GREMLIN Database
RS12 - 30S ribosomal protein S12
UniProt: P0CX00 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (137)
Sequences: 232 (116)
Seq/√Len: 9.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_V100_I5.2691.00
22_D25_Y3.6040.97
127_V140_P3.3070.96
53_V80_T3.1530.94
131_E136_N3.0730.93
67_C117_V2.6750.87
69_R83_C2.3750.80
8_A12_K2.3100.78
130_I134_R2.2980.77
95_H103_I1.8040.58
29_E79_V1.7970.58
16_Q92_I1.7960.58
39_L100_I1.7530.56
40_E46_R1.7340.55
85_G88_A1.7150.54
29_E36_S1.6620.52
18_R21_S1.6130.50
54_G64_I1.6010.49
70_V100_I1.5920.49
20_W26_A1.5820.48
114_L120_K1.5580.47
39_L44_Q1.5560.47
55_I135_G1.5270.46
50_L134_R1.5140.45
63_A131_E1.5140.45
42_A79_V1.5000.44
82_F86_D1.4990.44
111_M114_L1.4680.43
59_Q102_G1.4460.42
70_V75_N1.4290.41
56_E59_Q1.3950.40
5_K30_R1.3930.40
26_A30_R1.3880.39
36_S73_I1.3460.38
111_M125_N1.3420.37
23_S43_P1.2990.36
57_A114_L1.2940.35
21_S33_G1.2910.35
99_T120_K1.2880.35
22_D27_R1.2790.35
59_Q62_S1.2640.34
9_R16_Q1.2610.34
78_Q103_I1.2610.34
106_A118_N1.2530.34
23_S107_K1.2440.33
94_E97_E1.2330.33
95_H125_N1.2110.32
90_S114_L1.1710.31
81_A86_D1.1670.30
41_G47_G1.1610.30
128_S131_E1.1600.30
58_K138_E1.1570.30
58_K111_M1.1550.30
83_C88_A1.1510.30
34_K37_D1.1350.29
83_C89_I1.1340.29
71_Q74_K1.1330.29
86_D112_G1.1310.29
100_I121_V1.1260.29
8_A69_R1.1250.29
70_V126_G1.1220.29
16_Q27_R1.1100.28
118_N124_V1.0740.27
88_A133_V1.0450.26
76_G137_A1.0270.25
14_D18_R1.0240.25
61_N113_D1.0220.25
30_R134_R1.0200.25
130_I136_N1.0180.25
57_A64_I1.0120.25
13_K36_S1.0110.25
9_R102_G1.0040.24
35_K94_E0.9960.24
93_D133_V0.9890.24
79_V86_D0.9840.24
88_A138_E0.9700.23
119_Y130_I0.9700.23
23_S110_A0.9680.23
71_Q75_N0.9620.23
137_A140_P0.9570.23
78_Q95_H0.9500.23
124_V129_L0.9460.23
16_Q119_Y0.9390.22
119_Y123_K0.9370.22
71_Q123_K0.9290.22
76_G138_E0.9230.22
43_P46_R0.9210.22
77_K106_A0.9160.22
11_L87_G0.9100.21
47_G56_E0.9060.21
65_R113_D0.9020.21
5_K26_A0.8900.21
120_K134_R0.8860.21
38_P67_C0.8800.21
89_I93_D0.8720.20
47_G115_S0.8720.20
60_P96_D0.8670.20
99_T103_I0.8540.20
44_Q58_K0.8490.20
72_L116_G0.8480.20
21_S24_E0.8470.20
69_R100_I0.8460.20
63_A71_Q0.8400.19
87_G90_S0.8330.19
10_K91_F0.8310.19
62_S102_G0.8190.19
4_G8_A0.8170.19
46_R78_Q0.8160.19
25_Y57_A0.8090.19
22_D44_Q0.8010.18
44_Q123_K0.8000.18
7_A28_R0.7970.18
72_L75_N0.7950.18
25_Y63_A0.7940.18
67_C75_N0.7940.18
49_V68_V0.7900.18
91_F132_L0.7850.18
22_D51_E0.7770.18
6_Y43_P0.7760.18
101_A120_K0.7750.18
77_K83_C0.7700.17
50_L69_R0.7700.17
133_V136_N0.7670.17
38_P74_K0.7640.17
93_D132_L0.7640.17
3_N43_P0.7600.17
54_G127_V0.7560.17
7_A13_K0.7550.17
31_G34_K0.7390.17
57_A113_D0.7310.16
5_K32_L0.7300.16
75_N118_N0.7300.16
37_D100_I0.7280.16
31_G92_I0.7250.16
128_S135_G0.7220.16
129_L137_A0.7170.16
93_D111_M0.7160.16
9_R82_F0.7110.16
14_D132_L0.7030.16
16_Q22_D0.7010.16
39_L121_V0.6860.15
77_K132_L0.6820.15
68_V97_E0.6790.15
13_K90_S0.6780.15
79_V116_G0.6740.15
110_A121_V0.6730.15
13_K16_Q0.6690.15
120_K124_V0.6650.15
18_R134_R0.6570.15
89_I92_I0.6450.14
40_E91_F0.6380.14
53_V91_F0.6200.14
38_P47_G0.6190.14
7_A53_V0.6160.14
60_P84_P0.6150.14
73_I127_V0.6130.14
41_G117_V0.6080.14
27_R78_Q0.6070.14
66_K98_V0.6050.14
74_K77_K0.6040.14
120_K137_A0.6040.14
91_F131_E0.6000.13
96_D108_G0.6000.13
77_K110_A0.6000.13
68_V76_G0.5980.13
32_L40_E0.5980.13
31_G100_I0.5970.13
125_N135_G0.5950.13
95_H111_M0.5850.13
44_Q101_A0.5840.13
56_E66_K0.5840.13
10_K72_L0.5810.13
18_R39_L0.5780.13
6_Y50_L0.5770.13
5_K123_K0.5760.13
19_R125_N0.5710.13
38_P80_T0.5630.13
104_G113_D0.5630.13
15_R97_E0.5590.13
17_Q37_D0.5580.13
123_K127_V0.5570.13
107_K128_S0.5550.13
86_D140_P0.5530.12
63_A116_G0.5490.12
10_K20_W0.5430.12
32_L95_H0.5410.12
128_S137_A0.5410.12
88_A95_H0.5350.12
14_D26_A0.5350.12
7_A139_K0.5340.12
45_G136_N0.5250.12
12_K61_N0.5230.12
107_K110_A0.5230.12
17_Q21_S0.5180.12
86_D136_N0.5140.12
102_G129_L0.5130.12
63_A67_C0.5120.12
41_G75_N0.5120.12
96_D102_G0.5110.12
97_E108_G0.5080.12
49_V79_V0.5040.12
8_A71_Q0.5030.12
126_G139_K0.5030.12
12_K69_R0.5020.11
70_V74_K0.5020.11
51_E114_L0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j20N 1 1 100 0.202 Contact Map
3zeyS 1 0.993 100 0.22 Contact Map
4ujpY 1 0.993 100 0.224 Contact Map
4bpeL 1 0.9648 100 0.236 Contact Map
5aj3L 1 0.7254 100 0.58 Contact Map
4ji1L 1 0.8028 100 0.587 Contact Map
4rb5L 1 0.8099 100 0.589 Contact Map
2vawA 1 0.3451 10.1 0.966 Contact Map
1ofuA 1 0.2958 8.8 0.967 Contact Map
2vxyA 2 0.2887 8.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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