GREMLIN Database
RL10 - 50S ribosomal protein L10
UniProt: P13553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 352 (298)
Sequences: 563 (346)
Seq/√Len: 20.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_G266_L4.9321.00
128_E161_D4.9211.00
307_G310_D4.0811.00
130_D155_S3.7361.00
56_Q104_Q3.5681.00
31_D95_N3.3831.00
172_S175_V3.2941.00
302_A306_G3.2101.00
14_E18_Q3.1561.00
87_G94_T3.1100.99
26_L58_A3.0550.99
298_V301_P3.0430.99
274_A278_V2.9320.99
299_D303_A2.7420.99
127_P161_D2.6690.98
119_V170_T2.5730.98
262_E267_A2.5530.98
38_V61_M2.5420.98
271_V278_V2.5410.98
123_D167_E2.4640.97
306_G309_A2.4040.97
137_P181_E2.3570.96
283_A286_D2.2790.95
292_P295_L2.0160.91
71_L75_G2.0140.91
25_D29_T1.9970.91
34_G193_L1.9380.89
272_S279_R1.9310.89
268_D272_S1.9030.89
126_V161_D1.9030.89
84_Y195_G1.8060.86
95_N222_A1.7980.85
300_A303_A1.7710.85
253_K269_D1.7430.84
299_D302_A1.7260.83
302_A309_A1.7240.83
297_D301_P1.7080.82
256_G262_E1.7060.82
305_A309_A1.6760.81
256_G261_V1.6530.80
303_A307_G1.6430.80
13_P229_L1.6010.78
266_L269_D1.5890.77
216_R220_Q1.5830.77
232_N258_Q1.5640.76
142_L149_A1.5570.76
284_Q287_D1.5550.76
163_V166_E1.5510.76
21_A25_D1.5430.75
42_P222_A1.5280.74
166_E169_E1.5270.74
292_P296_Q1.5190.74
44_K48_D1.5090.74
305_A308_E1.5020.73
13_P17_R1.5020.73
27_L59_L1.4800.72
271_V275_D1.4490.70
226_A229_L1.4370.70
304_P307_G1.4350.70
88_E143_Q1.4350.70
242_P245_I1.4340.70
230_S238_E1.4320.69
125_V163_V1.4300.69
294_E302_A1.4230.69
265_D268_D1.4230.69
43_S171_V1.4230.69
33_V129_G1.4220.69
303_A309_A1.4200.69
125_V161_D1.4130.68
298_V309_A1.4030.68
17_R233_A1.4020.68
210_I256_G1.3960.67
160_D249_R1.3960.67
93_A147_A1.3700.66
291_L295_L1.3680.66
18_Q21_A1.3510.65
228_N232_N1.3450.64
293_E296_Q1.3280.63
114_I171_V1.3160.63
281_L285_I1.3080.62
147_A158_V1.3070.62
205_P254_S1.3060.62
41_I45_Q1.2890.61
291_L298_V1.2890.61
302_A305_A1.2880.61
47_Q201_V1.2800.61
46_L92_V1.2760.60
30_Y58_A1.2690.60
255_L258_Q1.2600.59
51_R248_G1.2590.59
144_T174_D1.2560.59
271_V279_R1.2530.59
81_L246_A1.2510.59
263_S266_L1.2270.57
298_V302_A1.2240.57
275_D279_R1.2230.57
306_G310_D1.2190.57
163_V168_G1.2080.56
206_E212_V1.2050.56
70_A137_P1.2040.56
289_D292_P1.2040.56
115_N206_E1.1940.55
214_E217_A1.1910.55
301_P305_A1.1860.55
18_Q213_D1.1760.54
288_E299_D1.1730.54
298_V303_A1.1680.53
193_L224_A1.1590.53
122_N167_E1.1560.53
302_A308_E1.1530.52
300_A306_G1.1520.52
147_A162_S1.1470.52
56_Q96_D1.1380.51
128_E210_I1.1340.51
219_I223_A1.1310.51
286_D292_P1.1230.51
300_A304_P1.1160.50
245_I290_A1.1100.50
253_K257_L1.1090.50
139_V149_A1.1070.49
87_G203_F1.1020.49
129_G136_G1.1020.49
112_A143_Q1.0960.49
90_G157_Q1.0870.48
293_E299_D1.0770.48
59_L72_E1.0690.47
45_Q112_A1.0670.47
19_E62_S1.0600.46
70_A180_S1.0590.46
249_R252_A1.0520.46
150_R159_L1.0490.46
108_S156_I1.0430.45
155_S181_E1.0380.45
291_L294_E1.0380.45
22_E83_E1.0380.45
224_A301_P1.0320.45
38_V46_L1.0320.45
165_T169_E1.0290.44
63_R189_V1.0270.44
38_V67_L1.0190.44
36_V92_V1.0190.44
123_D169_E1.0130.43
240_T244_L1.0070.43
14_E168_G1.0050.43
102_Y209_E0.9950.42
103_Q107_N0.9910.42
14_E84_Y0.9790.41
96_D298_V0.9760.41
94_T155_S0.9750.41
287_D291_L0.9750.41
76_D79_D0.9690.41
111_P155_S0.9630.40
25_D217_A0.9630.40
126_V305_A0.9630.40
252_A255_L0.9570.40
81_L203_F0.9520.40
242_P266_L0.9490.39
123_D165_T0.9450.39
160_D197_F0.9340.38
165_T211_D0.9320.38
260_S270_L0.9250.38
33_V59_L0.9230.38
173_D206_E0.9220.38
251_E268_D0.9220.38
44_K47_Q0.9210.38
136_G146_G0.9170.37
143_Q151_I0.9160.37
219_I222_A0.9120.37
36_V90_G0.9110.37
17_R21_A0.9080.37
45_Q156_I0.9080.37
218_D274_A0.9070.37
271_V274_A0.9030.37
197_F214_E0.9010.36
214_E218_D0.9010.36
19_E23_L0.9000.36
216_R223_A0.8980.36
170_T198_S0.8970.36
246_A264_P0.8950.36
299_D306_G0.8870.36
164_V170_T0.8770.35
19_E189_V0.8720.35
85_V92_V0.8700.35
84_Y202_L0.8670.34
191_L211_D0.8640.34
94_T130_D0.8600.34
89_V156_I0.8540.34
161_D267_A0.8490.33
92_V144_T0.8460.33
89_V194_R0.8460.33
301_P304_P0.8440.33
185_E203_F0.8430.33
296_Q300_A0.8400.33
25_D115_N0.8370.33
80_T83_E0.8340.33
63_R149_A0.8320.32
171_V236_P0.8320.32
45_Q200_G0.8290.32
296_Q301_P0.8250.32
92_V246_A0.8250.32
53_L133_I0.8250.32
137_P152_Q0.8250.32
303_A308_E0.8240.32
64_N236_P0.8210.32
248_G297_D0.8210.32
105_L189_V0.8170.32
72_E308_E0.8170.32
217_A221_S0.8150.31
12_V15_W0.8150.31
290_A293_E0.8120.31
275_D278_V0.8090.31
156_I161_D0.8090.31
295_L303_A0.8090.31
281_L295_L0.8080.31
13_P75_G0.8040.31
126_V206_E0.8040.31
123_D148_N0.8020.31
35_V158_V0.8010.31
13_P164_V0.7990.31
202_L301_P0.7960.30
95_N159_L0.7950.30
256_G265_D0.7940.30
69_R205_P0.7940.30
13_P283_A0.7920.30
27_L35_V0.7920.30
287_D297_D0.7840.30
159_L241_A0.7830.30
41_I71_L0.7790.29
81_L190_G0.7780.29
41_I110_T0.7770.29
126_V302_A0.7750.29
271_V277_Q0.7720.29
302_A307_G0.7710.29
245_I252_A0.7710.29
154_G186_P0.7700.29
47_Q134_D0.7680.29
136_G165_T0.7680.29
81_L229_L0.7670.29
40_G118_E0.7660.29
85_V165_T0.7640.29
245_I293_E0.7640.29
257_L261_V0.7630.29
76_D80_T0.7600.28
145_I157_Q0.7580.28
29_T167_E0.7580.28
69_R159_L0.7570.28
286_D299_D0.7530.28
69_R146_G0.7510.28
64_N191_L0.7500.28
199_E212_V0.7490.28
295_L301_P0.7460.28
99_F103_Q0.7430.28
285_I289_D0.7410.27
127_P130_D0.7400.27
113_P272_S0.7360.27
26_L30_Y0.7340.27
303_A310_D0.7320.27
14_E17_R0.7320.27
226_A239_R0.7320.27
24_V191_L0.7310.27
35_V85_V0.7310.27
290_A295_L0.7290.27
111_P185_E0.7290.27
26_L93_A0.7280.27
230_S255_L0.7280.27
300_A305_A0.7270.27
83_E219_I0.7250.27
301_P307_G0.7240.27
96_D101_L0.7240.27
258_Q264_P0.7240.27
255_L301_P0.7230.27
276_A279_R0.7210.26
121_P142_L0.7190.26
247_K251_E0.7170.26
38_V91_L0.7140.26
282_A290_A0.7140.26
15_W42_P0.7130.26
164_V266_L0.7090.26
15_W248_G0.7080.26
250_G254_S0.7080.26
124_I205_P0.7070.26
48_D51_R0.7070.26
293_E297_D0.7070.26
32_S136_G0.7060.26
140_G149_A0.7060.26
65_T205_P0.7050.26
297_D300_A0.7040.26
164_V175_V0.7030.26
254_S258_Q0.6990.25
30_Y79_D0.6980.25
48_D52_G0.6970.25
245_I310_D0.6940.25
240_T243_D0.6930.25
262_E266_L0.6930.25
174_D254_S0.6920.25
24_V257_L0.6920.25
80_T256_G0.6910.25
294_E303_A0.6910.25
282_A286_D0.6890.25
33_V74_A0.6860.25
305_A310_D0.6860.25
253_K266_L0.6860.25
49_M197_F0.6860.25
249_R253_K0.6850.25
304_P309_A0.6830.25
265_D310_D0.6830.25
249_R265_D0.6810.24
31_D217_A0.6770.24
99_F123_D0.6760.24
101_L106_E0.6760.24
37_N192_D0.6750.24
38_V199_E0.6730.24
25_D164_V0.6720.24
45_Q143_Q0.6710.24
26_L244_L0.6700.24
37_N246_A0.6700.24
301_P306_G0.6690.24
113_P190_G0.6680.24
144_T171_V0.6670.24
44_K147_A0.6670.24
79_D91_L0.6630.24
15_W18_Q0.6610.24
59_L257_L0.6600.23
293_E298_V0.6600.23
124_I261_V0.6590.23
41_I153_E0.6590.23
15_W70_A0.6580.23
72_E76_D0.6550.23
273_K277_Q0.6550.23
119_V205_P0.6550.23
168_G219_I0.6540.23
288_E291_L0.6530.23
290_A294_E0.6520.23
95_N203_F0.6510.23
70_A148_N0.6470.23
132_G161_D0.6460.23
43_S162_S0.6440.23
132_G155_S0.6430.23
59_L95_N0.6430.23
28_E204_T0.6420.23
199_E297_D0.6390.23
290_A305_A0.6380.22
153_E213_D0.6360.22
28_E196_V0.6350.22
41_I143_Q0.6340.22
149_A178_V0.6320.22
295_L298_V0.6290.22
98_P242_P0.6280.22
27_L254_S0.6270.22
294_E297_D0.6240.22
19_E41_I0.6210.22
133_I183_G0.6200.22
143_Q209_E0.6190.22
147_A150_R0.6160.21
162_S263_S0.6160.21
24_V37_N0.6150.21
107_N290_A0.6150.21
62_S187_K0.6120.21
41_I189_V0.6100.21
145_I172_S0.6080.21
129_G161_D0.6060.21
299_D305_A0.6060.21
85_V107_N0.6020.21
61_M141_E0.6010.21
134_D148_N0.6010.21
294_E310_D0.6010.21
59_L92_V0.6000.21
41_I144_T0.5990.21
63_R86_E0.5990.21
56_Q101_L0.5970.21
225_S246_A0.5970.21
226_A255_L0.5960.21
272_S277_Q0.5910.20
139_V143_Q0.5900.20
274_A277_Q0.5880.20
85_V257_L0.5860.20
20_V66_L0.5830.20
35_V223_A0.5820.20
75_G202_L0.5820.20
194_R246_A0.5810.20
252_A274_A0.5800.20
136_G248_G0.5800.20
67_L169_E0.5790.20
170_T226_A0.5770.20
66_L182_L0.5740.20
106_E173_D0.5740.20
72_E213_D0.5730.20
55_G58_A0.5710.20
122_N128_E0.5700.20
141_E145_I0.5690.20
96_D245_I0.5690.20
19_E60_R0.5670.19
251_E259_A0.5670.19
70_A76_D0.5670.19
283_A294_E0.5660.19
116_A137_P0.5620.19
113_P196_V0.5620.19
65_T190_G0.5590.19
161_D164_V0.5580.19
25_D95_N0.5580.19
15_W105_L0.5580.19
227_R243_D0.5580.19
258_Q271_V0.5570.19
146_G222_A0.5560.19
59_L90_G0.5550.19
20_V156_I0.5530.19
212_V216_R0.5510.19
125_V290_A0.5470.19
203_F220_Q0.5460.19
31_D180_S0.5460.19
98_P172_S0.5450.19
270_L279_R0.5450.19
199_E202_L0.5450.19
101_L201_V0.5430.18
105_L204_T0.5430.18
69_R114_I0.5400.18
34_G105_L0.5390.18
33_V136_G0.5370.18
169_E242_P0.5360.18
109_K190_G0.5360.18
78_L249_R0.5360.18
302_A310_D0.5350.18
26_L219_I0.5330.18
15_W137_P0.5300.18
53_L217_A0.5280.18
65_T200_G0.5280.18
256_G259_A0.5260.18
299_D304_P0.5260.18
191_L235_Y0.5250.18
299_D310_D0.5230.18
132_G139_V0.5220.18
115_N208_L0.5220.18
30_Y93_A0.5180.18
59_L194_R0.5150.17
57_A146_G0.5150.17
78_L202_L0.5130.17
280_A283_A0.5110.17
17_R69_R0.5100.17
15_W261_V0.5100.17
289_D300_A0.5080.17
113_P132_G0.5070.17
62_S88_E0.5060.17
103_Q160_D0.5040.17
243_D250_G0.5040.17
167_E206_E0.5010.17
143_Q190_G0.5010.17
72_E214_E0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vq8G 1 0.0028 100 0.219 Contact Map
3j21k 1 0.5852 100 0.25 Contact Map
3j3bq 1 0.7869 100 0.285 Contact Map
3j61q 1 0.7301 100 0.292 Contact Map
4ujti 1 0.3977 100 0.293 Contact Map
3a1yG 1 0.5824 100 0.314 Contact Map
4hubG 1 0.5852 100 0.388 Contact Map
3jsyA 1 0.5909 100 0.463 Contact Map
4w22q 1 0.5653 100 0.482 Contact Map
3j65n 1 0.5994 100 0.534 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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