Y1111 - HALSA - GREMLIN Contacts

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Y1111 - Uncharacterized GTP-binding protein VNG_1111G

UniProt:	P17103	Sequences: MGLEEDIESLEEEIANTPYNKSTEAHIGRLKAKLAEQKEKLEAQQSGSGGGGGYAVEQHGDATVALVGFPSVGKSSLINAMTNADSEVGAYEFTTLNVNPGMLEYRGANIQLLDVPGLIEGAAGGRGGGKEILSVIRGADLVIFVLSAFEIEQYDRLAEELYNVNIRVDAEPPSVTVRRKGKDGIDVNTSGELELDSDTVKGILRERGFINANVTIRGNPSVDRLIDGVMDNRVYMPSLVTVNKVDLIEPSYAGTMKDALRDHGVSPDDAIFISAAEEKGLDVLKERMWRALGLIRIYMDKPGRGVDREEPLIIRRGETVDDAVQKLGGTLDERFRFARVTGPSAQHDDQQVGRDHVLEDEDVLRVVARR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	370 (298)
Sequences:	3826 (2206)
Seq/√Len:	127.8

ECOLI - YCHF
BACSU - YCHF
HALSA - Y1111 Q9HP92 Q9HRX2
SULSO - Q97W55 Q7LXL0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
358_L	364_L	4.900	1.00
322_D	332_D	3.854	1.00
246_D	249_E	3.443	1.00
351_Q	367_V	3.141	1.00
315_R	318_E	2.819	1.00
342_G	346_Q	2.703	1.00
300_D	305_G	2.622	1.00
295_I	316_R	2.622	1.00
340_V	364_L	2.602	1.00
87_E	94_T	2.554	1.00
314_I	318_E	2.545	1.00
271_I	274_S	2.491	1.00
271_I	275_A	2.325	1.00
318_E	322_D	2.314	1.00
270_A	274_S	2.293	1.00
173_P	197_S	2.264	1.00
340_V	358_L	2.194	1.00
272_F	275_A	2.194	1.00
249_E	252_Y	2.170	1.00
314_I	323_A	2.157	1.00
276_A	280_G	2.104	1.00
267_P	271_I	2.102	1.00
197_S	201_K	2.069	1.00
267_P	272_F	2.068	1.00
319_T	357_V	2.068	1.00
271_I	276_A	2.066	1.00
267_P	275_A	2.058	1.00
272_F	276_A	2.044	1.00
339_R	367_V	2.026	1.00
337_F	351_Q	2.010	1.00
267_P	276_A	2.001	1.00
244_K	249_E	2.001	1.00
334_R	368_A	1.996	1.00
143_I	241_T	1.977	1.00
342_G	345_A	1.972	1.00
64_V	288_M	1.970	1.00
245_V	248_I	1.967	1.00
255_T	258_D	1.928	1.00
290_R	316_R	1.915	1.00
270_A	275_A	1.914	1.00
144_F	238_S	1.890	1.00
344_S	349_D	1.882	1.00
215_T	218_G	1.864	1.00
316_R	359_E	1.858	1.00
337_F	367_V	1.831	1.00
198_D	201_K	1.825	1.00
146_L	154_Y	1.822	1.00
277_E	280_G	1.791	1.00
210_I	213_N	1.775	1.00
202_G	224_R	1.723	1.00
293_G	316_R	1.705	1.00
241_T	284_L	1.694	1.00
174_S	177_V	1.683	1.00
256_M	259_A	1.671	1.00
239_L	291_A	1.660	1.00
184_G	187_V	1.658	1.00
248_I	252_Y	1.655	1.00
244_K	247_L	1.625	1.00
203_I	215_T	1.618	1.00
159_E	163_N	1.608	1.00
215_T	235_Y	1.604	1.00
221_S	224_R	1.590	1.00
201_K	205_R	1.570	1.00
62_A	288_M	1.570	1.00
267_P	270_A	1.560	1.00
267_P	274_S	1.559	1.00
273_I	280_G	1.554	1.00
245_V	249_E	1.530	1.00
164_V	168_V	1.527	1.00
257_K	272_F	1.511	1.00
286_E	290_R	1.503	1.00
343_P	349_D	1.499	1.00
256_M	261_R	1.498	1.00
270_A	276_A	1.491	1.00
341_T	344_S	1.464	1.00
295_I	314_I	1.461	1.00
269_D	272_F	1.459	1.00
177_V	201_K	1.452	1.00
257_K	261_R	1.443	1.00
349_D	365_R	1.442	1.00
258_D	262_D	1.434	1.00
204_L	208_G	1.419	1.00
206_E	218_G	1.417	1.00
244_K	248_I	1.400	1.00
198_D	202_G	1.395	1.00
257_K	263_H	1.387	1.00
249_E	253_A	1.384	1.00
274_S	277_E	1.377	1.00
339_R	365_R	1.357	1.00
255_T	259_A	1.348	1.00
120_E	156_R	1.321	1.00
259_A	263_H	1.301	1.00
196_D	202_G	1.280	1.00
206_E	209_F	1.275	1.00
314_I	326_K	1.268	1.00
185_I	188_N	1.264	1.00
166_I	204_L	1.260	1.00
295_I	318_E	1.259	1.00
106_R	285_K	1.253	1.00
302_P	305_G	1.252	1.00
271_I	280_G	1.250	1.00
287_R	290_R	1.237	1.00
256_M	260_L	1.237	1.00
64_V	143_I	1.227	1.00
134_S	138_G	1.216	0.99
287_R	291_A	1.214	0.99
340_V	351_Q	1.204	0.99
318_E	326_K	1.202	0.99
176_T	197_S	1.195	0.99
244_K	253_A	1.177	0.99
325_Q	332_D	1.171	0.99
270_A	273_I	1.170	0.99
102_M	111_Q	1.167	0.99
273_I	277_E	1.160	0.99
273_I	276_A	1.160	0.99
269_D	275_A	1.153	0.99
203_I	206_E	1.148	0.99
248_I	254_G	1.146	0.99
76_S	275_A	1.146	0.99
276_A	279_K	1.133	0.99
63_T	111_Q	1.129	0.99
156_R	160_E	1.120	0.99
206_E	210_I	1.119	0.99
250_P	253_A	1.101	0.99
175_V	179_R	1.100	0.99
183_D	186_D	1.093	0.99
200_V	204_L	1.088	0.99
63_T	139_A	1.087	0.99
168_V	172_P	1.086	0.99
271_I	277_E	1.079	0.99
86_S	89_G	1.076	0.99
331_L	366_V	1.071	0.99
79_N	88_V	1.070	0.99
209_F	212_A	1.068	0.99
173_P	200_V	1.065	0.99
257_K	273_I	1.064	0.99
148_A	242_V	1.063	0.99
265_V	271_I	1.053	0.98
205_R	211_N	1.051	0.98
65_A	139_A	1.051	0.98
269_D	274_S	1.047	0.98
263_H	273_I	1.045	0.98
259_A	262_D	1.044	0.98
323_A	358_L	1.034	0.98
225_L	235_Y	1.030	0.98
215_T	232_N	1.030	0.98
222_V	225_L	1.013	0.98
220_P	228_G	1.009	0.98
273_I	279_K	0.997	0.98
247_L	250_P	0.993	0.98
351_Q	365_R	0.982	0.98
169_D	200_V	0.982	0.98
209_F	213_N	0.982	0.98
184_G	188_N	0.977	0.98
200_V	203_I	0.974	0.97
268_D	271_I	0.973	0.97
179_R	184_G	0.964	0.97
196_D	204_L	0.960	0.97
203_I	207_R	0.952	0.97
223_D	226_I	0.948	0.97
156_R	161_L	0.945	0.97
251_S	254_G	0.944	0.97
195_L	199_T	0.944	0.97
257_K	277_E	0.941	0.97
355_D	367_V	0.939	0.97
267_P	280_G	0.938	0.97
257_K	271_I	0.933	0.97
176_T	179_R	0.928	0.97
110_I	139_A	0.928	0.97
199_T	202_G	0.928	0.97
269_D	290_R	0.918	0.96
120_E	124_G	0.914	0.96
214_V	217_R	0.913	0.96
274_S	280_G	0.913	0.96
297_I	326_K	0.911	0.96
321_D	332_D	0.911	0.96
244_K	252_Y	0.906	0.96
168_V	171_E	0.904	0.96
333_E	369_R	0.900	0.96
153_Q	160_E	0.893	0.96
214_V	218_G	0.892	0.96
264_G	273_I	0.891	0.96
75_S	95_T	0.887	0.96
160_E	164_V	0.877	0.95
135_V	139_A	0.877	0.95
261_R	270_A	0.876	0.95
247_L	253_A	0.874	0.95
297_I	303_G	0.869	0.95
114_D	117_G	0.865	0.95
166_I	170_A	0.863	0.95
257_K	260_L	0.861	0.95
318_E	323_A	0.861	0.95
341_T	345_A	0.860	0.95
67_V	142_V	0.859	0.95
204_L	210_I	0.858	0.95
196_D	203_I	0.858	0.95
150_E	256_M	0.857	0.95
63_T	113_L	0.857	0.95
158_A	162_Y	0.855	0.95
343_P	363_V	0.849	0.94
303_G	365_R	0.848	0.94
157_L	160_E	0.847	0.94
199_T	227_D	0.841	0.94
156_R	159_E	0.840	0.94
79_N	86_S	0.839	0.94
289_W	313_I	0.837	0.94
64_V	110_I	0.836	0.94
275_A	280_G	0.834	0.94
263_H	280_G	0.833	0.94
272_F	280_G	0.831	0.94
89_G	94_T	0.830	0.94
165_N	172_P	0.827	0.94
289_W	296_R	0.826	0.94
196_D	200_V	0.824	0.93
122_A	127_G	0.824	0.93
264_G	267_P	0.822	0.93
154_Y	260_L	0.821	0.93
268_D	272_F	0.820	0.93
257_K	280_G	0.817	0.93
339_R	351_Q	0.816	0.93
125_G	129_G	0.815	0.93
77_L	145_V	0.811	0.93
62_A	110_I	0.807	0.93
248_I	253_A	0.804	0.93
155_D	159_E	0.803	0.93
329_G	333_E	0.802	0.93
301_K	304_R	0.800	0.92
203_I	208_G	0.794	0.92
110_I	288_M	0.789	0.92
319_T	355_D	0.788	0.92
112_L	143_I	0.788	0.92
160_E	163_N	0.787	0.92
333_E	368_A	0.774	0.91
320_V	335_F	0.773	0.91
330_T	333_E	0.773	0.91
108_A	286_E	0.772	0.91
319_T	332_D	0.771	0.91
208_G	211_N	0.770	0.91
162_Y	165_N	0.765	0.91
303_G	329_G	0.761	0.90
153_Q	156_R	0.757	0.90
257_K	275_A	0.754	0.90
314_I	322_D	0.752	0.90
257_K	267_P	0.752	0.90
258_D	261_R	0.752	0.90
122_A	129_G	0.747	0.90
86_S	99_N	0.746	0.90
257_K	274_S	0.744	0.89
96_L	116_P	0.741	0.89
231_D	235_Y	0.741	0.89
206_E	213_N	0.737	0.89
312_L	323_A	0.737	0.89
213_N	217_R	0.734	0.89
156_R	163_N	0.731	0.89
245_V	252_Y	0.730	0.89
264_G	272_F	0.727	0.88
165_N	170_A	0.724	0.88
203_I	228_G	0.720	0.88
319_T	322_D	0.719	0.88
68_G	73_G	0.718	0.88
246_D	251_S	0.718	0.88
331_L	365_R	0.718	0.88
93_F	119_I	0.714	0.87
253_A	260_L	0.713	0.87
131_E	171_E	0.713	0.87
334_R	369_R	0.713	0.87
321_D	331_L	0.711	0.87
220_P	224_R	0.709	0.87
63_T	138_G	0.707	0.87
156_R	164_V	0.707	0.87
253_A	257_K	0.703	0.87
201_K	204_L	0.703	0.87
296_R	311_P	0.701	0.87
122_A	125_G	0.699	0.86
325_Q	329_G	0.697	0.86
220_P	225_L	0.697	0.86
267_P	273_I	0.696	0.86
248_I	251_S	0.696	0.86
263_H	271_I	0.696	0.86
249_E	254_G	0.694	0.86
195_L	198_D	0.693	0.86
264_G	271_I	0.692	0.86
269_D	276_A	0.692	0.86
228_G	235_Y	0.692	0.86
256_M	275_A	0.689	0.86
297_I	331_L	0.689	0.86
77_L	81_M	0.688	0.85
153_Q	163_N	0.687	0.85
80_A	281_L	0.686	0.85
199_T	203_I	0.685	0.85
256_M	263_H	0.685	0.85
268_D	273_I	0.685	0.85
278_E	286_E	0.679	0.85
257_K	270_A	0.677	0.85
183_D	188_N	0.676	0.84
79_N	84_A	0.671	0.84
326_K	331_L	0.670	0.84
182_K	185_I	0.668	0.84
172_P	175_V	0.667	0.84
282_D	285_K	0.665	0.84
159_E	162_Y	0.665	0.84
259_A	267_P	0.663	0.83
294_L	299_M	0.660	0.83
169_D	232_N	0.660	0.83
113_L	140_D	0.659	0.83
103_L	112_L	0.654	0.82
129_G	132_I	0.650	0.82
146_L	242_V	0.649	0.82
219_N	225_L	0.649	0.82
168_V	231_D	0.646	0.82
282_D	286_E	0.646	0.82
91_Y	94_T	0.644	0.82
199_T	228_G	0.642	0.81
295_I	360_D	0.642	0.81
71_S	75_S	0.642	0.81
154_Y	158_A	0.641	0.81
256_M	274_S	0.641	0.81
300_D	303_G	0.641	0.81
199_T	206_E	0.641	0.81
157_L	164_V	0.640	0.81
197_S	200_V	0.640	0.81
226_I	230_M	0.639	0.81
257_K	276_A	0.639	0.81
71_S	95_T	0.639	0.81
166_I	169_D	0.637	0.81
207_R	210_I	0.631	0.80
169_D	173_P	0.630	0.80
136_I	142_V	0.628	0.80
146_L	158_A	0.627	0.80
79_N	85_D	0.626	0.80
221_S	226_I	0.625	0.80
260_L	263_H	0.625	0.80
263_H	270_A	0.622	0.79
212_A	216_I	0.622	0.79
165_N	168_V	0.621	0.79
254_G	257_K	0.620	0.79
112_L	281_L	0.619	0.79
64_V	296_R	0.617	0.79
281_L	288_M	0.617	0.79
202_G	206_E	0.616	0.79
89_G	92_E	0.616	0.79
206_E	211_N	0.607	0.78
157_L	161_L	0.607	0.78
299_M	304_R	0.606	0.77
268_D	277_E	0.605	0.77
244_K	250_P	0.605	0.77
259_A	280_G	0.604	0.77
270_A	280_G	0.603	0.77
300_D	365_R	0.602	0.77
225_L	229_V	0.601	0.77
228_G	231_D	0.600	0.77
154_Y	157_L	0.600	0.77
257_K	264_G	0.599	0.77
321_D	354_R	0.597	0.76
128_G	131_E	0.596	0.76
142_V	236_M	0.596	0.76
247_L	254_G	0.594	0.76
205_R	209_F	0.592	0.76
246_D	252_Y	0.591	0.76
172_P	196_D	0.588	0.75
258_D	280_G	0.586	0.75
63_T	100_P	0.583	0.75
259_A	275_A	0.582	0.75
92_E	96_L	0.582	0.75
179_R	183_D	0.582	0.75
331_L	368_A	0.581	0.74
173_P	176_T	0.581	0.74
62_A	104_E	0.581	0.74
176_T	196_D	0.580	0.74
88_V	94_T	0.579	0.74
182_K	186_D	0.577	0.74
265_V	274_S	0.576	0.74
131_E	138_G	0.575	0.74
224_R	228_G	0.574	0.74
202_G	218_G	0.574	0.74
90_A	96_L	0.574	0.74
161_L	175_V	0.574	0.74
159_E	172_P	0.573	0.73
255_T	260_L	0.573	0.73
260_L	273_I	0.572	0.73
205_R	210_I	0.570	0.73
256_M	280_G	0.565	0.72
182_K	187_V	0.564	0.72
170_A	224_R	0.564	0.72
202_G	205_R	0.563	0.72
235_Y	238_S	0.562	0.72
180_K	183_D	0.561	0.72
199_T	218_G	0.560	0.72
86_S	94_T	0.560	0.72
266_S	270_A	0.559	0.72
75_S	93_F	0.559	0.72
70_P	91_Y	0.559	0.72
220_P	230_M	0.556	0.71
208_G	213_N	0.555	0.71
183_D	187_V	0.554	0.71
177_V	181_G	0.554	0.71
87_E	91_Y	0.554	0.71
160_E	165_N	0.553	0.71
272_F	277_E	0.553	0.71
162_Y	168_V	0.551	0.71
204_L	207_R	0.551	0.71
260_L	268_D	0.550	0.70
324_V	327_L	0.549	0.70
153_Q	165_N	0.549	0.70
264_G	270_A	0.547	0.70
96_L	119_I	0.546	0.70
265_V	275_A	0.545	0.70
264_G	268_D	0.542	0.69
63_T	94_T	0.537	0.69
324_V	328_G	0.534	0.68
265_V	270_A	0.533	0.68
297_I	302_P	0.532	0.68
220_P	227_D	0.530	0.68
171_E	179_R	0.529	0.67
127_G	132_I	0.529	0.67
197_S	202_G	0.528	0.67
245_V	253_A	0.527	0.67
113_L	183_D	0.527	0.67
93_F	122_A	0.525	0.67
180_K	185_I	0.524	0.67
143_I	288_M	0.524	0.67
131_E	167_R	0.523	0.67
196_D	199_T	0.522	0.66
79_N	117_G	0.521	0.66
279_K	282_D	0.520	0.66
161_L	164_V	0.518	0.66
300_D	363_V	0.516	0.66
171_E	181_G	0.516	0.66
68_G	74_K	0.515	0.65
227_D	230_M	0.515	0.65
263_H	274_S	0.514	0.65
264_G	280_G	0.514	0.65
70_P	119_I	0.513	0.65
197_S	205_R	0.513	0.65
100_P	111_Q	0.512	0.65
246_D	250_P	0.512	0.65
161_L	172_P	0.512	0.65
157_L	163_N	0.511	0.65
71_S	93_F	0.511	0.65
180_K	187_V	0.505	0.64
314_I	357_V	0.504	0.64
80_A	278_E	0.503	0.64
261_R	276_A	0.502	0.63
169_D	204_L	0.502	0.63
272_F	279_K	0.501	0.63
82_T	164_V	0.500	0.63
268_D	274_S	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1jalA	1	0.7784	100	0.381	Contact Map
4a9aA	1	0.9622	100	0.384	Contact Map
2dbyA	1	0.7865	100	0.388	Contact Map
1ni3A	1	0.8324	100	0.405	Contact Map
1wxqA	1	0.7189	100	0.426	Contact Map
2ohfA	1	0.7081	100	0.479	Contact Map
1lnzA	1	0.6568	100	0.627	Contact Map
4csu9	1	0.6405	100	0.638	Contact Map
1udxA	1	0.8054	100	0.657	Contact Map
3geeA	2	0.7027	99.9	0.68	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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