GREMLIN Database
FLAA2 - Flagellin A2
UniProt: P13075 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 194 (182)
Sequences: 306 (231)
Seq/√Len: 17.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_A57_Q4.4471.00
70_N77_D4.2691.00
182_V186_L4.1181.00
42_F54_A3.1610.99
11_R34_G2.4000.95
46_K59_S2.3540.94
150_Y153_G2.3080.93
149_M164_V2.2970.93
11_R14_V2.0890.89
12_G38_N2.0820.89
140_Q161_G1.9760.86
12_G28_V1.9290.85
16_I22_F1.9080.84
21_V98_T1.8960.84
61_R86_A1.8590.83
12_G21_V1.8130.81
57_Q63_N1.7820.80
112_H137_V1.7790.80
18_T32_A1.7770.80
14_V21_V1.7520.79
164_V180_A1.7490.78
62_I96_K1.7040.77
14_V48_S1.6950.76
14_V68_Y1.6950.76
40_A82_T1.6620.75
19_L30_A1.6140.72
144_R182_V1.6120.72
25_M36_L1.6100.72
131_K134_N1.5990.72
79_V149_M1.5690.70
73_N123_E1.5650.70
55_S59_S1.5550.70
161_G171_Q1.5400.69
25_M87_A1.5280.68
34_G40_A1.4980.67
34_G161_G1.4950.66
166_L178_Y1.4920.66
31_I40_A1.4450.64
22_F28_V1.4440.64
64_I178_Y1.4340.63
79_V104_P1.4330.63
15_G19_L1.4320.63
52_E56_A1.4050.61
101_W158_L1.3910.61
36_L40_A1.3840.60
79_V101_W1.3810.60
36_L50_T1.3790.60
59_S176_T1.3350.57
22_F26_V1.3060.56
110_L149_M1.2980.55
120_T135_D1.2890.55
42_F52_E1.2870.55
132_G143_D1.2580.53
8_E89_A1.2420.52
170_T182_V1.2370.52
31_I46_K1.2360.52
172_Y175_K1.2310.51
16_I24_A1.2280.51
75_E188_D1.2040.50
116_A153_G1.2030.50
12_G42_F1.2020.49
46_K55_S1.1930.49
166_L180_A1.1870.49
20_I24_A1.1840.48
116_A123_E1.1840.48
42_F63_N1.1790.48
85_Q166_L1.1700.48
113_A150_Y1.1700.48
20_I23_I1.1680.47
54_A63_N1.1620.47
14_V34_G1.1570.47
49_A55_S1.1560.47
27_L41_G1.1430.46
38_N42_F1.1370.46
105_D116_A1.1280.45
72_N123_E1.0960.43
28_V53_E1.0940.43
26_V41_G1.0870.43
42_F57_Q1.0820.42
86_A170_T1.0810.42
12_G22_F1.0690.42
46_K64_I1.0610.41
40_A49_A1.0530.41
57_Q170_T1.0510.41
72_N83_V1.0490.40
14_V146_K1.0470.40
128_T148_I1.0440.40
85_Q89_A1.0430.40
142_S147_V1.0400.40
102_I164_V1.0370.40
12_G53_E1.0190.39
11_R52_E1.0180.39
49_A63_N1.0040.38
41_G174_S1.0020.38
118_K121_L0.9940.37
9_D52_E0.9890.37
26_V39_T0.9880.37
84_R181_N0.9870.37
18_T30_A0.9810.37
95_S189_K0.9790.36
26_V55_S0.9760.36
173_G183_P0.9760.36
15_G22_F0.9620.36
45_S60_N0.9590.35
83_V114_N0.9590.35
21_V71_V0.9590.35
77_D155_S0.9540.35
168_V178_Y0.9520.35
73_N145_I0.9490.35
165_Q169_T0.9490.35
61_R176_T0.9420.34
55_S61_R0.9300.34
65_V108_T0.9290.34
121_L149_M0.9250.33
101_W164_V0.9230.33
171_Q178_Y0.9200.33
65_V144_R0.9140.33
99_I145_I0.9110.33
74_E149_M0.9100.33
46_K50_T0.9060.32
12_G26_V0.9060.32
64_I110_L0.9040.32
130_I134_N0.8970.32
34_G48_S0.8910.32
92_I169_T0.8880.32
83_V107_A0.8880.32
81_L149_M0.8780.31
40_A90_D0.8730.31
9_D49_A0.8700.31
126_N137_V0.8670.30
26_V53_E0.8620.30
81_L101_W0.8600.30
64_I99_I0.8570.30
162_D186_L0.8550.30
98_T147_V0.8550.30
12_G131_K0.8500.30
41_G50_T0.8420.29
42_F64_I0.8410.29
18_T26_V0.8360.29
21_V42_F0.8320.29
112_H143_D0.8320.29
15_G18_T0.8290.29
103_G151_A0.8240.28
106_K168_V0.8220.28
14_V18_T0.8210.28
72_N152_G0.8180.28
74_E101_W0.8180.28
62_I92_I0.8140.28
56_A141_Q0.8110.28
64_I91_N0.8100.28
132_G160_A0.8090.28
21_V36_L0.8030.27
138_L165_Q0.8020.27
14_V66_S0.8000.27
126_N131_K0.7980.27
26_V38_N0.7920.27
35_V40_A0.7830.26
108_T113_A0.7830.26
73_N117_D0.7790.26
117_D121_L0.7760.26
41_G55_S0.7750.26
40_A186_L0.7710.26
178_Y181_N0.7700.26
110_L127_T0.7650.26
86_A166_L0.7600.25
42_F186_L0.7580.25
49_A179_W0.7550.25
48_S57_Q0.7550.25
144_R170_T0.7520.25
49_A59_S0.7490.25
77_D159_G0.7470.25
121_L125_F0.7460.25
18_T38_N0.7420.24
112_H125_F0.7400.24
61_R85_Q0.7350.24
161_G172_Y0.7350.24
119_T126_N0.7260.24
60_N67_A0.7140.23
45_S177_T0.7130.23
72_N105_D0.7130.23
24_A33_A0.7100.23
25_M32_A0.7100.23
110_L167_T0.7100.23
10_E62_I0.7090.23
143_D168_V0.7040.23
97_S149_M0.7040.23
31_I52_E0.7030.23
42_F46_K0.7030.23
39_T43_L0.6940.22
89_A174_S0.6940.22
56_A97_S0.6920.22
60_N140_Q0.6900.22
134_N140_Q0.6880.22
134_N143_D0.6880.22
74_E147_V0.6870.22
105_D121_L0.6870.22
70_N189_K0.6860.22
136_N150_Y0.6860.22
38_N54_A0.6850.22
144_R161_G0.6820.22
19_L22_F0.6800.22
64_I152_G0.6780.22
79_V116_A0.6770.22
157_K189_K0.6760.22
129_S132_G0.6750.22
34_G49_A0.6700.21
82_T85_Q0.6680.21
99_I151_A0.6680.21
16_I21_V0.6670.21
21_V54_A0.6660.21
42_F49_A0.6650.21
55_S179_W0.6610.21
79_V108_T0.6590.21
110_L169_T0.6550.21
55_S170_T0.6540.21
114_N117_D0.6530.21
118_K135_D0.6510.21
170_T186_L0.6470.21
24_A35_V0.6430.20
124_E155_S0.6330.20
27_L53_E0.6270.20
42_F61_R0.6230.20
45_S50_T0.6090.19
40_A45_S0.6050.19
85_Q177_T0.6030.19
40_A134_N0.5990.19
21_V156_S0.5970.19
45_S61_R0.5930.18
76_V79_V0.5930.18
68_Y188_D0.5930.18
65_V153_G0.5920.18
29_A32_A0.5920.18
68_Y103_G0.5870.18
91_N138_L0.5830.18
120_T123_E0.5790.18
102_I137_V0.5780.18
59_S66_S0.5770.18
160_A165_Q0.5730.18
117_D150_Y0.5730.18
40_A51_G0.5730.18
72_N113_A0.5730.18
81_L141_Q0.5710.18
123_E133_N0.5700.18
65_V68_Y0.5670.18
16_I26_V0.5660.18
114_N135_D0.5620.17
166_L176_T0.5600.17
84_R174_S0.5550.17
125_F171_Q0.5550.17
113_A123_E0.5530.17
79_V151_A0.5490.17
85_Q92_I0.5460.17
11_R38_N0.5440.17
130_I153_G0.5440.17
19_L43_L0.5390.17
31_I186_L0.5380.17
184_E188_D0.5330.16
78_Y119_T0.5330.16
55_S171_Q0.5310.16
76_V150_Y0.5290.16
115_A123_E0.5290.16
21_V39_T0.5290.16
92_I174_S0.5280.16
17_G20_I0.5270.16
131_K143_D0.5250.16
62_I169_T0.5230.16
11_R45_S0.5150.16
163_E179_W0.5120.16
31_I61_R0.5060.16
126_N148_I0.5030.15
83_V121_L0.5010.15
22_F43_L0.5000.15
52_E102_I0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kxtA 1 0.5361 5.1 0.965 Contact Map
4ue3S 2 0.0309 5 0.966 Contact Map
3ibzA 1 0.5412 4.5 0.966 Contact Map
2l8aA 1 0.6443 4.3 0.967 Contact Map
2zy9A 2 0.3763 3.8 0.967 Contact Map
3ncxA 1 0.5309 3.7 0.968 Contact Map
3rb5A 2 0.6237 3.5 0.968 Contact Map
3uljA 3 0.4485 3.3 0.968 Contact Map
1c7sA 2 0.6082 3.2 0.969 Contact Map
2xbtA 1 0.6701 3.1 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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