GREMLIN Database
Y1111 - Uncharacterized GTP-binding protein VNG_1111G
UniProt: P17103 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 370 (298)
Sequences: 3826 (2206)
Seq/√Len: 127.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
358_L364_L4.9001.00
322_D332_D3.8541.00
246_D249_E3.4431.00
351_Q367_V3.1411.00
315_R318_E2.8191.00
342_G346_Q2.7031.00
300_D305_G2.6221.00
295_I316_R2.6221.00
340_V364_L2.6021.00
87_E94_T2.5541.00
314_I318_E2.5451.00
271_I274_S2.4911.00
271_I275_A2.3251.00
318_E322_D2.3141.00
270_A274_S2.2931.00
173_P197_S2.2641.00
340_V358_L2.1941.00
272_F275_A2.1941.00
249_E252_Y2.1701.00
314_I323_A2.1571.00
276_A280_G2.1041.00
267_P271_I2.1021.00
197_S201_K2.0691.00
267_P272_F2.0681.00
319_T357_V2.0681.00
271_I276_A2.0661.00
267_P275_A2.0581.00
272_F276_A2.0441.00
339_R367_V2.0261.00
337_F351_Q2.0101.00
267_P276_A2.0011.00
244_K249_E2.0011.00
334_R368_A1.9961.00
143_I241_T1.9771.00
342_G345_A1.9721.00
64_V288_M1.9701.00
245_V248_I1.9671.00
255_T258_D1.9281.00
290_R316_R1.9151.00
270_A275_A1.9141.00
144_F238_S1.8901.00
344_S349_D1.8821.00
215_T218_G1.8641.00
316_R359_E1.8581.00
337_F367_V1.8311.00
198_D201_K1.8251.00
146_L154_Y1.8221.00
277_E280_G1.7911.00
210_I213_N1.7751.00
202_G224_R1.7231.00
293_G316_R1.7051.00
241_T284_L1.6941.00
174_S177_V1.6831.00
256_M259_A1.6711.00
239_L291_A1.6601.00
184_G187_V1.6581.00
248_I252_Y1.6551.00
244_K247_L1.6251.00
203_I215_T1.6181.00
159_E163_N1.6081.00
215_T235_Y1.6041.00
221_S224_R1.5901.00
201_K205_R1.5701.00
62_A288_M1.5701.00
267_P270_A1.5601.00
267_P274_S1.5591.00
273_I280_G1.5541.00
245_V249_E1.5301.00
164_V168_V1.5271.00
257_K272_F1.5111.00
286_E290_R1.5031.00
343_P349_D1.4991.00
256_M261_R1.4981.00
270_A276_A1.4911.00
341_T344_S1.4641.00
295_I314_I1.4611.00
269_D272_F1.4591.00
177_V201_K1.4521.00
257_K261_R1.4431.00
349_D365_R1.4421.00
258_D262_D1.4341.00
204_L208_G1.4191.00
206_E218_G1.4171.00
244_K248_I1.4001.00
198_D202_G1.3951.00
257_K263_H1.3871.00
249_E253_A1.3841.00
274_S277_E1.3771.00
339_R365_R1.3571.00
255_T259_A1.3481.00
120_E156_R1.3211.00
259_A263_H1.3011.00
196_D202_G1.2801.00
206_E209_F1.2751.00
314_I326_K1.2681.00
185_I188_N1.2641.00
166_I204_L1.2601.00
295_I318_E1.2591.00
106_R285_K1.2531.00
302_P305_G1.2521.00
271_I280_G1.2501.00
287_R290_R1.2371.00
256_M260_L1.2371.00
64_V143_I1.2271.00
134_S138_G1.2160.99
287_R291_A1.2140.99
340_V351_Q1.2040.99
318_E326_K1.2020.99
176_T197_S1.1950.99
244_K253_A1.1770.99
325_Q332_D1.1710.99
270_A273_I1.1700.99
102_M111_Q1.1670.99
273_I277_E1.1600.99
273_I276_A1.1600.99
269_D275_A1.1530.99
203_I206_E1.1480.99
248_I254_G1.1460.99
76_S275_A1.1460.99
276_A279_K1.1330.99
63_T111_Q1.1290.99
156_R160_E1.1200.99
206_E210_I1.1190.99
250_P253_A1.1010.99
175_V179_R1.1000.99
183_D186_D1.0930.99
200_V204_L1.0880.99
63_T139_A1.0870.99
168_V172_P1.0860.99
271_I277_E1.0790.99
86_S89_G1.0760.99
331_L366_V1.0710.99
79_N88_V1.0700.99
209_F212_A1.0680.99
173_P200_V1.0650.99
257_K273_I1.0640.99
148_A242_V1.0630.99
265_V271_I1.0530.98
205_R211_N1.0510.98
65_A139_A1.0510.98
269_D274_S1.0470.98
263_H273_I1.0450.98
259_A262_D1.0440.98
323_A358_L1.0340.98
225_L235_Y1.0300.98
215_T232_N1.0300.98
222_V225_L1.0130.98
220_P228_G1.0090.98
273_I279_K0.9970.98
247_L250_P0.9930.98
351_Q365_R0.9820.98
169_D200_V0.9820.98
209_F213_N0.9820.98
184_G188_N0.9770.98
200_V203_I0.9740.97
268_D271_I0.9730.97
179_R184_G0.9640.97
196_D204_L0.9600.97
203_I207_R0.9520.97
223_D226_I0.9480.97
156_R161_L0.9450.97
251_S254_G0.9440.97
195_L199_T0.9440.97
257_K277_E0.9410.97
355_D367_V0.9390.97
267_P280_G0.9380.97
257_K271_I0.9330.97
176_T179_R0.9280.97
110_I139_A0.9280.97
199_T202_G0.9280.97
269_D290_R0.9180.96
120_E124_G0.9140.96
214_V217_R0.9130.96
274_S280_G0.9130.96
297_I326_K0.9110.96
321_D332_D0.9110.96
244_K252_Y0.9060.96
168_V171_E0.9040.96
333_E369_R0.9000.96
153_Q160_E0.8930.96
214_V218_G0.8920.96
264_G273_I0.8910.96
75_S95_T0.8870.96
160_E164_V0.8770.95
135_V139_A0.8770.95
261_R270_A0.8760.95
247_L253_A0.8740.95
297_I303_G0.8690.95
114_D117_G0.8650.95
166_I170_A0.8630.95
257_K260_L0.8610.95
318_E323_A0.8610.95
341_T345_A0.8600.95
67_V142_V0.8590.95
204_L210_I0.8580.95
196_D203_I0.8580.95
150_E256_M0.8570.95
63_T113_L0.8570.95
158_A162_Y0.8550.95
343_P363_V0.8490.94
303_G365_R0.8480.94
157_L160_E0.8470.94
199_T227_D0.8410.94
156_R159_E0.8400.94
79_N86_S0.8390.94
289_W313_I0.8370.94
64_V110_I0.8360.94
275_A280_G0.8340.94
263_H280_G0.8330.94
272_F280_G0.8310.94
89_G94_T0.8300.94
165_N172_P0.8270.94
289_W296_R0.8260.94
196_D200_V0.8240.93
122_A127_G0.8240.93
264_G267_P0.8220.93
154_Y260_L0.8210.93
268_D272_F0.8200.93
257_K280_G0.8170.93
339_R351_Q0.8160.93
125_G129_G0.8150.93
77_L145_V0.8110.93
62_A110_I0.8070.93
248_I253_A0.8040.93
155_D159_E0.8030.93
329_G333_E0.8020.93
301_K304_R0.8000.92
203_I208_G0.7940.92
110_I288_M0.7890.92
319_T355_D0.7880.92
112_L143_I0.7880.92
160_E163_N0.7870.92
333_E368_A0.7740.91
320_V335_F0.7730.91
330_T333_E0.7730.91
108_A286_E0.7720.91
319_T332_D0.7710.91
208_G211_N0.7700.91
162_Y165_N0.7650.91
303_G329_G0.7610.90
153_Q156_R0.7570.90
257_K275_A0.7540.90
314_I322_D0.7520.90
257_K267_P0.7520.90
258_D261_R0.7520.90
122_A129_G0.7470.90
86_S99_N0.7460.90
257_K274_S0.7440.89
96_L116_P0.7410.89
231_D235_Y0.7410.89
206_E213_N0.7370.89
312_L323_A0.7370.89
213_N217_R0.7340.89
156_R163_N0.7310.89
245_V252_Y0.7300.89
264_G272_F0.7270.88
165_N170_A0.7240.88
203_I228_G0.7200.88
319_T322_D0.7190.88
68_G73_G0.7180.88
246_D251_S0.7180.88
331_L365_R0.7180.88
93_F119_I0.7140.87
253_A260_L0.7130.87
131_E171_E0.7130.87
334_R369_R0.7130.87
321_D331_L0.7110.87
220_P224_R0.7090.87
63_T138_G0.7070.87
156_R164_V0.7070.87
253_A257_K0.7030.87
201_K204_L0.7030.87
296_R311_P0.7010.87
122_A125_G0.6990.86
325_Q329_G0.6970.86
220_P225_L0.6970.86
267_P273_I0.6960.86
248_I251_S0.6960.86
263_H271_I0.6960.86
249_E254_G0.6940.86
195_L198_D0.6930.86
264_G271_I0.6920.86
269_D276_A0.6920.86
228_G235_Y0.6920.86
256_M275_A0.6890.86
297_I331_L0.6890.86
77_L81_M0.6880.85
153_Q163_N0.6870.85
80_A281_L0.6860.85
199_T203_I0.6850.85
256_M263_H0.6850.85
268_D273_I0.6850.85
278_E286_E0.6790.85
257_K270_A0.6770.85
183_D188_N0.6760.84
79_N84_A0.6710.84
326_K331_L0.6700.84
182_K185_I0.6680.84
172_P175_V0.6670.84
282_D285_K0.6650.84
159_E162_Y0.6650.84
259_A267_P0.6630.83
294_L299_M0.6600.83
169_D232_N0.6600.83
113_L140_D0.6590.83
103_L112_L0.6540.82
129_G132_I0.6500.82
146_L242_V0.6490.82
219_N225_L0.6490.82
168_V231_D0.6460.82
282_D286_E0.6460.82
91_Y94_T0.6440.82
199_T228_G0.6420.81
295_I360_D0.6420.81
71_S75_S0.6420.81
154_Y158_A0.6410.81
256_M274_S0.6410.81
300_D303_G0.6410.81
199_T206_E0.6410.81
157_L164_V0.6400.81
197_S200_V0.6400.81
226_I230_M0.6390.81
257_K276_A0.6390.81
71_S95_T0.6390.81
166_I169_D0.6370.81
207_R210_I0.6310.80
169_D173_P0.6300.80
136_I142_V0.6280.80
146_L158_A0.6270.80
79_N85_D0.6260.80
221_S226_I0.6250.80
260_L263_H0.6250.80
263_H270_A0.6220.79
212_A216_I0.6220.79
165_N168_V0.6210.79
254_G257_K0.6200.79
112_L281_L0.6190.79
64_V296_R0.6170.79
281_L288_M0.6170.79
202_G206_E0.6160.79
89_G92_E0.6160.79
206_E211_N0.6070.78
157_L161_L0.6070.78
299_M304_R0.6060.77
268_D277_E0.6050.77
244_K250_P0.6050.77
259_A280_G0.6040.77
270_A280_G0.6030.77
300_D365_R0.6020.77
225_L229_V0.6010.77
228_G231_D0.6000.77
154_Y157_L0.6000.77
257_K264_G0.5990.77
321_D354_R0.5970.76
128_G131_E0.5960.76
142_V236_M0.5960.76
247_L254_G0.5940.76
205_R209_F0.5920.76
246_D252_Y0.5910.76
172_P196_D0.5880.75
258_D280_G0.5860.75
63_T100_P0.5830.75
259_A275_A0.5820.75
92_E96_L0.5820.75
179_R183_D0.5820.75
331_L368_A0.5810.74
173_P176_T0.5810.74
62_A104_E0.5810.74
176_T196_D0.5800.74
88_V94_T0.5790.74
182_K186_D0.5770.74
265_V274_S0.5760.74
131_E138_G0.5750.74
224_R228_G0.5740.74
202_G218_G0.5740.74
90_A96_L0.5740.74
161_L175_V0.5740.74
159_E172_P0.5730.73
255_T260_L0.5730.73
260_L273_I0.5720.73
205_R210_I0.5700.73
256_M280_G0.5650.72
182_K187_V0.5640.72
170_A224_R0.5640.72
202_G205_R0.5630.72
235_Y238_S0.5620.72
180_K183_D0.5610.72
199_T218_G0.5600.72
86_S94_T0.5600.72
266_S270_A0.5590.72
75_S93_F0.5590.72
70_P91_Y0.5590.72
220_P230_M0.5560.71
208_G213_N0.5550.71
183_D187_V0.5540.71
177_V181_G0.5540.71
87_E91_Y0.5540.71
160_E165_N0.5530.71
272_F277_E0.5530.71
162_Y168_V0.5510.71
204_L207_R0.5510.71
260_L268_D0.5500.70
324_V327_L0.5490.70
153_Q165_N0.5490.70
264_G270_A0.5470.70
96_L119_I0.5460.70
265_V275_A0.5450.70
264_G268_D0.5420.69
63_T94_T0.5370.69
324_V328_G0.5340.68
265_V270_A0.5330.68
297_I302_P0.5320.68
220_P227_D0.5300.68
171_E179_R0.5290.67
127_G132_I0.5290.67
197_S202_G0.5280.67
245_V253_A0.5270.67
113_L183_D0.5270.67
93_F122_A0.5250.67
180_K185_I0.5240.67
143_I288_M0.5240.67
131_E167_R0.5230.67
196_D199_T0.5220.66
79_N117_G0.5210.66
279_K282_D0.5200.66
161_L164_V0.5180.66
300_D363_V0.5160.66
171_E181_G0.5160.66
68_G74_K0.5150.65
227_D230_M0.5150.65
263_H274_S0.5140.65
264_G280_G0.5140.65
70_P119_I0.5130.65
197_S205_R0.5130.65
100_P111_Q0.5120.65
246_D250_P0.5120.65
161_L172_P0.5120.65
157_L163_N0.5110.65
71_S93_F0.5110.65
180_K187_V0.5050.64
314_I357_V0.5040.64
80_A278_E0.5030.64
261_R276_A0.5020.63
169_D204_L0.5020.63
272_F279_K0.5010.63
82_T164_V0.5000.63
268_D274_S0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jalA 1 0.7784 100 0.381 Contact Map
4a9aA 1 0.9622 100 0.384 Contact Map
2dbyA 1 0.7865 100 0.388 Contact Map
1ni3A 1 0.8324 100 0.405 Contact Map
1wxqA 1 0.7189 100 0.426 Contact Map
2ohfA 1 0.7081 100 0.479 Contact Map
1lnzA 1 0.6568 100 0.627 Contact Map
4csu9 1 0.6405 100 0.638 Contact Map
1udxA 1 0.8054 100 0.657 Contact Map
3geeA 2 0.7027 99.9 0.68 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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