GREMLIN Database
RL12 - 50S ribosomal protein L12
UniProt: P05768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 114 (103)
Sequences: 190 (140)
Seq/√Len: 13.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_T21_N5.3891.00
33_V38_A2.5990.93
76_A80_D2.5880.93
26_L37_R2.3160.89
26_L29_A2.2240.86
74_A78_D2.1580.85
77_D81_D2.1470.84
16_E35_E2.0160.80
13_A31_V1.8960.76
57_A61_P1.8650.75
49_D97_G1.8040.72
23_T27_E1.7180.68
49_D52_E1.7050.68
17_L67_A1.6450.65
36_S44_A1.6170.63
9_I25_V1.6140.63
24_G27_E1.5810.62
64_A68_S1.5520.60
75_A79_G1.4900.57
12_E34_E1.4790.56
65_P69_G1.4640.55
7_A41_L1.4100.53
101_D104_P1.3900.52
9_I57_A1.3490.49
76_A81_D1.3140.47
77_D82_D1.3120.47
6_A44_A1.3020.47
1_M5_Y1.2910.46
42_V57_A1.2900.46
8_L12_E1.2680.45
49_D55_E1.2630.45
14_D100_D1.2510.44
60_A63_A1.2440.44
99_D110_G1.2230.43
23_T78_D1.2170.42
17_L43_A1.2020.42
37_R110_G1.1840.41
66_A75_A1.1670.40
51_E106_G1.1520.39
16_E55_E1.1270.38
6_A28_A1.1230.37
47_D56_E1.1170.37
68_S71_D1.1150.37
37_R40_A1.1110.37
71_D74_A1.1050.37
70_S73_E1.1040.37
54_V98_D1.0960.36
41_L107_E1.0920.36
67_A73_E1.0900.36
48_V105_S1.0780.35
23_T38_A1.0640.35
8_L106_G1.0620.34
6_A18_T1.0500.34
2_E5_Y1.0350.33
41_L111_D1.0110.32
100_D103_E0.9920.31
11_N51_E0.9710.30
95_D103_E0.9680.30
51_E54_V0.9670.30
4_V61_P0.9670.30
41_L53_A0.9490.29
22_I53_A0.9470.29
65_P70_S0.9420.29
102_E111_D0.9330.28
68_S81_D0.9030.27
47_D78_D0.9030.27
108_G114_G0.8970.27
4_V78_D0.8970.27
32_D59_A0.8930.27
36_S107_E0.8870.27
101_D106_G0.8840.26
25_V33_V0.8800.26
66_A71_D0.8650.26
100_D105_S0.8650.26
60_A64_A0.8440.25
4_V107_E0.8410.25
42_V61_P0.8390.25
32_D56_E0.8290.24
51_E56_E0.8220.24
4_V60_A0.8210.24
53_A60_A0.8200.24
9_I111_D0.8180.24
101_D105_S0.8170.24
68_S73_E0.8120.23
98_D101_D0.8070.23
49_D110_G0.8060.23
26_L43_A0.8040.23
25_V73_E0.8030.23
37_R44_A0.8000.23
23_T34_E0.7980.23
26_L100_D0.7970.23
14_D104_P0.7810.22
44_A55_E0.7770.22
5_Y50_I0.7760.22
15_E24_G0.7670.22
4_V49_D0.7630.22
28_A45_L0.7580.21
73_E77_D0.7550.21
79_G82_D0.7420.21
107_E111_D0.7320.21
46_E111_D0.7300.20
103_E111_D0.7300.20
29_A40_A0.7300.20
52_E56_E0.7270.20
5_Y9_I0.7200.20
40_A44_A0.7070.20
68_S77_D0.7000.19
1_M50_I0.6980.19
98_D104_P0.6950.19
3_Y112_L0.6930.19
54_V58_A0.6920.19
64_A78_D0.6850.19
31_V37_R0.6740.19
78_D82_D0.6720.19
48_V94_E0.6590.18
43_A100_D0.6520.18
99_D106_G0.6520.18
41_L60_A0.6490.18
95_D104_P0.6300.17
21_N43_A0.6300.17
100_D104_P0.6290.17
8_L51_E0.6260.17
54_V110_G0.6110.17
53_A58_A0.6110.17
28_A43_A0.6020.16
82_D94_E0.6000.16
17_L48_V0.5970.16
72_D77_D0.5960.16
17_L26_L0.5930.16
70_S95_D0.5910.16
28_A70_S0.5860.16
53_A110_G0.5810.16
12_E106_G0.5780.16
59_A111_D0.5710.15
53_A59_A0.5670.15
23_T55_E0.5650.15
21_N102_E0.5590.15
37_R100_D0.5570.15
6_A35_E0.5510.15
16_E49_D0.5380.15
4_V19_E0.5370.15
71_D75_A0.5350.14
21_N81_D0.5350.14
22_I104_P0.5320.14
27_E44_A0.5220.14
17_L22_I0.5210.14
34_E106_G0.5190.14
13_A66_A0.5170.14
67_A81_D0.5120.14
35_E79_G0.5100.14
35_E74_A0.5070.14
56_E110_G0.5060.14
11_N15_E0.5040.14
69_G72_D0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3izsv 1 0.5 99.7 0.535 Contact Map
3j3bs 1 0.5 99.7 0.536 Contact Map
3j3bu 1 0.4825 99.7 0.54 Contact Map
3j61s 1 0.4912 99.7 0.548 Contact Map
3izst 1 0.4912 99.7 0.566 Contact Map
3j61u 2 0.5088 99.6 0.581 Contact Map
3a1yA 3 0.5088 99.5 0.606 Contact Map
1vq8G 1 0.0088 99.3 0.645 Contact Map
3j21k 1 0 97.6 0.794 Contact Map
3wy9C 1 0.2281 96.9 0.816 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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