GREMLIN Database
BACS1 - Sensory rhodopsin-1
UniProt: P0DMH8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (214)
Sequences: 709 (511)
Seq/√Len: 34.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
47_F79_V7.3971.00
14_A202_V4.1241.00
81_T106_D3.8451.00
54_G127_L3.4541.00
71_G75_I3.4371.00
19_V45_P3.3391.00
16_I49_G3.2961.00
76_D80_T3.2941.00
76_D205_K3.2771.00
9_L56_A3.1881.00
128_F132_S2.7711.00
108_L134_F2.6931.00
112_V131_S2.6461.00
170_L203_L2.5221.00
42_A209_V2.4001.00
109_M113_G2.3080.99
18_G206_V2.1430.99
45_P209_V2.0330.98
106_D109_M1.8400.97
81_T205_K1.8360.97
62_V118_V1.8240.97
23_W27_R1.8170.97
105_A137_S1.8080.97
182_P193_V1.8050.97
80_T205_K1.8040.97
42_A87_Y1.7880.96
81_T109_M1.7480.96
8_Y194_A1.7470.96
177_V196_T1.7410.96
77_W113_G1.7280.96
41_L83_I1.7200.95
113_G205_K1.7040.95
11_G198_V1.6820.95
51_S55_M1.6220.94
195_L199_F1.6020.93
76_D81_T1.6020.93
80_T83_I1.5980.93
173_A177_V1.5880.93
86_G103_M1.5680.93
116_A178_W1.5630.92
48_A55_M1.5430.92
16_I46_V1.5280.92
53_V119_T1.5140.91
171_W205_K1.5120.91
112_V204_A1.4910.91
15_L48_A1.4840.90
140_A144_V1.4420.89
48_A80_T1.4390.89
178_W193_V1.4300.89
85_V106_D1.4300.89
112_V127_L1.4250.88
78_L107_A1.4020.88
74_Y77_W1.3900.87
48_A175_P1.3840.87
18_G210_Y1.3750.87
135_H139_F1.3570.86
109_M138_L1.3410.85
19_V46_V1.3310.85
124_K129_G1.3160.84
48_A205_K1.3130.84
128_F172_L1.3050.84
137_S141_Y1.2920.83
179_L185_I1.2580.81
12_A49_G1.2370.80
72_L79_V1.2050.78
48_A76_D1.1950.78
48_A87_Y1.1900.77
129_G191_A1.1720.76
19_V49_G1.1690.76
180_F196_T1.1540.75
112_V130_V1.1520.75
81_T113_G1.1470.75
80_T106_D1.1430.74
173_A196_T1.1280.73
11_G15_L1.1200.73
20_A46_V1.1130.72
77_W175_P1.1090.72
24_L209_V1.1070.72
61_T70_V1.1020.72
68_Q181_G1.0960.71
14_A206_V1.0870.71
7_A11_G1.0860.71
46_V203_L1.0810.70
44_I83_I1.0720.70
114_A121_G1.0470.68
16_I202_V1.0460.68
85_V113_G1.0430.67
15_L206_V1.0420.67
166_H211_F1.0360.67
79_V137_S1.0350.67
80_T113_G1.0340.67
102_V141_Y1.0320.67
40_P95_S1.0260.66
177_V200_L1.0260.66
93_G168_G1.0190.66
64_V158_G1.0180.66
9_L114_A1.0110.65
85_V94_A1.0100.65
48_A109_M0.9980.64
46_V50_L0.9910.63
24_L45_P0.9860.63
189_T192_G0.9830.63
72_L115_G0.9810.63
160_F164_K0.9800.63
110_I205_K0.9750.62
84_L87_Y0.9710.62
130_V147_P0.9700.62
135_H168_G0.9650.61
51_S54_G0.9570.61
48_A84_L0.9540.60
93_G125_W0.9540.60
81_T171_W0.9530.60
49_G53_V0.9530.60
125_W179_L0.9500.60
106_D204_A0.9470.60
129_G133_I0.9380.59
150_V154_P0.9290.58
50_L108_L0.9290.58
165_N169_L0.9280.58
51_S117_V0.9260.58
77_W82_P0.9230.58
147_P164_K0.9210.58
188_A192_G0.9160.57
114_A197_Y0.9110.57
113_G208_Y0.9070.57
127_L189_T0.9060.56
75_I143_Y0.9020.56
114_A118_V0.9020.56
89_G99_I0.9000.56
16_I160_F0.8870.55
74_Y82_P0.8870.55
185_I188_A0.8850.55
126_A192_G0.8820.54
18_G148_R0.8730.54
101_G141_Y0.8560.52
113_G175_P0.8490.52
108_L130_V0.8480.52
215_R218_V0.8470.51
123_L185_I0.8440.51
127_L199_F0.8400.51
178_W200_L0.8330.50
133_I207_P0.8320.50
42_A103_M0.8300.50
130_V180_F0.8290.50
18_G24_L0.8290.50
166_H170_L0.8230.49
70_V194_A0.8200.49
208_Y213_Y0.8200.49
34_H43_I0.8170.49
103_M107_A0.8150.49
138_L141_Y0.8150.49
154_P157_I0.8080.48
20_A155_E0.8010.47
27_R100_I0.7940.47
110_I206_V0.7920.47
178_W184_G0.7910.47
15_L113_G0.7890.46
74_Y208_Y0.7830.46
11_G48_A0.7820.46
11_G50_L0.7820.46
135_H172_L0.7750.45
12_A16_I0.7750.45
152_D199_F0.7690.45
94_A98_S0.7690.45
97_R101_G0.7680.45
42_A45_P0.7610.44
129_G185_I0.7610.44
68_Q190_A0.7580.44
170_L204_A0.7570.44
83_I116_A0.7570.44
92_A155_E0.7550.44
192_G196_T0.7530.43
18_G207_P0.7530.43
122_T179_L0.7520.43
95_S188_A0.7510.43
143_Y168_G0.7460.43
60_G193_V0.7450.43
52_Y55_M0.7420.42
24_L162_L0.7420.42
150_V170_L0.7370.42
6_T10_G0.7360.42
69_I188_A0.7340.42
11_G202_V0.7280.41
188_A195_L0.7240.41
167_I204_A0.7240.41
25_L49_G0.7220.41
81_T110_I0.7210.41
60_G67_N0.7180.40
87_Y212_F0.7180.40
17_V202_V0.7110.40
58_D70_V0.7100.40
76_D83_I0.7090.40
64_V121_G0.7090.40
7_A13_V0.7070.40
106_D205_K0.7070.40
27_R30_D0.7060.39
12_A53_V0.7030.39
54_G219_F0.6970.39
172_L175_P0.6970.39
179_L196_T0.6950.39
148_R156_Q0.6930.38
150_V156_Q0.6900.38
53_V126_A0.6890.38
48_A171_W0.6780.37
161_N169_L0.6780.37
120_D207_P0.6750.37
109_M131_S0.6740.37
139_F163_L0.6730.37
122_T149_V0.6720.37
173_A176_L0.6720.37
13_V50_L0.6590.36
205_K209_V0.6560.35
128_F133_I0.6540.35
109_M175_P0.6520.35
118_V129_G0.6510.35
8_Y136_L0.6490.35
57_Y184_G0.6450.35
158_G161_N0.6440.35
67_N70_V0.6440.35
65_N69_I0.6430.34
93_G146_F0.6430.34
44_I84_L0.6400.34
73_R205_K0.6370.34
27_R39_A0.6360.34
85_V99_I0.6350.34
44_I87_Y0.6330.34
139_F143_Y0.6300.33
69_I117_V0.6280.33
102_V106_D0.6280.33
193_V197_Y0.6280.33
78_L195_L0.6260.33
102_V146_F0.6250.33
58_D119_T0.6230.33
116_A128_F0.6190.33
111_A161_N0.6170.32
15_L76_D0.6150.32
80_T204_A0.6100.32
85_V204_A0.6060.32
71_G193_V0.6060.32
106_D138_L0.6030.31
20_A202_V0.6030.31
23_W26_Y0.6020.31
159_L166_H0.6020.31
136_L186_G0.5980.31
76_D87_Y0.5980.31
4_V118_V0.5970.31
20_A210_Y0.5950.31
109_M132_S0.5940.31
126_A179_L0.5930.31
136_L172_L0.5910.31
53_V185_I0.5900.30
41_L124_K0.5900.30
28_S46_V0.5900.30
100_I140_A0.5890.30
129_G132_S0.5890.30
91_A216_R0.5870.30
123_L176_L0.5820.30
57_Y125_W0.5810.30
164_K176_L0.5810.30
182_P197_Y0.5760.29
152_D180_F0.5740.29
108_L128_F0.5730.29
104_V108_L0.5710.29
28_S32_S0.5700.29
180_F188_A0.5680.29
159_L177_V0.5670.29
109_M171_W0.5650.29
65_N169_L0.5620.28
119_T123_L0.5590.28
115_G119_T0.5580.28
201_D212_F0.5570.28
15_L140_A0.5510.28
121_G184_G0.5510.28
53_V57_Y0.5480.28
19_V139_F0.5470.27
122_T126_A0.5470.27
103_M199_F0.5450.27
26_Y30_D0.5450.27
97_R192_G0.5450.27
49_G111_A0.5440.27
128_F131_S0.5440.27
44_I208_Y0.5420.27
170_L176_L0.5400.27
100_I149_V0.5380.27
167_I212_F0.5360.27
186_G198_V0.5360.27
80_T116_A0.5340.27
185_I198_V0.5340.27
59_I123_L0.5330.27
136_L165_N0.5330.27
14_A110_I0.5310.26
66_G192_G0.5310.26
19_V161_N0.5300.26
121_G186_G0.5290.26
63_I69_I0.5280.26
108_L152_D0.5280.26
167_I208_Y0.5270.26
13_V49_G0.5240.26
111_A214_A0.5230.26
44_I178_W0.5220.26
25_L30_D0.5210.26
17_V140_A0.5210.26
4_V212_F0.5190.26
123_L126_A0.5190.26
92_A103_M0.5180.26
59_I119_T0.5160.25
92_A163_L0.5160.25
214_A218_V0.5140.25
165_N170_L0.5120.25
97_R144_V0.5100.25
137_S142_L0.5090.25
13_V78_L0.5090.25
142_L204_A0.5060.25
77_W174_Y0.5060.25
9_L12_A0.5060.25
103_M218_V0.5050.25
61_T68_Q0.5030.25
118_V123_L0.5030.25
11_G14_A0.5010.24
43_I178_W0.5000.24
28_S218_V0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qi1A 3 0.9079 100 0.183 Contact Map
3wqjA 3 0.9038 100 0.186 Contact Map
3qapA 1 0.9079 100 0.186 Contact Map
1xioA 2 0.8787 100 0.191 Contact Map
4fbzA 3 0.9414 100 0.192 Contact Map
4l35A 3 0.9498 100 0.205 Contact Map
3wt9A 1 0.9163 100 0.205 Contact Map
1m0kA 3 0.8912 100 0.208 Contact Map
3am6A 3 0.8996 100 0.208 Contact Map
3ddlA 2 0.9289 100 0.232 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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