GREMLIN Database
FLAB2 - Flagellin B2
UniProt: P13077 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (182)
Sequences: 315 (234)
Seq/√Len: 17.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
184_V188_L4.1961.00
54_A57_Q4.1281.00
133_G137_D3.9341.00
70_N81_N3.8451.00
42_Y54_A3.0990.99
11_R34_G2.3010.93
46_K59_S2.2440.93
12_G38_N2.0670.89
150_M166_V2.0300.88
16_I22_F2.0030.87
166_V182_A1.9910.87
72_D81_N1.9820.87
25_M36_L1.9450.86
21_V102_T1.9320.85
79_V190_D1.8780.84
61_R90_A1.8770.84
114_L150_M1.8770.84
12_G28_V1.8720.83
12_G21_V1.8570.83
118_G121_A1.8480.83
168_L180_Y1.8250.82
14_V68_Y1.8170.82
11_R14_V1.7740.80
18_T32_A1.7590.79
34_G40_A1.6570.75
14_V21_V1.6500.75
36_L50_T1.6240.73
137_D141_D1.6160.73
151_D154_E1.5930.72
15_G19_L1.5920.72
78_E117_D1.5900.72
14_V48_S1.5650.71
83_A150_M1.5280.69
25_M91_A1.5230.68
36_L40_A1.4770.66
112_T155_I1.4710.66
163_G173_Q1.4630.65
172_T184_V1.4570.65
16_I24_A1.4500.64
117_D151_D1.4460.64
57_Q63_N1.4370.64
83_A105_W1.4340.64
83_A108_P1.4290.63
19_L30_A1.4010.62
20_I23_I1.3700.60
34_G163_G1.3690.60
22_F28_V1.3690.60
20_I24_A1.3510.59
65_V145_R1.3470.59
62_I100_K1.3460.59
145_R184_V1.3250.57
105_W160_L1.3040.56
59_S178_T1.2960.56
54_A63_N1.2860.55
57_Q172_T1.2860.55
40_A49_A1.2850.55
31_I46_K1.2810.55
31_I40_A1.2710.54
135_N141_D1.2460.53
8_E93_A1.2360.52
40_A86_T1.2240.51
22_F26_V1.2230.51
21_V36_L1.2170.51
99_S191_K1.1870.49
12_G42_Y1.1830.49
107_G152_A1.1730.48
89_Q93_A1.1680.48
27_L41_G1.1640.48
49_A181_W1.1500.47
125_N153_A1.1410.46
40_A188_L1.1370.46
15_G22_F1.1360.46
12_G22_F1.1300.46
38_N42_Y1.1290.46
42_Y57_Q1.1250.45
116_Y138_V1.1120.45
52_E56_A1.1090.44
129_N149_V1.1060.44
26_V41_G1.1010.44
64_I95_N1.0850.43
12_G53_E1.0800.43
85_L156_T1.0770.42
42_Y52_E1.0700.42
61_R178_T1.0660.42
28_V53_E1.0660.42
55_S172_T1.0600.41
90_A172_T1.0560.41
116_Y126_F1.0470.41
55_S59_S1.0460.41
138_V141_D1.0420.40
132_K136_A1.0400.40
168_L182_A1.0350.40
73_T76_S1.0310.40
129_N147_E1.0310.40
106_I166_V1.0260.39
172_T188_L1.0230.39
133_G165_E1.0220.39
135_N144_D1.0180.39
15_G18_T1.0170.39
125_N154_E1.0150.39
46_K55_S1.0080.38
89_Q168_L1.0030.38
174_Y177_K1.0000.38
85_L150_M0.9870.37
144_D185_P0.9870.37
12_G132_K0.9830.37
21_V71_V0.9820.37
135_N162_A0.9690.36
42_Y188_L0.9640.36
52_E139_L0.9620.36
58_V131_I0.9550.35
123_A153_A0.9500.35
14_V147_E0.9470.35
136_A157_T0.9410.35
73_T117_D0.9330.34
102_T148_I0.9300.34
14_V34_G0.9260.34
35_V40_A0.9250.34
21_V42_Y0.9210.34
26_V53_E0.9190.33
14_V167_Q0.9160.33
9_D52_E0.9130.33
141_D163_G0.9050.33
45_S179_T0.9050.33
26_V55_S0.9050.33
127_T149_V0.8940.32
49_A63_N0.8910.32
64_I180_Y0.8890.32
119_T125_N0.8880.32
46_K50_T0.8860.32
26_V39_T0.8860.32
42_Y64_I0.8790.31
88_R183_N0.8770.31
19_L22_F0.8730.31
128_T132_K0.8730.31
136_A162_A0.8690.31
34_G46_K0.8680.31
133_G162_A0.8610.30
18_T26_V0.8580.30
152_A155_I0.8440.30
126_F133_G0.8430.30
16_I21_V0.8200.28
120_T123_A0.8190.28
18_T30_A0.8170.28
42_Y142_Q0.8140.28
53_E73_T0.8090.28
129_N148_I0.8090.28
42_Y63_N0.8000.27
120_T191_K0.7940.27
155_I159_G0.7880.27
61_R172_T0.7880.27
112_T171_T0.7860.27
45_S60_N0.7830.27
143_S172_T0.7810.27
9_D49_A0.7710.26
95_N139_L0.7540.25
116_Y144_D0.7510.25
45_S94_D0.7450.25
14_V18_T0.7410.25
25_M32_A0.7390.25
117_D121_A0.7360.24
17_G20_I0.7340.24
31_I188_L0.7340.24
34_G48_S0.7300.24
49_A52_E0.7280.24
14_V66_S0.7240.24
28_V150_M0.7210.24
87_V171_T0.7210.24
29_A32_A0.7180.24
167_Q171_T0.7170.24
89_Q95_N0.7120.23
55_S61_R0.7100.23
144_D170_V0.7070.23
41_G176_S0.7060.23
24_A35_V0.7040.23
17_G22_F0.7040.23
11_R38_N0.6950.23
81_N123_A0.6920.23
103_I174_Y0.6920.23
101_S132_K0.6870.22
88_R176_S0.6860.22
90_A168_L0.6850.22
86_T89_Q0.6820.22
18_T38_N0.6820.22
49_A55_S0.6790.22
12_G26_V0.6770.22
96_I171_T0.6750.22
39_T43_L0.6710.22
42_Y49_A0.6660.21
117_D161_K0.6650.21
133_G144_D0.6610.21
27_L53_E0.6610.21
186_E190_D0.6580.21
97_N179_T0.6570.21
31_I52_E0.6570.21
21_V91_A0.6570.21
62_I96_I0.6560.21
164_E188_L0.6560.21
110_T170_V0.6540.21
173_Q180_Y0.6530.21
119_T122_D0.6440.21
130_S133_G0.6420.20
105_W166_V0.6400.20
46_K64_I0.6390.20
57_Q68_Y0.6390.20
24_A33_A0.6380.20
25_M187_S0.6350.20
73_T159_G0.6320.20
79_V159_G0.6220.20
16_I20_I0.6210.20
12_G23_I0.6210.20
170_V180_Y0.6200.20
45_S88_R0.6130.19
17_G25_M0.6110.19
71_V83_A0.6080.19
77_T123_A0.6070.19
73_T81_N0.6070.19
113_T147_E0.6070.19
164_E184_V0.6070.19
127_T138_V0.6060.19
11_R52_E0.6020.19
134_D163_G0.6020.19
72_D124_E0.6000.19
48_S57_Q0.6000.19
56_A142_Q0.5990.19
78_E81_N0.5990.19
20_I92_G0.5980.19
41_G55_S0.5980.19
15_G24_A0.5890.18
89_Q96_I0.5850.18
40_A51_G0.5840.18
56_A116_Y0.5800.18
80_V152_A0.5800.18
111_A171_T0.5790.18
133_G141_D0.5790.18
41_G50_T0.5720.18
121_A151_D0.5700.18
95_N140_V0.5690.18
15_G23_I0.5630.18
9_D42_Y0.5630.18
115_T159_G0.5560.17
16_I23_I0.5530.17
21_V54_A0.5520.17
26_V38_N0.5480.17
10_E13_Q0.5470.17
109_D191_K0.5450.17
148_I152_A0.5430.17
64_I103_I0.5430.17
85_L180_Y0.5380.17
67_A162_A0.5380.17
122_D127_T0.5360.17
15_G20_I0.5320.16
68_Y190_D0.5320.16
65_V112_T0.5290.16
71_V81_N0.5290.16
81_N161_K0.5280.16
114_L169_T0.5280.16
64_I114_L0.5220.16
157_T191_K0.5210.16
31_I184_V0.5150.16
19_L43_L0.5130.16
180_Y183_N0.5060.16
131_I140_V0.5050.16
114_L141_D0.5050.16
80_V83_A0.5040.16
61_R177_K0.5040.16
148_I170_V0.5030.16
159_G164_E0.5030.16
64_I113_T0.5020.16
132_K135_N0.5010.15
85_L105_W0.5010.15
128_T135_N0.5000.15
118_G161_K0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m8rA 4 0.3265 10.5 0.961 Contact Map
3ibzA 1 0.5561 8.9 0.962 Contact Map
2kxtA 1 0.5612 7.8 0.963 Contact Map
4b9fA 1 0.6531 6.5 0.964 Contact Map
4ue3S 2 0.0306 5.1 0.966 Contact Map
2l8aA 1 0.648 5.1 0.966 Contact Map
2zy9A 2 0.3571 5 0.966 Contact Map
1yq8A 3 0.4286 4.8 0.967 Contact Map
1wlhA 2 0.4082 4.6 0.967 Contact Map
2yrlA 1 0.4847 3.8 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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