GREMLIN Database
SODM1 - Superoxide dismutase [Mn] 1
UniProt: P09737 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (190)
Sequences: 4209 (2412)
Seq/√Len: 175.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_Q38_N4.0371.00
171_D174_S2.9361.00
108_N111_A2.5681.00
96_A100_A2.5261.00
187_E190_E2.4691.00
129_D136_R2.3811.00
23_Q169_G2.3481.00
117_A124_A2.3311.00
39_G42_D2.2871.00
95_L189_T2.2361.00
22_E26_T2.2241.00
157_L176_V2.1991.00
187_E191_R2.1901.00
111_A115_A2.0821.00
97_D100_A2.0021.00
83_M179_F1.9221.00
102_D134_T1.9191.00
114_E177_D1.8911.00
13_Y30_D1.8581.00
21_S167_D1.8551.00
108_N112_E1.8501.00
81_Q187_E1.8241.00
117_A157_L1.7871.00
174_S177_D1.7871.00
98_R101_A1.7741.00
37_V73_H1.7621.00
20_I79_F1.7591.00
98_R192_F1.7251.00
19_H181_E1.7071.00
117_A176_V1.6921.00
155_L188_P1.6761.00
115_A119_A1.6231.00
42_D45_E1.6111.00
127_V138_V1.6061.00
112_E115_A1.6001.00
5_E8_P1.5991.00
14_D22_E1.5741.00
189_T193_E1.5701.00
38_N42_D1.5581.00
40_W70_G1.5571.00
94_A193_E1.5511.00
98_R102_D1.5461.00
60_A63_L1.5401.00
7_P77_T1.5261.00
109_W113_F1.4981.00
166_Y169_G1.4951.00
157_L179_F1.4341.00
82_S188_P1.4111.00
33_H80_W1.4031.00
118_S173_G1.3881.00
52_E55_D1.3821.00
114_E118_S1.3751.00
73_H77_T1.3621.00
124_A139_A1.3581.00
168_Y178_A1.3471.00
84_S87_G1.3351.00
125_L140_V1.3161.00
94_A97_D1.3061.00
23_Q26_T1.2851.00
25_L79_F1.2841.00
118_S176_V1.2791.00
90_E107_E1.2711.00
127_V136_R1.2581.00
51_R59_T1.2541.00
128_Y192_F1.2531.00
12_D15_A1.2421.00
114_E176_V1.2321.00
129_D151_S1.2251.00
27_W169_G1.2181.00
26_T30_D1.2091.00
82_S187_E1.2081.00
39_G69_N1.2071.00
6_L29_H1.2011.00
114_E180_F1.1941.00
40_W66_V1.1931.00
183_V188_P1.1911.00
190_E194_Q1.1851.00
136_R151_S1.1801.00
81_Q191_R1.1681.00
116_A124_A1.1661.00
159_V172_R1.1601.00
164_Y172_R1.1561.00
186_D189_T1.1511.00
13_Y29_H1.1351.00
13_Y26_T1.1351.00
154_I188_P1.1221.00
71_S143_H1.1061.00
74_I145_E1.1051.00
180_F183_V1.1021.00
4_Y40_W1.0981.00
113_F157_L1.0981.00
116_A137_N1.0941.00
90_E96_A1.0931.00
105_S108_N1.0911.00
184_D187_E1.0801.00
10_P81_Q1.0731.00
74_I78_L1.0721.00
106_Y109_W1.0691.00
94_A189_T1.0661.00
111_A177_D1.0611.00
82_S191_R1.0551.00
67_T144_D1.0501.00
32_H165_Y1.0360.99
4_Y44_E1.0340.99
77_T81_Q1.0320.99
35_G39_G1.0320.99
92_S189_T1.0290.99
131_H134_T1.0220.99
79_F175_F1.0110.99
179_F183_V1.0020.99
115_A118_S1.0000.99
116_A139_A0.9930.99
97_D101_A0.9880.99
109_W137_N0.9870.99
78_L187_E0.9800.99
127_V151_S0.9720.99
90_E100_A0.9700.99
21_S24_V0.9690.99
99_I109_W0.9670.99
24_V167_D0.9520.99
107_E110_R0.9470.99
113_F179_F0.9430.99
51_R55_D0.9390.99
155_L183_V0.9370.99
33_H77_T0.9220.99
84_S88_G0.9170.99
13_Y22_E0.9100.99
174_S178_A0.9050.99
138_V151_S0.8990.99
37_V41_N0.8960.98
110_R181_E0.8910.98
72_G143_H0.8900.98
186_D190_E0.8750.98
98_R128_Y0.8680.98
83_M182_V0.8650.98
93_G97_D0.8530.98
53_T74_I0.8490.98
112_E116_A0.8440.98
79_F157_L0.8440.98
102_D135_L0.8420.98
46_T49_E0.8410.98
14_D17_E0.8410.98
35_G38_N0.8340.98
23_Q167_D0.8300.97
99_I106_Y0.8280.97
74_I147_A0.8270.97
129_D134_T0.8210.97
106_Y110_R0.8190.97
95_L188_P0.8190.97
95_L192_F0.8140.97
128_Y133_N0.8070.97
31_T171_D0.8050.97
95_L99_I0.8030.97
23_Q27_W0.8010.97
84_S186_D0.7990.97
44_E48_A0.7900.97
124_A157_L0.7880.97
7_P33_H0.7860.97
128_Y154_I0.7770.96
11_Y83_M0.7650.96
73_H80_W0.7600.96
45_E49_E0.7570.96
30_D34_Q0.7570.96
101_A134_T0.7550.96
177_D181_E0.7530.96
178_A181_E0.7460.95
90_E110_R0.7440.95
6_L33_H0.7380.95
13_Y25_L0.7320.95
76_H158_D0.7310.95
84_S184_D0.7280.95
64_G67_T0.7260.95
86_A89_D0.7250.95
49_E53_T0.7220.94
148_L151_S0.7160.94
110_R114_E0.7110.94
33_H73_H0.7080.94
17_E22_E0.7060.94
20_I175_F0.7040.94
31_T34_Q0.7010.94
128_Y152_H0.6990.93
4_Y56_H0.6960.93
138_V148_L0.6930.93
103_F112_E0.6910.93
55_D58_S0.6840.93
107_E111_A0.6830.93
91_P96_A0.6830.93
35_G118_S0.6820.93
110_R180_F0.6780.92
75_L125_L0.6730.92
121_S142_N0.6720.92
39_G65_D0.6650.92
125_L156_A0.6640.92
28_H76_H0.6620.91
31_T170_P0.6600.91
78_L191_R0.6560.91
110_R177_D0.6560.91
19_H178_A0.6540.91
100_A105_S0.6540.91
156_A175_F0.6530.91
40_W53_T0.6510.91
91_P106_Y0.6480.91
122_G159_V0.6480.91
185_W188_P0.6460.90
92_S186_D0.6440.90
20_I25_L0.6430.90
145_E148_L0.6380.90
37_V77_T0.6360.90
20_I83_M0.6350.90
25_L175_F0.6310.89
67_T143_H0.6300.89
36_Y72_G0.6290.89
93_G96_A0.6280.89
34_Q37_V0.6280.89
47_L59_T0.6280.89
84_S89_D0.6280.89
6_L37_V0.6240.89
44_E56_H0.6220.89
165_Y170_P0.6200.89
124_A159_V0.6200.89
168_Y174_S0.6180.88
8_P12_D0.6140.88
96_A106_Y0.6130.88
92_S96_A0.6090.88
6_L34_Q0.6050.87
19_H182_V0.6040.87
28_H158_D0.5980.87
119_A139_A0.5960.87
67_T72_G0.5940.86
32_H170_P0.5900.86
93_G106_Y0.5890.86
143_H156_A0.5850.86
158_D162_H0.5830.85
76_H162_H0.5750.85
112_E137_N0.5750.85
10_P184_D0.5740.84
75_L143_H0.5700.84
176_V180_F0.5670.84
19_H179_F0.5650.84
173_G177_D0.5620.83
71_S75_L0.5580.83
19_H167_D0.5580.83
40_W56_H0.5570.83
21_S27_W0.5570.83
8_P30_D0.5570.83
17_E23_Q0.5540.82
102_D136_R0.5510.82
43_A65_D0.5510.82
43_A66_V0.5500.82
106_Y180_F0.5500.82
82_S154_I0.5490.82
191_R194_Q0.5490.82
117_A159_V0.5440.81
28_H162_H0.5430.81
48_A51_R0.5430.81
27_W30_D0.5410.81
130_S133_N0.5400.81
190_E193_E0.5380.80
27_W166_Y0.5370.80
126_L135_L0.5370.80
141_D144_D0.5330.80
40_W44_E0.5320.80
93_G189_T0.5320.80
103_F135_L0.5300.79
50_N55_D0.5290.79
92_S95_L0.5290.79
113_F137_N0.5270.79
55_D59_T0.5260.79
43_A69_N0.5260.79
27_W31_T0.5230.79
92_S106_Y0.5220.78
79_F156_A0.5220.78
171_D177_D0.5190.78
20_I24_V0.5170.78
130_S134_T0.5170.78
102_D192_F0.5130.77
44_E49_E0.5110.77
46_T50_N0.5100.77
144_D149_W0.5060.76
4_Y74_I0.5050.76
87_G93_G0.5030.76
46_T61_G0.5030.76
130_S151_S0.5010.76
147_A153_P0.5010.76
94_A192_F0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xreA 2 0.96 100 0.032 Contact Map
1ma1A 4 0.98 100 0.034 Contact Map
3ak2A 4 0.995 100 0.039 Contact Map
1mngA 3 0.94 100 0.043 Contact Map
1gv3A 2 0.97 100 0.043 Contact Map
2rcvA 2 0.955 100 0.044 Contact Map
1b06A 4 0.99 100 0.044 Contact Map
4h3eA 1 0.98 100 0.045 Contact Map
1pl4A 4 0.97 100 0.045 Contact Map
1dt0A 2 0.97 100 0.046 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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