HTR4 - HALSA - GREMLIN Contacts

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HTR4 - Transducer protein Htr4

UniProt:	P0DMI4	Sequences: MSIRSFAHRILRRALPGFVRRSYLAKFGVALLAVVVCISAAGGVMYLNTSEHLQQSSRTELKKAAELSSSAVDNWHDERTNNARMLAQYGVFDNDNATEVQQFFTDEQHHLPSDVRDIHYVSLTDARVITSTDAGLRNASFGSEAAPWSRQQLTPGDDGVFVSQPYVNDGITEVAYVARVSSTPGRRTAVVMTASLAAISSSFWDPTPHSFTQLVDGTGSVIADDSKRATRQPYVENATSPIVGARAVGFQPAAQAAKEMDQAHETAYAPVDGTPWVVTLHVPTSEAYGLASNMAENVLLILGIALAGLVFIALTLGRGTVRALNDLEAKAAALERGEYDTDLDVARVDELGRLFEAFASLRDTVQARIRDANEQQVDAEAARSEAEAAQADAEAAQAEAEAAREESEAQARRLETTAEAFSETMRAYAAGDLTVRLDADVEQAAMADIAAAFNEMAADMEATIADVVAFADEVATASTDASDSAAAVEQTGRDVSDAVGRIRDRAADQRDQLEAVASETDEMSATIEEVAASADQVAETSQRAAALGDDGQAAAQDAVAQLEEIEDETQAAATAVDDLEAKMSEIETIVAAITDIAEQTNMLALNANIEAARADQDGDGFAVVADEVKDLADESKASAAEIEALVAEVRAQTETSVAAMDRIQERVSDGVETVSETERSLSEIAGRIAEADTGVQEISNAMDDQAASVSDVTTAVGDVAALGEETATEAESTADAAAEQATTLSDVAAQTETLAEHAVALREHAAQFEVAADNEPGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	778 (659)
Sequences:	958 (868)
Seq/√Len:	33.8

BACSU - TLPB TLPA MCPA MCPB MCPC
HALSA - HTR4 HTR2 Q9HRA1 COST Q9HR88 Q9HRN6 Q9HP10 Q9HS86

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
427_A	432_D	6.401	1.00
333_A	338_E	5.695	1.00
347_R	352_G	4.469	1.00
731_E	735_D	4.117	1.00
26_K	349_D	3.288	1.00
608_N	630_D	3.225	1.00
555_A	678_E	3.193	1.00
530_V	702_M	3.191	1.00
331_A	354_L	2.991	1.00
339_Y	366_Q	2.909	1.00
606_N	624_V	2.908	1.00
626_D	630_D	2.775	1.00
377_V	380_E	2.746	1.00
601_N	610_E	2.687	1.00
615_D	618_G	2.651	1.00
557_D	676_E	2.642	1.00
614_A	618_G	2.627	1.00
331_A	361_L	2.595	1.00
376_Q	379_A	2.542	1.00
359_A	362_R	2.525	1.00
598_E	609_I	2.494	1.00
84_R	87_A	2.411	0.99
608_N	634_E	2.402	0.99
589_I	646_V	2.401	0.99
728_T	735_D	2.392	0.99
23_Y	320_T	2.388	0.99
583_M	589_I	2.351	0.99
354_L	361_L	2.306	0.99
331_A	358_F	2.294	0.99
672_E	676_E	2.283	0.99
516_V	715_A	2.260	0.99
460_M	691_A	2.220	0.99
630_D	637_A	2.187	0.99
618_G	622_A	2.182	0.99
531_A	534_A	2.180	0.99
372_A	375_Q	2.172	0.99
447_A	450_A	2.162	0.99
500_G	738_A	2.134	0.99
437_L	449_I	2.133	0.99
599_Q	610_E	2.131	0.99
207_T	210_S	2.098	0.99
620_G	627_E	2.088	0.99
361_L	365_V	2.082	0.98
349_D	352_G	2.072	0.98
667_V	671_V	2.067	0.98
436_R	458_A	2.060	0.98
506_A	730_A	2.049	0.98
153_L	187_R	2.048	0.98
477_A	541_S	2.041	0.98
598_E	636_K	2.039	0.98
728_T	732_S	2.002	0.98
354_L	365_V	2.002	0.98
594_T	598_E	1.997	0.98
747_V	754_L	1.996	0.98
437_L	450_A	1.987	0.98
379_A	383_R	1.981	0.98
612_A	623_V	1.973	0.98
441_V	450_A	1.970	0.98
327_L	358_F	1.963	0.98
602_M	612_A	1.938	0.98
374_E	378_D	1.925	0.97
538_A	699_S	1.922	0.97
327_L	343_L	1.922	0.97
165_P	168_N	1.918	0.97
370_R	374_E	1.917	0.97
605_L	622_A	1.912	0.97
75_W	79_R	1.909	0.97
677_T	681_L	1.900	0.97
728_T	731_E	1.894	0.97
605_L	629_K	1.879	0.97
436_R	461_E	1.873	0.97
592_A	727_A	1.870	0.97
317_G	321_V	1.861	0.97
579_L	663_I	1.857	0.97
219_G	224_D	1.849	0.97
667_V	670_G	1.849	0.97
690_E	693_T	1.848	0.97
622_A	627_E	1.848	0.97
354_L	358_F	1.823	0.96
317_G	320_T	1.819	0.96
708_S	715_A	1.815	0.96
594_T	643_E	1.814	0.96
334_L	365_V	1.810	0.96
27_F	320_T	1.808	0.96
602_M	681_L	1.802	0.96
548_G	552_Q	1.796	0.96
589_I	645_L	1.795	0.96
378_D	381_A	1.792	0.96
211_F	224_D	1.767	0.96
422_S	425_M	1.766	0.96
579_L	639_A	1.749	0.95
604_A	613_R	1.745	0.95
506_A	729_E	1.736	0.95
524_S	713_T	1.726	0.95
608_N	626_D	1.714	0.95
276_W	279_T	1.710	0.95
499_V	737_A	1.710	0.95
517_A	716_V	1.708	0.95
589_I	670_G	1.708	0.95
583_M	754_L	1.691	0.95
582_K	666_R	1.686	0.94
681_L	684_I	1.684	0.94
375_Q	379_A	1.683	0.94
597_A	622_A	1.682	0.94
598_E	726_T	1.664	0.94
579_L	670_G	1.662	0.94
646_V	670_G	1.658	0.94
578_D	581_A	1.657	0.94
166_Y	196_L	1.655	0.94
551_G	608_N	1.649	0.94
629_K	740_Q	1.649	0.94
630_D	633_D	1.637	0.94
595_D	626_D	1.635	0.93
424_T	453_F	1.632	0.93
612_A	622_A	1.629	0.93
545_A	549_D	1.625	0.93
421_F	450_A	1.624	0.93
599_Q	605_L	1.618	0.93
440_D	447_A	1.617	0.93
609_I	726_T	1.604	0.93
605_L	612_A	1.595	0.93
166_Y	193_T	1.595	0.93
447_A	451_A	1.588	0.92
598_E	633_D	1.581	0.92
353_R	356_E	1.578	0.92
471_A	474_V	1.576	0.92
209_H	286_E	1.570	0.92
418_A	446_M	1.564	0.92
594_T	609_I	1.564	0.92
450_A	456_M	1.553	0.92
440_D	450_A	1.552	0.92
597_A	614_A	1.550	0.92
509_Q	730_A	1.549	0.91
533_S	694_G	1.545	0.91
561_Q	590_V	1.542	0.91
342_D	359_A	1.542	0.91
623_V	627_E	1.539	0.91
626_D	643_E	1.535	0.91
729_E	740_Q	1.534	0.91
593_I	670_G	1.533	0.91
726_T	729_E	1.530	0.91
418_A	421_F	1.523	0.91
324_L	354_L	1.521	0.91
73_D	76_H	1.521	0.91
82_N	115_V	1.520	0.91
505_R	722_L	1.516	0.91
585_E	648_E	1.515	0.91
334_L	361_L	1.513	0.90
643_E	730_A	1.506	0.90
593_I	627_E	1.496	0.90
145_A	148_W	1.493	0.90
433_L	446_M	1.492	0.90
498_A	729_E	1.490	0.90
128_V	131_S	1.488	0.90
677_T	719_V	1.487	0.90
334_L	362_R	1.486	0.90
646_V	663_I	1.486	0.90
583_M	673_T	1.485	0.90
355_F	361_L	1.482	0.90
436_R	454_N	1.481	0.90
590_V	694_G	1.474	0.89
579_L	598_E	1.466	0.89
122_S	125_D	1.462	0.89
579_L	609_I	1.461	0.89
681_L	698_I	1.455	0.89
626_D	636_K	1.455	0.89
327_L	354_L	1.449	0.88
97_A	101_Q	1.443	0.88
454_N	460_M	1.437	0.88
548_G	684_I	1.430	0.88
633_D	730_A	1.427	0.88
509_Q	722_L	1.423	0.88
592_A	642_I	1.406	0.87
618_G	623_V	1.402	0.87
418_A	450_A	1.394	0.86
437_L	446_M	1.391	0.86
589_I	592_A	1.381	0.86
559_V	706_A	1.379	0.86
244_G	248_V	1.370	0.85
629_K	634_E	1.367	0.85
602_M	608_N	1.367	0.85
615_D	620_G	1.362	0.85
514_E	518_S	1.358	0.85
175_A	193_T	1.357	0.85
125_D	129_I	1.357	0.85
598_E	629_K	1.357	0.85
607_A	624_V	1.354	0.85
83_A	86_L	1.353	0.85
444_A	456_M	1.349	0.85
614_A	622_A	1.348	0.84
642_I	670_G	1.348	0.84
589_I	638_S	1.348	0.84
126_A	130_T	1.341	0.84
42_G	302_L	1.340	0.84
126_A	276_W	1.340	0.84
639_A	663_I	1.339	0.84
516_V	519_E	1.324	0.83
724_E	728_T	1.320	0.83
441_V	446_M	1.319	0.83
379_A	382_A	1.318	0.83
727_A	734_A	1.317	0.83
193_T	199_I	1.316	0.83
608_N	629_K	1.312	0.83
530_V	608_N	1.308	0.83
170_G	173_E	1.306	0.83
561_Q	598_E	1.306	0.83
437_L	448_D	1.301	0.82
630_D	670_G	1.296	0.82
526_T	636_K	1.293	0.82
453_F	585_E	1.291	0.82
537_V	555_A	1.288	0.82
537_V	562_L	1.288	0.82
620_G	623_V	1.282	0.81
414_L	446_M	1.282	0.81
629_K	723_G	1.281	0.81
610_E	613_R	1.278	0.81
531_A	698_I	1.274	0.81
579_L	709_V	1.274	0.81
38_I	324_L	1.272	0.81
720_A	723_G	1.271	0.81
583_M	663_I	1.267	0.81
106_D	109_H	1.265	0.80
512_Q	640_A	1.261	0.80
450_A	454_N	1.257	0.80
673_T	677_T	1.257	0.80
677_T	691_A	1.253	0.80
460_M	464_I	1.247	0.79
358_F	365_V	1.243	0.79
243_V	246_R	1.241	0.79
450_A	453_F	1.240	0.79
100_V	191_V	1.238	0.79
522_E	708_S	1.234	0.79
324_L	351_L	1.232	0.79
93_D	97_A	1.231	0.79
339_Y	365_V	1.231	0.79
598_E	605_L	1.226	0.78
179_R	270_P	1.224	0.78
414_L	417_T	1.223	0.78
676_E	712_V	1.223	0.78
592_A	663_I	1.220	0.78
199_I	203_F	1.218	0.78
425_M	441_V	1.217	0.78
374_E	377_V	1.217	0.78
552_Q	685_A	1.214	0.78
327_L	331_A	1.204	0.77
445_A	456_M	1.199	0.77
115_V	193_T	1.199	0.77
373_N	377_V	1.195	0.76
530_V	726_T	1.187	0.76
514_E	522_E	1.186	0.76
496_S	738_A	1.185	0.76
160_V	180_V	1.181	0.76
509_Q	709_V	1.179	0.76
552_Q	591_A	1.174	0.75
510_R	598_E	1.173	0.75
554_A	602_M	1.171	0.75
414_L	418_A	1.166	0.75
635_S	645_L	1.166	0.75
591_A	643_E	1.166	0.75
681_L	705_Q	1.165	0.75
72_V	289_G	1.160	0.74
343_L	355_F	1.158	0.74
609_I	640_A	1.157	0.74
519_E	740_Q	1.156	0.74
215_V	279_T	1.154	0.74
601_N	606_N	1.152	0.74
609_I	626_D	1.149	0.74
513_L	517_A	1.149	0.74
592_A	634_E	1.149	0.74
519_E	608_N	1.147	0.73
682_S	706_A	1.145	0.73
593_I	601_N	1.145	0.73
375_Q	378_D	1.137	0.73
635_S	639_A	1.136	0.73
580_E	639_A	1.135	0.73
610_E	629_K	1.131	0.72
510_R	724_E	1.128	0.72
609_I	643_E	1.121	0.72
519_E	551_G	1.120	0.72
559_V	695_V	1.120	0.72
511_D	516_V	1.119	0.72
598_E	617_D	1.118	0.72
740_Q	753_T	1.116	0.71
679_R	682_S	1.116	0.71
512_Q	626_D	1.116	0.71
421_F	453_F	1.115	0.71
511_D	518_S	1.114	0.71
511_D	724_E	1.112	0.71
509_Q	552_Q	1.101	0.70
359_A	363_D	1.097	0.70
579_L	723_G	1.094	0.70
601_N	629_K	1.092	0.70
494_D	739_E	1.092	0.70
554_A	609_I	1.092	0.70
541_S	691_A	1.084	0.69
512_Q	590_V	1.083	0.69
505_R	729_E	1.082	0.69
629_K	645_L	1.075	0.68
613_R	674_V	1.074	0.68
579_L	720_A	1.070	0.68
372_A	379_A	1.064	0.68
431_G	460_M	1.063	0.68
367_A	371_D	1.062	0.68
548_G	602_M	1.057	0.67
24_L	318_R	1.057	0.67
608_N	729_E	1.053	0.67
303_G	307_A	1.052	0.67
502_I	635_S	1.050	0.67
339_Y	369_I	1.050	0.67
678_E	740_Q	1.045	0.66
627_E	670_G	1.043	0.66
208_P	214_L	1.043	0.66
48_N	76_H	1.042	0.66
207_T	215_V	1.041	0.66
579_L	594_T	1.041	0.66
705_Q	712_V	1.041	0.66
444_A	447_A	1.039	0.66
73_D	80_T	1.038	0.66
548_G	596_I	1.038	0.66
588_T	608_N	1.037	0.66
618_G	670_G	1.037	0.66
495_V	506_A	1.034	0.65
43_G	47_L	1.033	0.65
538_A	696_Q	1.032	0.65
618_G	624_V	1.032	0.65
578_D	666_R	1.032	0.65
152_Q	190_V	1.029	0.65
608_N	691_A	1.027	0.65
521_D	708_S	1.026	0.65
594_T	723_G	1.026	0.65
323_A	351_L	1.023	0.65
621_F	625_A	1.020	0.64
623_V	670_G	1.017	0.64
581_A	584_S	1.017	0.64
306_L	314_L	1.016	0.64
96_N	99_E	1.015	0.64
530_V	626_D	1.013	0.64
450_A	533_S	1.011	0.64
516_V	720_A	1.011	0.64
174_V	216_D	1.011	0.64
233_P	236_E	1.010	0.64
582_K	673_T	1.010	0.64
494_D	725_E	1.009	0.63
31_L	313_A	1.003	0.63
732_S	735_D	0.995	0.62
450_A	608_N	0.995	0.62
614_A	625_A	0.995	0.62
579_L	726_T	0.995	0.62
582_K	754_L	0.989	0.62
740_Q	747_V	0.989	0.62
138_N	449_I	0.987	0.62
335_E	544_A	0.986	0.62
599_Q	622_A	0.985	0.62
417_T	447_A	0.984	0.61
471_A	543_R	0.978	0.61
219_G	276_W	0.975	0.61
207_T	213_Q	0.974	0.61
590_V	643_E	0.974	0.61
508_D	719_V	0.974	0.61
431_G	454_N	0.972	0.61
730_A	734_A	0.970	0.60
534_A	667_V	0.967	0.60
243_V	252_P	0.964	0.60
587_E	695_V	0.962	0.60
76_H	85_M	0.961	0.60
596_I	606_N	0.956	0.59
428_Y	457_A	0.952	0.59
744_L	747_V	0.951	0.59
192_M	196_L	0.950	0.59
97_A	134_A	0.948	0.59
456_M	715_A	0.948	0.59
276_W	288_Y	0.945	0.58
515_A	518_S	0.945	0.58
87_A	189_A	0.944	0.58
639_A	645_L	0.943	0.58
563_E	580_E	0.942	0.58
39_S	43_G	0.941	0.58
554_A	673_T	0.939	0.58
604_A	681_L	0.939	0.58
534_A	559_V	0.937	0.58
593_I	620_G	0.936	0.58
505_R	726_T	0.934	0.57
561_Q	726_T	0.933	0.57
601_N	624_V	0.931	0.57
597_A	605_L	0.931	0.57
663_I	681_L	0.930	0.57
128_V	132_T	0.930	0.57
558_A	642_I	0.929	0.57
622_A	670_G	0.929	0.57
713_T	726_T	0.929	0.57
464_I	523_M	0.929	0.57
468_V	751_T	0.928	0.57
242_I	246_R	0.926	0.57
513_L	720_A	0.926	0.57
672_E	712_V	0.925	0.57
116_R	120_Y	0.925	0.57
29_V	305_A	0.915	0.56
740_Q	754_L	0.913	0.56
524_S	643_E	0.913	0.56
79_R	85_M	0.912	0.56
688_I	736_A	0.912	0.56
330_K	341_T	0.912	0.56
34_V	72_V	0.911	0.56
514_E	598_E	0.907	0.55
347_R	362_R	0.904	0.55
433_L	460_M	0.904	0.55
558_A	635_S	0.904	0.55
87_A	92_F	0.901	0.55
456_M	629_K	0.901	0.55
514_E	724_E	0.900	0.55
555_A	740_Q	0.899	0.55
194_A	199_I	0.898	0.54
501_R	505_R	0.897	0.54
645_L	670_G	0.894	0.54
425_M	450_A	0.893	0.54
494_D	731_E	0.893	0.54
196_L	282_V	0.892	0.54
578_D	584_S	0.891	0.54
609_I	636_K	0.891	0.54
76_H	300_L	0.890	0.54
647_A	740_Q	0.890	0.54
509_Q	534_A	0.889	0.54
320_T	343_L	0.888	0.54
179_R	261_D	0.888	0.54
589_I	663_I	0.885	0.53
608_N	628_V	0.885	0.53
612_A	627_E	0.884	0.53
711_D	727_A	0.884	0.53
602_M	629_K	0.884	0.53
516_V	723_G	0.883	0.53
131_S	134_A	0.882	0.53
422_S	452_A	0.882	0.53
598_E	724_E	0.881	0.53
523_M	531_A	0.877	0.53
345_V	359_A	0.877	0.53
591_A	740_Q	0.877	0.53
549_D	558_A	0.876	0.53
116_R	119_H	0.875	0.53
179_R	188_T	0.875	0.53
530_V	609_I	0.875	0.53
643_E	726_T	0.874	0.52
192_M	199_I	0.872	0.52
50_S	54_Q	0.868	0.52
87_A	180_V	0.866	0.52
264_H	276_W	0.866	0.52
609_I	729_E	0.865	0.52
100_V	168_N	0.862	0.51
76_H	84_R	0.862	0.51
446_M	470_F	0.862	0.51
629_K	715_A	0.860	0.51
617_D	716_V	0.859	0.51
76_H	79_R	0.858	0.51
507_A	731_E	0.857	0.51
433_L	531_A	0.856	0.51
626_D	734_A	0.851	0.50
503_R	513_L	0.851	0.50
168_N	171_I	0.850	0.50
747_V	755_A	0.850	0.50
513_L	719_V	0.848	0.50
418_A	475_A	0.847	0.50
433_L	474_V	0.844	0.50
452_A	599_Q	0.842	0.50
505_R	598_E	0.842	0.50
638_S	670_G	0.841	0.50
502_I	754_L	0.840	0.50
639_A	724_E	0.838	0.49
371_D	375_Q	0.837	0.49
619_D	677_T	0.837	0.49
432_D	454_N	0.836	0.49
208_P	212_T	0.836	0.49
335_E	358_F	0.834	0.49
417_T	453_F	0.829	0.49
126_A	133_D	0.829	0.49
518_S	720_A	0.828	0.49
460_M	474_V	0.826	0.48
26_K	365_V	0.826	0.48
611_A	623_V	0.825	0.48
31_L	37_C	0.824	0.48
276_W	283_P	0.824	0.48
493_R	725_E	0.821	0.48
517_A	521_D	0.820	0.48
680_S	722_L	0.819	0.48
590_V	639_A	0.819	0.48
530_V	701_A	0.819	0.48
593_I	646_V	0.817	0.48
321_V	351_L	0.817	0.48
213_Q	279_T	0.816	0.48
177_V	190_V	0.816	0.48
724_E	729_E	0.816	0.48
23_Y	324_L	0.816	0.48
429_A	432_D	0.815	0.47
595_D	602_M	0.815	0.47
598_E	608_N	0.813	0.47
463_T	687_R	0.813	0.47
594_T	640_A	0.811	0.47
193_T	196_L	0.809	0.47
720_A	727_A	0.808	0.47
548_G	678_E	0.807	0.47
578_D	727_A	0.807	0.47
441_V	530_V	0.805	0.47
332_A	353_R	0.805	0.47
138_N	141_F	0.803	0.46
548_G	634_E	0.803	0.46
591_A	641_E	0.801	0.46
701_A	706_A	0.801	0.46
699_S	740_Q	0.798	0.46
691_A	754_L	0.797	0.46
165_P	276_W	0.796	0.46
507_A	711_D	0.796	0.46
86_L	267_A	0.795	0.46
663_I	691_A	0.794	0.46
211_F	225_D	0.794	0.46
460_M	510_R	0.793	0.46
505_R	730_A	0.789	0.45
620_G	641_E	0.789	0.45
663_I	678_E	0.789	0.45
508_D	512_Q	0.789	0.45
733_T	743_T	0.788	0.45
125_D	130_T	0.788	0.45
723_G	726_T	0.787	0.45
453_F	456_M	0.786	0.45
60_E	63_K	0.786	0.45
518_S	522_E	0.785	0.45
417_T	630_D	0.785	0.45
494_D	735_D	0.784	0.45
646_V	691_A	0.784	0.45
511_D	514_E	0.783	0.45
200_S	266_T	0.783	0.45
424_T	437_L	0.783	0.45
515_A	724_E	0.782	0.45
474_V	734_A	0.781	0.45
511_D	726_T	0.781	0.45
528_E	706_A	0.781	0.45
96_N	100_V	0.781	0.45
735_D	738_A	0.780	0.45
174_V	179_R	0.780	0.45
594_T	726_T	0.779	0.44
498_A	502_I	0.777	0.44
177_V	210_S	0.775	0.44
602_M	674_V	0.775	0.44
514_E	726_T	0.775	0.44
613_R	728_T	0.774	0.44
579_L	633_D	0.773	0.44
304_I	311_F	0.773	0.44
177_V	187_R	0.772	0.44
558_A	681_L	0.772	0.44
189_A	287_A	0.771	0.44
437_L	453_F	0.770	0.44
93_D	175_A	0.769	0.44
554_A	720_A	0.767	0.43
119_H	122_S	0.766	0.43
722_L	726_T	0.766	0.43
505_R	609_I	0.766	0.43
737_A	741_A	0.765	0.43
551_G	677_T	0.764	0.43
598_E	628_V	0.761	0.43
361_L	530_V	0.761	0.43
551_G	750_Q	0.761	0.43
462_A	500_G	0.760	0.43
610_E	615_D	0.757	0.43
44_V	316_L	0.756	0.43
596_I	624_V	0.755	0.42
121_V	128_V	0.754	0.42
640_A	719_V	0.753	0.42
624_V	627_E	0.753	0.42
608_N	667_V	0.752	0.42
362_R	366_Q	0.752	0.42
448_D	452_A	0.752	0.42
595_D	633_D	0.751	0.42
33_A	316_L	0.750	0.42
368_R	372_A	0.750	0.42
436_R	457_A	0.750	0.42
514_E	594_T	0.748	0.42
598_E	720_A	0.747	0.42
547_L	683_E	0.747	0.42
137_R	140_S	0.746	0.42
117_D	145_A	0.746	0.42
638_S	642_I	0.746	0.42
242_I	270_P	0.745	0.42
243_V	248_V	0.744	0.42
148_W	166_Y	0.744	0.42
593_I	618_G	0.744	0.42
210_S	225_D	0.742	0.41
500_G	710_S	0.742	0.41
629_K	754_L	0.739	0.41
264_H	283_P	0.739	0.41
222_I	226_S	0.736	0.41
331_A	334_L	0.736	0.41
535_D	703_D	0.735	0.41
593_I	638_S	0.735	0.41
580_E	684_I	0.734	0.41
251_Q	553_A	0.734	0.41
303_G	336_R	0.734	0.41
72_V	214_L	0.732	0.41
149_S	193_T	0.731	0.40
307_A	716_V	0.729	0.40
494_D	527_I	0.729	0.40
709_V	726_T	0.728	0.40
517_A	719_V	0.725	0.40
79_R	82_N	0.725	0.40
498_A	608_N	0.725	0.40
538_A	691_A	0.725	0.40
531_A	642_I	0.724	0.40
464_I	467_V	0.723	0.40
516_V	522_E	0.723	0.40
630_D	730_A	0.722	0.40
645_L	678_E	0.721	0.40
80_T	83_A	0.720	0.40
605_L	704_D	0.719	0.40
719_V	730_A	0.717	0.39
450_A	709_V	0.717	0.39
579_L	729_E	0.716	0.39
196_L	283_P	0.715	0.39
431_G	613_R	0.714	0.39
519_E	711_D	0.713	0.39
598_E	602_M	0.712	0.39
360_S	365_V	0.711	0.39
247_A	251_Q	0.711	0.39
104_F	128_V	0.708	0.39
163_S	166_Y	0.707	0.39
127_R	130_T	0.707	0.39
216_D	220_S	0.707	0.39
711_D	714_T	0.706	0.38
533_S	630_D	0.705	0.38
605_L	623_V	0.705	0.38
494_D	676_E	0.704	0.38
467_V	474_V	0.703	0.38
425_M	437_L	0.703	0.38
638_S	705_Q	0.702	0.38
52_H	317_G	0.702	0.38
608_N	613_R	0.701	0.38
604_A	667_V	0.700	0.38
449_I	521_D	0.698	0.38
626_D	719_V	0.696	0.38
439_A	671_V	0.695	0.38
512_Q	719_V	0.695	0.38
216_D	219_G	0.695	0.38
562_L	670_G	0.695	0.38
592_A	670_G	0.694	0.38
166_Y	175_A	0.694	0.38
588_T	744_L	0.693	0.37
705_Q	724_E	0.692	0.37
467_V	585_E	0.691	0.37
598_E	723_G	0.691	0.37
284_T	288_Y	0.690	0.37
120_Y	191_V	0.689	0.37
432_D	456_M	0.689	0.37
579_L	643_E	0.688	0.37
337_G	361_L	0.688	0.37
634_E	720_A	0.688	0.37
205_D	215_V	0.687	0.37
588_T	730_A	0.687	0.37
526_T	530_V	0.687	0.37
618_G	642_I	0.686	0.37
148_W	276_W	0.685	0.37
595_D	634_E	0.685	0.37
548_G	685_A	0.685	0.37
495_V	663_I	0.684	0.37
113_S	117_D	0.683	0.37
550_D	553_A	0.682	0.37
30_A	318_R	0.680	0.36
602_M	642_I	0.680	0.36
72_V	198_A	0.680	0.36
97_A	117_D	0.679	0.36
456_M	740_Q	0.677	0.36
530_V	709_V	0.675	0.36
56_S	311_F	0.675	0.36
417_T	450_A	0.674	0.36
138_N	143_S	0.674	0.36
530_V	674_V	0.674	0.36
523_M	619_D	0.673	0.36
460_M	754_L	0.671	0.36
149_S	274_T	0.671	0.36
510_R	594_T	0.670	0.36
418_A	453_F	0.668	0.35
639_A	727_A	0.668	0.35
101_Q	222_I	0.667	0.35
523_M	716_V	0.667	0.35
586_I	626_D	0.666	0.35
598_E	670_G	0.664	0.35
79_R	90_G	0.664	0.35
686_G	693_T	0.664	0.35
22_S	25_A	0.662	0.35
460_M	582_K	0.662	0.35
638_S	678_E	0.661	0.35
434_T	454_N	0.660	0.35
454_N	674_V	0.660	0.35
496_S	639_A	0.659	0.35
215_V	276_W	0.659	0.35
598_E	634_E	0.659	0.35
509_Q	613_R	0.659	0.35
626_D	633_D	0.659	0.35
716_V	719_V	0.658	0.35
364_T	369_I	0.656	0.35
130_T	134_A	0.655	0.35
453_F	608_N	0.655	0.35
734_A	739_E	0.655	0.35
417_T	421_F	0.654	0.34
670_G	673_T	0.654	0.34
411_A	417_T	0.654	0.34
544_A	622_A	0.654	0.34
546_A	679_R	0.654	0.34
636_K	730_A	0.654	0.34
744_L	754_L	0.653	0.34
563_E	675_S	0.653	0.34
211_F	221_V	0.652	0.34
129_I	172_T	0.652	0.34
616_Q	623_V	0.651	0.34
551_G	737_A	0.646	0.34
614_A	623_V	0.645	0.34
151_Q	154_T	0.645	0.34
216_D	222_I	0.645	0.34
512_Q	583_M	0.643	0.34
464_I	751_T	0.642	0.34
697_E	700_N	0.642	0.34
152_Q	177_V	0.641	0.33
665_E	669_D	0.641	0.33
699_S	747_V	0.640	0.33
543_R	546_A	0.639	0.33
663_I	670_G	0.638	0.33
53_L	57_S	0.637	0.33
666_R	681_L	0.636	0.33
527_I	688_I	0.636	0.33
456_M	464_I	0.635	0.33
308_G	749_A	0.635	0.33
62_K	76_H	0.634	0.33
544_A	681_L	0.634	0.33
526_T	559_V	0.634	0.33
167_V	170_G	0.634	0.33
439_A	451_A	0.634	0.33
506_A	726_T	0.633	0.33
593_I	712_V	0.632	0.33
421_F	427_A	0.632	0.33
327_L	355_F	0.632	0.33
433_L	457_A	0.630	0.33
65_A	126_A	0.630	0.33
561_Q	594_T	0.630	0.33
530_V	691_A	0.629	0.33
210_S	224_D	0.627	0.32
207_T	744_L	0.627	0.32
593_I	610_E	0.626	0.32
594_T	636_K	0.626	0.32
594_T	729_E	0.625	0.32
165_P	175_A	0.624	0.32
612_A	618_G	0.624	0.32
665_E	702_M	0.623	0.32
79_R	87_A	0.622	0.32
506_A	590_V	0.620	0.32
27_F	42_G	0.620	0.32
593_I	623_V	0.620	0.32
187_R	243_V	0.620	0.32
718_D	723_G	0.619	0.32
498_A	579_L	0.618	0.32
177_V	290_L	0.618	0.32
602_M	630_D	0.617	0.32
101_Q	105_T	0.617	0.32
464_I	499_V	0.615	0.32
175_A	178_A	0.612	0.31
608_N	617_D	0.612	0.31
90_G	125_D	0.612	0.31
179_R	276_W	0.612	0.31
21_R	32_L	0.611	0.31
620_G	624_V	0.611	0.31
664_Q	668_S	0.610	0.31
62_K	81_N	0.609	0.31
136_L	139_A	0.609	0.31
411_A	415_E	0.609	0.31
495_V	673_T	0.607	0.31
24_L	312_I	0.607	0.31
459_D	753_T	0.607	0.31
512_Q	712_V	0.607	0.31
505_R	723_G	0.606	0.31
516_V	548_G	0.606	0.31
595_D	598_E	0.606	0.31
371_D	383_R	0.606	0.31
701_A	705_Q	0.606	0.31
548_G	555_A	0.605	0.31
505_R	720_A	0.605	0.31
265_E	268_Y	0.604	0.31
368_R	371_D	0.604	0.31
599_Q	608_N	0.603	0.31
93_D	117_D	0.603	0.31
301_I	331_A	0.603	0.31
715_A	723_G	0.601	0.31
612_A	670_G	0.601	0.31
494_D	720_A	0.600	0.30
506_A	663_I	0.600	0.30
521_D	525_A	0.600	0.30
537_V	743_T	0.599	0.30
519_E	712_V	0.598	0.30
63_K	462_A	0.597	0.30
596_I	634_E	0.596	0.30
213_Q	278_V	0.596	0.30
561_Q	608_N	0.596	0.30
289_G	328_E	0.594	0.30
35_V	254_A	0.594	0.30
530_V	579_L	0.594	0.30
617_D	711_D	0.593	0.30
715_A	740_Q	0.592	0.30
598_E	639_A	0.592	0.30
66_E	69_S	0.591	0.30
362_R	558_A	0.590	0.30
500_G	716_V	0.590	0.30
608_N	711_D	0.589	0.30
45_M	323_A	0.588	0.30
512_Q	595_D	0.587	0.30
551_G	694_G	0.587	0.30
609_I	709_V	0.587	0.30
588_T	691_A	0.586	0.29
301_I	333_A	0.586	0.29
535_D	538_A	0.586	0.29
587_E	593_I	0.585	0.29
171_I	234_Y	0.585	0.29
446_M	601_N	0.585	0.29
425_M	639_A	0.585	0.29
126_A	134_A	0.584	0.29
635_S	642_I	0.583	0.29
83_A	192_M	0.583	0.29
519_E	529_E	0.583	0.29
185_G	194_A	0.583	0.29
583_M	642_I	0.583	0.29
558_A	602_M	0.582	0.29
30_A	33_A	0.582	0.29
523_M	526_T	0.582	0.29
512_Q	726_T	0.581	0.29
115_V	121_V	0.581	0.29
354_L	360_S	0.581	0.29
417_T	441_V	0.580	0.29
189_A	712_V	0.580	0.29
503_R	510_R	0.580	0.29
593_I	636_K	0.579	0.29
525_A	543_R	0.579	0.29
611_A	625_A	0.579	0.29
510_R	720_A	0.579	0.29
514_E	731_E	0.579	0.29
507_A	728_T	0.578	0.29
84_R	89_Y	0.576	0.29
688_I	691_A	0.575	0.29
414_L	506_A	0.575	0.29
146_A	168_N	0.573	0.29
594_T	645_L	0.573	0.29
513_L	639_A	0.573	0.29
586_I	620_G	0.573	0.29
39_S	432_D	0.572	0.28
677_T	705_Q	0.572	0.28
681_L	740_Q	0.572	0.28
586_I	610_E	0.572	0.28
507_A	723_G	0.572	0.28
527_I	705_Q	0.572	0.28
165_P	193_T	0.570	0.28
588_T	743_T	0.569	0.28
302_L	357_A	0.568	0.28
148_W	152_Q	0.568	0.28
54_Q	265_E	0.567	0.28
520_T	716_V	0.566	0.28
528_E	710_S	0.565	0.28
115_V	133_D	0.565	0.28
510_R	709_V	0.565	0.28
174_V	222_I	0.565	0.28
523_M	677_T	0.565	0.28
551_G	594_T	0.565	0.28
734_A	738_A	0.565	0.28
27_F	317_G	0.564	0.28
454_N	594_T	0.564	0.28
330_K	343_L	0.564	0.28
355_F	362_R	0.564	0.28
595_D	719_V	0.564	0.28
496_S	741_A	0.559	0.28
425_M	589_I	0.559	0.28
28_G	68_S	0.558	0.28
582_K	671_V	0.557	0.27
615_D	627_E	0.557	0.27
606_N	620_G	0.557	0.27
300_L	304_I	0.557	0.27
23_Y	323_A	0.556	0.27
629_K	636_K	0.556	0.27
179_R	349_D	0.554	0.27
350_E	632_A	0.554	0.27
75_W	199_I	0.554	0.27
561_Q	634_E	0.553	0.27
321_V	550_D	0.552	0.27
609_I	733_T	0.552	0.27
617_D	695_V	0.552	0.27
594_T	639_A	0.551	0.27
104_F	120_Y	0.550	0.27
615_D	623_V	0.550	0.27
496_S	526_T	0.549	0.27
150_R	154_T	0.549	0.27
527_I	718_D	0.546	0.27
179_R	189_A	0.545	0.27
502_I	673_T	0.545	0.27
507_A	555_A	0.545	0.27
165_P	174_V	0.545	0.27
512_Q	561_Q	0.543	0.27
441_V	579_L	0.543	0.27
319_G	474_V	0.543	0.27
425_M	428_Y	0.542	0.26
456_M	460_M	0.541	0.26
663_I	667_V	0.540	0.26
719_V	727_A	0.539	0.26
594_T	638_S	0.538	0.26
598_E	754_L	0.537	0.26
41_A	45_M	0.537	0.26
444_A	453_F	0.537	0.26
513_L	555_A	0.536	0.26
516_V	640_A	0.536	0.26
129_I	270_P	0.535	0.26
610_E	628_V	0.535	0.26
667_V	677_T	0.535	0.26
41_A	302_L	0.534	0.26
200_S	212_T	0.533	0.26
369_I	372_A	0.533	0.26
439_A	446_M	0.533	0.26
635_S	670_G	0.533	0.26
462_A	640_A	0.530	0.26
548_G	737_A	0.530	0.26
517_A	622_A	0.530	0.26
179_R	219_G	0.530	0.26
582_K	634_E	0.530	0.26
191_V	199_I	0.530	0.26
667_V	678_E	0.529	0.26
34_V	324_L	0.529	0.26
509_Q	643_E	0.529	0.26
541_S	551_G	0.529	0.26
210_S	219_G	0.529	0.26
592_A	639_A	0.527	0.25
613_R	720_A	0.527	0.25
125_D	132_T	0.526	0.25
555_A	667_V	0.526	0.25
648_E	669_D	0.525	0.25
267_A	270_P	0.525	0.25
331_A	335_E	0.525	0.25
614_A	620_G	0.525	0.25
210_S	282_V	0.525	0.25
421_F	424_T	0.524	0.25
334_L	437_L	0.524	0.25
207_T	259_E	0.523	0.25
72_V	148_W	0.522	0.25
720_A	729_E	0.522	0.25
87_A	191_V	0.522	0.25
598_E	729_E	0.522	0.25
121_V	129_I	0.522	0.25
342_D	366_Q	0.522	0.25
598_E	645_L	0.522	0.25
441_V	453_F	0.521	0.25
347_R	359_A	0.521	0.25
613_R	626_D	0.521	0.25
95_D	100_V	0.520	0.25
635_S	726_T	0.520	0.25
519_E	694_G	0.520	0.25
549_D	680_S	0.519	0.25
608_N	743_T	0.518	0.25
551_G	681_L	0.518	0.25
206_P	210_S	0.518	0.25
60_E	69_S	0.517	0.25
585_E	589_I	0.516	0.25
747_V	756_E	0.516	0.25
429_A	635_S	0.516	0.25
446_M	456_M	0.515	0.25
510_R	515_A	0.515	0.25
498_A	719_V	0.515	0.25
615_D	622_A	0.515	0.25
639_A	723_G	0.514	0.25
454_N	458_A	0.513	0.25
562_L	712_V	0.512	0.25
600_T	605_L	0.511	0.24
534_A	671_V	0.511	0.24
533_S	729_E	0.509	0.24
418_A	447_A	0.509	0.24
219_G	282_V	0.509	0.24
511_D	519_E	0.508	0.24
715_A	726_T	0.508	0.24
645_L	663_I	0.507	0.24
561_Q	599_Q	0.507	0.24
520_T	738_A	0.507	0.24
473_E	533_S	0.505	0.24
358_F	579_L	0.505	0.24
537_V	613_R	0.504	0.24
537_V	733_T	0.504	0.24
618_G	629_K	0.504	0.24
605_L	615_D	0.503	0.24
495_V	499_V	0.503	0.24
375_Q	382_A	0.503	0.24
609_I	633_D	0.502	0.24
499_V	680_S	0.501	0.24
203_F	289_G	0.501	0.24
624_V	628_V	0.501	0.24
667_V	674_V	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.3907	100	0.616	Contact Map
1qu7A	2	0.2918	100	0.673	Contact Map
2ch7A	2	0.3972	100	0.685	Contact Map
3g67A	2	0.2686	100	0.746	Contact Map
4i3mA	2	0.1928	99.9	0.853	Contact Map
3lifA	1	0.3046	99.8	0.873	Contact Map
3e4oA	2	0.2853	99.8	0.876	Contact Map
3c8cA	2	0.3008	99.8	0.878	Contact Map
3licA	2	0.2969	99.8	0.878	Contact Map
3li9A	2	0.2943	99.8	0.879	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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