CHEB - HALSA - GREMLIN Contacts

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CHEB - Chemotaxis response regulator protein-glutamate methylesterase/glutamine deamidase

UniProt:	P0DMI2	Sequences: MTEALVVDDSHFMRTVISDILEDGGVDVVGTAENGARALDAVTDVQPDVITMDVEMPEMDGIEATAEIMREQPTPILMVSALTTEDADATLEAMEKGAIDTFAKPGGTISTELSGHSEELVAAVERVASADPTAGHDVEMEPASPPDATTSEYADNPTLLIGASTGGPNVVESILASLPAEADFRVLIVQHMPDQFTSRFADRLDAASQYDITEAEDGSRIGGGEGLVARGDYHMRVSGYSNGRLRVRLDQSERLHSVRPAIDVTFKSAAERVTDPLVSVVLTGMGSDGADGVRAVKDAGGATLAQNEATSAVFGIPERAIETGCVDDVLPVDQLTEAIADSIRRTT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	347 (332)
Sequences:	3609 (2888)
Seq/√Len:	158.5

ECOLI - CHEB
BACSU - CHEB
HALSA - CHEB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
314_F	321_I	4.427	1.00
296_V	301_G	3.901	1.00
60_D	63_E	3.474	1.00
328_D	338_A	3.174	1.00
34_N	58_E	3.061	1.00
294_R	298_D	2.990	1.00
21_L	26_V	2.977	1.00
160_L	269_A	2.825	1.00
210_Y	226_G	2.806	1.00
162_G	262_I	2.729	1.00
297_K	327_D	2.701	1.00
30_G	45_V	2.646	1.00
318_E	322_E	2.595	1.00
213_T	216_E	2.549	1.00
305_A	321_I	2.535	1.00
205_D	211_D	2.516	1.00
36_A	58_E	2.497	1.00
267_K	295_A	2.480	1.00
213_T	219_S	2.476	1.00
7_V	38_A	2.313	1.00
305_A	326_V	2.312	1.00
304_L	335_L	2.301	1.00
3_E	27_D	2.298	1.00
112_E	120_L	2.298	1.00
235_M	247_V	2.258	1.00
321_I	329_V	2.199	1.00
233_Y	251_Q	2.190	1.00
43_T	71_E	2.111	1.00
198_S	202_D	2.104	1.00
52_M	64_A	2.074	1.00
33_E	37_R	2.069	1.00
279_S	296_V	2.042	1.00
217_D	248_R	2.018	1.00
192_M	197_T	1.928	1.00
69_M	73_P	1.899	1.00
18_S	31_T	1.870	1.00
54_V	78_M	1.858	1.00
161_I	174_I	1.843	1.00
293_V	303_T	1.823	1.00
320_A	326_V	1.819	1.00
305_A	329_V	1.804	1.00
307_N	311_S	1.797	1.00
59_M	63_E	1.795	1.00
310_T	331_P	1.793	1.00
307_N	331_P	1.791	1.00
238_S	248_R	1.784	1.00
211_D	225_E	1.783	1.00
314_F	318_E	1.773	1.00
50_I	74_T	1.766	1.00
251_Q	259_R	1.765	1.00
175_L	208_S	1.763	1.00
39_L	64_A	1.731	1.00
65_T	76_I	1.715	1.00
173_S	333_D	1.692	1.00
319_R	322_E	1.682	1.00
119_E	123_A	1.622	1.00
219_S	227_L	1.621	1.00
42_V	47_P	1.608	1.00
42_V	50_I	1.606	1.00
306_Q	311_S	1.571	1.00
294_R	325_C	1.560	1.00
187_L	221_I	1.555	1.00
302_A	327_D	1.555	1.00
213_T	225_E	1.548	1.00
290_A	323_T	1.546	1.00
185_R	221_I	1.528	1.00
245_L	273_V	1.527	1.00
330_L	335_L	1.510	1.00
112_E	119_E	1.499	1.00
87_A	90_T	1.485	1.00
277_L	296_V	1.481	1.00
306_Q	309_A	1.468	1.00
290_A	325_C	1.462	1.00
174_I	282_L	1.459	1.00
263_D	292_G	1.444	1.00
30_G	41_A	1.438	1.00
227_L	247_V	1.436	1.00
269_A	277_L	1.436	1.00
67_E	71_E	1.432	1.00
310_T	333_D	1.429	1.00
119_E	127_V	1.422	1.00
52_M	65_T	1.420	1.00
116_H	120_L	1.404	1.00
222_G	225_E	1.398	1.00
92_E	96_K	1.387	1.00
331_P	334_Q	1.386	1.00
123_A	127_V	1.385	1.00
66_A	96_K	1.377	1.00
189_V	265_T	1.373	1.00
64_A	68_I	1.370	1.00
320_A	325_C	1.370	1.00
92_E	95_E	1.365	1.00
40_D	44_D	1.340	1.00
67_E	70_R	1.330	1.00
180_A	209_Q	1.329	1.00
179_P	340_A	1.326	1.00
112_E	115_G	1.304	1.00
119_E	122_A	1.285	1.00
31_T	41_A	1.285	1.00
174_I	335_L	1.283	1.00
302_A	328_D	1.283	1.00
295_A	298_D	1.283	1.00
305_A	314_F	1.279	1.00
255_L	267_K	1.273	1.00
170_V	332_V	1.269	1.00
41_A	44_D	1.264	1.00
326_V	329_V	1.262	1.00
163_A	282_L	1.262	1.00
311_S	314_F	1.260	1.00
37_R	41_A	1.253	1.00
4_A	49_V	1.249	1.00
88_D	92_E	1.243	1.00
314_F	329_V	1.241	1.00
23_D	117_S	1.235	1.00
303_T	325_C	1.233	1.00
115_G	120_L	1.225	1.00
236_R	250_D	1.225	1.00
50_I	68_I	1.223	1.00
197_T	214_E	1.222	1.00
281_V	293_V	1.221	1.00
115_G	119_E	1.214	1.00
36_A	40_D	1.214	1.00
66_A	92_E	1.209	1.00
14_R	31_T	1.202	1.00
303_T	320_A	1.197	1.00
202_D	206_A	1.187	1.00
330_L	338_A	1.176	1.00
293_V	320_A	1.175	1.00
23_D	26_V	1.173	1.00
293_V	325_C	1.163	1.00
32_A	41_A	1.160	1.00
115_G	118_E	1.158	1.00
39_L	42_V	1.154	1.00
221_I	237_V	1.145	1.00
120_L	123_A	1.143	1.00
4_A	26_V	1.142	1.00
8_D	56_M	1.136	1.00
17_I	79_V	1.136	1.00
112_E	116_H	1.133	1.00
290_A	320_A	1.127	1.00
294_R	323_T	1.126	1.00
41_A	45_V	1.112	1.00
83_T	90_T	1.112	1.00
182_A	339_I	1.112	1.00
11_H	14_R	1.106	1.00
202_D	205_D	1.102	1.00
78_M	83_T	1.101	1.00
84_T	103_A	1.093	0.99
6_V	17_I	1.088	0.99
157_P	276_P	1.083	0.99
182_A	186_V	1.076	0.99
258_V	261_A	1.068	0.99
334_Q	337_E	1.066	0.99
188_I	226_G	1.065	0.99
281_V	303_T	1.061	0.99
18_S	22_E	1.060	0.99
293_V	323_T	1.054	0.99
116_H	119_E	1.054	0.99
69_M	99_I	1.038	0.99
280_V	339_I	1.033	0.99
56_M	59_M	1.029	0.99
318_E	321_I	1.028	0.99
35_G	64_A	1.026	0.99
177_S	336_T	1.023	0.99
42_V	74_T	1.020	0.99
53_D	56_M	1.019	0.99
178_L	186_V	1.013	0.99
63_E	67_E	1.012	0.99
113_L	116_H	1.009	0.99
42_V	45_V	1.001	0.99
8_D	104_K	0.992	0.99
303_T	323_T	0.991	0.99
293_V	326_V	0.988	0.99
90_T	101_T	0.980	0.99
4_A	21_L	0.978	0.99
290_A	319_R	0.978	0.99
282_L	335_L	0.976	0.99
54_V	89_A	0.976	0.99
46_Q	72_Q	0.976	0.99
122_A	127_V	0.972	0.99
9_D	53_D	0.970	0.99
175_L	226_G	0.969	0.99
124_V	127_V	0.965	0.99
40_D	43_T	0.965	0.99
5_L	30_G	0.961	0.99
83_T	86_D	0.959	0.99
330_L	334_Q	0.957	0.99
6_V	18_S	0.956	0.99
321_I	326_V	0.954	0.99
120_L	124_V	0.943	0.98
122_A	126_R	0.942	0.98
141_E	145_P	0.941	0.98
171_V	188_I	0.941	0.98
287_S	291_D	0.941	0.98
107_G	110_S	0.939	0.98
77_L	99_I	0.935	0.98
115_G	123_A	0.935	0.98
52_M	76_I	0.933	0.98
188_I	228_V	0.926	0.98
291_D	323_T	0.922	0.98
323_T	326_V	0.922	0.98
118_E	122_A	0.922	0.98
281_V	320_A	0.919	0.98
50_I	64_A	0.915	0.98
62_I	96_K	0.907	0.98
281_V	323_T	0.906	0.98
25_G	117_S	0.904	0.98
187_L	235_M	0.904	0.98
30_G	47_P	0.897	0.98
120_L	128_A	0.896	0.98
213_T	227_L	0.896	0.98
119_E	126_R	0.887	0.98
120_L	127_V	0.883	0.98
113_L	117_S	0.882	0.98
36_A	67_E	0.879	0.98
171_V	200_F	0.875	0.98
232_D	251_Q	0.873	0.97
8_D	14_R	0.872	0.97
281_V	326_V	0.868	0.97
53_D	104_K	0.866	0.97
127_V	130_A	0.864	0.97
123_A	126_R	0.862	0.97
35_G	39_L	0.857	0.97
264_V	269_A	0.856	0.97
239_G	242_N	0.850	0.97
29_V	45_V	0.849	0.97
14_R	33_E	0.846	0.97
269_A	272_R	0.843	0.97
163_A	171_V	0.840	0.97
219_S	225_E	0.840	0.97
291_D	294_R	0.831	0.97
117_S	123_A	0.828	0.97
116_H	123_A	0.826	0.96
52_M	68_I	0.825	0.96
234_H	259_R	0.824	0.96
9_D	56_M	0.821	0.96
265_T	269_A	0.817	0.96
35_G	56_M	0.817	0.96
123_A	128_A	0.815	0.96
281_V	292_G	0.814	0.96
158_T	187_L	0.812	0.96
35_G	58_E	0.812	0.96
304_L	330_L	0.810	0.96
128_A	131_D	0.810	0.96
51_T	79_V	0.807	0.96
56_M	61_G	0.806	0.96
127_V	131_D	0.804	0.96
177_S	337_E	0.803	0.96
320_A	323_T	0.801	0.96
9_D	61_G	0.799	0.96
266_F	281_V	0.798	0.96
112_E	123_A	0.794	0.96
211_D	222_G	0.792	0.96
271_E	295_A	0.792	0.96
178_L	182_A	0.792	0.96
5_L	42_V	0.791	0.96
220_R	244_R	0.789	0.95
3_E	45_V	0.784	0.95
99_I	119_E	0.784	0.95
65_T	78_M	0.783	0.95
216_E	219_S	0.781	0.95
233_Y	259_R	0.780	0.95
78_M	101_T	0.775	0.95
55_E	82_L	0.774	0.95
119_E	124_V	0.768	0.95
174_I	339_I	0.766	0.95
121_V	124_V	0.765	0.95
125_E	128_A	0.764	0.95
112_E	121_V	0.763	0.95
112_E	122_A	0.760	0.94
291_D	298_D	0.760	0.94
330_L	337_E	0.759	0.94
173_S	177_S	0.759	0.94
69_M	75_P	0.757	0.94
95_E	172_E	0.755	0.94
28_V	31_T	0.755	0.94
117_S	121_V	0.754	0.94
236_R	248_R	0.752	0.94
35_G	59_M	0.752	0.94
270_A	292_G	0.749	0.94
140_M	143_A	0.748	0.94
258_V	264_V	0.743	0.94
58_E	64_A	0.742	0.94
234_H	249_L	0.741	0.94
34_N	37_R	0.740	0.94
21_L	116_H	0.739	0.94
55_E	60_D	0.738	0.94
297_K	325_C	0.736	0.93
256_H	261_A	0.732	0.93
171_V	176_A	0.729	0.93
21_L	28_V	0.728	0.93
115_G	122_A	0.728	0.93
255_L	264_V	0.728	0.93
237_V	273_V	0.727	0.93
35_G	168_P	0.726	0.93
261_A	264_V	0.724	0.93
116_H	124_V	0.724	0.93
126_R	130_A	0.724	0.93
59_M	64_A	0.724	0.93
303_T	327_D	0.724	0.93
159_L	339_I	0.723	0.93
117_S	120_L	0.722	0.93
119_E	130_A	0.721	0.93
304_L	328_D	0.720	0.93
295_A	299_A	0.719	0.93
113_L	119_E	0.719	0.93
46_Q	74_T	0.719	0.93
266_F	279_S	0.719	0.93
50_I	76_I	0.718	0.93
178_L	339_I	0.715	0.92
62_I	93_A	0.712	0.92
9_D	57_P	0.711	0.92
290_A	303_T	0.705	0.92
86_D	90_T	0.704	0.92
236_R	271_E	0.703	0.92
110_S	115_G	0.702	0.92
63_E	66_A	0.702	0.92
193_P	197_T	0.702	0.92
113_L	120_L	0.701	0.92
137_D	141_E	0.701	0.92
237_V	245_L	0.701	0.92
7_V	50_I	0.697	0.91
126_R	129_S	0.696	0.91
42_V	46_Q	0.694	0.91
52_M	56_M	0.693	0.91
100_D	115_G	0.693	0.91
160_L	265_T	0.692	0.91
53_D	61_G	0.689	0.91
304_L	338_A	0.688	0.91
172_E	176_A	0.685	0.91
159_L	182_A	0.685	0.91
194_D	232_D	0.684	0.91
42_V	68_I	0.683	0.91
113_L	123_A	0.683	0.91
334_Q	338_A	0.681	0.90
6_V	51_T	0.681	0.90
142_P	145_P	0.680	0.90
333_D	336_T	0.679	0.90
308_E	311_S	0.677	0.90
5_L	32_A	0.677	0.90
59_M	67_E	0.671	0.90
186_V	210_Y	0.669	0.90
314_F	326_V	0.667	0.90
141_E	144_S	0.665	0.89
108_T	112_E	0.663	0.89
236_R	267_K	0.658	0.89
113_L	127_V	0.651	0.88
54_V	83_T	0.650	0.88
90_T	100_D	0.647	0.88
228_V	231_G	0.647	0.88
112_E	117_S	0.643	0.88
311_S	318_E	0.641	0.88
193_P	214_E	0.640	0.88
124_V	130_A	0.640	0.88
15_T	19_D	0.638	0.87
124_V	128_A	0.637	0.87
113_L	121_V	0.634	0.87
29_V	47_P	0.633	0.87
57_P	61_G	0.633	0.87
116_H	127_V	0.630	0.87
203_R	214_E	0.630	0.87
69_M	74_T	0.630	0.87
116_H	122_A	0.630	0.87
263_D	281_V	0.628	0.87
200_F	208_S	0.627	0.87
150_T	153_Y	0.627	0.87
215_A	218_G	0.626	0.86
273_V	277_L	0.625	0.86
39_L	67_E	0.623	0.86
139_E	142_P	0.622	0.86
41_A	47_P	0.619	0.86
121_V	126_R	0.618	0.86
83_T	87_A	0.618	0.86
254_R	257_S	0.616	0.86
113_L	118_E	0.616	0.86
220_R	246_R	0.615	0.85
162_G	165_T	0.613	0.85
106_G	110_S	0.612	0.85
39_L	59_M	0.611	0.85
138_V	142_P	0.611	0.85
170_V	174_I	0.610	0.85
121_V	128_A	0.610	0.85
56_M	64_A	0.610	0.85
117_S	122_A	0.608	0.85
203_R	212_I	0.606	0.85
309_A	331_P	0.606	0.85
294_R	297_K	0.606	0.85
138_V	141_E	0.603	0.84
307_N	310_T	0.599	0.84
123_A	129_S	0.598	0.84
241_S	246_R	0.597	0.84
308_E	314_F	0.596	0.84
91_L	94_M	0.595	0.84
297_K	326_V	0.593	0.83
255_L	258_V	0.593	0.83
6_V	28_V	0.590	0.83
173_S	336_T	0.590	0.83
94_M	98_A	0.589	0.83
230_R	249_L	0.589	0.83
217_D	249_L	0.586	0.83
61_G	104_K	0.584	0.82
39_L	71_E	0.584	0.82
5_L	38_A	0.583	0.82
176_A	207_A	0.583	0.82
162_G	166_G	0.582	0.82
108_T	113_L	0.577	0.82
119_E	131_D	0.576	0.82
266_F	296_V	0.576	0.82
304_L	329_V	0.576	0.82
215_A	235_M	0.575	0.81
182_A	210_Y	0.575	0.81
122_A	129_S	0.574	0.81
287_S	319_R	0.573	0.81
198_S	214_E	0.571	0.81
65_T	96_K	0.570	0.81
175_L	188_I	0.569	0.81
124_V	129_S	0.569	0.81
136_H	140_M	0.568	0.81
290_A	294_R	0.566	0.80
120_L	126_R	0.564	0.80
333_D	337_E	0.562	0.80
319_R	323_T	0.562	0.80
193_P	231_G	0.562	0.80
323_T	327_D	0.561	0.80
185_R	227_L	0.561	0.80
19_D	22_E	0.560	0.80
162_G	167_G	0.558	0.79
62_I	66_A	0.557	0.79
42_V	64_A	0.556	0.79
193_P	203_R	0.555	0.79
219_S	222_G	0.553	0.79
302_A	338_A	0.552	0.79
3_E	29_V	0.552	0.79
163_A	166_G	0.552	0.79
22_E	27_D	0.552	0.79
68_I	76_I	0.552	0.79
149_T	152_E	0.552	0.79
33_E	41_A	0.551	0.79
267_K	271_E	0.551	0.79
32_A	38_A	0.550	0.79
241_S	244_R	0.550	0.79
205_D	212_I	0.550	0.79
308_E	318_E	0.549	0.78
5_L	45_V	0.549	0.78
122_A	130_A	0.549	0.78
186_V	226_G	0.548	0.78
137_D	140_M	0.547	0.78
54_V	62_I	0.545	0.78
121_V	125_E	0.544	0.78
114_S	118_E	0.544	0.78
198_S	216_E	0.543	0.78
5_L	41_A	0.539	0.77
89_A	92_E	0.539	0.77
278_V	339_I	0.538	0.77
232_D	259_R	0.538	0.77
54_V	105_P	0.537	0.77
15_T	18_S	0.536	0.77
270_A	277_L	0.535	0.77
53_D	57_P	0.533	0.76
164_S	167_G	0.531	0.76
260_P	269_A	0.529	0.76
128_A	132_P	0.529	0.76
113_L	124_V	0.529	0.76
161_I	165_T	0.529	0.76
80_S	104_K	0.528	0.76
236_R	252_S	0.527	0.76
264_V	267_K	0.527	0.76
145_P	149_T	0.523	0.75
12_F	15_T	0.521	0.75
39_L	68_I	0.521	0.75
12_F	101_T	0.519	0.74
86_D	89_A	0.518	0.74
163_A	176_A	0.518	0.74
169_N	172_E	0.518	0.74
331_P	336_T	0.516	0.74
314_F	322_E	0.515	0.74
125_E	129_S	0.513	0.74
119_E	128_A	0.513	0.74
256_H	263_D	0.512	0.73
7_V	52_M	0.512	0.73
119_E	125_E	0.512	0.73
263_D	291_D	0.511	0.73
156_N	159_L	0.510	0.73
13_M	62_I	0.508	0.73
18_S	28_V	0.508	0.73
291_D	295_A	0.507	0.73
254_R	258_V	0.505	0.72
261_A	269_A	0.504	0.72
201_A	205_D	0.503	0.72
189_V	258_V	0.503	0.72
117_S	129_S	0.502	0.72
55_E	86_D	0.502	0.72
51_T	78_M	0.501	0.72
162_G	281_V	0.501	0.72
260_P	264_V	0.501	0.72
253_E	258_V	0.501	0.72
168_P	192_M	0.501	0.72
164_S	170_V	0.500	0.72

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a2oA	1	0.9597	100	0.16	Contact Map
3sftA	1	0.5447	100	0.505	Contact Map
1chdA	1	0.5591	100	0.51	Contact Map
4g97A	1	0.3718	100	0.581	Contact Map
3n0rA	1	0.3487	100	0.583	Contact Map
4l4uA	2	0.9481	100	0.593	Contact Map
3c3wA	2	0.5591	100	0.593	Contact Map
4ldzA	2	0.5418	100	0.594	Contact Map
4gvpA	1	0.5591	100	0.595	Contact Map
1yioA	1	0.5447	100	0.597	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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