GREMLIN Database
FTSZ2 - Cell division protein FtsZ 2
UniProt: P0DMR7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (330)
Sequences: 3082 (1504)
Seq/√Len: 82.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_I80_V5.3171.00
98_E171_K4.6481.00
130_T168_G4.2611.00
105_Q138_K3.9801.00
247_E322_K3.9481.00
105_Q139_I3.9161.00
156_N185_N3.8381.00
171_K174_E3.6601.00
51_N73_K3.3391.00
253_K291_E3.2411.00
38_C132_A3.1911.00
104_A107_T3.1271.00
138_K175_K3.1101.00
110_E113_G2.9771.00
252_N256_E2.9701.00
249_Q322_K2.8741.00
120_V133_A2.8551.00
149_G176_A2.8351.00
176_A179_I2.7421.00
279_V296_A2.6461.00
285_P317_E2.6351.00
202_V205_Q2.5561.00
138_K142_E2.5081.00
153_T162_T2.4941.00
124_M169_L2.4431.00
160_A163_V2.2771.00
34_V115_A2.1841.00
62_I136_V2.1681.00
232_T236_N2.1661.00
205_Q208_A2.1111.00
109_K143_Q2.0831.00
98_E102_E2.0651.00
43_N68_H2.0571.00
105_Q109_K2.0531.00
235_M330_T2.0331.00
170_E174_E2.0291.00
153_T166_E2.0131.00
36_V112_L2.0101.00
109_K142_E1.9741.00
283_G287_L1.9551.00
99_R102_E1.9251.00
149_G179_I1.9211.00
109_K139_I1.9081.00
115_A118_V1.8281.00
47_N73_K1.7861.00
46_V61_A1.7841.00
66_K70_K1.7771.00
163_V167_E1.7681.00
297_D301_E1.7511.00
258_V299_I1.7261.00
255_N294_G1.7041.00
247_E324_R1.6781.00
78_I111_V1.6521.00
95_S99_R1.6521.00
50_Y74_A1.6471.00
112_L118_V1.6461.00
256_E259_K1.6411.00
102_E138_K1.6361.00
248_T256_E1.6321.00
112_L143_Q1.6231.00
48_R204_D1.6051.00
217_T226_L1.5971.00
167_E171_K1.5811.00
208_A212_K1.5781.00
262_M327_A1.5781.00
195_P198_K1.5611.00
60_V76_T1.5541.00
292_A311_W1.5521.00
255_N259_K1.5441.00
122_A151_V1.5431.00
62_I108_I1.5371.00
191_V202_V1.5351.00
60_V74_A1.5220.99
106_G109_K1.5200.99
47_N72_I1.5150.99
149_G172_L1.5110.99
178_S235_M1.5100.99
101_T132_A1.5080.99
293_E297_D1.4940.99
234_I276_G1.4660.99
139_I143_Q1.4650.99
193_N290_K1.4580.99
286_D320_K1.4480.99
223_L313_A1.4460.99
351_R354_Q1.4300.99
107_T110_E1.4260.99
86_N116_D1.4140.99
224_I311_W1.4130.99
222_S314_R1.3990.99
118_V145_A1.3830.99
61_A69_L1.3810.99
277_G303_L1.3570.99
287_L323_V1.3500.99
38_C136_V1.3490.99
92_G233_A1.3290.99
286_D321_G1.3270.99
191_V194_L1.3210.99
254_T258_V1.3090.98
197_G285_P1.2970.98
276_G307_A1.2940.98
92_G310_I1.2930.98
259_K263_N1.2680.98
197_G315_I1.2570.98
186_R189_D1.2300.98
34_V58_D1.2290.98
166_E170_E1.2270.98
349_S353_L1.2260.98
194_L199_A1.2200.98
272_R302_R1.2190.97
95_S98_E1.2070.97
115_A145_A1.1760.97
198_K201_S1.1750.97
54_V208_A1.1570.97
188_L293_E1.1530.96
210_T243_M1.1500.96
82_K107_T1.1500.96
242_V269_V1.1500.96
93_D233_A1.1480.96
196_I313_A1.1470.96
150_M211_V1.1440.96
90_A96_M1.1330.96
319_Y324_R1.1270.96
295_I323_V1.1260.96
108_I139_I1.1110.96
276_G304_D1.1020.95
171_K175_K1.0960.95
38_C120_V1.0890.95
347_D350_R1.0880.95
280_H314_R1.0860.95
43_N61_A1.0850.95
287_L292_A1.0820.95
275_S304_D1.0730.95
58_D76_T1.0690.95
60_V111_V1.0660.95
282_T314_R1.0620.94
50_Y59_T1.0570.94
55_E220_Q1.0530.94
37_G42_G1.0420.94
193_N288_T1.0420.94
350_R353_L1.0390.94
36_V62_I1.0380.94
298_N302_R1.0260.93
45_T49_L1.0220.93
257_V325_V1.0220.93
234_I310_I1.0170.93
31_P116_D1.0150.93
212_K216_E1.0080.93
109_K113_G1.0080.93
39_G42_G1.0030.93
178_S238_G1.0010.92
52_I208_A0.9930.92
194_L290_K0.9930.92
117_L148_V0.9900.92
254_T323_V0.9900.92
61_A72_I0.9850.92
167_E170_E0.9720.91
244_L261_A0.9710.91
80_V132_A0.9700.91
341_S345_Q0.9680.91
348_K352_E0.9630.91
169_L181_V0.9590.91
71_M297_D0.9500.90
91_G127_G0.9480.90
222_S280_H0.9470.90
84_L99_R0.9440.90
61_A74_A0.9430.90
101_T135_V0.9420.90
352_E355_D0.9420.90
316_Q324_R0.9410.90
159_R309_V0.9400.90
282_T319_Y0.9370.90
253_K288_T0.9350.90
249_Q321_G0.9350.90
256_E260_D0.9340.90
47_N71_M0.9320.90
78_I108_I0.9300.89
303_L307_A0.9280.89
111_V115_A0.9130.89
192_P202_V0.9090.88
49_L59_T0.9080.88
89_G127_G0.9050.88
48_R210_T0.9040.88
120_V136_V0.9030.88
118_V136_V0.9010.88
195_P288_T0.8990.88
61_A73_K0.8960.88
338_L341_S0.8920.87
298_N301_E0.8910.87
40_G44_N0.8900.87
257_V261_A0.8880.87
347_D355_D0.8840.87
297_D300_T0.8810.87
185_N189_D0.8800.87
93_D99_R0.8800.87
346_A349_S0.8800.87
120_V137_S0.8790.87
342_T349_S0.8770.86
255_N298_N0.8750.86
116_D188_L0.8740.86
51_N201_S0.8720.86
346_A351_R0.8680.86
162_T166_E0.8670.86
122_A133_A0.8660.86
185_N188_L0.8660.86
153_T183_D0.8530.85
156_N297_D0.8530.85
342_T345_Q0.8520.85
101_T108_I0.8490.85
201_S204_D0.8490.85
72_I77_K0.8470.85
296_A311_W0.8450.84
79_L82_K0.8430.84
348_K351_R0.8410.84
340_P343_Q0.8400.84
295_I325_V0.8390.84
153_T169_L0.8380.84
186_R264_H0.8360.84
238_G245_V0.8330.84
135_V139_I0.8320.83
246_G257_V0.8290.83
31_P226_L0.8220.83
276_G308_N0.8130.82
343_Q348_K0.8120.82
252_N294_G0.8040.81
124_M151_V0.8000.81
283_G292_A0.8000.81
112_L115_A0.7960.81
34_V60_V0.7960.81
170_E173_R0.7950.81
196_I200_F0.7920.80
351_R355_D0.7840.80
279_V325_V0.7830.80
339_G343_Q0.7760.79
259_K298_N0.7750.79
58_D115_A0.7750.79
348_K353_L0.7730.79
82_K104_A0.7720.79
187_L203_M0.7710.79
173_R240_V0.7690.78
343_Q346_A0.7680.78
106_G110_E0.7680.78
340_P346_A0.7670.78
346_A354_Q0.7650.78
163_V166_E0.7630.78
31_P229_A0.7600.78
192_P290_K0.7600.78
240_V279_V0.7590.77
349_S354_Q0.7590.77
342_T346_A0.7590.77
349_S352_E0.7540.77
347_D353_L0.7540.77
344_K347_D0.7490.76
84_L96_M0.7490.76
323_V335_A0.7420.76
45_T59_T0.7400.76
41_A332_V0.7340.75
343_Q353_L0.7320.75
63_N127_G0.7300.75
63_N90_A0.7260.74
204_D296_A0.7250.74
343_Q347_D0.7230.74
108_I112_L0.7210.74
117_L235_M0.7200.74
173_R333_Q0.7190.74
163_V306_S0.7180.73
246_G261_A0.7180.73
187_L289_L0.7160.73
341_S344_K0.7130.73
304_D307_A0.7120.73
347_D354_Q0.7090.72
283_G323_V0.7070.72
285_P315_I0.7050.72
283_G315_I0.7040.72
153_T328_I0.7030.72
264_H332_V0.7020.72
139_I142_E0.7010.72
41_A152_S0.6990.71
135_V138_K0.6920.71
328_I332_V0.6920.71
47_N50_Y0.6900.70
223_L315_I0.6860.70
61_A77_K0.6840.70
341_S346_A0.6840.70
233_A310_I0.6840.70
67_Q88_L0.6820.70
117_L294_G0.6770.69
342_T347_D0.6770.69
238_G276_G0.6760.69
272_R305_A0.6750.69
191_V195_P0.6720.68
121_T193_N0.6710.68
187_L204_D0.6700.68
52_I201_S0.6690.68
157_V311_W0.6680.68
223_L292_A0.6660.68
62_I111_V0.6660.68
145_A242_V0.6650.68
220_Q314_R0.6610.67
161_R310_I0.6610.67
76_T111_V0.6610.67
63_N91_G0.6610.67
164_K167_E0.6570.67
119_F241_A0.6570.67
336_Q339_G0.6570.67
212_K316_Q0.6550.66
350_R354_Q0.6540.66
141_K237_Q0.6540.66
276_G331_G0.6510.66
282_T330_T0.6510.66
212_K245_V0.6500.66
287_L311_W0.6500.66
113_G143_Q0.6490.66
183_D206_I0.6470.66
48_R62_I0.6460.65
221_P314_R0.6420.65
157_V200_F0.6420.65
343_Q352_E0.6410.65
344_K348_K0.6410.65
216_E219_T0.6410.65
337_V340_P0.6400.65
277_G329_M0.6400.65
66_K242_V0.6390.65
213_G243_M0.6380.64
341_S349_S0.6380.64
28_F73_K0.6380.64
316_Q319_Y0.6370.64
344_K354_Q0.6350.64
348_K354_Q0.6340.64
339_G342_T0.6340.64
71_M221_P0.6330.64
350_R355_D0.6310.64
54_V219_T0.6290.63
28_F70_K0.6280.63
146_I228_Y0.6270.63
74_A135_V0.6270.63
44_N130_T0.6250.63
45_T207_I0.6250.63
182_L233_A0.6230.63
345_Q353_L0.6230.63
121_T207_I0.6230.63
96_M99_R0.6200.62
27_E30_D0.6200.62
339_G347_D0.6190.62
349_S355_D0.6160.62
348_K355_D0.6160.62
248_T325_V0.6130.61
195_P208_A0.6110.61
293_E300_T0.6100.61
341_S352_E0.6080.61
54_V212_K0.6070.61
345_Q350_R0.6060.60
35_I59_T0.6060.60
213_G326_M0.6040.60
337_V341_S0.6000.60
340_P350_R0.6000.60
142_E233_A0.5990.60
345_Q351_R0.5980.59
343_Q354_Q0.5980.59
342_T348_K0.5970.59
80_V104_A0.5970.59
240_V333_Q0.5950.59
70_K77_K0.5920.59
217_T328_I0.5920.59
182_L339_G0.5910.59
338_L342_T0.5910.59
120_V149_G0.5910.59
344_K350_R0.5900.58
125_G165_A0.5900.58
36_V145_A0.5890.58
204_D292_A0.5890.58
338_L345_Q0.5880.58
151_V181_V0.5840.58
191_V203_M0.5840.58
253_K287_L0.5830.58
99_R103_M0.5830.58
188_L290_K0.5830.58
196_I311_W0.5820.57
344_K352_E0.5820.57
29_G66_K0.5820.57
223_L281_I0.5790.57
54_V124_M0.5790.57
214_I231_M0.5790.57
210_T245_V0.5790.57
106_G111_V0.5790.57
97_G127_G0.5780.57
243_M276_G0.5770.57
31_P88_L0.5770.57
148_V330_T0.5770.57
59_T124_M0.5760.57
92_G100_A0.5740.56
335_A338_L0.5730.56
92_G164_K0.5720.56
335_A339_G0.5700.56
284_G288_T0.5690.56
83_S103_M0.5670.55
213_G226_L0.5670.55
233_A308_N0.5660.55
341_S355_D0.5650.55
205_Q209_E0.5630.55
342_T350_R0.5630.55
250_D253_K0.5620.55
210_T268_D0.5620.55
275_S331_G0.5610.55
28_F226_L0.5600.55
35_I187_L0.5600.55
102_E105_Q0.5590.54
260_D272_R0.5570.54
217_T251_K0.5560.54
217_T222_S0.5550.54
63_N87_G0.5540.54
52_I205_Q0.5540.54
58_D75_D0.5530.54
344_K355_D0.5530.54
238_G307_A0.5500.53
342_T352_E0.5490.53
189_D255_N0.5480.53
342_T353_L0.5480.53
337_V343_Q0.5470.53
281_I295_I0.5460.53
213_G307_A0.5460.53
44_N91_G0.5440.52
340_P354_Q0.5440.52
338_L343_Q0.5440.52
344_K351_R0.5440.52
196_I292_A0.5440.52
183_D222_S0.5430.52
303_L309_V0.5420.52
234_I307_A0.5410.52
149_G169_L0.5410.52
283_G290_K0.5400.52
346_A350_R0.5390.52
50_Y75_D0.5390.52
178_S241_A0.5380.52
235_M276_G0.5380.52
67_Q267_L0.5380.52
339_G344_K0.5380.52
204_D311_W0.5370.52
104_A240_V0.5350.51
191_V289_L0.5350.51
39_G154_P0.5350.51
54_V216_E0.5350.51
338_L352_E0.5330.51
183_D268_D0.5330.51
344_K353_L0.5310.51
278_L324_R0.5310.51
318_S348_K0.5300.51
345_Q355_D0.5290.50
185_N293_E0.5290.50
339_G350_R0.5290.50
345_Q354_Q0.5290.50
46_V68_H0.5280.50
275_S333_Q0.5270.50
45_T121_T0.5270.50
59_T204_D0.5260.50
270_D277_G0.5250.50
340_P344_K0.5240.50
189_D195_P0.5240.50
94_P130_T0.5240.50
106_G353_L0.5230.50
178_S194_L0.5210.49
49_L180_I0.5200.49
29_G86_N0.5190.49
47_N337_V0.5190.49
151_V172_L0.5190.49
63_N88_L0.5180.49
141_K177_D0.5180.49
248_T254_T0.5180.49
112_L140_A0.5170.49
337_V346_A0.5170.49
334_S339_G0.5170.49
200_F224_I0.5160.49
62_I112_L0.5160.49
192_P245_V0.5150.49
117_L180_I0.5150.49
196_I238_G0.5150.49
218_I231_M0.5140.48
63_N67_Q0.5130.48
133_A172_L0.5130.48
289_L313_A0.5130.48
346_A352_E0.5130.48
45_T329_M0.5110.48
133_A136_V0.5110.48
197_G223_L0.5100.48
116_D229_A0.5090.48
47_N74_A0.5090.48
338_L346_A0.5080.48
258_V281_I0.5080.48
89_G97_G0.5050.47
44_N225_N0.5050.47
105_Q142_E0.5050.47
220_Q328_I0.5020.47
53_G325_V0.5020.47
87_G127_G0.5020.47
347_D351_R0.5010.47
45_T210_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vapA 1 0.8422 100 0.278 Contact Map
2r751 1 0.8142 100 0.291 Contact Map
1rq2A 2 0.7608 100 0.294 Contact Map
2vawA 1 0.7939 100 0.295 Contact Map
4m8iA 1 0.7863 100 0.295 Contact Map
2vxyA 2 0.7735 100 0.296 Contact Map
1w5fA 2 0.7888 100 0.303 Contact Map
1ofuA 1 0.7735 100 0.307 Contact Map
4ei7A 1 0.855 100 0.328 Contact Map
4b45A 1 0.7939 100 0.365 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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