RL22 - HALSA - GREMLIN Contacts

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RL22 - 50S ribosomal protein L22

UniProt:	P15008	Sequences: MGISYSVDVDSEASAKAMLRERSISLKHSKAIAREISGETVADAKEYLQAVIDEERSVPFKQHNSGVGHRNDIDGWDAGRYPEKASKDFLKLLSNVSNNADQQGFDADEMVIEHVAPHKVGESQGRKPRAMGRATTWNATLCDVEIVVTETEEVTA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	156 (148)
Sequences:	509 (303)
Seq/√Len:	24.9

HALSA - RL22
SULSO - RL22

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
50_A	56_R	5.842	1.00
96_V	148_V	5.732	1.00
43_D	56_R	3.958	1.00
47_Y	58_V	3.601	1.00
21_E	121_G	3.541	1.00
45_K	97_S	3.210	1.00
57_S	73_I	2.972	1.00
52_I	86_S	2.784	0.99
57_S	70_R	2.763	0.99
19_L	22_R	2.691	0.99
50_A	55_E	2.587	0.99
43_D	50_A	2.413	0.98
33_A	89_F	2.345	0.98
28_H	85_A	1.919	0.94
49_Q	90_L	1.916	0.94
57_S	79_G	1.900	0.93
32_I	85_A	1.860	0.92
58_V	86_S	1.817	0.92
41_V	146_I	1.792	0.91
45_K	49_Q	1.786	0.91
28_H	32_I	1.767	0.90
83_E	87_K	1.743	0.90
94_S	97_S	1.743	0.90
29_S	85_A	1.684	0.88
116_A	145_E	1.633	0.86
63_H	119_K	1.633	0.86
70_R	73_I	1.607	0.85
113_E	149_T	1.539	0.83
67_V	78_A	1.531	0.83
7_V	147_V	1.466	0.80
72_D	81_Y	1.466	0.80
60_F	64_N	1.412	0.77
52_I	58_V	1.392	0.76
32_I	86_S	1.380	0.75
73_I	79_G	1.356	0.74
49_Q	53_D	1.344	0.73
49_Q	83_E	1.305	0.71
32_I	89_F	1.268	0.69
15_A	148_V	1.245	0.67
40_T	111_V	1.237	0.67
68_G	74_D	1.219	0.66
62_Q	133_R	1.210	0.65
127_K	137_W	1.189	0.64
110_M	143_D	1.186	0.64
90_L	97_S	1.172	0.63
64_N	67_V	1.172	0.63
10_D	13_A	1.158	0.62
43_D	87_K	1.125	0.59
19_L	92_L	1.117	0.59
24_I	113_E	1.115	0.59
14_S	149_T	1.103	0.58
35_E	58_V	1.089	0.57
33_A	115_V	1.083	0.56
130_A	145_E	1.080	0.56
76_W	112_I	1.056	0.54
60_F	67_V	1.056	0.54
45_K	94_S	1.046	0.54
41_V	45_K	1.046	0.54
65_S	71_N	1.046	0.54
15_A	96_V	1.045	0.54
63_H	78_A	1.041	0.53
7_V	14_S	1.021	0.52
40_T	43_D	1.020	0.52
6_S	114_H	1.012	0.51
127_K	135_T	1.010	0.51
58_V	76_W	1.005	0.51
61_K	80_R	1.003	0.51
128_P	134_A	0.997	0.50
25_S	60_F	0.987	0.49
126_R	141_L	0.973	0.48
39_E	43_D	0.969	0.48
31_A	68_G	0.941	0.46
30_K	62_Q	0.937	0.46
17_A	61_K	0.935	0.46
33_A	146_I	0.929	0.45
107_A	110_M	0.921	0.45
104_G	150_E	0.920	0.45
29_S	89_F	0.919	0.45
6_S	145_E	0.906	0.44
40_T	109_E	0.903	0.43
54_E	58_V	0.898	0.43
7_V	37_S	0.895	0.43
57_S	72_D	0.893	0.43
106_D	150_E	0.890	0.43
45_K	90_L	0.882	0.42
62_Q	80_R	0.875	0.41
123_S	139_A	0.872	0.41
43_D	55_E	0.869	0.41
112_I	115_V	0.861	0.40
25_S	33_A	0.860	0.40
29_S	32_I	0.860	0.40
24_I	29_S	0.853	0.40
51_V	59_P	0.842	0.39
65_S	131_M	0.830	0.38
9_V	14_S	0.826	0.38
101_D	150_E	0.823	0.38
35_E	47_Y	0.822	0.38
51_V	132_G	0.794	0.36
125_G	138_N	0.793	0.36
26_L	118_H	0.781	0.35
11_S	14_S	0.775	0.35
9_V	113_E	0.771	0.34
37_S	65_S	0.769	0.34
10_D	89_F	0.767	0.34
84_K	129_R	0.760	0.34
128_P	135_T	0.755	0.33
9_V	71_N	0.753	0.33
49_Q	106_D	0.746	0.33
69_H	134_A	0.746	0.33
23_S	41_V	0.745	0.33
71_N	74_D	0.743	0.33
98_N	111_V	0.740	0.32
51_V	120_V	0.739	0.32
26_L	63_H	0.739	0.32
68_G	121_G	0.736	0.32
16_K	93_L	0.735	0.32
101_D	107_A	0.734	0.32
4_S	115_V	0.732	0.32
38_G	75_G	0.727	0.32
60_F	80_R	0.726	0.32
41_V	97_S	0.725	0.31
66_G	73_I	0.724	0.31
97_S	100_A	0.723	0.31
88_D	94_S	0.721	0.31
120_V	141_L	0.714	0.31
99_N	144_V	0.713	0.31
119_K	122_E	0.712	0.31
60_F	78_A	0.711	0.31
75_G	86_S	0.707	0.30
113_E	119_K	0.706	0.30
34_R	123_S	0.701	0.30
6_S	112_I	0.699	0.30
39_E	109_E	0.699	0.30
11_S	16_K	0.698	0.30
139_A	142_C	0.698	0.30
19_L	55_E	0.694	0.30
59_P	93_L	0.692	0.29
28_H	68_G	0.690	0.29
64_N	78_A	0.689	0.29
9_V	16_K	0.686	0.29
21_E	143_D	0.684	0.29
25_S	140_T	0.677	0.29
47_Y	50_A	0.676	0.28
46_E	118_H	0.671	0.28
88_D	151_T	0.666	0.28
37_S	114_H	0.664	0.28
26_L	141_L	0.662	0.28
148_V	151_T	0.658	0.27
23_S	139_A	0.657	0.27
115_V	146_I	0.645	0.27
88_D	135_T	0.643	0.27
32_I	83_E	0.637	0.26
95_N	127_K	0.634	0.26
24_I	138_N	0.632	0.26
34_R	37_S	0.632	0.26
120_V	128_P	0.624	0.26
110_M	116_A	0.623	0.25
14_S	103_Q	0.617	0.25
38_G	99_N	0.617	0.25
10_D	14_S	0.616	0.25
126_R	142_C	0.616	0.25
70_R	79_G	0.610	0.25
126_R	134_A	0.610	0.25
146_I	149_T	0.608	0.25
117_P	142_C	0.607	0.25
19_L	96_V	0.604	0.24
21_E	87_K	0.603	0.24
36_I	76_W	0.601	0.24
108_D	151_T	0.601	0.24
42_A	108_D	0.599	0.24
126_R	131_M	0.598	0.24
125_G	132_G	0.595	0.24
110_M	148_V	0.594	0.24
48_L	133_R	0.590	0.24
8_D	16_K	0.588	0.24
59_P	84_K	0.588	0.24
39_E	79_G	0.585	0.23
54_E	83_E	0.577	0.23
13_A	145_E	0.577	0.23
22_R	37_S	0.576	0.23
93_L	110_M	0.573	0.23
21_E	28_H	0.568	0.23
51_V	60_F	0.561	0.22
119_K	124_Q	0.560	0.22
105_F	150_E	0.559	0.22
17_A	96_V	0.556	0.22
8_D	11_S	0.553	0.22
32_I	36_I	0.550	0.22
137_W	141_L	0.549	0.22
32_I	87_K	0.549	0.22
46_E	50_A	0.544	0.21
103_Q	122_E	0.542	0.21
28_H	67_V	0.541	0.21
45_K	52_I	0.539	0.21
78_A	128_P	0.538	0.21
51_V	82_P	0.537	0.21
80_R	129_R	0.537	0.21
133_R	136_T	0.536	0.21
109_E	150_E	0.535	0.21
28_H	86_S	0.530	0.21
94_S	146_I	0.529	0.21
120_V	126_R	0.526	0.21
74_D	128_P	0.525	0.20
102_Q	109_E	0.524	0.20
42_A	119_K	0.523	0.20
38_G	132_G	0.523	0.20
18_M	145_E	0.519	0.20
21_E	145_E	0.515	0.20
16_K	114_H	0.515	0.20
48_L	80_R	0.513	0.20
127_K	141_L	0.512	0.20
129_R	145_E	0.512	0.20
129_R	135_T	0.510	0.20
33_A	117_P	0.509	0.20
55_E	117_P	0.509	0.20
91_K	111_V	0.507	0.20
17_A	90_L	0.505	0.20
16_K	79_G	0.504	0.20
67_V	73_I	0.504	0.20
7_V	42_A	0.501	0.19
21_E	140_T	0.501	0.19
81_Y	124_Q	0.500	0.19

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4a17Q	1	0.9872	100	0.192	Contact Map
1vx7W	1	0.9487	100	0.193	Contact Map
1vq8R	1	0.9615	100	0.194	Contact Map
4ujrC	1	0.9872	100	0.199	Contact Map
3j39P	1	0.9872	100	0.205	Contact Map
3j21S	1	0.9551	100	0.207	Contact Map
3j61P	1	0.9936	100	0.212	Contact Map
3zf7R	1	0.9679	100	0.225	Contact Map
3j3bP	1	0.9551	100	0.247	Contact Map
4w20P	1	0.9615	100	0.252	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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