HTR7 - HALSA - GREMLIN Contacts

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HTR7 - Transducer protein Htr7

UniProt:	P0DMI5	Sequences: MSGAAVFVDAVVAPLGDAVGAIGFGAAAALGYRNYRDTDAEAAFWMAFTFASLLGVTWTVSLMLEKAGVATQIFNLATGPLMATTVAVFAIGGTATLAIVEDMEALVEERAQRRQEAEEERAEAERAREKAEQKQAEAERQTAEAESAKQDARERSAEIEQLAADLESQATEVGATLEAASDGDLTARVDATTDNAEIAEVATVVNDMLTTMERTIDEIQGFSTNVTTASREATAGAKEIQDASQTVSESVQEIAAGTDDQREQLESVAEEMDSYSATVEEVAATAQSVADTAADTTDVATAGKQTAEDAIDAIDAVQETMQTTVANVDALEDLTTEIDDIAELISDIAEQTNMLALNANIEAARAGSGGGSNGDGFAVVADEVKELATESQRSAKDIAELIEEVQSQTATTVEEIRVAEQRVNDGAAAVEETVDAFGAVTENIQETTDGVQEISQAMDEQAQRSERVVSSVDDIATISQATADRAENVSAASEEQTASITEVTSSLQSLAAQADTLEDRLNEFRTEATGTAHGEATDAPAGQSD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	545 (454)
Sequences:	13670 (11586)
Seq/√Len:	543.8

ECOLI - MCP2 MCP4 MCP3 AER MCP1
BACSU - YVAQ MCPB TLPA MCPA YOAH MCPC TLPB TLPC HEMAT
HALSA - HTR7 Q9HPA2 Q9HQX8 HTR4 Q9HS86 HMAT HTR2 Q9HRA1 Q9HRN6 Q9HP10 HTR9 COST Q9HR88 Q9HPQ5 HTR1 Q9HQT5 Q9HPW6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
179_A	184_D	3.602	1.00
96_T	99_I	2.811	1.00
179_A	187_A	2.613	1.00
206_N	209_L	2.477	1.00
257_G	478_I	2.368	1.00
164_A	168_S	2.307	1.00
178_E	207_D	2.281	1.00
305_Q	309_D	2.280	1.00
173_V	202_A	2.275	1.00
188_R	213_E	2.249	1.00
178_E	200_E	2.229	1.00
51_A	55_G	2.193	1.00
174_G	200_E	2.137	1.00
174_G	204_V	2.115	1.00
178_E	182_D	2.104	1.00
196_A	199_A	2.024	1.00
317_V	426_G	2.018	1.00
177_L	208_M	2.001	1.00
44_F	48_F	1.978	1.00
316_A	422_R	1.965	1.00
177_L	205_V	1.960	1.00
55_G	59_T	1.959	1.00
180_A	208_M	1.952	1.00
428_A	432_E	1.944	1.00
474_D	477_T	1.930	1.00
334_L	404_E	1.926	1.00
48_F	52_S	1.916	1.00
163_A	167_E	1.915	1.00
206_N	210_T	1.902	1.00
298_D	302_A	1.895	1.00
334_L	408_Q	1.886	1.00
343_E	347_D	1.885	1.00
40_A	44_F	1.875	1.00
299_V	439_A	1.872	1.00
337_E	340_D	1.860	1.00
180_A	209_L	1.843	1.00
87_A	90_A	1.828	1.00
72_Q	76_L	1.822	1.00
281_E	284_A	1.809	1.00
128_R	132_E	1.806	1.00
311_I	434_V	1.793	1.00
68_G	72_Q	1.779	1.00
302_A	305_Q	1.774	1.00
54_L	58_W	1.763	1.00
333_D	336_T	1.762	1.00
159_I	163_A	1.754	1.00
79_G	83_A	1.744	1.00
424_N	428_A	1.737	1.00
330_A	408_Q	1.726	1.00
312_D	316_A	1.723	1.00
188_R	206_N	1.723	1.00
138_A	141_Q	1.718	1.00
69_V	73_I	1.714	1.00
119_E	123_E	1.713	1.00
432_E	435_D	1.693	1.00
86_V	90_A	1.693	1.00
121_R	125_E	1.689	1.00
64_L	67_A	1.682	1.00
57_T	60_V	1.678	1.00
146_E	150_Q	1.658	1.00
446_E	449_D	1.646	1.00
47_A	51_A	1.644	1.00
502_E	505_S	1.644	1.00
291_D	294_A	1.629	1.00
214_R	218_E	1.616	1.00
200_E	203_T	1.616	1.00
309_D	312_D	1.603	1.00
295_D	298_D	1.603	1.00
137_E	141_Q	1.601	1.00
177_L	204_V	1.601	1.00
178_E	204_V	1.595	1.00
309_D	432_E	1.594	1.00
431_E	435_D	1.591	1.00
58_W	61_S	1.583	1.00
501_T	505_S	1.579	1.00
495_E	498_A	1.575	1.00
315_D	431_E	1.571	1.00
445_Q	449_D	1.559	1.00
213_E	217_D	1.558	1.00
328_V	412_T	1.555	1.00
421_Q	425_D	1.543	1.00
435_D	439_A	1.536	1.00
188_R	210_T	1.535	1.00
386_E	389_T	1.529	1.00
52_S	55_G	1.513	1.00
43_A	47_A	1.513	1.00
49_T	52_S	1.511	1.00
173_V	201_V	1.509	1.00
327_N	412_T	1.496	1.00
308_E	312_D	1.494	1.00
78_T	82_M	1.493	1.00
301_T	305_Q	1.487	1.00
188_R	209_L	1.482	1.00
291_D	295_D	1.480	1.00
173_V	205_V	1.473	1.00
73_I	77_A	1.466	1.00
467_R	470_S	1.465	1.00
393_R	397_D	1.461	1.00
339_D	406_Q	1.446	1.00
289_V	451_V	1.445	1.00
309_D	429_A	1.442	1.00
61_S	75_N	1.436	1.00
90_A	94_T	1.434	1.00
391_S	395_A	1.432	1.00
105_A	109_E	1.431	1.00
332_E	413_V	1.431	1.00
498_A	502_E	1.422	1.00
466_E	470_S	1.421	1.00
50_F	53_L	1.420	1.00
337_E	397_D	1.420	1.00
264_Q	474_D	1.415	1.00
67_A	71_T	1.409	1.00
103_M	107_V	1.405	1.00
329_D	333_D	1.403	1.00
399_A	403_E	1.398	1.00
46_M	50_F	1.397	1.00
72_Q	75_N	1.396	1.00
65_E	68_G	1.392	1.00
438_G	442_E	1.386	1.00
435_D	438_G	1.385	1.00
340_D	343_E	1.383	1.00
327_N	411_T	1.379	1.00
112_Q	116_E	1.378	1.00
459_D	463_Q	1.376	1.00
66_K	69_V	1.375	1.00
191_A	206_N	1.371	1.00
221_G	224_T	1.368	1.00
315_D	319_E	1.361	1.00
312_D	315_D	1.358	1.00
117_A	121_R	1.357	1.00
68_G	71_T	1.355	1.00
303_G	440_V	1.353	1.00
107_V	111_A	1.350	1.00
209_L	213_E	1.347	1.00
288_S	291_D	1.339	1.00
142_T	146_E	1.337	1.00
334_L	337_E	1.337	1.00
84_T	87_A	1.335	1.00
280_E	284_A	1.335	1.00
42_A	45_W	1.331	1.00
306_T	432_E	1.320	1.00
37_D	41_E	1.318	1.00
360_N	382_D	1.311	1.00
253_E	256_A	1.308	1.00
220_Q	224_T	1.307	1.00
65_E	69_V	1.301	1.00
45_W	49_T	1.301	1.00
389_T	393_R	1.292	1.00
177_L	201_V	1.292	1.00
82_M	86_V	1.292	1.00
172_E	190_D	1.290	1.00
316_A	319_E	1.287	1.00
300_A	441_T	1.285	1.00
78_T	81_L	1.283	1.00
76_L	80_P	1.281	1.00
439_A	442_E	1.280	1.00
442_E	446_E	1.270	1.00
102_D	105_A	1.265	1.00
41_E	44_F	1.261	1.00
52_S	56_V	1.260	1.00
155_R	159_I	1.259	1.00
134_K	138_A	1.252	1.00
287_Q	459_D	1.250	1.00
184_D	187_A	1.250	1.00
160_E	164_A	1.248	1.00
301_T	445_Q	1.247	1.00
58_W	62_L	1.244	1.00
43_A	46_M	1.243	1.00
37_D	40_A	1.242	1.00
108_E	112_Q	1.241	1.00
210_T	214_R	1.240	1.00
51_A	54_L	1.239	1.00
102_D	106_L	1.237	1.00
171_T	174_G	1.235	1.00
48_F	51_A	1.230	1.00
76_L	79_G	1.220	1.00
425_D	428_A	1.219	1.00
330_A	333_D	1.219	1.00
346_S	399_A	1.212	1.00
44_F	47_A	1.211	1.00
282_V	458_M	1.210	1.00
382_D	385_K	1.205	1.00
273_D	277_A	1.205	1.00
218_E	221_G	1.203	1.00
75_N	79_G	1.203	1.00
83_A	87_A	1.199	1.00
322_Q	326_A	1.198	1.00
170_A	198_I	1.198	1.00
55_G	58_W	1.197	1.00
344_L	394_S	1.197	1.00
81_L	85_T	1.197	1.00
488_N	491_A	1.193	1.00
263_E	267_S	1.193	1.00
142_T	145_A	1.193	1.00
175_A	178_E	1.191	1.00
151_D	155_R	1.184	1.00
249_E	253_E	1.174	1.00
211_T	214_R	1.171	1.00
73_I	76_L	1.167	1.00
91_I	96_T	1.167	1.00
360_N	385_K	1.162	1.00
284_A	288_S	1.161	1.00
263_E	266_E	1.157	1.00
38_T	41_E	1.156	1.00
267_S	270_E	1.155	1.00
80_P	83_A	1.154	1.00
56_V	59_T	1.154	1.00
129_E	133_Q	1.149	1.00
54_L	57_T	1.148	1.00
165_D	169_Q	1.148	1.00
189_V	206_N	1.145	1.00
156_S	160_E	1.139	1.00
157_A	161_Q	1.137	1.00
484_D	487_E	1.136	1.00
477_T	481_A	1.134	1.00
491_A	495_E	1.130	1.00
410_A	414_E	1.129	1.00
494_E	498_A	1.129	1.00
161_Q	164_A	1.126	1.00
115_Q	119_E	1.122	1.00
484_D	488_N	1.118	1.00
203_T	206_N	1.116	1.00
77_A	80_P	1.116	1.00
174_G	201_V	1.114	1.00
116_E	120_E	1.113	1.00
456_Q	460_E	1.113	1.00
145_A	149_K	1.112	1.00
166_L	169_Q	1.112	1.00
396_K	400_E	1.109	1.00
287_Q	291_D	1.108	1.00
135_Q	139_E	1.106	1.00
63_M	67_A	1.105	1.00
176_T	189_V	1.102	1.00
298_D	301_T	1.101	1.00
319_E	323_T	1.097	1.00
304_K	438_G	1.095	1.00
302_A	432_E	1.094	1.00
302_A	439_A	1.093	1.00
218_E	502_E	1.087	1.00
182_D	207_D	1.085	1.00
174_G	178_E	1.084	1.00
250_S	485_R	1.083	1.00
294_A	298_D	1.078	1.00
252_Q	256_A	1.075	1.00
292_T	446_E	1.074	1.00
328_V	413_V	1.074	1.00
45_W	48_F	1.073	1.00
310_A	433_T	1.065	1.00
39_D	42_A	1.063	1.00
319_E	322_Q	1.056	1.00
321_M	423_V	1.056	1.00
202_A	206_N	1.056	1.00
396_K	399_A	1.055	1.00
473_D	477_T	1.053	1.00
421_Q	424_N	1.052	1.00
106_L	109_E	1.050	1.00
337_E	404_E	1.047	1.00
221_G	225_N	1.044	1.00
304_K	441_T	1.044	1.00
270_E	274_S	1.041	1.00
504_T	508_Q	1.040	1.00
310_A	430_V	1.038	1.00
224_T	228_T	1.033	1.00
89_F	93_G	1.032	1.00
191_A	202_A	1.032	1.00
477_T	480_Q	1.031	1.00
275_Y	465_S	1.031	1.00
304_K	308_E	1.030	1.00
187_A	209_L	1.030	1.00
326_A	329_D	1.029	1.00
179_A	182_D	1.028	1.00
274_S	277_A	1.025	1.00
307_A	433_T	1.024	1.00
393_R	396_K	1.023	1.00
323_T	326_A	1.019	1.00
305_Q	308_E	1.018	1.00
280_E	466_E	1.017	1.00
481_A	484_D	1.017	1.00
191_A	203_T	1.017	1.00
107_V	110_R	1.013	1.00
246_T	249_E	1.011	1.00
297_T	301_T	1.011	1.00
189_V	202_A	1.011	1.00
50_F	54_L	1.006	1.00
71_T	75_N	1.006	1.00
87_A	91_I	1.004	1.00
256_A	260_D	1.000	1.00
113_R	116_E	1.000	1.00
171_T	175_A	0.999	1.00
42_A	46_M	0.998	1.00
121_R	124_A	0.996	1.00
41_E	45_W	0.995	1.00
172_E	175_A	0.991	1.00
97_L	101_E	0.984	1.00
170_A	201_V	0.984	1.00
175_A	179_A	0.983	1.00
456_Q	459_D	0.982	1.00
284_A	287_Q	0.982	1.00
169_Q	197_E	0.981	1.00
39_D	43_A	0.979	1.00
260_D	263_E	0.974	1.00
119_E	122_A	0.974	1.00
90_A	93_G	0.971	1.00
104_E	108_E	0.966	1.00
169_Q	198_I	0.960	1.00
303_G	437_F	0.959	1.00
168_S	172_E	0.958	1.00
120_E	123_E	0.956	1.00
505_S	508_Q	0.953	1.00
190_D	206_N	0.950	1.00
313_A	425_D	0.949	1.00
256_A	259_D	0.944	1.00
173_V	177_L	0.942	1.00
99_I	102_D	0.942	1.00
400_E	404_E	0.941	1.00
149_K	153_R	0.936	1.00
217_D	221_G	0.933	1.00
346_S	350_E	0.933	1.00
219_I	222_F	0.932	1.00
403_E	407_S	0.931	1.00
134_K	137_E	0.930	1.00
127_A	134_K	0.928	1.00
134_K	141_Q	0.928	1.00
109_E	112_Q	0.928	1.00
318_Q	427_A	0.923	1.00
205_V	208_M	0.922	1.00
273_D	469_V	0.918	1.00
180_A	205_V	0.915	1.00
259_D	263_E	0.914	1.00
299_V	443_N	0.913	1.00
346_S	395_A	0.913	1.00
207_D	210_T	0.911	1.00
69_V	72_Q	0.906	1.00
117_A	120_E	0.904	1.00
470_S	474_D	0.904	1.00
296_T	444_I	0.903	1.00
74_F	78_T	0.902	1.00
46_M	53_L	0.902	1.00
71_T	81_L	0.898	1.00
89_F	92_G	0.897	1.00
324_T	415_E	0.896	1.00
507_L	510_L	0.894	1.00
335_T	409_T	0.892	1.00
480_Q	484_D	0.889	1.00
111_A	115_Q	0.889	1.00
327_N	415_E	0.889	1.00
314_I	426_G	0.887	1.00
57_T	61_S	0.887	1.00
336_T	410_A	0.885	1.00
255_A	259_D	0.884	1.00
92_G	96_T	0.884	1.00
397_D	400_E	0.882	1.00
103_M	106_L	0.881	1.00
487_E	491_A	0.880	1.00
333_D	337_E	0.879	1.00
118_E	121_R	0.878	1.00
59_T	62_L	0.877	1.00
198_I	202_A	0.876	1.00
130_K	133_Q	0.873	1.00
53_L	57_T	0.872	1.00
207_D	211_T	0.872	1.00
112_Q	115_Q	0.871	1.00
179_A	208_M	0.870	1.00
185_L	212_M	0.869	1.00
215_T	219_I	0.856	1.00
80_P	84_T	0.855	1.00
452_Q	456_Q	0.855	1.00
130_K	134_K	0.854	1.00
277_A	281_E	0.853	1.00
176_T	205_V	0.851	1.00
335_T	405_V	0.848	1.00
246_T	488_N	0.846	1.00
503_V	510_L	0.845	1.00
127_A	131_A	0.843	1.00
97_L	100_V	0.843	1.00
104_E	107_V	0.843	1.00
442_E	445_Q	0.842	1.00
83_A	86_V	0.837	1.00
118_E	122_A	0.835	1.00
129_E	132_E	0.833	1.00
265_L	475_I	0.831	1.00
317_V	423_V	0.831	1.00
331_L	405_V	0.830	1.00
176_T	179_A	0.828	1.00
116_E	119_E	0.828	1.00
260_D	264_Q	0.827	1.00
176_T	187_A	0.827	1.00
496_Q	510_L	0.822	1.00
53_L	56_V	0.822	1.00
54_L	82_M	0.819	1.00
127_A	132_E	0.819	1.00
98_A	101_E	0.817	1.00
120_E	124_A	0.816	1.00
390_E	397_D	0.813	1.00
60_V	67_A	0.812	1.00
122_A	126_R	0.807	1.00
50_F	57_T	0.806	1.00
326_A	330_A	0.805	1.00
341_I	401_L	0.805	1.00
172_E	176_T	0.802	1.00
498_A	501_T	0.793	1.00
320_T	422_R	0.792	1.00
428_A	431_E	0.791	1.00
332_E	410_A	0.790	1.00
253_E	481_A	0.790	1.00
266_E	270_E	0.784	1.00
409_T	412_T	0.782	1.00
429_A	432_E	0.782	1.00
39_D	46_M	0.777	1.00
86_V	89_F	0.775	1.00
167_E	198_I	0.774	1.00
79_G	82_M	0.774	1.00
318_Q	424_N	0.773	1.00
506_S	509_S	0.771	1.00
491_A	494_E	0.771	1.00
122_A	125_E	0.770	1.00
337_E	401_L	0.770	1.00
92_G	95_A	0.769	1.00
390_E	393_R	0.768	1.00
132_E	136_A	0.763	1.00
463_Q	467_R	0.762	1.00
297_T	445_Q	0.760	1.00
131_A	134_K	0.756	1.00
338_I	402_I	0.755	1.00
449_D	453_E	0.754	1.00
64_L	68_G	0.754	1.00
135_Q	138_A	0.754	1.00
191_A	199_A	0.752	1.00
176_T	202_A	0.751	1.00
177_L	180_A	0.749	1.00
133_Q	137_E	0.749	1.00
314_I	317_V	0.748	1.00
111_A	114_R	0.745	1.00
214_R	217_D	0.745	1.00
332_E	336_T	0.741	1.00
272_M	472_V	0.738	1.00
254_I	258_T	0.738	1.00
63_M	66_K	0.737	1.00
43_A	93_G	0.736	1.00
222_F	225_N	0.732	1.00
88_V	92_G	0.731	1.00
117_A	124_A	0.730	1.00
131_A	138_A	0.729	1.00
109_E	113_R	0.727	1.00
392_Q	396_K	0.727	1.00
295_D	443_N	0.727	1.00
197_E	200_E	0.725	1.00
195_N	199_A	0.725	1.00
218_E	222_F	0.725	1.00
105_A	108_E	0.725	1.00
136_A	140_R	0.724	1.00
162_L	166_L	0.724	1.00
261_Q	265_L	0.723	1.00
73_I	80_P	0.721	1.00
85_T	89_F	0.719	1.00
276_S	469_V	0.717	1.00
137_E	140_R	0.714	1.00
82_M	85_T	0.714	1.00
193_T	199_A	0.712	1.00
171_T	200_E	0.711	1.00
91_I	95_A	0.711	1.00
95_A	100_V	0.709	1.00
216_I	219_I	0.708	1.00
205_V	209_L	0.705	1.00
245_Q	249_E	0.704	1.00
167_E	171_T	0.702	1.00
169_Q	199_A	0.701	1.00
400_E	403_E	0.699	1.00
103_M	110_R	0.698	1.00
295_D	299_V	0.698	1.00
268_V	468_V	0.697	1.00
123_E	126_R	0.696	1.00
185_L	216_I	0.696	1.00
87_A	102_D	0.694	1.00
143_A	146_E	0.694	1.00
290_A	294_A	0.690	1.00
449_D	452_Q	0.689	1.00
275_Y	461_Q	0.688	1.00
336_T	340_D	0.686	1.00
322_Q	424_N	0.685	1.00
279_V	465_S	0.680	1.00
146_E	149_K	0.679	1.00
107_V	114_R	0.677	1.00
43_A	50_F	0.674	1.00
466_E	469_V	0.674	1.00
39_D	50_F	0.673	1.00
277_A	280_E	0.672	1.00
251_V	489_V	0.671	1.00
77_A	81_L	0.671	1.00
314_I	427_A	0.670	1.00
249_E	252_Q	0.668	1.00
49_T	53_L	0.666	1.00
258_T	265_L	0.663	1.00
499_S	502_E	0.660	1.00
307_A	430_V	0.657	1.00
78_T	85_T	0.657	1.00
54_L	75_N	0.656	1.00
330_A	334_L	0.655	1.00
244_S	247_V	0.655	1.00
181_S	207_D	0.654	1.00
347_D	390_E	0.654	1.00
322_Q	420_E	0.653	1.00
128_R	131_A	0.653	1.00
71_T	80_P	0.652	1.00
347_D	350_E	0.651	1.00
300_A	304_K	0.650	1.00
494_E	497_T	0.645	1.00
67_A	70_A	0.645	1.00
422_R	425_D	0.644	1.00
40_A	43_A	0.643	1.00
58_W	75_N	0.643	1.00
106_L	110_R	0.640	1.00
110_R	113_R	0.640	1.00
340_D	344_L	0.640	1.00
329_D	332_E	0.639	1.00
330_A	411_T	0.639	1.00
117_A	125_E	0.638	1.00
411_T	414_E	0.638	1.00
181_S	204_V	0.638	1.00
289_V	450_G	0.638	1.00
437_F	440_V	0.638	1.00
40_A	93_G	0.638	1.00
126_R	129_E	0.637	1.00
168_S	171_T	0.636	1.00
127_A	130_K	0.633	1.00
341_I	402_I	0.632	1.00
66_K	70_A	0.632	1.00
342_A	399_A	0.631	1.00
297_T	448_T	0.629	1.00
219_I	223_S	0.628	1.00
104_E	111_A	0.627	1.00
469_V	473_D	0.625	1.00
85_T	88_V	0.625	1.00
70_A	77_A	0.624	1.00
407_S	411_T	0.624	1.00
159_I	167_E	0.623	1.00
38_T	42_A	0.621	1.00
50_F	60_V	0.620	1.00
460_E	463_Q	0.619	1.00
61_S	67_A	0.617	1.00
461_Q	464_R	0.617	1.00
271_E	274_S	0.617	1.00
223_S	226_V	0.612	1.00
279_V	458_M	0.610	1.00
323_T	415_E	0.610	1.00
219_I	226_V	0.610	1.00
91_I	99_I	0.610	1.00
96_T	100_V	0.609	1.00
285_T	453_E	0.608	1.00
299_V	302_A	0.608	1.00
180_A	212_M	0.607	1.00
321_M	324_T	0.607	1.00
353_N	385_K	0.605	1.00
470_S	473_D	0.603	1.00
295_D	439_A	0.602	1.00
224_T	227_T	0.602	1.00
150_Q	157_A	0.601	1.00
293_A	444_I	0.600	1.00
306_T	309_D	0.600	1.00
42_A	53_L	0.600	1.00
134_K	139_E	0.599	1.00
485_R	488_N	0.598	1.00
223_S	227_T	0.598	1.00
382_D	386_E	0.598	1.00
81_L	84_T	0.598	1.00
311_I	430_V	0.596	1.00
208_M	212_M	0.595	1.00
300_A	303_G	0.595	1.00
503_V	507_L	0.593	1.00
157_A	160_E	0.590	1.00
368_S	373_N	0.590	1.00
54_L	60_V	0.590	1.00
270_E	273_D	0.589	1.00
88_V	91_I	0.588	1.00
245_Q	497_T	0.588	1.00
478_I	482_T	0.587	1.00
292_T	450_G	0.587	1.00
306_T	429_A	0.587	1.00
251_V	486_A	0.585	0.99
467_R	471_S	0.585	0.99
211_T	509_S	0.583	0.99
153_R	157_A	0.583	0.99
53_L	60_V	0.583	0.99
42_A	54_L	0.583	0.99
176_T	209_L	0.581	0.99
423_V	426_G	0.581	0.99
101_E	104_E	0.580	0.99
321_M	419_A	0.580	0.99
257_G	482_T	0.579	0.99
288_S	450_G	0.578	0.99
182_D	211_T	0.578	0.99
101_E	105_A	0.578	0.99
95_A	98_A	0.577	0.99
356_A	385_K	0.577	0.99
479_S	483_A	0.575	0.99
456_Q	463_Q	0.575	0.99
407_S	410_A	0.573	0.99
276_S	465_S	0.573	0.99
324_T	419_A	0.571	0.99
187_A	191_A	0.570	0.99
53_L	61_S	0.570	0.99
486_A	489_V	0.569	0.99
174_G	198_I	0.568	0.99
453_E	456_Q	0.566	0.99
169_Q	173_V	0.563	0.99
201_V	205_V	0.561	0.99
43_A	57_T	0.560	0.99
253_E	485_R	0.560	0.99
476_A	480_Q	0.558	0.99
106_L	114_R	0.557	0.99
54_L	78_T	0.557	0.99
294_A	452_Q	0.557	0.99
199_A	203_T	0.556	0.99
47_A	50_F	0.555	0.99
47_A	86_V	0.553	0.99
385_K	389_T	0.553	0.99
509_S	512_A	0.552	0.99
115_Q	118_E	0.552	0.99
176_T	180_A	0.552	0.99
315_D	318_Q	0.551	0.99
314_I	430_V	0.549	0.99
331_L	412_T	0.549	0.99
42_A	49_T	0.548	0.99
306_T	436_A	0.542	0.99
146_E	153_R	0.542	0.99
64_L	71_T	0.538	0.99
224_T	504_T	0.538	0.99
183_G	208_M	0.536	0.99
42_A	60_V	0.536	0.99
208_M	211_T	0.535	0.99
251_V	254_I	0.534	0.99
290_A	455_S	0.534	0.99
341_I	344_L	0.532	0.99
268_V	471_S	0.531	0.99
273_D	276_S	0.531	0.99
215_T	218_E	0.531	0.99
388_A	391_S	0.531	0.99
420_E	424_N	0.531	0.99
271_E	464_R	0.530	0.99
320_T	323_T	0.530	0.99
281_E	453_E	0.530	0.99
201_V	204_V	0.529	0.99
436_A	440_V	0.528	0.99
110_R	117_A	0.527	0.99
357_L	365_R	0.526	0.99
208_M	213_E	0.525	0.99
433_T	436_A	0.525	0.99
258_T	482_T	0.521	0.99
255_A	258_T	0.520	0.99
302_A	436_A	0.520	0.99
402_I	406_Q	0.518	0.99
183_G	209_L	0.518	0.99
308_E	438_G	0.518	0.99
323_T	327_N	0.515	0.99
61_S	68_G	0.514	0.99
499_S	503_V	0.512	0.99
290_A	293_A	0.511	0.99
183_G	201_V	0.511	0.99
441_T	445_Q	0.509	0.99
446_E	450_G	0.509	0.99
172_E	192_T	0.508	0.99
225_N	228_T	0.508	0.99
505_S	509_S	0.507	0.99
496_Q	500_I	0.507	0.99
103_M	108_E	0.507	0.99
303_G	307_A	0.507	0.99
455_S	458_M	0.506	0.99
265_L	472_V	0.506	0.99
269_A	274_S	0.506	0.99
493_S	497_T	0.506	0.99
180_A	185_L	0.506	0.99
266_E	476_A	0.506	0.99
296_T	443_N	0.506	0.99
306_T	433_T	0.504	0.99
285_T	450_G	0.504	0.99
500_I	510_L	0.504	0.99
255_A	483_A	0.503	0.98
342_A	346_S	0.502	0.98
211_T	215_T	0.502	0.98
139_E	142_T	0.501	0.98
174_G	177_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.5578	100	0.421	Contact Map
2ch7A	2	0.567	100	0.521	Contact Map
1qu7A	2	0.4165	100	0.547	Contact Map
3g67A	2	0.3835	100	0.618	Contact Map
4i3mA	2	0.2697	99.9	0.759	Contact Map
2f95B	2	0.0972	99.1	0.875	Contact Map
4cq4A	4	0.178	99	0.878	Contact Map
3zccA	2	0.2018	98.9	0.882	Contact Map
4gycB	2	0.1119	98.9	0.884	Contact Map
2rm8A	1	0.1248	98.3	0.904	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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