GREMLIN Database
HTR1 - Sensory rhodopsin I transducer
UniProt: P0DMI3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 536 (446)
Sequences: 16561 (14584)
Seq/√Len: 690.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_T184_E4.1071.00
164_A169_D3.1721.00
173_R198_Q2.9921.00
164_A172_Q2.8581.00
242_Q461_L2.8031.00
146_E149_A2.5821.00
301_S405_R2.5481.00
284_A422_T2.5481.00
318_D321_A2.4851.00
191_N194_M2.4691.00
319_Q391_Q2.3451.00
302_I409_G2.3211.00
411_E415_S2.3141.00
159_G185_T2.3101.00
163_E185_T2.2871.00
296_L417_L2.2421.00
290_D294_S2.2011.00
173_R195_D2.1701.00
319_Q387_K2.1681.00
283_T287_A2.1621.00
266_E269_A2.1511.00
158_Y187_G2.1381.00
249_E457_R2.0511.00
322_E325_D2.0501.00
159_G189_A2.0481.00
180_H184_E2.0241.00
163_E192_Q1.9981.00
315_Q391_Q1.9741.00
407_E411_E1.9711.00
162_M190_F1.9611.00
148_A152_Q1.9581.00
294_S415_S1.9541.00
165_A193_M1.9331.00
280_D283_T1.9051.00
414_E418_R1.8971.00
163_E167_T1.8851.00
48_T52_I1.8681.00
312_Q395_V1.8611.00
165_A194_M1.8521.00
287_A290_D1.8511.00
51_S55_A1.8441.00
457_R460_G1.8331.00
415_S418_R1.8291.00
485_E488_A1.8091.00
478_G481_E1.7901.00
274_L434_I1.7881.00
429_E432_N1.7811.00
162_M189_A1.7731.00
213_A217_R1.7681.00
163_E189_A1.7511.00
173_R194_M1.7501.00
276_S279_E1.7481.00
404_T408_S1.7441.00
276_S280_D1.7291.00
418_R422_T1.7061.00
162_M193_M1.7051.00
294_S297_D1.7031.00
146_E151_Y1.6981.00
173_R191_N1.6961.00
418_R421_R1.6821.00
328_D332_D1.6751.00
484_E488_A1.6531.00
374_T378_A1.6481.00
317_R396_T1.6471.00
273_D276_S1.6471.00
467_A471_D1.6451.00
294_S412_T1.6351.00
312_Q394_D1.6321.00
267_I441_T1.6301.00
103_R107_N1.6271.00
369_D372_E1.6181.00
382_A386_E1.6001.00
297_D300_S1.5941.00
319_Q322_E1.5901.00
297_D301_S1.5891.00
199_A203_T1.5891.00
293_K297_D1.5861.00
442_S446_E1.5861.00
450_S453_T1.5741.00
198_Q202_R1.5711.00
324_T389_T1.5681.00
34_D39_I1.5661.00
272_D442_S1.5651.00
282_A286_D1.5591.00
269_A273_D1.5591.00
422_T425_D1.5341.00
313_V395_V1.5341.00
449_Q453_T1.5341.00
408_S411_E1.5331.00
325_D328_D1.5261.00
428_A432_N1.5231.00
331_T382_A1.5221.00
220_E224_D1.5151.00
285_S424_A1.5021.00
35_V39_I1.4951.00
291_S415_S1.4901.00
155_A183_M1.4861.00
300_S414_E1.4841.00
96_E100_Q1.4751.00
185_T188_T1.4741.00
481_E485_E1.4731.00
289_R424_A1.4711.00
477_I481_E1.4701.00
100_Q104_G1.4481.00
146_E152_Q1.4481.00
376_D380_E1.4471.00
315_Q318_D1.4461.00
272_D276_S1.4381.00
104_G107_N1.4241.00
279_E283_T1.4211.00
305_E401_Q1.4131.00
404_T407_E1.4111.00
258_Q262_A1.4041.00
314_E318_D1.3881.00
196_D199_A1.3801.00
287_A422_T1.3771.00
286_D428_A1.3751.00
50_G54_A1.3721.00
106_L110_E1.3691.00
286_D290_D1.3621.00
149_A153_D1.3611.00
425_D429_E1.3561.00
158_Y190_F1.3531.00
36_P39_I1.3441.00
345_S365_D1.3411.00
460_G464_D1.3411.00
147_L151_Y1.3381.00
288_A423_I1.3311.00
400_Q404_T1.3211.00
322_E380_E1.3171.00
289_R421_R1.3161.00
393_E397_A1.3121.00
313_V399_I1.3101.00
456_E460_G1.3101.00
288_A420_I1.3091.00
169_D172_Q1.3061.00
298_E408_S1.3001.00
149_A152_Q1.2991.00
295_A416_T1.2991.00
421_R425_D1.2921.00
176_V191_N1.2911.00
467_A470_S1.2911.00
290_D293_K1.2901.00
365_D368_K1.2891.00
379_N383_A1.2871.00
318_D322_E1.2861.00
89_G93_D1.2831.00
205_T209_D1.2831.00
372_E376_D1.2791.00
295_A413_V1.2791.00
154_T183_M1.2781.00
159_G163_E1.2651.00
317_R321_A1.2581.00
100_Q103_R1.2491.00
158_Y186_V1.2461.00
174_V191_N1.2431.00
287_A415_S1.2421.00
265_E269_A1.2401.00
329_V377_R1.2391.00
203_T485_E1.2351.00
46_L50_G1.2311.00
376_D379_N1.2281.00
161_T174_V1.2251.00
156_K159_G1.2201.00
176_V187_G1.2191.00
195_D199_A1.2141.00
289_R293_K1.2101.00
464_D467_A1.2081.00
283_T286_D1.2071.00
90_S93_D1.2061.00
108_E112_T1.2031.00
248_T252_S1.2011.00
345_S368_K1.1951.00
259_Q262_A1.1931.00
331_T378_A1.1861.00
248_T251_D1.1861.00
164_A167_T1.1841.00
470_S474_S1.1831.00
217_R220_E1.1821.00
206_T209_D1.1811.00
460_G463_D1.1761.00
284_A426_S1.1681.00
194_M198_Q1.1641.00
129_E132_Q1.1641.00
216_E220_E1.1611.00
32_T36_P1.1581.00
110_E114_A1.1481.00
250_L458_V1.1461.00
481_E484_E1.1431.00
68_T72_A1.1391.00
92_A96_E1.1351.00
314_E400_Q1.1341.00
320_V392_T1.1251.00
154_T181_E1.1211.00
101_S104_G1.1201.00
489_S492_Q1.1171.00
269_A272_D1.1131.00
104_G108_E1.1121.00
32_T35_V1.1071.00
439_R442_S1.1071.00
282_A431_S1.1051.00
308_D311_G1.1041.00
157_R175_D1.1041.00
134_K138_Q1.1031.00
299_M409_G1.1001.00
241_S244_N1.1001.00
107_N111_R1.0991.00
304_T308_D1.0991.00
277_R429_E1.0981.00
257_V455_V1.0961.00
255_D259_Q1.0931.00
306_V406_V1.0921.00
160_E163_E1.0911.00
56_E59_A1.0881.00
265_E449_Q1.0791.00
160_E164_A1.0771.00
49_L53_N1.0761.00
471_D474_S1.0761.00
157_R161_T1.0741.00
157_R160_E1.0671.00
175_D191_N1.0621.00
252_S255_D1.0601.00
109_M113_R1.0561.00
312_Q398_S1.0531.00
67_Q70_R1.0521.00
411_E414_E1.0521.00
244_N248_T1.0521.00
375_Q379_N1.0521.00
206_T210_E1.0471.00
161_T190_F1.0461.00
292_S416_T1.0461.00
401_Q404_T1.0451.00
112_T115_D1.0451.00
102_L106_L1.0431.00
99_R103_R1.0411.00
280_D426_S1.0381.00
174_V187_G1.0381.00
281_V427_I1.0311.00
98_M102_L1.0301.00
110_E113_R1.0271.00
439_R443_E1.0201.00
136_E139_A1.0191.00
102_L105_R1.0151.00
57_T61_I1.0131.00
326_I384_V1.0111.00
128_E132_Q1.0101.00
34_D37_S1.0101.00
245_D248_T1.0071.00
155_A186_V1.0061.00
397_A400_Q1.0061.00
311_G315_Q1.0051.00
132_Q136_E1.0051.00
317_R393_E1.0011.00
379_N382_A1.0011.00
487_A491_E0.9981.00
87_E90_S0.9951.00
303_E410_S0.9941.00
313_V396_T0.9931.00
307_D403_R0.9901.00
124_E128_E0.9891.00
111_R114_A0.9881.00
122_E127_R0.9861.00
131_E134_K0.9841.00
176_V188_T0.9821.00
463_D467_A0.9781.00
380_E383_A0.9781.00
305_E405_R0.9771.00
85_T89_G0.9741.00
245_D249_E0.9731.00
162_M186_V0.9731.00
172_Q194_M0.9711.00
196_D492_Q0.9661.00
34_D47_L0.9621.00
315_Q319_Q0.9621.00
474_S477_I0.9591.00
474_S478_G0.9581.00
90_S94_S0.9531.00
282_A428_A0.9501.00
38_T45_G0.9501.00
191_N195_D0.9471.00
148_A151_Y0.9431.00
135_Q139_A0.9411.00
121_A125_T0.9411.00
125_T128_E0.9411.00
261_S452_A0.9401.00
39_I42_G0.9401.00
241_S245_D0.9391.00
258_Q452_A0.9341.00
165_A190_F0.9341.00
274_L433_S0.9341.00
373_E376_D0.9301.00
488_A491_E0.9301.00
273_D433_S0.9281.00
93_D97_Q0.9271.00
213_A216_E0.9241.00
125_T129_E0.9221.00
164_A193_M0.9211.00
34_D38_T0.9201.00
260_V444_Q0.9201.00
35_V38_T0.9171.00
131_E135_Q0.9141.00
146_E153_D0.9131.00
183_M187_G0.9131.00
383_A386_E0.9121.00
311_G314_E0.9111.00
111_R115_D0.9071.00
302_I406_V0.9071.00
167_T192_Q0.9061.00
97_Q100_Q0.9021.00
392_T395_V0.9011.00
89_G92_A0.9001.00
54_A58_V0.9001.00
47_L51_S0.9001.00
65_A68_T0.8971.00
253_A451_T0.8951.00
133_A136_E0.8931.00
260_V448_V0.8901.00
96_E99_R0.8901.00
203_T206_T0.8891.00
300_S304_T0.8861.00
127_R131_E0.8831.00
299_M302_I0.8811.00
107_N110_E0.8811.00
386_E390_A0.8801.00
353_G356_D0.8791.00
246_Q462_S0.8781.00
270_T436_E0.8781.00
170_L197_L0.8761.00
446_E450_S0.8751.00
108_E111_R0.8751.00
139_A143_E0.8731.00
405_R408_S0.8731.00
105_R109_M0.8711.00
436_E439_R0.8701.00
459_A463_D0.8691.00
412_T415_S0.8681.00
138_Q142_R0.8621.00
307_D311_G0.8621.00
90_S95_I0.8611.00
187_G191_N0.8561.00
397_A401_Q0.8551.00
55_A59_A0.8541.00
88_F92_A0.8531.00
432_N435_D0.8531.00
316_L388_V0.8521.00
114_A117_E0.8481.00
220_E223_A0.8471.00
124_E127_R0.8471.00
401_Q405_R0.8461.00
38_T42_G0.8451.00
253_A454_S0.8431.00
97_Q101_S0.8421.00
62_K65_A0.8401.00
121_A124_E0.8401.00
161_T164_A0.8391.00
284_A287_A0.8371.00
304_T307_D0.8371.00
141_E145_R0.8341.00
154_T178_T0.8341.00
338_N368_K0.8331.00
35_V42_G0.8331.00
266_E436_E0.8321.00
192_Q195_D0.8321.00
93_D96_E0.8301.00
279_E435_D0.8291.00
486_I493_F0.8261.00
57_T60_S0.8251.00
109_M112_T0.8221.00
69_E73_N0.8191.00
264_A441_T0.8191.00
209_D487_A0.8191.00
332_D373_E0.8171.00
92_A95_I0.8131.00
159_G186_V0.8121.00
166_A189_A0.8121.00
126_A129_E0.8091.00
281_V426_S0.8081.00
156_K160_E0.8061.00
293_K421_R0.8051.00
321_A393_E0.8041.00
306_V399_I0.8031.00
443_E446_E0.8021.00
98_M101_S0.8011.00
63_E67_Q0.7941.00
327_V382_A0.7941.00
262_A266_E0.7911.00
170_L201_V0.7901.00
162_M165_A0.7891.00
113_R117_E0.7881.00
63_E66_A0.7881.00
109_M116_L0.7861.00
332_D335_E0.7841.00
62_K66_A0.7831.00
106_L109_M0.7831.00
371_A374_T0.7811.00
86_D89_G0.7791.00
188_T191_N0.7771.00
468_L471_D0.7771.00
79_E82_S0.7771.00
325_D329_V0.7771.00
202_R205_T0.7721.00
33_N36_P0.7711.00
292_S413_V0.7691.00
310_V403_R0.7691.00
202_R206_T0.7691.00
242_Q465_T0.7681.00
280_D284_A0.7651.00
190_F193_M0.7651.00
432_N436_E0.7621.00
435_D439_R0.7601.00
490_L493_F0.7591.00
287_A419_D0.7591.00
190_F194_M0.7571.00
113_R116_L0.7571.00
483_A493_F0.7551.00
368_K372_E0.7541.00
453_T456_E0.7541.00
83_T86_D0.7541.00
66_A70_R0.7541.00
253_A455_V0.7531.00
134_K137_A0.7531.00
278_S427_I0.7521.00
309_A398_S0.7511.00
316_L395_V0.7491.00
161_T172_Q0.7461.00
135_Q138_Q0.7451.00
156_K185_T0.7441.00
209_D213_A0.7431.00
130_A133_A0.7431.00
255_D258_Q0.7421.00
261_S448_V0.7391.00
429_E433_S0.7301.00
275_A435_D0.7291.00
155_A181_E0.7271.00
84_R87_E0.7251.00
472_A475_A0.7251.00
65_A69_E0.7251.00
56_E60_S0.7241.00
275_A279_E0.7221.00
137_A140_A0.7211.00
446_E449_Q0.7211.00
291_S412_T0.7201.00
141_E144_A0.7191.00
161_T165_A0.7181.00
176_V184_E0.7181.00
139_A142_R0.7171.00
216_E480_R0.7161.00
301_S304_T0.7161.00
212_E216_E0.7131.00
264_A448_V0.7131.00
165_A197_L0.7121.00
158_Y162_M0.7101.00
129_E133_A0.7101.00
192_Q196_D0.7101.00
308_D398_S0.7101.00
383_A387_K0.7091.00
251_D255_D0.7081.00
78_Q81_T0.7071.00
103_R106_L0.7061.00
461_L465_T0.7051.00
275_A431_S0.7041.00
168_G197_L0.7011.00
46_L49_L0.7011.00
130_A137_A0.6991.00
309_A402_T0.6971.00
417_L421_R0.6951.00
298_E412_T0.6931.00
240_E466_T0.6921.00
94_S97_Q0.6911.00
34_D55_A0.6871.00
326_I385_V0.6861.00
327_V331_T0.6861.00
133_A140_A0.6831.00
249_E454_S0.6811.00
88_F91_L0.6811.00
270_T433_S0.6801.00
414_E417_L0.6791.00
307_D407_E0.6791.00
310_V400_Q0.6781.00
166_A192_Q0.6781.00
320_V388_V0.6781.00
42_G46_L0.6761.00
403_R407_E0.6701.00
322_E387_K0.6691.00
193_M197_L0.6691.00
66_A69_E0.6691.00
150_T153_D0.6681.00
122_E126_A0.6661.00
34_D46_L0.6651.00
43_I46_L0.6651.00
199_A202_R0.6641.00
488_A492_Q0.6641.00
132_Q135_Q0.6631.00
168_G193_M0.6611.00
120_Q124_E0.6601.00
245_D457_R0.6601.00
309_A399_I0.6591.00
37_S40_V0.6581.00
479_Q493_F0.6551.00
449_Q452_A0.6551.00
322_E384_V0.6541.00
256_D447_T0.6541.00
240_E243_A0.6531.00
137_A141_E0.6531.00
306_V309_A0.6471.00
479_Q483_A0.6471.00
138_Q141_E0.6441.00
335_E375_Q0.6431.00
184_E187_G0.6431.00
453_T457_R0.6431.00
215_T476_V0.6431.00
169_D494_Q0.6411.00
161_T194_M0.6401.00
303_E407_E0.6381.00
296_L413_V0.6381.00
249_E252_S0.6371.00
373_E380_E0.6361.00
77_E81_T0.6361.00
484_E487_A0.6351.00
298_E301_S0.6351.00
285_S423_I0.6351.00
154_T185_T0.6331.00
305_E308_D0.6331.00
273_D429_E0.6311.00
335_E346_I0.6301.00
203_T489_S0.6291.00
147_L150_T0.6281.00
178_T183_M0.6281.00
39_I43_I0.6281.00
286_D424_A0.6261.00
256_D259_Q0.6251.00
204_V490_L0.6241.00
61_I64_I0.6231.00
291_S294_S0.6211.00
45_G49_L0.6211.00
443_E447_T0.6191.00
425_D428_A0.6191.00
184_E188_T0.6171.00
476_V480_R0.6161.00
294_S408_S0.6161.00
259_Q447_T0.6131.00
315_Q394_D0.6131.00
99_R102_L0.6131.00
142_R145_R0.6121.00
331_T335_E0.6111.00
32_T47_L0.6091.00
123_A127_R0.6081.00
40_V47_L0.6081.00
299_M413_V0.6081.00
424_A428_A0.6071.00
285_S288_A0.6071.00
298_E405_R0.6061.00
185_T189_A0.6031.00
464_D468_L0.6011.00
70_R73_N0.6011.00
278_S430_V0.5981.00
275_A438_Q0.5981.00
120_Q123_A0.5971.00
155_A185_T0.5961.00
450_S454_S0.5951.00
390_A394_D0.5931.00
105_R108_E0.5891.00
394_D397_A0.5891.00
137_A144_A0.5871.00
50_G53_N0.5871.00
439_R446_E0.5851.00
124_E129_E0.5841.00
82_S85_T0.5831.00
268_A438_Q0.5831.00
467_A474_S0.5821.00
33_N37_S0.5821.00
342_L350_R0.5821.00
91_L98_M0.5821.00
250_L455_V0.5821.00
218_M222_S0.5811.00
67_Q71_V0.5811.00
101_S105_R0.5811.00
262_A265_E0.5801.00
385_V389_T0.5801.00
413_V417_L0.5781.00
256_D450_S0.5781.00
34_D51_S0.5761.00
293_K417_L0.5751.00
69_E72_A0.5751.00
146_E150_T0.5741.00
87_E91_L0.5741.00
83_T87_E0.5731.00
133_A137_A0.5721.00
211_I215_T0.5721.00
326_I377_R0.5691.00
239_I243_A0.5681.00
79_E84_R0.5671.00
157_R187_G0.5651.00
287_A291_S0.5651.00
122_E125_T0.5651.00
112_T117_E0.5631.00
171_T495_N0.5601.00
277_R280_D0.5601.00
325_D380_E0.5591.00
151_Y154_T0.5591.00
254_A455_V0.5581.00
210_E213_A0.5581.00
263_S443_E0.5571.00
108_E113_R0.5561.00
54_A57_T0.5561.00
323_I385_V0.5561.00
291_S419_D0.5551.00
223_A241_S0.5551.00
95_I102_L0.5541.00
395_V399_I0.5541.00
413_V416_T0.5521.00
452_A456_E0.5511.00
247_R463_D0.5501.00
154_T186_V0.5501.00
258_Q261_S0.5491.00
178_T187_G0.5481.00
482_S485_E0.5481.00
167_T196_D0.5461.00
280_D422_T0.5431.00
244_N470_S0.5411.00
98_M108_E0.5401.00
314_E317_R0.5401.00
420_I423_I0.5391.00
240_E244_N0.5381.00
84_R95_I0.5371.00
292_S295_A0.5361.00
46_L53_N0.5351.00
395_V398_S0.5331.00
72_A75_N0.5321.00
165_A170_L0.5311.00
157_R176_V0.5311.00
179_D184_E0.5301.00
267_I440_T0.5301.00
374_T384_V0.5291.00
158_Y183_M0.5291.00
482_S486_I0.5291.00
40_V43_I0.5291.00
123_A126_A0.5291.00
95_I99_R0.5281.00
204_V207_V0.5281.00
154_T184_E0.5271.00
193_M196_D0.5261.00
94_S98_M0.5261.00
147_L152_Q0.5251.00
126_A134_K0.5231.00
133_A141_E0.5231.00
341_A368_K0.5221.00
473_E476_V0.5211.00
246_Q461_L0.5211.00
321_A325_D0.5211.00
306_V402_T0.5201.00
258_Q456_E0.5191.00
365_D369_D0.5191.00
176_V180_H0.5180.99
150_T154_T0.5150.99
154_T180_H0.5150.99
268_A271_I0.5140.99
213_A220_E0.5140.99
128_E131_E0.5130.99
39_I53_N0.5100.99
280_D429_E0.5090.99
36_P40_V0.5080.99
320_V326_I0.5080.99
61_I65_A0.5060.99
201_V495_N0.5040.99
122_E128_E0.5030.99
134_K140_A0.5010.99
163_E166_A0.5000.99
98_M106_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zx6A 2 0.5653 100 0.42 Contact Map
2ch7A 2 0.5765 100 0.509 Contact Map
1qu7A 2 0.4235 100 0.538 Contact Map
3g67A 2 0.3899 100 0.608 Contact Map
4i3mA 2 0.2743 99.8 0.778 Contact Map
3zccA 2 0.2034 98.5 0.891 Contact Map
2rm8A 1 0.1269 97.9 0.907 Contact Map
2f95B 2 0.0784 97.1 0.921 Contact Map
4cq4A 4 0.181 96.7 0.925 Contact Map
4gycB 2 0.084 96.6 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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