GREMLIN Database
SODM2 - Superoxide dismutase [Mn] 2
UniProt: P09224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 200 (190)
Sequences: 4207 (2406)
Seq/√Len: 174.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_Q38_D4.0841.00
171_D174_S3.0011.00
108_N111_A2.5991.00
96_A100_A2.5701.00
187_P190_A2.5211.00
129_D136_R2.3981.00
23_Q169_G2.3861.00
117_A124_A2.3541.00
39_G42_S2.3311.00
95_L189_A2.2671.00
22_E26_T2.2581.00
157_L176_V2.2511.00
187_P191_N2.2111.00
111_A115_V2.1441.00
97_D100_A2.0561.00
102_D134_Q1.9511.00
83_M179_F1.9271.00
114_E177_D1.9201.00
108_N112_E1.8921.00
13_Y30_D1.8851.00
21_S167_D1.8621.00
117_A157_L1.8331.00
81_E187_P1.8261.00
20_I79_F1.8191.00
98_R101_A1.8091.00
37_V73_H1.7841.00
174_S177_D1.7741.00
19_H181_E1.7361.00
98_R192_Y1.7171.00
117_A176_V1.7121.00
155_L188_I1.6831.00
42_S45_E1.6701.00
115_V119_A1.6531.00
127_V138_V1.6511.00
112_E115_V1.6211.00
60_A63_L1.5981.00
5_E8_S1.5931.00
98_R102_D1.5881.00
189_A193_D1.5811.00
14_D22_E1.5691.00
40_L70_G1.5521.00
38_D42_S1.5401.00
7_P77_T1.5391.00
94_A193_D1.5381.00
109_W113_F1.5181.00
166_Y169_G1.4941.00
157_L179_F1.4361.00
82_H188_I1.4251.00
73_H77_T1.4241.00
114_E118_G1.4081.00
33_H80_W1.4001.00
52_E55_D1.3901.00
118_G173_G1.3831.00
124_A139_A1.3791.00
168_Y178_A1.3501.00
118_G176_V1.3171.00
25_V79_F1.3121.00
127_V136_R1.3071.00
125_L140_V1.3051.00
84_S87_G1.3031.00
90_E107_E1.2811.00
23_Q26_T1.2801.00
94_A97_D1.2721.00
128_Y192_Y1.2621.00
12_D15_A1.2531.00
114_E176_V1.2441.00
183_I188_I1.2291.00
82_H187_P1.2221.00
190_A194_D1.2211.00
6_L29_H1.2201.00
26_T30_D1.2181.00
27_W169_G1.2161.00
40_L66_V1.2061.00
39_G69_N1.2041.00
114_E180_F1.1991.00
136_R151_S1.1971.00
129_D151_S1.1961.00
116_A124_A1.1661.00
186_D189_A1.1581.00
81_E191_N1.1471.00
159_V172_R1.1421.00
13_Y26_T1.1381.00
164_Y172_R1.1341.00
180_F183_I1.1321.00
154_I188_I1.1271.00
13_Y29_H1.1191.00
90_E96_A1.1091.00
116_A137_N1.1081.00
74_Y145_E1.1031.00
71_C143_H1.0901.00
106_Y109_W1.0851.00
105_S108_N1.0841.00
113_F157_L1.0841.00
4_H40_L1.0771.00
74_Y78_M1.0771.00
67_T144_D1.0741.00
10_P81_E1.0711.00
111_A177_D1.0661.00
32_H165_Y1.0641.00
184_D187_P1.0561.00
94_A189_A1.0561.00
92_S189_A1.0501.00
46_T49_E1.0410.99
82_H191_N1.0390.99
79_F175_F1.0360.99
35_S39_G1.0300.99
4_H44_E1.0240.99
77_T81_E1.0140.99
90_E100_A1.0080.99
97_D101_A1.0060.99
115_V118_G0.9990.99
179_F183_I0.9980.99
78_M187_P0.9870.99
51_R59_T0.9770.99
116_A139_A0.9750.99
113_F179_F0.9720.99
99_I109_W0.9700.99
109_W137_N0.9680.99
21_S24_V0.9680.99
107_E110_R0.9520.99
131_V134_Q0.9480.99
127_V151_S0.9480.99
51_R55_D0.9420.99
155_L183_I0.9290.99
138_V151_S0.9260.99
24_V167_D0.9230.99
174_S178_A0.9180.99
13_Y22_E0.9140.99
33_H77_T0.8990.98
84_S88_G0.8830.98
37_V41_N0.8780.98
98_R128_Y0.8720.98
186_D190_A0.8720.98
79_F157_L0.8720.98
110_R181_E0.8640.98
102_D135_L0.8630.98
83_M182_V0.8610.98
72_G143_H0.8590.98
14_D17_E0.8540.98
53_T74_Y0.8510.98
93_G97_D0.8490.98
23_Q167_D0.8420.98
35_S38_D0.8380.98
95_L188_I0.8330.98
23_Q27_W0.8320.97
106_Y110_R0.8300.97
112_E116_A0.8250.97
95_L192_Y0.8180.97
74_Y147_A0.8030.97
99_I106_Y0.7970.97
84_S186_D0.7950.97
31_T171_D0.7890.97
124_A157_L0.7850.96
95_L99_I0.7730.96
7_P33_H0.7720.96
128_Y154_I0.7680.96
129_D134_Q0.7670.96
177_D181_E0.7590.96
30_D34_Q0.7570.96
11_Y83_M0.7560.96
4_H56_H0.7530.96
73_H80_W0.7510.95
6_L33_H0.7450.95
64_G67_T0.7350.95
84_S184_D0.7310.95
76_H158_D0.7210.94
101_A134_Q0.7210.94
110_R114_E0.7200.94
178_A181_E0.7160.94
78_M191_N0.7150.94
55_D58_S0.7120.94
86_D89_G0.7110.94
33_H73_H0.7090.94
17_E22_E0.7030.94
91_P96_A0.7010.93
90_E110_R0.6970.93
128_Y152_H0.6930.93
35_S118_G0.6890.93
13_Y25_V0.6870.93
103_F112_E0.6810.92
31_T34_Q0.6810.92
110_R177_D0.6790.92
91_P106_Y0.6750.92
107_E111_A0.6750.92
110_R180_F0.6730.92
121_S142_N0.6720.92
19_H178_A0.6700.92
49_E53_T0.6650.92
40_L53_T0.6630.91
20_I175_F0.6620.91
145_E148_L0.6610.91
128_Y132_A0.6560.91
20_I25_V0.6550.91
75_L125_L0.6520.91
96_A106_Y0.6480.90
34_Q37_V0.6480.90
28_H76_H0.6460.90
125_L156_A0.6410.90
84_S89_G0.6410.90
92_S186_D0.6410.90
31_T170_P0.6380.90
37_V77_T0.6370.90
39_G65_D0.6330.89
67_T143_H0.6280.89
25_V175_F0.6280.89
8_S12_D0.6270.89
138_V148_L0.6240.89
185_W188_I0.6230.89
156_A175_F0.6230.89
20_I83_M0.6220.89
122_G159_V0.6200.88
100_A105_S0.6190.88
124_A159_V0.6140.88
36_Y72_G0.6140.88
48_A51_R0.6110.88
47_L59_T0.6100.88
119_A139_A0.6080.88
28_H158_D0.6040.87
6_L34_Q0.6030.87
19_H182_V0.6010.87
6_L37_V0.6000.87
93_G106_Y0.5970.87
93_G96_A0.5960.86
44_E56_H0.5950.86
168_Y174_S0.5940.86
10_P184_D0.5890.86
143_H156_A0.5790.85
21_S27_W0.5770.85
103_F135_L0.5760.85
19_H179_F0.5710.84
67_T72_G0.5710.84
19_H167_D0.5710.84
173_G177_D0.5700.84
92_S96_A0.5700.84
32_H170_P0.5700.84
76_H162_H0.5700.84
44_E48_A0.5690.84
165_Y170_P0.5660.84
102_D136_R0.5660.84
17_E23_Q0.5650.83
71_C75_L0.5600.83
158_D162_H0.5590.83
27_W171_D0.5540.82
43_A65_D0.5530.82
40_L56_H0.5530.82
129_D132_A0.5510.82
106_Y180_F0.5490.82
112_E137_N0.5490.82
126_L135_L0.5480.82
40_L44_E0.5470.81
82_H154_I0.5450.81
50_N54_G0.5450.81
176_V180_F0.5440.81
45_E49_E0.5440.81
148_L151_S0.5430.81
117_A159_V0.5420.81
27_W166_Y0.5400.81
113_F137_N0.5400.81
27_W30_D0.5390.80
8_S30_D0.5380.80
28_H162_H0.5370.80
87_G93_G0.5330.80
43_A66_V0.5330.80
190_A193_D0.5320.80
191_N194_D0.5310.80
92_S106_Y0.5300.79
93_G189_A0.5290.79
75_L143_H0.5260.79
73_H79_F0.5250.79
102_D192_Y0.5220.78
27_W31_T0.5220.78
144_D149_W0.5210.78
37_V53_T0.5200.78
167_D182_V0.5140.77
92_S95_L0.5140.77
79_F156_A0.5130.77
47_L61_G0.5080.76
141_D144_D0.5070.76
171_D177_D0.5070.76
4_H53_T0.5060.76
147_A153_P0.5050.76
42_S46_T0.5050.76
20_I24_V0.5020.76
4_H74_Y0.5020.76
31_T174_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xreA 2 0.96 100 0.032 Contact Map
1ma1A 4 0.98 100 0.035 Contact Map
3ak2A 4 0.995 100 0.041 Contact Map
2rcvA 2 0.955 100 0.044 Contact Map
1gv3A 2 0.97 100 0.044 Contact Map
1mngA 3 0.94 100 0.045 Contact Map
1dt0A 2 0.97 100 0.046 Contact Map
4h3eA 1 0.98 100 0.046 Contact Map
1b06A 4 0.99 100 0.047 Contact Map
1pl4A 4 0.97 100 0.048 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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