GREMLIN Database
HTR7 - Transducer protein Htr7
UniProt: P0DMI5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 545 (454)
Sequences: 13670 (11586)
Seq/√Len: 543.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
179_A184_D3.6021.00
96_T99_I2.8111.00
179_A187_A2.6131.00
206_N209_L2.4771.00
257_G478_I2.3681.00
164_A168_S2.3071.00
178_E207_D2.2811.00
305_Q309_D2.2801.00
173_V202_A2.2751.00
188_R213_E2.2491.00
178_E200_E2.2291.00
51_A55_G2.1931.00
174_G200_E2.1371.00
174_G204_V2.1151.00
178_E182_D2.1041.00
196_A199_A2.0241.00
317_V426_G2.0181.00
177_L208_M2.0011.00
44_F48_F1.9781.00
316_A422_R1.9651.00
177_L205_V1.9601.00
55_G59_T1.9591.00
180_A208_M1.9521.00
428_A432_E1.9441.00
474_D477_T1.9301.00
334_L404_E1.9261.00
48_F52_S1.9161.00
163_A167_E1.9151.00
206_N210_T1.9021.00
298_D302_A1.8951.00
334_L408_Q1.8861.00
343_E347_D1.8851.00
40_A44_F1.8751.00
299_V439_A1.8721.00
337_E340_D1.8601.00
180_A209_L1.8431.00
87_A90_A1.8281.00
72_Q76_L1.8221.00
281_E284_A1.8091.00
128_R132_E1.8061.00
311_I434_V1.7931.00
68_G72_Q1.7791.00
302_A305_Q1.7741.00
54_L58_W1.7631.00
333_D336_T1.7621.00
159_I163_A1.7541.00
79_G83_A1.7441.00
424_N428_A1.7371.00
330_A408_Q1.7261.00
312_D316_A1.7231.00
188_R206_N1.7231.00
138_A141_Q1.7181.00
69_V73_I1.7141.00
119_E123_E1.7131.00
432_E435_D1.6931.00
86_V90_A1.6931.00
121_R125_E1.6891.00
64_L67_A1.6821.00
57_T60_V1.6781.00
146_E150_Q1.6581.00
446_E449_D1.6461.00
47_A51_A1.6441.00
502_E505_S1.6441.00
291_D294_A1.6291.00
214_R218_E1.6161.00
200_E203_T1.6161.00
309_D312_D1.6031.00
295_D298_D1.6031.00
137_E141_Q1.6011.00
177_L204_V1.6011.00
178_E204_V1.5951.00
309_D432_E1.5941.00
431_E435_D1.5911.00
58_W61_S1.5831.00
501_T505_S1.5791.00
495_E498_A1.5751.00
315_D431_E1.5711.00
445_Q449_D1.5591.00
213_E217_D1.5581.00
328_V412_T1.5551.00
421_Q425_D1.5431.00
435_D439_A1.5361.00
188_R210_T1.5351.00
386_E389_T1.5291.00
52_S55_G1.5131.00
43_A47_A1.5131.00
49_T52_S1.5111.00
173_V201_V1.5091.00
327_N412_T1.4961.00
308_E312_D1.4941.00
78_T82_M1.4931.00
301_T305_Q1.4871.00
188_R209_L1.4821.00
291_D295_D1.4801.00
173_V205_V1.4731.00
73_I77_A1.4661.00
467_R470_S1.4651.00
393_R397_D1.4611.00
339_D406_Q1.4461.00
289_V451_V1.4451.00
309_D429_A1.4421.00
61_S75_N1.4361.00
90_A94_T1.4341.00
391_S395_A1.4321.00
105_A109_E1.4311.00
332_E413_V1.4311.00
498_A502_E1.4221.00
466_E470_S1.4211.00
50_F53_L1.4201.00
337_E397_D1.4201.00
264_Q474_D1.4151.00
67_A71_T1.4091.00
103_M107_V1.4051.00
329_D333_D1.4031.00
399_A403_E1.3981.00
46_M50_F1.3971.00
72_Q75_N1.3961.00
65_E68_G1.3921.00
438_G442_E1.3861.00
435_D438_G1.3851.00
340_D343_E1.3831.00
327_N411_T1.3791.00
112_Q116_E1.3781.00
459_D463_Q1.3761.00
66_K69_V1.3751.00
191_A206_N1.3711.00
221_G224_T1.3681.00
315_D319_E1.3611.00
312_D315_D1.3581.00
117_A121_R1.3571.00
68_G71_T1.3551.00
303_G440_V1.3531.00
107_V111_A1.3501.00
209_L213_E1.3471.00
288_S291_D1.3391.00
142_T146_E1.3371.00
334_L337_E1.3371.00
84_T87_A1.3351.00
280_E284_A1.3351.00
42_A45_W1.3311.00
306_T432_E1.3201.00
37_D41_E1.3181.00
360_N382_D1.3111.00
253_E256_A1.3081.00
220_Q224_T1.3071.00
65_E69_V1.3011.00
45_W49_T1.3011.00
389_T393_R1.2921.00
177_L201_V1.2921.00
82_M86_V1.2921.00
172_E190_D1.2901.00
316_A319_E1.2871.00
300_A441_T1.2851.00
78_T81_L1.2831.00
76_L80_P1.2811.00
439_A442_E1.2801.00
442_E446_E1.2701.00
102_D105_A1.2651.00
41_E44_F1.2611.00
52_S56_V1.2601.00
155_R159_I1.2591.00
134_K138_A1.2521.00
287_Q459_D1.2501.00
184_D187_A1.2501.00
160_E164_A1.2481.00
301_T445_Q1.2471.00
58_W62_L1.2441.00
43_A46_M1.2431.00
37_D40_A1.2421.00
108_E112_Q1.2411.00
210_T214_R1.2401.00
51_A54_L1.2391.00
102_D106_L1.2371.00
171_T174_G1.2351.00
48_F51_A1.2301.00
76_L79_G1.2201.00
425_D428_A1.2191.00
330_A333_D1.2191.00
346_S399_A1.2121.00
44_F47_A1.2111.00
282_V458_M1.2101.00
382_D385_K1.2051.00
273_D277_A1.2051.00
218_E221_G1.2031.00
75_N79_G1.2031.00
83_A87_A1.1991.00
322_Q326_A1.1981.00
170_A198_I1.1981.00
55_G58_W1.1971.00
344_L394_S1.1971.00
81_L85_T1.1971.00
488_N491_A1.1931.00
263_E267_S1.1931.00
142_T145_A1.1931.00
175_A178_E1.1911.00
151_D155_R1.1841.00
249_E253_E1.1741.00
211_T214_R1.1711.00
73_I76_L1.1671.00
91_I96_T1.1671.00
360_N385_K1.1621.00
284_A288_S1.1611.00
263_E266_E1.1571.00
38_T41_E1.1561.00
267_S270_E1.1551.00
80_P83_A1.1541.00
56_V59_T1.1541.00
129_E133_Q1.1491.00
54_L57_T1.1481.00
165_D169_Q1.1481.00
189_V206_N1.1451.00
156_S160_E1.1391.00
157_A161_Q1.1371.00
484_D487_E1.1361.00
477_T481_A1.1341.00
491_A495_E1.1301.00
410_A414_E1.1291.00
494_E498_A1.1291.00
161_Q164_A1.1261.00
115_Q119_E1.1221.00
484_D488_N1.1181.00
203_T206_N1.1161.00
77_A80_P1.1161.00
174_G201_V1.1141.00
116_E120_E1.1131.00
456_Q460_E1.1131.00
145_A149_K1.1121.00
166_L169_Q1.1121.00
396_K400_E1.1091.00
287_Q291_D1.1081.00
135_Q139_E1.1061.00
63_M67_A1.1051.00
176_T189_V1.1021.00
298_D301_T1.1011.00
319_E323_T1.0971.00
304_K438_G1.0951.00
302_A432_E1.0941.00
302_A439_A1.0931.00
218_E502_E1.0871.00
182_D207_D1.0851.00
174_G178_E1.0841.00
250_S485_R1.0831.00
294_A298_D1.0781.00
252_Q256_A1.0751.00
292_T446_E1.0741.00
328_V413_V1.0741.00
45_W48_F1.0731.00
310_A433_T1.0651.00
39_D42_A1.0631.00
319_E322_Q1.0561.00
321_M423_V1.0561.00
202_A206_N1.0561.00
396_K399_A1.0551.00
473_D477_T1.0531.00
421_Q424_N1.0521.00
106_L109_E1.0501.00
337_E404_E1.0471.00
221_G225_N1.0441.00
304_K441_T1.0441.00
270_E274_S1.0411.00
504_T508_Q1.0401.00
310_A430_V1.0381.00
224_T228_T1.0331.00
89_F93_G1.0321.00
191_A202_A1.0321.00
477_T480_Q1.0311.00
275_Y465_S1.0311.00
304_K308_E1.0301.00
187_A209_L1.0301.00
326_A329_D1.0291.00
179_A182_D1.0281.00
274_S277_A1.0251.00
307_A433_T1.0241.00
393_R396_K1.0231.00
323_T326_A1.0191.00
305_Q308_E1.0181.00
280_E466_E1.0171.00
481_A484_D1.0171.00
191_A203_T1.0171.00
107_V110_R1.0131.00
246_T249_E1.0111.00
297_T301_T1.0111.00
189_V202_A1.0111.00
50_F54_L1.0061.00
71_T75_N1.0061.00
87_A91_I1.0041.00
256_A260_D1.0001.00
113_R116_E1.0001.00
171_T175_A0.9991.00
42_A46_M0.9981.00
121_R124_A0.9961.00
41_E45_W0.9951.00
172_E175_A0.9911.00
97_L101_E0.9841.00
170_A201_V0.9841.00
175_A179_A0.9831.00
456_Q459_D0.9821.00
284_A287_Q0.9821.00
169_Q197_E0.9811.00
39_D43_A0.9791.00
260_D263_E0.9741.00
119_E122_A0.9741.00
90_A93_G0.9711.00
104_E108_E0.9661.00
169_Q198_I0.9601.00
303_G437_F0.9591.00
168_S172_E0.9581.00
120_E123_E0.9561.00
505_S508_Q0.9531.00
190_D206_N0.9501.00
313_A425_D0.9491.00
256_A259_D0.9441.00
173_V177_L0.9421.00
99_I102_D0.9421.00
400_E404_E0.9411.00
149_K153_R0.9361.00
217_D221_G0.9331.00
346_S350_E0.9331.00
219_I222_F0.9321.00
403_E407_S0.9311.00
134_K137_E0.9301.00
127_A134_K0.9281.00
134_K141_Q0.9281.00
109_E112_Q0.9281.00
318_Q427_A0.9231.00
205_V208_M0.9221.00
273_D469_V0.9181.00
180_A205_V0.9151.00
259_D263_E0.9141.00
299_V443_N0.9131.00
346_S395_A0.9131.00
207_D210_T0.9111.00
69_V72_Q0.9061.00
117_A120_E0.9041.00
470_S474_D0.9041.00
296_T444_I0.9031.00
74_F78_T0.9021.00
46_M53_L0.9021.00
71_T81_L0.8981.00
89_F92_G0.8971.00
324_T415_E0.8961.00
507_L510_L0.8941.00
335_T409_T0.8921.00
480_Q484_D0.8891.00
111_A115_Q0.8891.00
327_N415_E0.8891.00
314_I426_G0.8871.00
57_T61_S0.8871.00
336_T410_A0.8851.00
255_A259_D0.8841.00
92_G96_T0.8841.00
397_D400_E0.8821.00
103_M106_L0.8811.00
487_E491_A0.8801.00
333_D337_E0.8791.00
118_E121_R0.8781.00
59_T62_L0.8771.00
198_I202_A0.8761.00
130_K133_Q0.8731.00
53_L57_T0.8721.00
207_D211_T0.8721.00
112_Q115_Q0.8711.00
179_A208_M0.8701.00
185_L212_M0.8691.00
215_T219_I0.8561.00
80_P84_T0.8551.00
452_Q456_Q0.8551.00
130_K134_K0.8541.00
277_A281_E0.8531.00
176_T205_V0.8511.00
335_T405_V0.8481.00
246_T488_N0.8461.00
503_V510_L0.8451.00
127_A131_A0.8431.00
97_L100_V0.8431.00
104_E107_V0.8431.00
442_E445_Q0.8421.00
83_A86_V0.8371.00
118_E122_A0.8351.00
129_E132_E0.8331.00
265_L475_I0.8311.00
317_V423_V0.8311.00
331_L405_V0.8301.00
176_T179_A0.8281.00
116_E119_E0.8281.00
260_D264_Q0.8271.00
176_T187_A0.8271.00
496_Q510_L0.8221.00
53_L56_V0.8221.00
54_L82_M0.8191.00
127_A132_E0.8191.00
98_A101_E0.8171.00
120_E124_A0.8161.00
390_E397_D0.8131.00
60_V67_A0.8121.00
122_A126_R0.8071.00
50_F57_T0.8061.00
326_A330_A0.8051.00
341_I401_L0.8051.00
172_E176_T0.8021.00
498_A501_T0.7931.00
320_T422_R0.7921.00
428_A431_E0.7911.00
332_E410_A0.7901.00
253_E481_A0.7901.00
266_E270_E0.7841.00
409_T412_T0.7821.00
429_A432_E0.7821.00
39_D46_M0.7771.00
86_V89_F0.7751.00
167_E198_I0.7741.00
79_G82_M0.7741.00
318_Q424_N0.7731.00
506_S509_S0.7711.00
491_A494_E0.7711.00
122_A125_E0.7701.00
337_E401_L0.7701.00
92_G95_A0.7691.00
390_E393_R0.7681.00
132_E136_A0.7631.00
463_Q467_R0.7621.00
297_T445_Q0.7601.00
131_A134_K0.7561.00
338_I402_I0.7551.00
449_D453_E0.7541.00
64_L68_G0.7541.00
135_Q138_A0.7541.00
191_A199_A0.7521.00
176_T202_A0.7511.00
177_L180_A0.7491.00
133_Q137_E0.7491.00
314_I317_V0.7481.00
111_A114_R0.7451.00
214_R217_D0.7451.00
332_E336_T0.7411.00
272_M472_V0.7381.00
254_I258_T0.7381.00
63_M66_K0.7371.00
43_A93_G0.7361.00
222_F225_N0.7321.00
88_V92_G0.7311.00
117_A124_A0.7301.00
131_A138_A0.7291.00
109_E113_R0.7271.00
392_Q396_K0.7271.00
295_D443_N0.7271.00
197_E200_E0.7251.00
195_N199_A0.7251.00
218_E222_F0.7251.00
105_A108_E0.7251.00
136_A140_R0.7241.00
162_L166_L0.7241.00
261_Q265_L0.7231.00
73_I80_P0.7211.00
85_T89_F0.7191.00
276_S469_V0.7171.00
137_E140_R0.7141.00
82_M85_T0.7141.00
193_T199_A0.7121.00
171_T200_E0.7111.00
91_I95_A0.7111.00
95_A100_V0.7091.00
216_I219_I0.7081.00
205_V209_L0.7051.00
245_Q249_E0.7041.00
167_E171_T0.7021.00
169_Q199_A0.7011.00
400_E403_E0.6991.00
103_M110_R0.6981.00
295_D299_V0.6981.00
268_V468_V0.6971.00
123_E126_R0.6961.00
185_L216_I0.6961.00
87_A102_D0.6941.00
143_A146_E0.6941.00
290_A294_A0.6901.00
449_D452_Q0.6891.00
275_Y461_Q0.6881.00
336_T340_D0.6861.00
322_Q424_N0.6851.00
279_V465_S0.6801.00
146_E149_K0.6791.00
107_V114_R0.6771.00
43_A50_F0.6741.00
466_E469_V0.6741.00
39_D50_F0.6731.00
277_A280_E0.6721.00
251_V489_V0.6711.00
77_A81_L0.6711.00
314_I427_A0.6701.00
249_E252_Q0.6681.00
49_T53_L0.6661.00
258_T265_L0.6631.00
499_S502_E0.6601.00
307_A430_V0.6571.00
78_T85_T0.6571.00
54_L75_N0.6561.00
330_A334_L0.6551.00
244_S247_V0.6551.00
181_S207_D0.6541.00
347_D390_E0.6541.00
322_Q420_E0.6531.00
128_R131_A0.6531.00
71_T80_P0.6521.00
347_D350_E0.6511.00
300_A304_K0.6501.00
494_E497_T0.6451.00
67_A70_A0.6451.00
422_R425_D0.6441.00
40_A43_A0.6431.00
58_W75_N0.6431.00
106_L110_R0.6401.00
110_R113_R0.6401.00
340_D344_L0.6401.00
329_D332_E0.6391.00
330_A411_T0.6391.00
117_A125_E0.6381.00
411_T414_E0.6381.00
181_S204_V0.6381.00
289_V450_G0.6381.00
437_F440_V0.6381.00
40_A93_G0.6381.00
126_R129_E0.6371.00
168_S171_T0.6361.00
127_A130_K0.6331.00
341_I402_I0.6321.00
66_K70_A0.6321.00
342_A399_A0.6311.00
297_T448_T0.6291.00
219_I223_S0.6281.00
104_E111_A0.6271.00
469_V473_D0.6251.00
85_T88_V0.6251.00
70_A77_A0.6241.00
407_S411_T0.6241.00
159_I167_E0.6231.00
38_T42_A0.6211.00
50_F60_V0.6201.00
460_E463_Q0.6191.00
61_S67_A0.6171.00
461_Q464_R0.6171.00
271_E274_S0.6171.00
223_S226_V0.6121.00
279_V458_M0.6101.00
323_T415_E0.6101.00
219_I226_V0.6101.00
91_I99_I0.6101.00
96_T100_V0.6091.00
285_T453_E0.6081.00
299_V302_A0.6081.00
180_A212_M0.6071.00
321_M324_T0.6071.00
353_N385_K0.6051.00
470_S473_D0.6031.00
295_D439_A0.6021.00
224_T227_T0.6021.00
150_Q157_A0.6011.00
293_A444_I0.6001.00
306_T309_D0.6001.00
42_A53_L0.6001.00
134_K139_E0.5991.00
485_R488_N0.5981.00
223_S227_T0.5981.00
382_D386_E0.5981.00
81_L84_T0.5981.00
311_I430_V0.5961.00
208_M212_M0.5951.00
300_A303_G0.5951.00
503_V507_L0.5931.00
157_A160_E0.5901.00
368_S373_N0.5901.00
54_L60_V0.5901.00
270_E273_D0.5891.00
88_V91_I0.5881.00
245_Q497_T0.5881.00
478_I482_T0.5871.00
292_T450_G0.5871.00
306_T429_A0.5871.00
251_V486_A0.5850.99
467_R471_S0.5850.99
211_T509_S0.5830.99
153_R157_A0.5830.99
53_L60_V0.5830.99
42_A54_L0.5830.99
176_T209_L0.5810.99
423_V426_G0.5810.99
101_E104_E0.5800.99
321_M419_A0.5800.99
257_G482_T0.5790.99
288_S450_G0.5780.99
182_D211_T0.5780.99
101_E105_A0.5780.99
95_A98_A0.5770.99
356_A385_K0.5770.99
479_S483_A0.5750.99
456_Q463_Q0.5750.99
407_S410_A0.5730.99
276_S465_S0.5730.99
324_T419_A0.5710.99
187_A191_A0.5700.99
53_L61_S0.5700.99
486_A489_V0.5690.99
174_G198_I0.5680.99
453_E456_Q0.5660.99
169_Q173_V0.5630.99
201_V205_V0.5610.99
43_A57_T0.5600.99
253_E485_R0.5600.99
476_A480_Q0.5580.99
106_L114_R0.5570.99
54_L78_T0.5570.99
294_A452_Q0.5570.99
199_A203_T0.5560.99
47_A50_F0.5550.99
47_A86_V0.5530.99
385_K389_T0.5530.99
509_S512_A0.5520.99
115_Q118_E0.5520.99
176_T180_A0.5520.99
315_D318_Q0.5510.99
314_I430_V0.5490.99
331_L412_T0.5490.99
42_A49_T0.5480.99
306_T436_A0.5420.99
146_E153_R0.5420.99
64_L71_T0.5380.99
224_T504_T0.5380.99
183_G208_M0.5360.99
42_A60_V0.5360.99
208_M211_T0.5350.99
251_V254_I0.5340.99
290_A455_S0.5340.99
341_I344_L0.5320.99
268_V471_S0.5310.99
273_D276_S0.5310.99
215_T218_E0.5310.99
388_A391_S0.5310.99
420_E424_N0.5310.99
271_E464_R0.5300.99
320_T323_T0.5300.99
281_E453_E0.5300.99
201_V204_V0.5290.99
436_A440_V0.5280.99
110_R117_A0.5270.99
357_L365_R0.5260.99
208_M213_E0.5250.99
433_T436_A0.5250.99
258_T482_T0.5210.99
255_A258_T0.5200.99
302_A436_A0.5200.99
402_I406_Q0.5180.99
183_G209_L0.5180.99
308_E438_G0.5180.99
323_T327_N0.5150.99
61_S68_G0.5140.99
499_S503_V0.5120.99
290_A293_A0.5110.99
183_G201_V0.5110.99
441_T445_Q0.5090.99
446_E450_G0.5090.99
172_E192_T0.5080.99
225_N228_T0.5080.99
505_S509_S0.5070.99
496_Q500_I0.5070.99
103_M108_E0.5070.99
303_G307_A0.5070.99
455_S458_M0.5060.99
265_L472_V0.5060.99
269_A274_S0.5060.99
493_S497_T0.5060.99
180_A185_L0.5060.99
266_E476_A0.5060.99
296_T443_N0.5060.99
306_T433_T0.5040.99
285_T450_G0.5040.99
500_I510_L0.5040.99
255_A483_A0.5030.98
342_A346_S0.5020.98
211_T215_T0.5020.98
139_E142_T0.5010.98
174_G177_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.5578 100 0.421 Contact Map
2ch7A 2 0.567 100 0.521 Contact Map
1qu7A 2 0.4165 100 0.547 Contact Map
3g67A 2 0.3835 100 0.618 Contact Map
4i3mA 2 0.2697 99.9 0.759 Contact Map
2f95B 2 0.0972 99.1 0.875 Contact Map
4cq4A 4 0.178 99 0.878 Contact Map
3zccA 2 0.2018 98.9 0.882 Contact Map
4gycB 2 0.1119 98.9 0.884 Contact Map
2rm8A 1 0.1248 98.3 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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