	0.63
84_A	518_T	0.717	0.63
155_I	214_M	0.717	0.63
86_G	122_L	0.716	0.63
297_V	303_P	0.715	0.63
249_L	362_S	0.714	0.63
237_D	240_S	0.712	0.62
136_Y	453_V	0.710	0.62
137_F	141_L	0.706	0.62
507_A	510_G	0.705	0.62
295_P	303_P	0.704	0.61
63_F	564_V	0.703	0.61
93_M	114_L	0.701	0.61
351_D	355_R	0.701	0.61
205_L	208_T	0.701	0.61
520_I	524_N	0.700	0.61
206_H	265_L	0.700	0.61
213_T	258_G	0.700	0.61
94_R	97_L	0.699	0.61
122_L	300_L	0.699	0.61
459_Q	528_S	0.699	0.61
66_V	154_A	0.698	0.61
147_M	219_F	0.697	0.61
143_D	455_G	0.696	0.61
248_G	262_I	0.695	0.60
508_T	512_F	0.694	0.60
355_R	418_L	0.693	0.60
125_F	243_M	0.692	0.60
373_V	398_V	0.691	0.60
536_D	552_D	0.690	0.60
104_L	109_L	0.690	0.60
108_S	180_Q	0.690	0.60
58_G	63_F	0.690	0.60
131_A	282_P	0.688	0.60
550_T	560_E	0.688	0.60
389_A	393_F	0.688	0.60
366_S	374_F	0.688	0.60
447_Y	524_N	0.686	0.59
533_P	536_D	0.685	0.59
242_T	320_L	0.684	0.59
116_S	179_A	0.684	0.59
493_Y	504_H	0.683	0.59
506_L	510_G	0.683	0.59
535_V	538_T	0.683	0.59
434_V	437_A	0.681	0.59
283_I	422_D	0.681	0.59
298_Y	405_G	0.680	0.59
474_S	514_I	0.680	0.59
95_T	251_L	0.680	0.59
118_G	430_F	0.679	0.59
454_T	457_M	0.679	0.59
254_F	296_E	0.678	0.59
470_A	526_A	0.678	0.59
287_H	345_M	0.678	0.59
248_G	334_G	0.676	0.58
162_P	165_I	0.675	0.58
81_I	165_I	0.672	0.58
135_N	146_D	0.672	0.58
476_A	509_V	0.671	0.58
457_M	536_D	0.671	0.58
127_T	292_F	0.669	0.58
90_V	435_Y	0.669	0.58
228_G	231_V	0.667	0.57
460_K	465_A	0.666	0.57
301_V	376_W	0.665	0.57
105_I	109_L	0.665	0.57
457_M	528_S	0.663	0.57
321_F	379_T	0.663	0.57
305_M	333_I	0.660	0.57
182_S	492_R	0.660	0.57
517_S	545_E	0.658	0.56
88_V	210_V	0.657	0.56
346_F	414_I	0.657	0.56
476_A	513_L	0.656	0.56
551_N	559_K	0.656	0.56
156_A	219_F	0.655	0.56
216_A	253_A	0.654	0.56
248_G	332_A	0.650	0.55
230_D	463_A	0.650	0.55
253_A	412_A	0.648	0.55
294_H	343_H	0.647	0.55
102_E	107_P	0.647	0.55
538_T	550_T	0.646	0.55
258_G	262_I	0.645	0.55
440_F	467_F	0.641	0.54
267_D	273_T	0.641	0.54
406_V	436_G	0.641	0.54
79_G	125_F	0.641	0.54
450_F	456_R	0.641	0.54
203_L	262_I	0.641	0.54
305_M	329_S	0.640	0.54
332_A	554_A	0.640	0.54
124_L	163_G	0.638	0.54
357_S	361_V	0.637	0.54
88_V	165_I	0.636	0.54
400_N	471_L	0.635	0.54
336_L	368_P	0.634	0.54
143_D	230_D	0.632	0.53
287_H	422_D	0.631	0.53
454_T	528_S	0.630	0.53
93_M	300_L	0.629	0.53
125_F	394_C	0.628	0.53
489_M	496_Y	0.628	0.53
551_N	560_E	0.627	0.53
234_P	320_L	0.627	0.53
68_H	140_L	0.626	0.53
359_M	413_V	0.625	0.52
61_R	65_T	0.625	0.52
130_I	442_L	0.625	0.52
349_G	401_F	0.624	0.52
324_K	328_Y	0.624	0.52
153_N	222_T	0.622	0.52
149_F	221_A	0.622	0.52
208_T	211_S	0.620	0.52
397_F	433_I	0.619	0.52
219_F	243_M	0.619	0.52
301_V	433_I	0.618	0.52
309_S	366_S	0.618	0.52
126_G	442_L	0.618	0.52
120_T	167_I	0.618	0.52
300_L	438_I	0.617	0.52
262_I	265_L	0.617	0.52
188_P	491_R	0.615	0.51
504_H	508_T	0.615	0.51
390_P	444_A	0.614	0.51
63_F	410_F	0.614	0.51
84_A	393_F	0.613	0.51
87_G	515_G	0.612	0.51
465_A	523_F	0.612	0.51
439_G	453_V	0.609	0.51
87_G	91_L	0.609	0.51
99_T	501_A	0.608	0.51
68_H	342_A	0.608	0.51
312_L	394_C	0.608	0.51
313_P	540_P	0.607	0.50
391_M	394_C	0.607	0.50
68_H	72_G	0.606	0.50
92_L	472_V	0.606	0.50
110_Y	288_L	0.606	0.50
127_T	296_E	0.605	0.50
89_S	92_L	0.603	0.50
432_F	437_A	0.603	0.50
147_M	365_I	0.602	0.50
127_T	250_I	0.602	0.50
472_V	513_L	0.600	0.50
538_T	541_W	0.599	0.49
281_D	438_I	0.599	0.49
144_A	229_E	0.599	0.49
559_K	562_T	0.599	0.49
248_G	331_L	0.598	0.49
60_I	65_T	0.597	0.49
210_V	214_M	0.597	0.49
531_E	534_R	0.597	0.49
560_E	564_V	0.596	0.49
209_G	372_K	0.595	0.49
181_T	193_M	0.595	0.49
301_V	372_K	0.593	0.49
555_W	560_E	0.590	0.48
91_L	519_L	0.589	0.48
321_F	333_I	0.589	0.48
202_M	285_W	0.589	0.48
147_M	215_G	0.588	0.48
204_G	208_T	0.587	0.48
333_I	376_W	0.584	0.48
211_S	281_D	0.584	0.48
314_K	541_W	0.584	0.48
402_I	437_A	0.583	0.48
316_S	383_G	0.583	0.48
71_I	74_L	0.582	0.48
345_M	422_D	0.581	0.47
415_P	420_L	0.581	0.47
328_Y	332_A	0.581	0.47
242_T	325_F	0.581	0.47
115_T	119_I	0.580	0.47
540_P	543_L	0.580	0.47
452_M	548_Q	0.579	0.47
217_I	221_A	0.579	0.47
387_L	395_I	0.579	0.47
131_A	135_N	0.578	0.47
153_N	209_G	0.578	0.47
134_G	247_S	0.577	0.47
151_R	281_D	0.577	0.47
484_L	489_M	0.576	0.47
341_W	358_F	0.576	0.47
122_L	127_T	0.575	0.47
301_V	304_P	0.575	0.47
267_D	365_I	0.575	0.47
260_A	307_I	0.574	0.47
346_F	359_M	0.574	0.47
550_T	556_F	0.574	0.47
132_A	208_T	0.573	0.46
316_S	385_L	0.571	0.46
256_L	260_A	0.570	0.46
174_P	194_S	0.570	0.46
457_M	533_P	0.568	0.46
153_N	218_N	0.568	0.46
260_A	289_F	0.566	0.46
559_K	563_T	0.565	0.46
113_L	194_S	0.564	0.45
373_V	402_I	0.564	0.45
108_S	197_A	0.564	0.45
103_T	494_A	0.562	0.45
250_I	293_G	0.562	0.45
75_Y	135_N	0.562	0.45
325_F	421_H	0.558	0.45
459_Q	465_A	0.558	0.45
546_T	549_F	0.558	0.45
219_F	247_S	0.558	0.45
527_T	530_R	0.556	0.45
227_R	233_W	0.555	0.44
245_T	327_V	0.555	0.44
526_A	531_E	0.554	0.44
81_I	85_W	0.554	0.44
315_F	558_A	0.554	0.44
355_R	439_G	0.553	0.44
321_F	375_N	0.553	0.44
305_M	309_S	0.552	0.44
415_P	434_V	0.551	0.44
89_S	168_W	0.551	0.44
139_P	222_T	0.550	0.44
369_S	373_V	0.550	0.44
325_F	329_S	0.550	0.44
123_F	433_I	0.550	0.44
314_K	545_E	0.550	0.44
211_S	261_L	0.550	0.44
228_G	235_D	0.550	0.44
493_Y	496_Y	0.550	0.44
148_A	222_T	0.548	0.44
388_T	460_K	0.547	0.43
366_S	376_W	0.547	0.43
161_P	165_I	0.546	0.43
465_A	505_R	0.546	0.43
254_F	327_V	0.546	0.43
540_P	552_D	0.545	0.43
509_V	519_L	0.545	0.43
554_A	563_T	0.545	0.43
536_D	540_P	0.544	0.43
301_V	434_V	0.544	0.43
247_S	299_V	0.544	0.43
146_D	153_N	0.543	0.43
532_G	536_D	0.543	0.43
359_M	507_A	0.543	0.43
249_L	300_L	0.543	0.43
111_N	424_Y	0.541	0.43
332_A	335_V	0.540	0.43
225_T	428_G	0.540	0.43
98_A	196_P	0.540	0.43
353_R	357_S	0.540	0.43
315_F	387_L	0.539	0.43
68_H	148_A	0.537	0.42
235_D	558_A	0.537	0.42
82_A	86_G	0.537	0.42
535_V	540_P	0.536	0.42
221_A	251_L	0.536	0.42
549_F	555_W	0.535	0.42
483_W	487_G	0.534	0.42
117_H	431_H	0.534	0.42
547_D	553_W	0.534	0.42
366_S	369_S	0.534	0.42
442_L	446_S	0.534	0.42
206_H	209_G	0.534	0.42
229_E	323_F	0.534	0.42
371_V	459_Q	0.533	0.42
457_M	540_P	0.533	0.42
388_T	448_Y	0.532	0.42
187_T	417_D	0.532	0.42
270_F	384_K	0.532	0.42
238_I	421_H	0.531	0.42
188_P	282_P	0.530	0.42
304_P	308_V	0.530	0.42
195_S	549_F	0.529	0.41
178_T	197_A	0.529	0.41
84_A	519_L	0.528	0.41
147_M	160_L	0.528	0.41
534_R	551_N	0.528	0.41
529_W	533_P	0.526	0.41
516_V	520_I	0.526	0.41
546_T	565_L	0.526	0.41
144_A	226_E	0.526	0.41
116_S	201_M	0.525	0.41
295_P	340_V	0.524	0.41
254_F	263_M	0.524	0.41
119_I	181_T	0.524	0.41
88_V	278_A	0.523	0.41
73_I	77_V	0.523	0.41
106_S	517_S	0.523	0.41
64_T	85_W	0.522	0.41
170_G	201_M	0.522	0.41
208_T	212_A	0.521	0.41
541_W	552_D	0.521	0.41
321_F	372_K	0.520	0.40
393_F	521_W	0.518	0.40
527_T	532_G	0.516	0.40
347_T	440_F	0.516	0.40
61_R	556_F	0.516	0.40
169_S	465_A	0.515	0.40
548_Q	555_W	0.514	0.40
383_G	541_W	0.514	0.40
398_V	479_L	0.514	0.40
519_L	526_A	0.513	0.40
451_P	454_T	0.513	0.40
260_A	284_F	0.513	0.40
337_S	365_I	0.512	0.40
458_Y	532_G	0.512	0.40
457_M	532_G	0.512	0.40
464_H	467_F	0.511	0.39
187_T	212_A	0.510	0.39
562_T	565_L	0.509	0.39
373_V	433_I	0.509	0.39
456_R	534_R	0.508	0.39
118_G	122_L	0.508	0.39
289_F	297_V	0.507	0.39
469_T	505_R	0.507	0.39
250_I	299_V	0.507	0.39
546_T	563_T	0.507	0.39
435_Y	514_I	0.506	0.39
523_F	534_R	0.506	0.39
236_L	323_F	0.505	0.39
231_V	543_L	0.504	0.39
217_I	421_H	0.504	0.39
467_F	471_L	0.504	0.39
119_I	164_A	0.504	0.39
84_A	511_A	0.503	0.39
232_G	555_W	0.503	0.39
152_I	217_I	0.502	0.38
232_G	323_F	0.502	0.38
452_M	541_W	0.502	0.38
143_D	546_T	0.501	0.38
336_L	339_G	0.501	0.38
394_C	398_V	0.500	0.38
203_L	207_L	0.500	0.38

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1fftA	1	0.8297	100	0.173	Contact Map
2yevA	1	0.8938	100	0.183	Contact Map
2gsmA	1	0.8432	100	0.196	Contact Map
1v54A	1	0.8583	100	0.219	Contact Map
3s8fA	1	0.8634	100	0.338	Contact Map
3ayfA	2	0.8381	100	0.378	Contact Map
3mk7A	1	0.7403	100	0.406	Contact Map
3wfdB	1	0.7083	100	0.422	Contact Map
4c7rA	3	0.0995	29.4	0.983	Contact Map
4djkA	2	0.0658	29.4	0.983	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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