GREMLIN Database
Y1336 - Putative esterase VNG_1336C
UniProt: P20378 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (122)
Sequences: 5068 (3407)
Seq/√Len: 308.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_R103_D3.4691.00
31_E41_R3.1621.00
90_I117_V2.6641.00
39_R107_D2.5591.00
107_D125_V2.3381.00
32_D37_E2.2451.00
29_S41_R2.2221.00
32_D39_R2.1821.00
40_L70_A2.1001.00
126_T134_E2.0861.00
42_I62_I2.0411.00
34_S37_E2.0101.00
64_A92_L1.9971.00
123_S137_E1.9971.00
71_G122_I1.9701.00
37_E109_S1.8901.00
75_V118_G1.8271.00
41_R105_I1.7581.00
70_A106_A1.7561.00
43_P103_D1.6901.00
126_T136_T1.6891.00
37_E107_D1.6881.00
121_E140_V1.6781.00
98_R136_T1.6721.00
39_R105_I1.6611.00
109_S123_S1.6511.00
109_S121_E1.6451.00
67_I122_I1.6101.00
67_I141_G1.5791.00
31_E39_R1.5741.00
91_D95_S1.5421.00
111_V121_E1.5141.00
64_A96_Y1.4321.00
25_F47_K1.4001.00
111_V140_V1.3791.00
100_A138_V1.3581.00
64_A94_V1.3551.00
22_L62_I1.3311.00
110_V113_V1.3311.00
71_G143_G1.3271.00
78_A113_V1.3031.00
67_I124_V1.2961.00
14_Q18_D1.2861.00
36_G77_S1.2811.00
66_L106_A1.2611.00
22_L65_T1.2381.00
125_V135_P1.2351.00
106_A122_I1.2141.00
100_A104_L1.1951.00
63_A139_A1.1921.00
44_Y58_V1.1791.00
45_H48_L1.1761.00
58_V104_L1.1541.00
75_V145_F1.1321.00
123_S140_V1.1241.00
75_V120_A1.1241.00
74_A110_V1.1001.00
46_E49_T1.0961.00
49_T101_R1.0731.00
29_S103_D1.0711.00
94_V139_A1.0651.00
103_D127_P1.0421.00
118_G147_V1.0371.00
121_E142_R0.9781.00
97_L140_V0.9561.00
107_D123_S0.9471.00
68_D89_T0.9431.00
112_R117_V0.9381.00
42_I66_L0.9261.00
119_V144_S0.9241.00
29_S43_P0.9231.00
15_S18_D0.9221.00
63_A96_Y0.9201.00
63_A124_V0.9111.00
48_L62_I0.8861.00
76_R86_N0.8841.00
104_L138_V0.8801.00
125_V137_E0.8781.00
78_A110_V0.8721.00
60_G96_Y0.8691.00
57_D88_A0.8671.00
71_G120_A0.8521.00
80_P85_A0.8421.00
107_D135_P0.8261.00
95_S119_V0.8241.00
97_L112_R0.8231.00
71_G145_F0.8001.00
116_T146_R0.7991.00
28_V40_L0.7971.00
93_N142_R0.7881.00
110_V120_A0.7861.00
61_G65_T0.7841.00
106_A124_V0.7800.99
112_R119_V0.7790.99
51_H72_G0.7650.99
68_D72_G0.7580.99
105_I127_P0.7570.99
31_E103_D0.7540.99
44_Y48_L0.7510.99
35_D78_A0.7470.99
63_A100_A0.7460.99
74_A108_A0.7440.99
97_L137_E0.7410.99
104_L124_V0.7410.99
44_Y49_T0.7410.99
30_V40_L0.7340.99
43_P48_L0.7330.99
127_P134_E0.7280.99
23_L69_T0.7220.99
95_S144_S0.7220.99
28_V42_I0.7210.99
59_H69_T0.7190.99
92_L96_Y0.7150.99
71_G141_G0.7140.99
105_I135_P0.7120.99
117_V146_R0.7100.99
67_I94_V0.6960.99
46_E101_R0.6830.99
40_L108_A0.6800.99
98_R112_R0.6670.98
95_S142_R0.6660.98
92_L141_G0.6620.98
91_D142_R0.6620.98
108_A122_I0.6620.98
105_I125_V0.6540.98
36_G74_A0.6520.98
76_R87_V0.6420.98
27_G47_K0.6410.98
18_D24_S0.6390.98
91_D144_S0.6360.98
90_I146_R0.6350.98
24_S47_K0.6260.98
113_V118_G0.6230.98
72_G145_F0.6200.97
89_T145_F0.6070.97
79_L147_V0.6050.97
52_G57_D0.6000.97
95_S140_V0.6000.97
70_A108_A0.5980.97
38_M74_A0.5910.97
36_G78_A0.5900.97
119_V140_V0.5830.96
19_D24_S0.5810.96
97_L119_V0.5780.96
63_A138_V0.5780.96
85_A147_V0.5770.96
23_L73_L0.5740.96
41_R127_P0.5740.96
137_E140_V0.5740.96
89_T92_L0.5720.96
89_T143_G0.5710.96
122_I143_G0.5690.96
105_I126_T0.5680.96
75_V87_V0.5660.96
33_A77_S0.5660.96
49_T57_D0.5600.95
126_T138_V0.5540.95
52_G88_A0.5510.95
21_G24_S0.5480.95
50_N60_G0.5470.95
15_S19_D0.5440.95
74_A120_A0.5390.94
48_L58_V0.5360.94
126_T135_P0.5360.94
23_L28_V0.5350.94
31_E105_I0.5320.94
98_R126_T0.5300.94
75_V113_V0.5280.94
57_D99_P0.5220.93
79_L85_A0.5210.93
36_G110_V0.5180.93
44_Y104_L0.5170.93
25_F48_L0.5140.93
30_V73_L0.5140.93
98_R146_R0.5130.93
58_V100_A0.5090.93
20_H51_H0.5080.92
88_A146_R0.5060.92
111_V123_S0.5060.92
93_N144_S0.5050.92
111_V137_E0.5040.92
31_E40_L0.5020.92
122_I141_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3e8pA 3 0.9139 99.9 0.334 Contact Map
4rmmA 2 0.8874 99.9 0.335 Contact Map
3f1tA 2 0.8742 99.9 0.337 Contact Map
3lmbA 2 0.9669 99.9 0.343 Contact Map
3e1eA 3 0.9073 99.9 0.344 Contact Map
1sh8A 2 0.894 99.9 0.346 Contact Map
1t82A 2 0.9139 99.9 0.348 Contact Map
3gekA 3 0.8013 99.9 0.354 Contact Map
3hduA 4 0.9073 99.9 0.355 Contact Map
3nwzA 3 0.9272 99.9 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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