GREMLIN Database
CHEB - Chemotaxis response regulator protein-glutamate methylesterase/glutamine deamidase
UniProt: P0DMI2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 347 (332)
Sequences: 3609 (2888)
Seq/√Len: 158.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
314_F321_I4.4271.00
296_V301_G3.9011.00
60_D63_E3.4741.00
328_D338_A3.1741.00
34_N58_E3.0611.00
294_R298_D2.9901.00
21_L26_V2.9771.00
160_L269_A2.8251.00
210_Y226_G2.8061.00
162_G262_I2.7291.00
297_K327_D2.7011.00
30_G45_V2.6461.00
318_E322_E2.5951.00
213_T216_E2.5491.00
305_A321_I2.5351.00
205_D211_D2.5161.00
36_A58_E2.4971.00
267_K295_A2.4801.00
213_T219_S2.4761.00
7_V38_A2.3131.00
305_A326_V2.3121.00
304_L335_L2.3011.00
3_E27_D2.2981.00
112_E120_L2.2981.00
235_M247_V2.2581.00
321_I329_V2.1991.00
233_Y251_Q2.1901.00
43_T71_E2.1111.00
198_S202_D2.1041.00
52_M64_A2.0741.00
33_E37_R2.0691.00
279_S296_V2.0421.00
217_D248_R2.0181.00
192_M197_T1.9281.00
69_M73_P1.8991.00
18_S31_T1.8701.00
54_V78_M1.8581.00
161_I174_I1.8431.00
293_V303_T1.8231.00
320_A326_V1.8191.00
305_A329_V1.8041.00
307_N311_S1.7971.00
59_M63_E1.7951.00
310_T331_P1.7931.00
307_N331_P1.7911.00
238_S248_R1.7841.00
211_D225_E1.7831.00
314_F318_E1.7731.00
50_I74_T1.7661.00
251_Q259_R1.7651.00
175_L208_S1.7631.00
39_L64_A1.7311.00
65_T76_I1.7151.00
173_S333_D1.6921.00
319_R322_E1.6821.00
119_E123_A1.6221.00
219_S227_L1.6211.00
42_V47_P1.6081.00
42_V50_I1.6061.00
306_Q311_S1.5711.00
294_R325_C1.5601.00
187_L221_I1.5551.00
302_A327_D1.5551.00
213_T225_E1.5481.00
290_A323_T1.5461.00
185_R221_I1.5281.00
245_L273_V1.5271.00
330_L335_L1.5101.00
112_E119_E1.4991.00
87_A90_T1.4851.00
277_L296_V1.4811.00
306_Q309_A1.4681.00
290_A325_C1.4621.00
174_I282_L1.4591.00
263_D292_G1.4441.00
30_G41_A1.4381.00
227_L247_V1.4361.00
269_A277_L1.4361.00
67_E71_E1.4321.00
310_T333_D1.4291.00
119_E127_V1.4221.00
52_M65_T1.4201.00
116_H120_L1.4041.00
222_G225_E1.3981.00
92_E96_K1.3871.00
331_P334_Q1.3861.00
123_A127_V1.3851.00
66_A96_K1.3771.00
189_V265_T1.3731.00
64_A68_I1.3701.00
320_A325_C1.3701.00
92_E95_E1.3651.00
40_D44_D1.3401.00
67_E70_R1.3301.00
180_A209_Q1.3291.00
179_P340_A1.3261.00
112_E115_G1.3041.00
119_E122_A1.2851.00
31_T41_A1.2851.00
174_I335_L1.2831.00
302_A328_D1.2831.00
295_A298_D1.2831.00
305_A314_F1.2791.00
255_L267_K1.2731.00
170_V332_V1.2691.00
41_A44_D1.2641.00
326_V329_V1.2621.00
163_A282_L1.2621.00
311_S314_F1.2601.00
37_R41_A1.2531.00
4_A49_V1.2491.00
88_D92_E1.2431.00
314_F329_V1.2411.00
23_D117_S1.2351.00
303_T325_C1.2331.00
115_G120_L1.2251.00
236_R250_D1.2251.00
50_I68_I1.2231.00
197_T214_E1.2221.00
281_V293_V1.2211.00
115_G119_E1.2141.00
36_A40_D1.2141.00
66_A92_E1.2091.00
14_R31_T1.2021.00
303_T320_A1.1971.00
202_D206_A1.1871.00
330_L338_A1.1761.00
293_V320_A1.1751.00
23_D26_V1.1731.00
293_V325_C1.1631.00
32_A41_A1.1601.00
115_G118_E1.1581.00
39_L42_V1.1541.00
221_I237_V1.1451.00
120_L123_A1.1431.00
4_A26_V1.1421.00
8_D56_M1.1361.00
17_I79_V1.1361.00
112_E116_H1.1331.00
290_A320_A1.1271.00
294_R323_T1.1261.00
41_A45_V1.1121.00
83_T90_T1.1121.00
182_A339_I1.1121.00
11_H14_R1.1061.00
202_D205_D1.1021.00
78_M83_T1.1011.00
84_T103_A1.0930.99
6_V17_I1.0880.99
157_P276_P1.0830.99
182_A186_V1.0760.99
258_V261_A1.0680.99
334_Q337_E1.0660.99
188_I226_G1.0650.99
281_V303_T1.0610.99
18_S22_E1.0600.99
293_V323_T1.0540.99
116_H119_E1.0540.99
69_M99_I1.0380.99
280_V339_I1.0330.99
56_M59_M1.0290.99
318_E321_I1.0280.99
35_G64_A1.0260.99
177_S336_T1.0230.99
42_V74_T1.0200.99
53_D56_M1.0190.99
178_L186_V1.0130.99
63_E67_E1.0120.99
113_L116_H1.0090.99
42_V45_V1.0010.99
8_D104_K0.9920.99
303_T323_T0.9910.99
293_V326_V0.9880.99
90_T101_T0.9800.99
4_A21_L0.9780.99
290_A319_R0.9780.99
282_L335_L0.9760.99
54_V89_A0.9760.99
46_Q72_Q0.9760.99
122_A127_V0.9720.99
9_D53_D0.9700.99
175_L226_G0.9690.99
124_V127_V0.9650.99
40_D43_T0.9650.99
5_L30_G0.9610.99
83_T86_D0.9590.99
330_L334_Q0.9570.99
6_V18_S0.9560.99
321_I326_V0.9540.99
120_L124_V0.9430.98
122_A126_R0.9420.98
141_E145_P0.9410.98
171_V188_I0.9410.98
287_S291_D0.9410.98
107_G110_S0.9390.98
77_L99_I0.9350.98
115_G123_A0.9350.98
52_M76_I0.9330.98
188_I228_V0.9260.98
291_D323_T0.9220.98
323_T326_V0.9220.98
118_E122_A0.9220.98
281_V320_A0.9190.98
50_I64_A0.9150.98
62_I96_K0.9070.98
281_V323_T0.9060.98
25_G117_S0.9040.98
187_L235_M0.9040.98
30_G47_P0.8970.98
120_L128_A0.8960.98
213_T227_L0.8960.98
119_E126_R0.8870.98
120_L127_V0.8830.98
113_L117_S0.8820.98
36_A67_E0.8790.98
171_V200_F0.8750.98
232_D251_Q0.8730.97
8_D14_R0.8720.97
281_V326_V0.8680.97
53_D104_K0.8660.97
127_V130_A0.8640.97
123_A126_R0.8620.97
35_G39_L0.8570.97
264_V269_A0.8560.97
239_G242_N0.8500.97
29_V45_V0.8490.97
14_R33_E0.8460.97
269_A272_R0.8430.97
163_A171_V0.8400.97
219_S225_E0.8400.97
291_D294_R0.8310.97
117_S123_A0.8280.97
116_H123_A0.8260.96
52_M68_I0.8250.96
234_H259_R0.8240.96
9_D56_M0.8210.96
265_T269_A0.8170.96
35_G56_M0.8170.96
123_A128_A0.8150.96
281_V292_G0.8140.96
158_T187_L0.8120.96
35_G58_E0.8120.96
304_L330_L0.8100.96
128_A131_D0.8100.96
51_T79_V0.8070.96
56_M61_G0.8060.96
127_V131_D0.8040.96
177_S337_E0.8030.96
320_A323_T0.8010.96
9_D61_G0.7990.96
266_F281_V0.7980.96
112_E123_A0.7940.96
211_D222_G0.7920.96
271_E295_A0.7920.96
178_L182_A0.7920.96
5_L42_V0.7910.96
220_R244_R0.7890.95
3_E45_V0.7840.95
99_I119_E0.7840.95
65_T78_M0.7830.95
216_E219_S0.7810.95
233_Y259_R0.7800.95
78_M101_T0.7750.95
55_E82_L0.7740.95
119_E124_V0.7680.95
174_I339_I0.7660.95
121_V124_V0.7650.95
125_E128_A0.7640.95
112_E121_V0.7630.95
112_E122_A0.7600.94
291_D298_D0.7600.94
330_L337_E0.7590.94
173_S177_S0.7590.94
69_M75_P0.7570.94
95_E172_E0.7550.94
28_V31_T0.7550.94
117_S121_V0.7540.94
236_R248_R0.7520.94
35_G59_M0.7520.94
270_A292_G0.7490.94
140_M143_A0.7480.94
258_V264_V0.7430.94
58_E64_A0.7420.94
234_H249_L0.7410.94
34_N37_R0.7400.94
21_L116_H0.7390.94
55_E60_D0.7380.94
297_K325_C0.7360.93
256_H261_A0.7320.93
171_V176_A0.7290.93
21_L28_V0.7280.93
115_G122_A0.7280.93
255_L264_V0.7280.93
237_V273_V0.7270.93
35_G168_P0.7260.93
261_A264_V0.7240.93
116_H124_V0.7240.93
126_R130_A0.7240.93
59_M64_A0.7240.93
303_T327_D0.7240.93
159_L339_I0.7230.93
117_S120_L0.7220.93
119_E130_A0.7210.93
304_L328_D0.7200.93
295_A299_A0.7190.93
113_L119_E0.7190.93
46_Q74_T0.7190.93
266_F279_S0.7190.93
50_I76_I0.7180.93
178_L339_I0.7150.92
62_I93_A0.7120.92
9_D57_P0.7110.92
290_A303_T0.7050.92
86_D90_T0.7040.92
236_R271_E0.7030.92
110_S115_G0.7020.92
63_E66_A0.7020.92
193_P197_T0.7020.92
113_L120_L0.7010.92
137_D141_E0.7010.92
237_V245_L0.7010.92
7_V50_I0.6970.91
126_R129_S0.6960.91
42_V46_Q0.6940.91
52_M56_M0.6930.91
100_D115_G0.6930.91
160_L265_T0.6920.91
53_D61_G0.6890.91
304_L338_A0.6880.91
172_E176_A0.6850.91
159_L182_A0.6850.91
194_D232_D0.6840.91
42_V68_I0.6830.91
113_L123_A0.6830.91
334_Q338_A0.6810.90
6_V51_T0.6810.90
142_P145_P0.6800.90
333_D336_T0.6790.90
308_E311_S0.6770.90
5_L32_A0.6770.90
59_M67_E0.6710.90
186_V210_Y0.6690.90
314_F326_V0.6670.90
141_E144_S0.6650.89
108_T112_E0.6630.89
236_R267_K0.6580.89
113_L127_V0.6510.88
54_V83_T0.6500.88
90_T100_D0.6470.88
228_V231_G0.6470.88
112_E117_S0.6430.88
311_S318_E0.6410.88
193_P214_E0.6400.88
124_V130_A0.6400.88
15_T19_D0.6380.87
124_V128_A0.6370.87
113_L121_V0.6340.87
29_V47_P0.6330.87
57_P61_G0.6330.87
116_H127_V0.6300.87
203_R214_E0.6300.87
69_M74_T0.6300.87
116_H122_A0.6300.87
263_D281_V0.6280.87
200_F208_S0.6270.87
150_T153_Y0.6270.87
215_A218_G0.6260.86
273_V277_L0.6250.86
39_L67_E0.6230.86
139_E142_P0.6220.86
41_A47_P0.6190.86
121_V126_R0.6180.86
83_T87_A0.6180.86
254_R257_S0.6160.86
113_L118_E0.6160.86
220_R246_R0.6150.85
162_G165_T0.6130.85
106_G110_S0.6120.85
39_L59_M0.6110.85
138_V142_P0.6110.85
170_V174_I0.6100.85
121_V128_A0.6100.85
56_M64_A0.6100.85
117_S122_A0.6080.85
203_R212_I0.6060.85
309_A331_P0.6060.85
294_R297_K0.6060.85
138_V141_E0.6030.84
307_N310_T0.5990.84
123_A129_S0.5980.84
241_S246_R0.5970.84
308_E314_F0.5960.84
91_L94_M0.5950.84
297_K326_V0.5930.83
255_L258_V0.5930.83
6_V28_V0.5900.83
173_S336_T0.5900.83
94_M98_A0.5890.83
230_R249_L0.5890.83
217_D249_L0.5860.83
61_G104_K0.5840.82
39_L71_E0.5840.82
5_L38_A0.5830.82
176_A207_A0.5830.82
162_G166_G0.5820.82
108_T113_L0.5770.82
119_E131_D0.5760.82
266_F296_V0.5760.82
304_L329_V0.5760.82
215_A235_M0.5750.81
182_A210_Y0.5750.81
122_A129_S0.5740.81
287_S319_R0.5730.81
198_S214_E0.5710.81
65_T96_K0.5700.81
175_L188_I0.5690.81
124_V129_S0.5690.81
136_H140_M0.5680.81
290_A294_R0.5660.80
120_L126_R0.5640.80
333_D337_E0.5620.80
319_R323_T0.5620.80
193_P231_G0.5620.80
323_T327_D0.5610.80
185_R227_L0.5610.80
19_D22_E0.5600.80
162_G167_G0.5580.79
62_I66_A0.5570.79
42_V64_A0.5560.79
193_P203_R0.5550.79
219_S222_G0.5530.79
302_A338_A0.5520.79
3_E29_V0.5520.79
163_A166_G0.5520.79
22_E27_D0.5520.79
68_I76_I0.5520.79
149_T152_E0.5520.79
33_E41_A0.5510.79
267_K271_E0.5510.79
32_A38_A0.5500.79
241_S244_R0.5500.79
205_D212_I0.5500.79
308_E318_E0.5490.78
5_L45_V0.5490.78
122_A130_A0.5490.78
186_V226_G0.5480.78
137_D140_M0.5470.78
54_V62_I0.5450.78
121_V125_E0.5440.78
114_S118_E0.5440.78
198_S216_E0.5430.78
5_L41_A0.5390.77
89_A92_E0.5390.77
278_V339_I0.5380.77
232_D259_R0.5380.77
54_V105_P0.5370.77
15_T18_S0.5360.77
270_A277_L0.5350.77
53_D57_P0.5330.76
164_S167_G0.5310.76
260_P269_A0.5290.76
128_A132_P0.5290.76
113_L124_V0.5290.76
161_I165_T0.5290.76
80_S104_K0.5280.76
236_R252_S0.5270.76
264_V267_K0.5270.76
145_P149_T0.5230.75
12_F15_T0.5210.75
39_L68_I0.5210.75
12_F101_T0.5190.74
86_D89_A0.5180.74
163_A176_A0.5180.74
169_N172_E0.5180.74
331_P336_T0.5160.74
314_F322_E0.5150.74
125_E129_S0.5130.74
119_E128_A0.5130.74
256_H263_D0.5120.73
7_V52_M0.5120.73
119_E125_E0.5120.73
263_D291_D0.5110.73
156_N159_L0.5100.73
13_M62_I0.5080.73
18_S28_V0.5080.73
291_D295_A0.5070.73
254_R258_V0.5050.72
261_A269_A0.5040.72
201_A205_D0.5030.72
189_V258_V0.5030.72
117_S129_S0.5020.72
55_E86_D0.5020.72
51_T78_M0.5010.72
162_G281_V0.5010.72
260_P264_V0.5010.72
253_E258_V0.5010.72
168_P192_M0.5010.72
164_S170_V0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a2oA 1 0.9597 100 0.16 Contact Map
3sftA 1 0.5447 100 0.505 Contact Map
1chdA 1 0.5591 100 0.51 Contact Map
4g97A 1 0.3718 100 0.581 Contact Map
3n0rA 1 0.3487 100 0.583 Contact Map
4l4uA 2 0.9481 100 0.593 Contact Map
3c3wA 2 0.5591 100 0.593 Contact Map
4ldzA 2 0.5418 100 0.594 Contact Map
4gvpA 1 0.5591 100 0.595 Contact Map
1yioA 1 0.5447 100 0.597 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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