GREMLIN Database
DHEB - Glutamate dehydrogenase B
UniProt: P0DMG4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (369)
Sequences: 5395 (2496)
Seq/√Len: 129.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
243_L248_A4.2421.00
297_E319_R3.6451.00
229_V240_A3.4861.00
228_A300_V3.3781.00
300_V322_A3.2021.00
211_T326_V3.0461.00
273_S277_Q2.9221.00
299_D321_Q2.8721.00
267_D270_A2.8501.00
143_A173_A2.6871.00
339_R343_E2.6861.00
132_D136_R2.6801.00
220_I225_A2.4931.00
125_D128_T2.4701.00
115_F363_Y2.4531.00
226_T249_R2.4301.00
213_E216_N2.3641.00
342_E405_S2.3601.00
213_E389_L2.3101.00
252_A295_L2.3091.00
240_A253_V2.3091.00
108_C359_V2.2791.00
398_E402_G2.2511.00
160_M308_V2.2501.00
60_R66_T2.1971.00
227_V243_L2.1611.00
75_H101_S2.1391.00
207_V328_G2.1371.00
217_Y400_D2.1251.00
227_V248_A2.1021.00
291_T294_E2.1011.00
341_L346_V2.0921.00
241_L245_D2.0861.00
405_S408_D2.0671.00
57_P140_R2.0441.00
416_Q420_R2.0331.00
217_Y396_R2.0281.00
163_D166_T2.0011.00
392_W396_R2.0011.00
314_A336_A1.9951.00
210_A354_A1.9671.00
333_T341_L1.9561.00
326_V354_A1.9531.00
198_G377_P1.9511.00
397_S401_D1.8941.00
263_T288_N1.8741.00
349_I354_A1.8711.00
213_E393_N1.8641.00
313_T316_N1.8041.00
317_A340_I1.7981.00
208_A246_W1.7901.00
79_R112_D1.7741.00
86_L170_F1.7731.00
212_R246_W1.7711.00
312_I333_T1.7581.00
222_I248_A1.7561.00
146_R178_Q1.7551.00
139_R173_A1.7551.00
253_V271_I1.7461.00
73_A101_S1.7201.00
124_V129_L1.7151.00
217_Y392_W1.7081.00
82_Y118_A1.7031.00
192_V420_R1.6801.00
296_L303_V1.6771.00
228_A252_A1.6751.00
340_I344_R1.6631.00
212_R385_E1.6571.00
379_R383_E1.6491.00
305_P329_A1.6211.00
61_D130_S1.6191.00
209_I212_R1.6161.00
142_A170_F1.6061.00
221_P224_D1.6011.00
241_L272_P1.5981.00
256_V275_G1.5891.00
398_E416_Q1.5771.00
404_L412_V1.5731.00
143_A176_M1.5671.00
86_L141_F1.5551.00
312_I320_I1.5431.00
110_V353_L1.5421.00
214_A324_I1.5411.00
70_G141_F1.5351.00
352_I411_Y1.4941.00
329_A332_P1.4831.00
252_A298_L1.4731.00
93_S96_E1.4671.00
259_G290_L1.4601.00
235_V328_G1.4551.00
227_V304_I1.4271.00
173_A176_M1.4201.00
168_A190_P1.4141.00
239_A304_I1.4031.00
209_I385_E1.3991.00
146_R177_Q1.3981.00
180_E183_P1.3921.00
393_N397_S1.3901.00
314_A340_I1.3861.00
326_V349_I1.3841.00
59_E132_D1.3831.00
215_I302_V1.3761.00
209_I381_R1.3711.00
214_A349_I1.3711.00
272_P276_N1.3491.00
244_D269_H1.3481.00
75_H105_T1.3431.00
77_D82_Y1.3391.00
404_L409_A1.3381.00
257_N280_A1.3371.00
207_V326_V1.3361.00
164_A200_A1.3251.00
220_I323_D1.2791.00
239_A306_A1.2761.00
392_W406_W1.2761.00
401_D416_Q1.2701.00
120_G141_F1.2391.00
318_D340_I1.2371.00
56_V140_R1.2371.00
131_A165_Q1.2361.00
124_V137_L1.2351.00
274_H278_P1.2321.00
251_V261_L1.2251.00
386_S390_S1.2241.00
353_L395_V1.2201.00
71_Y123_V1.2201.00
212_R216_N1.2191.00
404_L408_D1.2110.99
106_W352_I1.2100.99
244_D268_T1.2060.99
89_H308_V1.2030.99
215_I222_I1.2000.99
217_Y393_N1.1960.99
385_E389_L1.1950.99
303_V320_I1.1940.99
335_S338_D1.1940.99
105_T418_I1.1920.99
208_A243_L1.1900.99
192_V424_A1.1880.99
251_V300_V1.1860.99
140_R143_A1.1860.99
226_T301_D1.1850.99
226_T245_D1.1850.99
218_Y323_D1.1850.99
211_T302_V1.1830.99
226_T263_T1.1830.99
227_V302_V1.1820.99
228_A298_L1.1810.99
340_I343_E1.1800.99
259_G292_N1.1780.99
73_A94_A1.1610.99
227_V250_V1.1610.99
369_D374_T1.1570.99
106_W418_I1.1380.99
398_E413_V1.1340.99
211_T304_I1.1260.99
243_L250_V1.1220.99
312_I341_L1.1170.99
129_L137_L1.1140.99
262_D270_A1.1110.99
153_Q179_G1.1110.99
111_M360_T1.1100.99
376_S386_S1.1070.99
69_D123_V1.1060.99
339_R342_E1.1060.99
228_A251_V1.1040.99
270_A284_H1.1040.99
314_A318_D1.1020.99
324_I347_P1.1010.99
76_D422_K1.0990.99
281_V284_H1.0950.99
90_P125_D1.0920.99
57_P67_V1.0880.99
207_V304_I1.0830.99
420_R423_E1.0690.99
226_T299_D1.0690.99
111_M356_A1.0680.99
143_A179_G1.0630.99
207_V306_A1.0560.99
390_S394_A1.0550.99
338_D407_R1.0500.99
162_T167_M1.0450.98
377_P381_R1.0370.98
140_R144_E1.0250.98
381_R385_E1.0190.98
207_V211_T1.0090.98
214_A326_V0.9950.98
212_R222_I0.9940.98
271_I284_H0.9930.98
415_L418_I0.9920.98
279_A283_R0.9900.98
237_A272_P0.9860.98
237_A276_N0.9850.98
218_Y347_P0.9830.98
260_V271_I0.9820.98
398_E412_V0.9810.98
91_G96_E0.9790.98
88_Y162_T0.9760.98
376_S379_R0.9760.98
261_L288_N0.9750.98
139_R172_D0.9740.98
200_A238_N0.9710.98
112_D387_E0.9660.97
238_N241_L0.9650.97
315_A318_D0.9650.97
402_G412_V0.9620.97
88_Y138_T0.9610.97
304_I326_V0.9570.97
239_A243_L0.9530.97
135_E139_R0.9460.97
318_D344_R0.9410.97
240_A250_V0.9360.97
190_P193_A0.9300.97
240_A271_I0.9280.97
140_R176_M0.9250.97
325_V341_L0.9220.97
205_R381_R0.9210.97
268_T272_P0.9170.97
244_D267_D0.9160.97
400_D403_D0.9130.96
232_Y253_V0.9090.96
205_R242_L0.9050.96
320_I325_V0.9050.96
95_E98_V0.9020.96
232_Y255_D0.9000.96
261_L298_L0.8990.96
211_T324_I0.8970.96
78_V418_I0.8940.96
193_A424_A0.8930.96
127_K256_V0.8870.96
142_A186_V0.8870.96
338_D342_E0.8850.96
147_D179_G0.8850.96
134_H278_P0.8810.96
303_V311_V0.8810.96
130_S133_E0.8780.96
274_H284_H0.8780.96
217_Y397_S0.8770.96
266_L271_I0.8740.95
399_V404_L0.8690.95
262_D286_A0.8650.95
396_R400_D0.8630.95
243_L304_I0.8630.95
101_S105_T0.8600.95
249_R264_D0.8580.95
145_L148_E0.8580.95
59_E66_T0.8570.95
119_K330_N0.8560.95
333_T337_A0.8550.95
60_R64_T0.8520.95
244_D250_V0.8500.95
60_R68_Y0.8470.95
378_E382_D0.8440.94
119_K203_P0.8440.94
325_V333_T0.8430.94
274_H283_R0.8410.94
382_D386_S0.8390.94
88_Y122_V0.8380.94
207_V239_A0.8340.94
79_R109_A0.8320.94
301_D323_D0.8290.94
89_H160_M0.8260.94
210_A395_V0.8240.94
152_S370_I0.8240.94
262_D284_H0.8210.94
144_E147_D0.8210.94
290_L298_L0.8170.93
293_E297_E0.8120.93
151_P182_V0.8110.93
259_G297_E0.8060.93
170_F173_A0.8060.93
312_I351_D0.8020.93
362_S365_E0.8010.93
240_A268_T0.8000.93
86_L156_P0.7980.93
127_K275_G0.7950.93
138_T142_A0.7890.92
260_V281_V0.7850.92
255_D275_G0.7830.92
367_L373_R0.7820.92
399_V402_G0.7810.92
347_P406_W0.7810.92
107_K330_N0.7790.92
151_P180_E0.7770.92
312_I317_A0.7760.92
294_E316_N0.7760.92
294_E297_E0.7760.92
71_Y94_A0.7740.92
66_T128_T0.7730.91
270_A273_S0.7730.91
171_M182_V0.7730.91
138_T170_F0.7730.91
407_R411_Y0.7720.91
255_D258_G0.7710.91
360_T364_F0.7630.91
359_V362_S0.7630.91
140_R173_A0.7600.91
167_M186_V0.7590.91
282_M289_T0.7590.91
222_I227_V0.7580.91
109_A414_A0.7560.91
58_V68_Y0.7560.91
284_H287_P0.7550.91
229_V253_V0.7510.90
161_G235_V0.7510.90
255_D280_A0.7490.90
70_G133_E0.7480.90
158_P199_R0.7460.90
297_E316_N0.7450.90
299_D322_A0.7420.90
235_V256_V0.7410.90
151_P183_P0.7370.89
361_V380_V0.7370.89
252_A259_G0.7320.89
360_T388_M0.7320.89
169_W172_D0.7310.89
173_A177_Q0.7300.89
242_L381_R0.7260.89
97_C101_S0.7250.89
83_K359_V0.7240.89
348_V351_D0.7230.89
138_T166_T0.7230.89
333_T348_V0.7200.88
312_I325_V0.7180.88
289_T292_N0.7170.88
304_I328_G0.7160.88
226_T261_L0.7160.88
368_Q375_W0.7110.88
322_A346_V0.7110.88
414_A418_I0.7110.88
384_L388_M0.7110.88
218_Y324_I0.7060.87
112_D390_S0.7050.87
420_R424_A0.7040.87
314_A338_D0.7040.87
273_S279_A0.7040.87
238_N242_L0.7020.87
79_R116_G0.7020.87
103_W331_G0.7020.87
229_V248_A0.6990.87
302_V324_I0.6980.87
402_G416_Q0.6970.87
313_T334_T0.6960.87
283_R289_T0.6960.87
92_V121_G0.6940.86
258_G281_V0.6930.86
229_V243_L0.6930.86
415_L419_G0.6920.86
349_I406_W0.6920.86
66_T129_L0.6880.86
397_S400_D0.6870.86
210_A326_V0.6870.86
196_S361_V0.6860.86
356_A360_T0.6840.86
207_V354_A0.6830.86
382_D385_E0.6800.85
149_V170_F0.6780.85
61_D136_R0.6760.85
396_R399_V0.6760.85
338_D348_V0.6760.85
167_M193_A0.6750.85
216_N389_L0.6730.85
394_A397_S0.6720.85
259_G298_L0.6710.85
312_I348_V0.6710.85
201_E238_N0.6700.84
203_P358_G0.6690.84
196_S375_W0.6670.84
399_V406_W0.6660.84
179_G182_V0.6660.84
257_N289_T0.6650.84
158_P234_S0.6630.84
313_T333_T0.6620.84
320_I341_L0.6600.84
273_S276_N0.6600.84
232_Y268_T0.6570.83
228_A259_G0.6570.83
214_A347_P0.6560.83
280_A283_R0.6560.83
142_A173_A0.6540.83
199_R361_V0.6520.83
203_P234_S0.6510.83
74_Q153_Q0.6510.83
205_R385_E0.6490.83
175_S425_R0.6490.83
204_G239_A0.6470.82
325_V346_V0.6460.82
215_I324_I0.6450.82
259_G295_L0.6420.82
170_F186_V0.6420.82
124_V130_S0.6410.82
258_G282_M0.6390.82
122_V141_F0.6370.81
171_M175_S0.6360.81
278_P283_R0.6360.81
328_G354_A0.6350.81
274_H279_A0.6330.81
208_A242_L0.6330.81
251_V298_L0.6310.81
165_Q168_A0.6300.81
56_V137_L0.6290.81
78_V422_K0.6290.81
232_Y271_I0.6280.80
271_I281_V0.6280.80
74_Q82_Y0.6270.80
226_T251_V0.6260.80
274_H285_D0.6260.80
202_A234_S0.6250.80
413_V417_R0.6240.80
375_W380_V0.6230.80
102_M106_W0.6220.80
399_V403_D0.6210.80
64_T67_V0.6210.80
262_D287_P0.6200.80
325_V337_A0.6200.80
230_Q311_V0.6200.80
363_Y367_L0.6190.80
115_F366_W0.6150.79
216_N401_D0.6150.79
165_Q169_W0.6140.79
390_S393_N0.6140.79
296_L311_V0.6130.79
167_M170_F0.6110.79
187_T362_S0.6110.79
212_R389_L0.6100.79
73_A118_A0.6090.78
317_A341_L0.6080.78
348_V407_R0.6080.78
99_G331_G0.6080.78
228_A322_A0.6070.78
272_P275_G0.6070.78
210_A353_L0.6070.78
199_R362_S0.6060.78
361_V375_W0.6060.78
401_D404_L0.6050.78
119_K157_A0.6050.78
387_E390_S0.6050.78
341_L348_V0.6050.78
367_L371_N0.6020.78
314_A337_A0.6010.78
143_A177_Q0.6010.78
360_T387_E0.6010.78
97_C121_G0.6010.78
391_A395_V0.6000.77
213_E217_Y0.6000.77
389_L393_N0.5990.77
228_A299_D0.5960.77
110_V394_A0.5960.77
318_D343_E0.5940.77
210_A349_I0.5930.77
215_I220_I0.5920.76
79_R417_R0.5920.76
152_S372_R0.5920.76
203_P355_N0.5900.76
157_A359_V0.5900.76
264_D286_A0.5880.76
71_Y140_R0.5860.76
373_R379_R0.5850.76
199_R234_S0.5850.76
208_A212_R0.5850.76
61_D72_R0.5850.76
333_T338_D0.5830.75
208_A239_A0.5810.75
241_L269_H0.5810.75
78_V421_A0.5800.75
214_A392_W0.5780.75
322_A325_V0.5770.75
314_A341_L0.5770.75
122_V162_T0.5770.75
306_A328_G0.5760.74
397_S403_D0.5750.74
68_Y124_V0.5750.74
235_V355_N0.5700.74
254_S296_L0.5700.74
275_G281_V0.5690.74
107_K119_K0.5670.73
243_L302_V0.5670.73
93_S123_V0.5640.73
280_A284_H0.5610.73
242_L246_W0.5600.72
305_P312_I0.5580.72
78_V105_T0.5580.72
278_P281_V0.5580.72
269_H272_P0.5570.72
237_A268_T0.5550.72
406_W410_A0.5550.72
252_A266_L0.5540.72
258_G289_T0.5530.71
202_A384_L0.5520.71
396_R406_W0.5510.71
202_A361_V0.5500.71
142_A174_Y0.5490.71
205_R241_L0.5490.71
267_D279_A0.5460.71
398_E408_D0.5460.71
158_P167_M0.5450.70
148_E153_Q0.5450.70
398_E401_D0.5440.70
217_Y347_P0.5420.70
59_E135_E0.5410.70
146_R176_M0.5410.70
367_L379_R0.5410.70
178_Q182_V0.5410.70
75_H102_M0.5410.70
211_T328_G0.5400.70
395_V410_A0.5400.70
257_N282_M0.5400.70
59_E65_V0.5390.70
89_H256_V0.5380.69
239_A328_G0.5380.69
285_D288_N0.5380.69
303_V325_V0.5370.69
261_L290_L0.5360.69
309_G331_G0.5350.69
131_A134_H0.5340.69
208_A211_T0.5340.69
83_K187_T0.5330.69
398_E409_A0.5310.68
225_A301_D0.5290.68
157_A199_R0.5290.68
275_G278_P0.5290.68
203_P235_V0.5280.68
111_M391_A0.5250.68
203_P206_S0.5240.67
210_A392_W0.5230.67
127_K130_S0.5220.67
133_E137_L0.5210.67
152_S373_R0.5200.67
223_D403_D0.5200.67
395_V399_V0.5200.67
271_I289_T0.5170.66
112_D394_A0.5170.66
253_V281_V0.5170.66
119_K234_S0.5160.66
214_A396_R0.5140.66
83_K115_F0.5140.66
157_A203_P0.5120.66
83_K366_W0.5110.66
188_G365_E0.5100.65
77_D425_R0.5090.65
245_D269_H0.5090.65
258_G292_N0.5070.65
111_M387_E0.5040.64
274_H277_Q0.5030.64
412_V415_L0.5030.64
262_D266_L0.5030.64
196_S380_V0.5030.64
308_V311_V0.5020.64
56_V70_G0.5020.64
83_K199_R0.5010.64
312_I316_N0.5010.64
99_G102_M0.5010.64
88_Y124_V0.5010.64
235_V275_G0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xgiA 6 0.965 100 0.09 Contact Map
2yfqA 5 0.9114 100 0.099 Contact Map
2tmgA 5 0.9487 100 0.106 Contact Map
3r3jA 5 0.9953 100 0.107 Contact Map
4fccA 5 0.9953 100 0.108 Contact Map
2bmaA 5 0.9953 100 0.11 Contact Map
3aoeE 3 0.972 100 0.112 Contact Map
3aogA 8 0.979 100 0.113 Contact Map
1v9lA 4 0.958 100 0.113 Contact Map
1bgvA 5 1 100 0.117 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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