HTR1 - HALSA - GREMLIN Contacts

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HTR1 - Sensory rhodopsin I transducer

UniProt:	P0DMI3	Sequences: MTIAWARRRYGVKLGLGYIATAGLLVGVGVTTNDVPSTIVAGIAGLLTLGSINAAETVASIKEIAAQTERVANGNLEQEVTSTRTDEFGSLADSIEQMRQSLRGRLNEMERTRADLEETQAEAETAREEAEQAKQEAQAAEREARELAATYQDTAKRYGETMEAAATGDLTQRVDVDTDHEAMETVGTAFNQMMDDLQATVRTVTTVADEIEAKTERMSETSADIEASAGDTVEAVSKIESQANDQRTELDSAADDVQQVSASAEEIAATIDDLASRSEDVATASDAARDSSKSALDEMSSIETEVDDAVGQVEQLRDQVAEITDIVDVITDIGEQTNMLALNASIEAARAGGNADGDGFSVVADEVKDLAEETQDRANEIAAVVEKVTAQTEDVTASIQQTRTRVESGSETVESTLRDIRTIADSIAEVSNSIDEIQRTTSEQAETVQSTATSVERVAGLSDDTTALASDAESAVIGQRESAEEIAASLEQFQNTAVEQLQSRVASFTVATEDSETAGGSVEQPVMRAGADGGGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	536 (446)
Sequences:	16561 (14584)
Seq/√Len:	690.6

ECOLI - AER MCP4 MCP3 MCP2 MCP1
BACSU - YVAQ YOAH TLPA MCPB TLPB MCPC MCPA TLPC HEMAT YFMS
HALSA - HTR1 Q9HS86 Q9HRN6 HTR4 HTR2 Q9HRA1 COST Q9HP10 Q9HR88 Q9HPQ5 Q9HPA2 HTR7 Q9HQX8 HTR9 HMAT Q9HQT5 Q9HPW6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
178_T	184_E	4.107	1.00
164_A	169_D	3.172	1.00
173_R	198_Q	2.992	1.00
164_A	172_Q	2.858	1.00
242_Q	461_L	2.803	1.00
146_E	149_A	2.582	1.00
301_S	405_R	2.548	1.00
284_A	422_T	2.548	1.00
318_D	321_A	2.485	1.00
191_N	194_M	2.469	1.00
319_Q	391_Q	2.345	1.00
302_I	409_G	2.321	1.00
411_E	415_S	2.314	1.00
159_G	185_T	2.310	1.00
163_E	185_T	2.287	1.00
296_L	417_L	2.242	1.00
290_D	294_S	2.201	1.00
173_R	195_D	2.170	1.00
319_Q	387_K	2.168	1.00
283_T	287_A	2.162	1.00
266_E	269_A	2.151	1.00
158_Y	187_G	2.138	1.00
249_E	457_R	2.051	1.00
322_E	325_D	2.050	1.00
159_G	189_A	2.048	1.00
180_H	184_E	2.024	1.00
163_E	192_Q	1.998	1.00
315_Q	391_Q	1.974	1.00
407_E	411_E	1.971	1.00
162_M	190_F	1.961	1.00
148_A	152_Q	1.958	1.00
294_S	415_S	1.954	1.00
165_A	193_M	1.933	1.00
280_D	283_T	1.905	1.00
414_E	418_R	1.897	1.00
163_E	167_T	1.885	1.00
48_T	52_I	1.868	1.00
312_Q	395_V	1.861	1.00
165_A	194_M	1.852	1.00
287_A	290_D	1.851	1.00
51_S	55_A	1.844	1.00
457_R	460_G	1.833	1.00
415_S	418_R	1.829	1.00
485_E	488_A	1.809	1.00
478_G	481_E	1.790	1.00
274_L	434_I	1.788	1.00
429_E	432_N	1.781	1.00
162_M	189_A	1.773	1.00
213_A	217_R	1.768	1.00
163_E	189_A	1.751	1.00
173_R	194_M	1.750	1.00
276_S	279_E	1.748	1.00
404_T	408_S	1.744	1.00
276_S	280_D	1.729	1.00
418_R	422_T	1.706	1.00
162_M	193_M	1.705	1.00
294_S	297_D	1.703	1.00
146_E	151_Y	1.698	1.00
173_R	191_N	1.696	1.00
418_R	421_R	1.682	1.00
328_D	332_D	1.675	1.00
484_E	488_A	1.653	1.00
374_T	378_A	1.648	1.00
317_R	396_T	1.647	1.00
273_D	276_S	1.647	1.00
467_A	471_D	1.645	1.00
294_S	412_T	1.635	1.00
312_Q	394_D	1.632	1.00
267_I	441_T	1.630	1.00
103_R	107_N	1.627	1.00
369_D	372_E	1.618	1.00
382_A	386_E	1.600	1.00
297_D	300_S	1.594	1.00
319_Q	322_E	1.590	1.00
297_D	301_S	1.589	1.00
199_A	203_T	1.589	1.00
293_K	297_D	1.586	1.00
442_S	446_E	1.586	1.00
450_S	453_T	1.574	1.00
198_Q	202_R	1.571	1.00
324_T	389_T	1.568	1.00
34_D	39_I	1.566	1.00
272_D	442_S	1.565	1.00
282_A	286_D	1.559	1.00
269_A	273_D	1.559	1.00
422_T	425_D	1.534	1.00
313_V	395_V	1.534	1.00
449_Q	453_T	1.534	1.00
408_S	411_E	1.533	1.00
325_D	328_D	1.526	1.00
428_A	432_N	1.523	1.00
331_T	382_A	1.522	1.00
220_E	224_D	1.515	1.00
285_S	424_A	1.502	1.00
35_V	39_I	1.495	1.00
291_S	415_S	1.490	1.00
155_A	183_M	1.486	1.00
300_S	414_E	1.484	1.00
96_E	100_Q	1.475	1.00
185_T	188_T	1.474	1.00
481_E	485_E	1.473	1.00
289_R	424_A	1.471	1.00
477_I	481_E	1.470	1.00
100_Q	104_G	1.448	1.00
146_E	152_Q	1.448	1.00
376_D	380_E	1.447	1.00
315_Q	318_D	1.446	1.00
272_D	276_S	1.438	1.00
104_G	107_N	1.424	1.00
279_E	283_T	1.421	1.00
305_E	401_Q	1.413	1.00
404_T	407_E	1.411	1.00
258_Q	262_A	1.404	1.00
314_E	318_D	1.388	1.00
196_D	199_A	1.380	1.00
287_A	422_T	1.377	1.00
286_D	428_A	1.375	1.00
50_G	54_A	1.372	1.00
106_L	110_E	1.369	1.00
286_D	290_D	1.362	1.00
149_A	153_D	1.361	1.00
425_D	429_E	1.356	1.00
158_Y	190_F	1.353	1.00
36_P	39_I	1.344	1.00
345_S	365_D	1.341	1.00
460_G	464_D	1.341	1.00
147_L	151_Y	1.338	1.00
288_A	423_I	1.331	1.00
400_Q	404_T	1.321	1.00
322_E	380_E	1.317	1.00
289_R	421_R	1.316	1.00
393_E	397_A	1.312	1.00
313_V	399_I	1.310	1.00
456_E	460_G	1.310	1.00
288_A	420_I	1.309	1.00
169_D	172_Q	1.306	1.00
298_E	408_S	1.300	1.00
149_A	152_Q	1.299	1.00
295_A	416_T	1.299	1.00
421_R	425_D	1.292	1.00
176_V	191_N	1.291	1.00
467_A	470_S	1.291	1.00
290_D	293_K	1.290	1.00
365_D	368_K	1.289	1.00
379_N	383_A	1.287	1.00
318_D	322_E	1.286	1.00
89_G	93_D	1.283	1.00
205_T	209_D	1.283	1.00
372_E	376_D	1.279	1.00
295_A	413_V	1.279	1.00
154_T	183_M	1.278	1.00
159_G	163_E	1.265	1.00
317_R	321_A	1.258	1.00
100_Q	103_R	1.249	1.00
158_Y	186_V	1.246	1.00
174_V	191_N	1.243	1.00
287_A	415_S	1.242	1.00
265_E	269_A	1.240	1.00
329_V	377_R	1.239	1.00
203_T	485_E	1.235	1.00
46_L	50_G	1.231	1.00
376_D	379_N	1.228	1.00
161_T	174_V	1.225	1.00
156_K	159_G	1.220	1.00
176_V	187_G	1.219	1.00
195_D	199_A	1.214	1.00
289_R	293_K	1.210	1.00
464_D	467_A	1.208	1.00
283_T	286_D	1.207	1.00
90_S	93_D	1.206	1.00
108_E	112_T	1.203	1.00
248_T	252_S	1.201	1.00
345_S	368_K	1.195	1.00
259_Q	262_A	1.193	1.00
331_T	378_A	1.186	1.00
248_T	251_D	1.186	1.00
164_A	167_T	1.184	1.00
470_S	474_S	1.183	1.00
217_R	220_E	1.182	1.00
206_T	209_D	1.181	1.00
460_G	463_D	1.176	1.00
284_A	426_S	1.168	1.00
194_M	198_Q	1.164	1.00
129_E	132_Q	1.164	1.00
216_E	220_E	1.161	1.00
32_T	36_P	1.158	1.00
110_E	114_A	1.148	1.00
250_L	458_V	1.146	1.00
481_E	484_E	1.143	1.00
68_T	72_A	1.139	1.00
92_A	96_E	1.135	1.00
314_E	400_Q	1.134	1.00
320_V	392_T	1.125	1.00
154_T	181_E	1.121	1.00
101_S	104_G	1.120	1.00
489_S	492_Q	1.117	1.00
269_A	272_D	1.113	1.00
104_G	108_E	1.112	1.00
32_T	35_V	1.107	1.00
439_R	442_S	1.107	1.00
282_A	431_S	1.105	1.00
308_D	311_G	1.104	1.00
157_R	175_D	1.104	1.00
134_K	138_Q	1.103	1.00
299_M	409_G	1.100	1.00
241_S	244_N	1.100	1.00
107_N	111_R	1.099	1.00
304_T	308_D	1.099	1.00
277_R	429_E	1.098	1.00
257_V	455_V	1.096	1.00
255_D	259_Q	1.093	1.00
306_V	406_V	1.092	1.00
160_E	163_E	1.091	1.00
56_E	59_A	1.088	1.00
265_E	449_Q	1.079	1.00
160_E	164_A	1.077	1.00
49_L	53_N	1.076	1.00
471_D	474_S	1.076	1.00
157_R	161_T	1.074	1.00
157_R	160_E	1.067	1.00
175_D	191_N	1.062	1.00
252_S	255_D	1.060	1.00
109_M	113_R	1.056	1.00
312_Q	398_S	1.053	1.00
67_Q	70_R	1.052	1.00
411_E	414_E	1.052	1.00
244_N	248_T	1.052	1.00
375_Q	379_N	1.052	1.00
206_T	210_E	1.047	1.00
161_T	190_F	1.046	1.00
292_S	416_T	1.046	1.00
401_Q	404_T	1.045	1.00
112_T	115_D	1.045	1.00
102_L	106_L	1.043	1.00
99_R	103_R	1.041	1.00
280_D	426_S	1.038	1.00
174_V	187_G	1.038	1.00
281_V	427_I	1.031	1.00
98_M	102_L	1.030	1.00
110_E	113_R	1.027	1.00
439_R	443_E	1.020	1.00
136_E	139_A	1.019	1.00
102_L	105_R	1.015	1.00
57_T	61_I	1.013	1.00
326_I	384_V	1.011	1.00
128_E	132_Q	1.010	1.00
34_D	37_S	1.010	1.00
245_D	248_T	1.007	1.00
155_A	186_V	1.006	1.00
397_A	400_Q	1.006	1.00
311_G	315_Q	1.005	1.00
132_Q	136_E	1.005	1.00
317_R	393_E	1.001	1.00
379_N	382_A	1.001	1.00
487_A	491_E	0.998	1.00
87_E	90_S	0.995	1.00
303_E	410_S	0.994	1.00
313_V	396_T	0.993	1.00
307_D	403_R	0.990	1.00
124_E	128_E	0.989	1.00
111_R	114_A	0.988	1.00
122_E	127_R	0.986	1.00
131_E	134_K	0.984	1.00
176_V	188_T	0.982	1.00
463_D	467_A	0.978	1.00
380_E	383_A	0.978	1.00
305_E	405_R	0.977	1.00
85_T	89_G	0.974	1.00
245_D	249_E	0.973	1.00
162_M	186_V	0.973	1.00
172_Q	194_M	0.971	1.00
196_D	492_Q	0.966	1.00
34_D	47_L	0.962	1.00
315_Q	319_Q	0.962	1.00
474_S	477_I	0.959	1.00
474_S	478_G	0.958	1.00
90_S	94_S	0.953	1.00
282_A	428_A	0.950	1.00
38_T	45_G	0.950	1.00
191_N	195_D	0.947	1.00
148_A	151_Y	0.943	1.00
135_Q	139_A	0.941	1.00
121_A	125_T	0.941	1.00
125_T	128_E	0.941	1.00
261_S	452_A	0.940	1.00
39_I	42_G	0.940	1.00
241_S	245_D	0.939	1.00
258_Q	452_A	0.934	1.00
165_A	190_F	0.934	1.00
274_L	433_S	0.934	1.00
373_E	376_D	0.930	1.00
488_A	491_E	0.930	1.00
273_D	433_S	0.928	1.00
93_D	97_Q	0.927	1.00
213_A	216_E	0.924	1.00
125_T	129_E	0.922	1.00
164_A	193_M	0.921	1.00
34_D	38_T	0.920	1.00
260_V	444_Q	0.920	1.00
35_V	38_T	0.917	1.00
131_E	135_Q	0.914	1.00
146_E	153_D	0.913	1.00
183_M	187_G	0.913	1.00
383_A	386_E	0.912	1.00
311_G	314_E	0.911	1.00
111_R	115_D	0.907	1.00
302_I	406_V	0.907	1.00
167_T	192_Q	0.906	1.00
97_Q	100_Q	0.902	1.00
392_T	395_V	0.901	1.00
89_G	92_A	0.900	1.00
54_A	58_V	0.900	1.00
47_L	51_S	0.900	1.00
65_A	68_T	0.897	1.00
253_A	451_T	0.895	1.00
133_A	136_E	0.893	1.00
260_V	448_V	0.890	1.00
96_E	99_R	0.890	1.00
203_T	206_T	0.889	1.00
300_S	304_T	0.886	1.00
127_R	131_E	0.883	1.00
299_M	302_I	0.881	1.00
107_N	110_E	0.881	1.00
386_E	390_A	0.880	1.00
353_G	356_D	0.879	1.00
246_Q	462_S	0.878	1.00
270_T	436_E	0.878	1.00
170_L	197_L	0.876	1.00
446_E	450_S	0.875	1.00
108_E	111_R	0.875	1.00
139_A	143_E	0.873	1.00
405_R	408_S	0.873	1.00
105_R	109_M	0.871	1.00
436_E	439_R	0.870	1.00
459_A	463_D	0.869	1.00
412_T	415_S	0.868	1.00
138_Q	142_R	0.862	1.00
307_D	311_G	0.862	1.00
90_S	95_I	0.861	1.00
187_G	191_N	0.856	1.00
397_A	401_Q	0.855	1.00
55_A	59_A	0.854	1.00
88_F	92_A	0.853	1.00
432_N	435_D	0.853	1.00
316_L	388_V	0.852	1.00
114_A	117_E	0.848	1.00
220_E	223_A	0.847	1.00
124_E	127_R	0.847	1.00
401_Q	405_R	0.846	1.00
38_T	42_G	0.845	1.00
253_A	454_S	0.843	1.00
97_Q	101_S	0.842	1.00
62_K	65_A	0.840	1.00
121_A	124_E	0.840	1.00
161_T	164_A	0.839	1.00
284_A	287_A	0.837	1.00
304_T	307_D	0.837	1.00
141_E	145_R	0.834	1.00
154_T	178_T	0.834	1.00
338_N	368_K	0.833	1.00
35_V	42_G	0.833	1.00
266_E	436_E	0.832	1.00
192_Q	195_D	0.832	1.00
93_D	96_E	0.830	1.00
279_E	435_D	0.829	1.00
486_I	493_F	0.826	1.00
57_T	60_S	0.825	1.00
109_M	112_T	0.822	1.00
69_E	73_N	0.819	1.00
264_A	441_T	0.819	1.00
209_D	487_A	0.819	1.00
332_D	373_E	0.817	1.00
92_A	95_I	0.813	1.00
159_G	186_V	0.812	1.00
166_A	189_A	0.812	1.00
126_A	129_E	0.809	1.00
281_V	426_S	0.808	1.00
156_K	160_E	0.806	1.00
293_K	421_R	0.805	1.00
321_A	393_E	0.804	1.00
306_V	399_I	0.803	1.00
443_E	446_E	0.802	1.00
98_M	101_S	0.801	1.00
63_E	67_Q	0.794	1.00
327_V	382_A	0.794	1.00
262_A	266_E	0.791	1.00
170_L	201_V	0.790	1.00
162_M	165_A	0.789	1.00
113_R	117_E	0.788	1.00
63_E	66_A	0.788	1.00
109_M	116_L	0.786	1.00
332_D	335_E	0.784	1.00
62_K	66_A	0.783	1.00
106_L	109_M	0.783	1.00
371_A	374_T	0.781	1.00
86_D	89_G	0.779	1.00
188_T	191_N	0.777	1.00
468_L	471_D	0.777	1.00
79_E	82_S	0.777	1.00
325_D	329_V	0.777	1.00
202_R	205_T	0.772	1.00
33_N	36_P	0.771	1.00
292_S	413_V	0.769	1.00
310_V	403_R	0.769	1.00
202_R	206_T	0.769	1.00
242_Q	465_T	0.768	1.00
280_D	284_A	0.765	1.00
190_F	193_M	0.765	1.00
432_N	436_E	0.762	1.00
435_D	439_R	0.760	1.00
490_L	493_F	0.759	1.00
287_A	419_D	0.759	1.00
190_F	194_M	0.757	1.00
113_R	116_L	0.757	1.00
483_A	493_F	0.755	1.00
368_K	372_E	0.754	1.00
453_T	456_E	0.754	1.00
83_T	86_D	0.754	1.00
66_A	70_R	0.754	1.00
253_A	455_V	0.753	1.00
134_K	137_A	0.753	1.00
278_S	427_I	0.752	1.00
309_A	398_S	0.751	1.00
316_L	395_V	0.749	1.00
161_T	172_Q	0.746	1.00
135_Q	138_Q	0.745	1.00
156_K	185_T	0.744	1.00
209_D	213_A	0.743	1.00
130_A	133_A	0.743	1.00
255_D	258_Q	0.742	1.00
261_S	448_V	0.739	1.00
429_E	433_S	0.730	1.00
275_A	435_D	0.729	1.00
155_A	181_E	0.727	1.00
84_R	87_E	0.725	1.00
472_A	475_A	0.725	1.00
65_A	69_E	0.725	1.00
56_E	60_S	0.724	1.00
275_A	279_E	0.722	1.00
137_A	140_A	0.721	1.00
446_E	449_Q	0.721	1.00
291_S	412_T	0.720	1.00
141_E	144_A	0.719	1.00
161_T	165_A	0.718	1.00
176_V	184_E	0.718	1.00
139_A	142_R	0.717	1.00
216_E	480_R	0.716	1.00
301_S	304_T	0.716	1.00
212_E	216_E	0.713	1.00
264_A	448_V	0.713	1.00
165_A	197_L	0.712	1.00
158_Y	162_M	0.710	1.00
129_E	133_A	0.710	1.00
192_Q	196_D	0.710	1.00
308_D	398_S	0.710	1.00
383_A	387_K	0.709	1.00
251_D	255_D	0.708	1.00
78_Q	81_T	0.707	1.00
103_R	106_L	0.706	1.00
461_L	465_T	0.705	1.00
275_A	431_S	0.704	1.00
168_G	197_L	0.701	1.00
46_L	49_L	0.701	1.00
130_A	137_A	0.699	1.00
309_A	402_T	0.697	1.00
417_L	421_R	0.695	1.00
298_E	412_T	0.693	1.00
240_E	466_T	0.692	1.00
94_S	97_Q	0.691	1.00
34_D	55_A	0.687	1.00
326_I	385_V	0.686	1.00
327_V	331_T	0.686	1.00
133_A	140_A	0.683	1.00
249_E	454_S	0.681	1.00
88_F	91_L	0.681	1.00
270_T	433_S	0.680	1.00
414_E	417_L	0.679	1.00
307_D	407_E	0.679	1.00
310_V	400_Q	0.678	1.00
166_A	192_Q	0.678	1.00
320_V	388_V	0.678	1.00
42_G	46_L	0.676	1.00
403_R	407_E	0.670	1.00
322_E	387_K	0.669	1.00
193_M	197_L	0.669	1.00
66_A	69_E	0.669	1.00
150_T	153_D	0.668	1.00
122_E	126_A	0.666	1.00
34_D	46_L	0.665	1.00
43_I	46_L	0.665	1.00
199_A	202_R	0.664	1.00
488_A	492_Q	0.664	1.00
132_Q	135_Q	0.663	1.00
168_G	193_M	0.661	1.00
120_Q	124_E	0.660	1.00
245_D	457_R	0.660	1.00
309_A	399_I	0.659	1.00
37_S	40_V	0.658	1.00
479_Q	493_F	0.655	1.00
449_Q	452_A	0.655	1.00
322_E	384_V	0.654	1.00
256_D	447_T	0.654	1.00
240_E	243_A	0.653	1.00
137_A	141_E	0.653	1.00
306_V	309_A	0.647	1.00
479_Q	483_A	0.647	1.00
138_Q	141_E	0.644	1.00
335_E	375_Q	0.643	1.00
184_E	187_G	0.643	1.00
453_T	457_R	0.643	1.00
215_T	476_V	0.643	1.00
169_D	494_Q	0.641	1.00
161_T	194_M	0.640	1.00
303_E	407_E	0.638	1.00
296_L	413_V	0.638	1.00
249_E	252_S	0.637	1.00
373_E	380_E	0.636	1.00
77_E	81_T	0.636	1.00
484_E	487_A	0.635	1.00
298_E	301_S	0.635	1.00
285_S	423_I	0.635	1.00
154_T	185_T	0.633	1.00
305_E	308_D	0.633	1.00
273_D	429_E	0.631	1.00
335_E	346_I	0.630	1.00
203_T	489_S	0.629	1.00
147_L	150_T	0.628	1.00
178_T	183_M	0.628	1.00
39_I	43_I	0.628	1.00
286_D	424_A	0.626	1.00
256_D	259_Q	0.625	1.00
204_V	490_L	0.624	1.00
61_I	64_I	0.623	1.00
291_S	294_S	0.621	1.00
45_G	49_L	0.621	1.00
443_E	447_T	0.619	1.00
425_D	428_A	0.619	1.00
184_E	188_T	0.617	1.00
476_V	480_R	0.616	1.00
294_S	408_S	0.616	1.00
259_Q	447_T	0.613	1.00
315_Q	394_D	0.613	1.00
99_R	102_L	0.613	1.00
142_R	145_R	0.612	1.00
331_T	335_E	0.611	1.00
32_T	47_L	0.609	1.00
123_A	127_R	0.608	1.00
40_V	47_L	0.608	1.00
299_M	413_V	0.608	1.00
424_A	428_A	0.607	1.00
285_S	288_A	0.607	1.00
298_E	405_R	0.606	1.00
185_T	189_A	0.603	1.00
464_D	468_L	0.601	1.00
70_R	73_N	0.601	1.00
278_S	430_V	0.598	1.00
275_A	438_Q	0.598	1.00
120_Q	123_A	0.597	1.00
155_A	185_T	0.596	1.00
450_S	454_S	0.595	1.00
390_A	394_D	0.593	1.00
105_R	108_E	0.589	1.00
394_D	397_A	0.589	1.00
137_A	144_A	0.587	1.00
50_G	53_N	0.587	1.00
439_R	446_E	0.585	1.00
124_E	129_E	0.584	1.00
82_S	85_T	0.583	1.00
268_A	438_Q	0.583	1.00
467_A	474_S	0.582	1.00
33_N	37_S	0.582	1.00
342_L	350_R	0.582	1.00
91_L	98_M	0.582	1.00
250_L	455_V	0.582	1.00
218_M	222_S	0.581	1.00
67_Q	71_V	0.581	1.00
101_S	105_R	0.581	1.00
262_A	265_E	0.580	1.00
385_V	389_T	0.580	1.00
413_V	417_L	0.578	1.00
256_D	450_S	0.578	1.00
34_D	51_S	0.576	1.00
293_K	417_L	0.575	1.00
69_E	72_A	0.575	1.00
146_E	150_T	0.574	1.00
87_E	91_L	0.574	1.00
83_T	87_E	0.573	1.00
133_A	137_A	0.572	1.00
211_I	215_T	0.572	1.00
326_I	377_R	0.569	1.00
239_I	243_A	0.568	1.00
79_E	84_R	0.567	1.00
157_R	187_G	0.565	1.00
287_A	291_S	0.565	1.00
122_E	125_T	0.565	1.00
112_T	117_E	0.563	1.00
171_T	495_N	0.560	1.00
277_R	280_D	0.560	1.00
325_D	380_E	0.559	1.00
151_Y	154_T	0.559	1.00
254_A	455_V	0.558	1.00
210_E	213_A	0.558	1.00
263_S	443_E	0.557	1.00
108_E	113_R	0.556	1.00
54_A	57_T	0.556	1.00
323_I	385_V	0.556	1.00
291_S	419_D	0.555	1.00
223_A	241_S	0.555	1.00
95_I	102_L	0.554	1.00
395_V	399_I	0.554	1.00
413_V	416_T	0.552	1.00
452_A	456_E	0.551	1.00
247_R	463_D	0.550	1.00
154_T	186_V	0.550	1.00
258_Q	261_S	0.549	1.00
178_T	187_G	0.548	1.00
482_S	485_E	0.548	1.00
167_T	196_D	0.546	1.00
280_D	422_T	0.543	1.00
244_N	470_S	0.541	1.00
98_M	108_E	0.540	1.00
314_E	317_R	0.540	1.00
420_I	423_I	0.539	1.00
240_E	244_N	0.538	1.00
84_R	95_I	0.537	1.00
292_S	295_A	0.536	1.00
46_L	53_N	0.535	1.00
395_V	398_S	0.533	1.00
72_A	75_N	0.532	1.00
165_A	170_L	0.531	1.00
157_R	176_V	0.531	1.00
179_D	184_E	0.530	1.00
267_I	440_T	0.530	1.00
374_T	384_V	0.529	1.00
158_Y	183_M	0.529	1.00
482_S	486_I	0.529	1.00
40_V	43_I	0.529	1.00
123_A	126_A	0.529	1.00
95_I	99_R	0.528	1.00
204_V	207_V	0.528	1.00
154_T	184_E	0.527	1.00
193_M	196_D	0.526	1.00
94_S	98_M	0.526	1.00
147_L	152_Q	0.525	1.00
126_A	134_K	0.523	1.00
133_A	141_E	0.523	1.00
341_A	368_K	0.522	1.00
473_E	476_V	0.521	1.00
246_Q	461_L	0.521	1.00
321_A	325_D	0.521	1.00
306_V	402_T	0.520	1.00
258_Q	456_E	0.519	1.00
365_D	369_D	0.519	1.00
176_V	180_H	0.518	0.99
150_T	154_T	0.515	0.99
154_T	180_H	0.515	0.99
268_A	271_I	0.514	0.99
213_A	220_E	0.514	0.99
128_E	131_E	0.513	0.99
39_I	53_N	0.510	0.99
280_D	429_E	0.509	0.99
36_P	40_V	0.508	0.99
320_V	326_I	0.508	0.99
61_I	65_A	0.506	0.99
201_V	495_N	0.504	0.99
122_E	128_E	0.503	0.99
134_K	140_A	0.501	0.99
163_E	166_A	0.500	0.99
98_M	106_L	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zx6A	2	0.5653	100	0.42	Contact Map
2ch7A	2	0.5765	100	0.509	Contact Map
1qu7A	2	0.4235	100	0.538	Contact Map
3g67A	2	0.3899	100	0.608	Contact Map
4i3mA	2	0.2743	99.8	0.778	Contact Map
3zccA	2	0.2034	98.5	0.891	Contact Map
2rm8A	1	0.1269	97.9	0.907	Contact Map
2f95B	2	0.0784	97.1	0.921	Contact Map
4cq4A	4	0.181	96.7	0.925	Contact Map
4gycB	2	0.084	96.6	0.926	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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