GREMLIN Database
RL22 - 50S ribosomal protein L22
UniProt: P15008 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (148)
Sequences: 509 (303)
Seq/√Len: 24.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_A56_R5.8421.00
96_V148_V5.7321.00
43_D56_R3.9581.00
47_Y58_V3.6011.00
21_E121_G3.5411.00
45_K97_S3.2101.00
57_S73_I2.9721.00
52_I86_S2.7840.99
57_S70_R2.7630.99
19_L22_R2.6910.99
50_A55_E2.5870.99
43_D50_A2.4130.98
33_A89_F2.3450.98
28_H85_A1.9190.94
49_Q90_L1.9160.94
57_S79_G1.9000.93
32_I85_A1.8600.92
58_V86_S1.8170.92
41_V146_I1.7920.91
45_K49_Q1.7860.91
28_H32_I1.7670.90
83_E87_K1.7430.90
94_S97_S1.7430.90
29_S85_A1.6840.88
116_A145_E1.6330.86
63_H119_K1.6330.86
70_R73_I1.6070.85
113_E149_T1.5390.83
67_V78_A1.5310.83
7_V147_V1.4660.80
72_D81_Y1.4660.80
60_F64_N1.4120.77
52_I58_V1.3920.76
32_I86_S1.3800.75
73_I79_G1.3560.74
49_Q53_D1.3440.73
49_Q83_E1.3050.71
32_I89_F1.2680.69
15_A148_V1.2450.67
40_T111_V1.2370.67
68_G74_D1.2190.66
62_Q133_R1.2100.65
127_K137_W1.1890.64
110_M143_D1.1860.64
90_L97_S1.1720.63
64_N67_V1.1720.63
10_D13_A1.1580.62
43_D87_K1.1250.59
19_L92_L1.1170.59
24_I113_E1.1150.59
14_S149_T1.1030.58
35_E58_V1.0890.57
33_A115_V1.0830.56
130_A145_E1.0800.56
76_W112_I1.0560.54
60_F67_V1.0560.54
45_K94_S1.0460.54
41_V45_K1.0460.54
65_S71_N1.0460.54
15_A96_V1.0450.54
63_H78_A1.0410.53
7_V14_S1.0210.52
40_T43_D1.0200.52
6_S114_H1.0120.51
127_K135_T1.0100.51
58_V76_W1.0050.51
61_K80_R1.0030.51
128_P134_A0.9970.50
25_S60_F0.9870.49
126_R141_L0.9730.48
39_E43_D0.9690.48
31_A68_G0.9410.46
30_K62_Q0.9370.46
17_A61_K0.9350.46
33_A146_I0.9290.45
107_A110_M0.9210.45
104_G150_E0.9200.45
29_S89_F0.9190.45
6_S145_E0.9060.44
40_T109_E0.9030.43
54_E58_V0.8980.43
7_V37_S0.8950.43
57_S72_D0.8930.43
106_D150_E0.8900.43
45_K90_L0.8820.42
62_Q80_R0.8750.41
123_S139_A0.8720.41
43_D55_E0.8690.41
112_I115_V0.8610.40
25_S33_A0.8600.40
29_S32_I0.8600.40
24_I29_S0.8530.40
51_V59_P0.8420.39
65_S131_M0.8300.38
9_V14_S0.8260.38
101_D150_E0.8230.38
35_E47_Y0.8220.38
51_V132_G0.7940.36
125_G138_N0.7930.36
26_L118_H0.7810.35
11_S14_S0.7750.35
9_V113_E0.7710.34
37_S65_S0.7690.34
10_D89_F0.7670.34
84_K129_R0.7600.34
128_P135_T0.7550.33
9_V71_N0.7530.33
49_Q106_D0.7460.33
69_H134_A0.7460.33
23_S41_V0.7450.33
71_N74_D0.7430.33
98_N111_V0.7400.32
51_V120_V0.7390.32
26_L63_H0.7390.32
68_G121_G0.7360.32
16_K93_L0.7350.32
101_D107_A0.7340.32
4_S115_V0.7320.32
38_G75_G0.7270.32
60_F80_R0.7260.32
41_V97_S0.7250.31
66_G73_I0.7240.31
97_S100_A0.7230.31
88_D94_S0.7210.31
120_V141_L0.7140.31
99_N144_V0.7130.31
119_K122_E0.7120.31
60_F78_A0.7110.31
75_G86_S0.7070.30
113_E119_K0.7060.30
34_R123_S0.7010.30
6_S112_I0.6990.30
39_E109_E0.6990.30
11_S16_K0.6980.30
139_A142_C0.6980.30
19_L55_E0.6940.30
59_P93_L0.6920.29
28_H68_G0.6900.29
64_N78_A0.6890.29
9_V16_K0.6860.29
21_E143_D0.6840.29
25_S140_T0.6770.29
47_Y50_A0.6760.28
46_E118_H0.6710.28
88_D151_T0.6660.28
37_S114_H0.6640.28
26_L141_L0.6620.28
148_V151_T0.6580.27
23_S139_A0.6570.27
115_V146_I0.6450.27
88_D135_T0.6430.27
32_I83_E0.6370.26
95_N127_K0.6340.26
24_I138_N0.6320.26
34_R37_S0.6320.26
120_V128_P0.6240.26
110_M116_A0.6230.25
14_S103_Q0.6170.25
38_G99_N0.6170.25
10_D14_S0.6160.25
126_R142_C0.6160.25
70_R79_G0.6100.25
126_R134_A0.6100.25
146_I149_T0.6080.25
117_P142_C0.6070.25
19_L96_V0.6040.24
21_E87_K0.6030.24
36_I76_W0.6010.24
108_D151_T0.6010.24
42_A108_D0.5990.24
126_R131_M0.5980.24
125_G132_G0.5950.24
110_M148_V0.5940.24
48_L133_R0.5900.24
8_D16_K0.5880.24
59_P84_K0.5880.24
39_E79_G0.5850.23
54_E83_E0.5770.23
13_A145_E0.5770.23
22_R37_S0.5760.23
93_L110_M0.5730.23
21_E28_H0.5680.23
51_V60_F0.5610.22
119_K124_Q0.5600.22
105_F150_E0.5590.22
17_A96_V0.5560.22
8_D11_S0.5530.22
32_I36_I0.5500.22
137_W141_L0.5490.22
32_I87_K0.5490.22
46_E50_A0.5440.21
103_Q122_E0.5420.21
28_H67_V0.5410.21
45_K52_I0.5390.21
78_A128_P0.5380.21
51_V82_P0.5370.21
80_R129_R0.5370.21
133_R136_T0.5360.21
109_E150_E0.5350.21
28_H86_S0.5300.21
94_S146_I0.5290.21
120_V126_R0.5260.21
74_D128_P0.5250.20
102_Q109_E0.5240.20
42_A119_K0.5230.20
38_G132_G0.5230.20
18_M145_E0.5190.20
21_E145_E0.5150.20
16_K114_H0.5150.20
48_L80_R0.5130.20
127_K141_L0.5120.20
129_R145_E0.5120.20
129_R135_T0.5100.20
33_A117_P0.5090.20
55_E117_P0.5090.20
91_K111_V0.5070.20
17_A90_L0.5050.20
16_K79_G0.5040.20
67_V73_I0.5040.20
7_V42_A0.5010.19
21_E140_T0.5010.19
81_Y124_Q0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a17Q 1 0.9872 100 0.192 Contact Map
1vx7W 1 0.9487 100 0.193 Contact Map
1vq8R 1 0.9615 100 0.194 Contact Map
4ujrC 1 0.9872 100 0.199 Contact Map
3j39P 1 0.9872 100 0.205 Contact Map
3j21S 1 0.9551 100 0.207 Contact Map
3j61P 1 0.9936 100 0.212 Contact Map
3zf7R 1 0.9679 100 0.225 Contact Map
3j3bP 1 0.9551 100 0.247 Contact Map
4w20P 1 0.9615 100 0.252 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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