GREMLIN Database
YIH50 - Uncharacterized protein in transposable element ISH50
UniProt: P04137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (255)
Sequences: 1038 (892)
Seq/√Len: 55.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_E171_R5.1661.00
167_V246_A4.4291.00
185_T188_R3.6521.00
130_F250_R3.5171.00
270_A274_R3.1231.00
89_I100_Y3.1221.00
183_A188_R3.1111.00
98_V102_T3.0941.00
231_E234_N3.0331.00
30_S55_R2.8171.00
49_L56_T2.6701.00
28_C31_C2.6521.00
265_T269_R2.6511.00
9_S12_R2.5961.00
167_V242_C2.4821.00
68_S75_W2.4501.00
127_I203_V2.4451.00
78_A92_L2.3591.00
92_L107_V2.3461.00
168_L192_L2.2921.00
207_G224_Y2.2861.00
253_L259_V2.2131.00
105_R109_R2.0841.00
33_A52_D2.0191.00
28_C53_C2.0151.00
71_A74_K2.0041.00
31_C53_C1.9521.00
238_H241_T1.9471.00
193_L197_Q1.8871.00
125_V201_L1.8791.00
13_A76_F1.8510.99
168_L177_H1.8490.99
129_E211_Y1.8440.99
74_K96_I1.8350.99
47_R56_T1.8170.99
239_V243_E1.8030.99
132_V165_V1.7990.99
226_V229_D1.7530.99
11_R15_N1.7360.99
227_H243_E1.7020.99
240_N243_E1.6670.99
171_R241_T1.6410.99
247_S251_R1.6030.98
128_D206_D1.5900.98
115_D269_R1.5720.98
104_Y108_Q1.5560.98
151_S157_T1.5530.98
157_T161_D1.5430.98
176_R245_H1.5390.98
227_H239_V1.5070.98
189_I208_F1.4990.98
117_P273_L1.4610.97
166_F205_T1.4610.97
181_A189_I1.4540.97
242_C246_A1.4530.97
98_V103_V1.4430.97
132_V249_A1.4420.97
205_T222_R1.4370.97
60_Q68_S1.4280.97
244_S275_R1.4270.97
170_D175_E1.3900.96
70_V106_R1.3680.96
28_C50_C1.3650.96
124_P204_Y1.3600.96
10_E13_A1.3540.96
78_A106_R1.3490.95
89_I107_V1.3400.95
249_A259_V1.3370.95
120_H198_Q1.3360.95
127_I205_T1.3320.95
166_F189_I1.2970.94
182_K188_R1.2960.94
243_E246_A1.2940.94
65_F68_S1.2790.94
178_V272_Q1.2760.94
239_V246_A1.2720.94
70_V102_T1.2710.94
248_L275_R1.2700.94
240_N244_S1.2580.93
163_L261_K1.2510.93
178_V245_H1.2470.93
78_A89_I1.2440.93
202_T223_E1.2340.93
17_L76_F1.2340.93
189_I210_A1.2250.92
169_A241_T1.2040.92
37_I51_K1.1950.91
177_H196_R1.1840.91
74_K97_D1.1820.91
211_Y222_R1.1800.91
108_Q266_P1.1800.91
129_E250_R1.1780.91
176_R276_E1.1510.90
81_T96_I1.1280.89
204_Y237_V1.1220.89
241_T244_S1.1190.89
151_S226_V1.1140.88
90_R93_D1.1140.88
194_A218_D1.1130.88
244_S248_L1.0990.88
121_L168_L1.0960.87
90_R100_Y1.0860.87
197_Q201_L1.0840.87
251_R254_S1.0790.87
78_A103_V1.0750.86
85_L255_P1.0720.86
180_P265_T1.0710.86
107_V111_L1.0700.86
207_G226_V1.0680.86
252_W271_F1.0520.85
179_I195_D1.0490.85
150_L153_R1.0490.85
75_W106_R1.0480.85
132_V268_L1.0440.85
184_A208_F1.0420.85
191_L195_D1.0400.85
15_N19_Q1.0400.85
125_V197_Q1.0330.84
61_T66_E1.0320.84
181_A188_R1.0300.84
36_V57_F1.0170.83
152_T156_G1.0080.83
187_S216_E1.0040.82
179_I192_L1.0000.82
166_F191_L0.9890.81
169_A244_S0.9890.81
15_N18_A0.9870.81
281_P284_E0.9860.81
130_F239_V0.9830.81
151_S154_G0.9820.81
9_S73_R0.9800.81
81_T95_E0.9800.81
88_S97_D0.9740.80
10_E60_Q0.9640.80
251_R257_R0.9610.80
126_E241_T0.9600.79
85_L257_R0.9580.79
129_E184_A0.9490.79
9_S13_A0.9480.79
79_V110_F0.9460.78
39_Y56_T0.9430.78
39_Y49_L0.9410.78
225_V236_D0.9310.77
82_Y107_V0.9310.77
132_V253_L0.9300.77
200_S220_F0.9270.77
116_A197_Q0.9250.77
70_V98_V0.9210.77
174_G256_H0.9170.76
38_R46_Q0.9120.76
164_P184_A0.9110.76
169_A242_C0.9110.76
31_C50_C0.9070.75
36_V39_Y0.9030.75
12_R15_N0.8970.75
254_S278_F0.8960.75
68_S106_R0.8930.74
130_F253_L0.8900.74
82_Y114_L0.8890.74
171_R204_Y0.8850.74
202_T221_T0.8850.74
256_H267_Y0.8750.73
11_R14_A0.8720.73
244_S247_S0.8700.72
225_V239_V0.8680.72
32_R52_D0.8650.72
130_F246_A0.8650.72
205_T211_Y0.8640.72
167_V178_V0.8570.71
78_A96_I0.8540.71
164_P181_A0.8520.71
165_V268_L0.8510.71
245_H277_V0.8490.71
190_R214_L0.8480.70
190_R203_V0.8470.70
149_G161_D0.8380.70
47_R57_F0.8380.70
63_T66_E0.8380.70
40_G79_V0.8350.69
211_Y225_V0.8320.69
206_D250_R0.8250.68
227_H240_N0.8210.68
164_P246_A0.8200.68
100_Y104_Y0.8200.68
171_R174_G0.8160.67
14_A48_Y0.8160.67
193_L196_R0.8110.67
27_Y32_R0.8100.67
117_P277_V0.8100.67
62_G66_E0.8090.67
259_V264_L0.8060.67
149_G154_G0.8040.66
169_A176_R0.8030.66
93_D100_Y0.8020.66
51_K54_D0.7960.66
10_E73_R0.7940.65
109_R127_I0.7910.65
66_E70_V0.7910.65
225_V231_E0.7880.65
27_Y34_E0.7840.64
197_Q203_V0.7760.64
64_V177_H0.7750.63
206_D225_V0.7720.63
166_F181_A0.7710.63
129_E206_D0.7680.63
50_C53_C0.7680.63
169_A275_R0.7610.62
26_V36_V0.7540.61
11_R46_Q0.7530.61
152_T157_T0.7520.61
18_A22_W0.7510.61
34_E52_D0.7510.61
252_W258_G0.7480.61
154_G157_T0.7450.60
40_G47_R0.7380.60
153_R156_G0.7370.60
129_E205_T0.7360.59
17_L21_R0.7340.59
247_S254_S0.7330.59
67_H70_V0.7320.59
53_C63_T0.7300.59
12_R23_R0.7290.59
114_L278_F0.7260.58
184_A210_A0.7240.58
168_L197_Q0.7240.58
275_R278_F0.7210.58
208_F211_Y0.7210.58
104_Y263_R0.7190.58
165_V223_E0.7140.57
126_E239_V0.7140.57
104_Y109_R0.7130.57
65_F93_D0.7120.57
252_W256_H0.7080.57
37_I40_G0.7070.56
209_R212_D0.7050.56
57_F61_T0.6990.56
90_R94_A0.6960.55
123_G201_L0.6930.55
203_V228_G0.6920.55
111_L270_A0.6900.55
168_L245_H0.6900.55
193_L220_F0.6850.54
206_D227_H0.6830.54
18_A36_V0.6820.54
186_E191_L0.6780.53
127_I193_L0.6780.53
122_E170_D0.6750.53
166_F192_L0.6730.53
224_Y235_G0.6690.52
29_P57_F0.6680.52
166_F198_Q0.6680.52
189_I211_Y0.6680.52
77_L81_T0.6620.52
165_V253_L0.6600.51
39_Y47_R0.6520.50
131_Y157_T0.6520.50
198_Q201_L0.6510.50
32_R190_R0.6490.50
156_G161_D0.6490.50
211_Y227_H0.6490.50
45_F60_Q0.6470.50
184_A188_R0.6430.50
18_A59_D0.6430.50
68_S72_L0.6420.49
34_E284_E0.6400.49
228_G231_E0.6390.49
263_R266_P0.6380.49
93_D99_S0.6370.49
14_A45_F0.6350.49
254_S257_R0.6340.49
48_Y230_G0.6330.48
133_K162_K0.6330.48
81_T189_I0.6300.48
231_E235_G0.6290.48
118_R221_T0.6280.48
89_I93_D0.6260.48
17_L72_L0.6230.47
131_Y164_P0.6220.47
189_I193_L0.6200.47
27_Y199_E0.6160.47
233_V238_H0.6160.47
131_Y162_K0.6130.46
182_K185_T0.6120.46
11_R38_R0.6100.46
127_I180_P0.6090.46
115_D185_T0.6050.45
247_S257_R0.6010.45
155_R162_K0.6000.45
47_R87_T0.5990.45
149_G152_T0.5980.45
65_F75_W0.5980.45
86_N113_A0.5970.45
181_A208_F0.5970.45
178_V268_L0.5970.45
151_S156_G0.5970.45
189_I220_F0.5960.44
88_S278_F0.5940.44
80_Y95_E0.5900.44
64_V79_V0.5870.43
68_S102_T0.5850.43
194_A219_A0.5840.43
273_L277_V0.5820.43
115_D265_T0.5820.43
163_L180_P0.5810.43
203_V220_F0.5810.43
21_R26_V0.5800.43
232_Y238_H0.5790.43
149_G157_T0.5770.42
108_Q263_R0.5760.42
165_V264_L0.5710.42
232_Y240_N0.5710.42
171_R238_H0.5700.42
88_S114_L0.5690.42
207_G243_E0.5680.41
18_A46_Q0.5640.41
152_T226_V0.5630.41
122_E198_Q0.5620.41
101_K105_R0.5620.41
190_R213_P0.5610.41
230_G234_N0.5580.40
205_T244_S0.5570.40
85_L91_Q0.5570.40
190_R219_A0.5570.40
186_E213_P0.5550.40
18_A24_N0.5540.40
282_G285_A0.5540.40
148_R151_S0.5500.40
28_C32_R0.5470.39
81_T92_L0.5460.39
20_I23_R0.5460.39
112_R176_R0.5460.39
22_W254_S0.5450.39
179_I265_T0.5440.39
51_K121_L0.5430.39
23_R63_T0.5420.39
134_A208_F0.5420.39
263_R267_Y0.5410.39
187_S194_A0.5380.38
237_V243_E0.5370.38
134_A163_L0.5370.38
184_A246_A0.5370.38
238_H242_C0.5370.38
148_R152_T0.5350.38
105_R285_A0.5340.38
103_V254_S0.5340.38
207_G245_H0.5330.38
148_R153_R0.5330.38
23_R56_T0.5320.38
10_E33_A0.5320.38
271_F275_R0.5300.38
184_A239_V0.5300.38
85_L95_E0.5290.37
185_T208_F0.5280.37
121_L177_H0.5280.37
29_P99_S0.5270.37
200_S219_A0.5270.37
63_T114_L0.5250.37
167_V188_R0.5220.37
249_A268_L0.5210.37
69_A109_R0.5200.37
225_V240_N0.5200.37
164_P167_V0.5200.37
166_F210_A0.5200.37
36_V41_S0.5190.36
122_E195_D0.5180.36
16_L20_I0.5160.36
105_R108_Q0.5130.36
29_P267_Y0.5130.36
35_S51_K0.5120.36
124_P256_H0.5110.36
41_S45_F0.5110.36
153_R157_T0.5100.36
85_L242_C0.5090.35
152_T223_E0.5080.35
207_G230_G0.5070.35
18_A48_Y0.5070.35
241_T275_R0.5060.35
36_V51_K0.5040.35
14_A18_A0.5020.35
170_D174_G0.5010.35
194_A198_Q0.5010.35
77_L80_Y0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u7bA 2 0.949 98.2 0.881 Contact Map
3l3uA 2 0.4864 96.7 0.911 Contact Map
4mq3A 1 0.4286 96.6 0.912 Contact Map
4fcyA 4 0.8673 96.4 0.914 Contact Map
3f2kA 1 0.5918 96.2 0.915 Contact Map
1c6vA 4 0.4592 95.9 0.918 Contact Map
4mdaA 1 0.585 95.7 0.919 Contact Map
4fw1A 2 0.5238 95.4 0.921 Contact Map
1bcoA 1 0.5442 95.1 0.922 Contact Map
3o9xA 2 0.3707 94.5 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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