GREMLIN Database
O54664 - Uncharacterized protein
UniProt: O54664 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (435)
Sequences: 1546 (1180)
Seq/√Len: 56.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_V123_Y5.6431.00
11_K16_D4.4781.00
18_R23_E4.1751.00
8_L12_L3.9231.00
314_Y380_T3.8031.00
19_I22_L3.4181.00
130_C133_C3.2781.00
40_R43_T3.2151.00
5_I8_L3.1421.00
266_T377_V3.1221.00
12_L15_K3.0301.00
334_Q371_F2.9721.00
342_E346_E2.9671.00
283_Q377_V2.9391.00
204_Y412_T2.8511.00
94_C130_C2.8071.00
268_I378_S2.8031.00
266_T283_Q2.7701.00
342_E365_L2.7271.00
306_I344_L2.6881.00
320_R333_L2.6331.00
91_C130_C2.5761.00
94_C133_C2.5581.00
345_I358_L2.5391.00
420_W425_R2.5351.00
289_I361_I2.5241.00
108_L122_R2.5201.00
269_C282_L2.5191.00
82_E119_E2.5001.00
165_H178_Q2.4831.00
353_P356_T2.4691.00
159_A193_T2.3931.00
338_R372_V2.3691.00
226_R246_V2.3301.00
111_E153_N2.3241.00
218_H384_A2.2811.00
313_V334_Q2.1991.00
91_C133_C2.1981.00
221_E232_W2.1861.00
207_I415_S2.1851.00
306_I341_L2.1511.00
91_C94_C2.1201.00
111_E151_G2.0521.00
38_K42_G2.0501.00
394_L398_I2.0311.00
159_A196_A2.0251.00
83_E122_R2.0201.00
249_S254_V2.0001.00
38_K41_S1.9951.00
386_N389_R1.9731.00
221_E250_R1.9621.00
219_I267_V1.9271.00
83_E124_N1.9061.00
392_V395_R1.9041.00
252_S274_A1.9001.00
15_K19_I1.8791.00
236_F258_V1.8671.00
433_R437_S1.8591.00
81_D108_L1.8510.99
305_P309_A1.8430.99
253_D257_E1.8370.99
365_L369_L1.8210.99
105_S138_V1.7670.99
293_A361_I1.7640.99
28_K32_P1.7630.99
284_R367_H1.7460.99
335_R339_R1.7460.99
113_P117_P1.7460.99
19_I23_E1.7450.99
371_F379_P1.7370.99
292_E295_D1.7340.99
27_R32_P1.7120.99
221_E275_Y1.7080.99
418_A421_R1.7050.99
208_R212_Q1.7040.99
145_P148_G1.6970.99
286_W310_L1.6710.99
169_Y193_T1.6640.99
206_Q209_R1.6620.99
370_T377_V1.6520.99
309_A340_E1.6460.99
81_D120_I1.6450.99
219_I236_F1.6290.99
341_L361_I1.5970.98
210_E213_D1.5840.98
158_S189_A1.5640.98
325_P328_R1.5470.98
268_I283_Q1.5430.98
223_G230_Q1.5380.98
159_A413_V1.5380.98
370_T373_G1.5140.98
50_Q53_E1.5140.98
62_G65_G1.5030.98
99_D131_D1.4970.98
9_E12_L1.4850.98
165_H175_R1.4770.97
428_Y432_R1.4760.97
247_R254_V1.4710.97
144_C155_I1.4700.97
28_K31_N1.4430.97
389_R392_V1.4410.97
173_A186_G1.4300.97
283_Q371_F1.4000.96
42_G45_E1.4000.96
5_I9_E1.3960.96
100_E104_V1.3940.96
201_R205_E1.3940.96
233_I391_P1.3920.96
231_A246_V1.3880.96
313_V371_F1.3760.96
157_Q428_Y1.3680.96
335_R372_V1.3670.96
242_T422_Q1.3540.96
284_R364_G1.3490.96
215_D376_A1.3400.95
294_E307_Y1.3370.95
311_R314_Y1.3320.95
236_F254_V1.3290.95
40_R44_D1.3280.95
150_F192_A1.3210.95
197_A412_T1.3150.95
271_G364_G1.3100.95
312_Q337_A1.3000.95
173_A189_A1.2980.95
410_H414_L1.2890.94
153_N432_R1.2710.94
289_I368_W1.2640.94
29_Y33_H1.2540.93
155_I196_A1.2530.93
425_R430_E1.2410.93
161_S175_R1.2300.93
226_R231_A1.2260.93
51_D54_D1.2240.93
335_R373_G1.2210.93
98_F133_C1.2210.93
381_N384_A1.2170.92
346_E362_E1.2150.92
317_L321_L1.2130.92
236_F245_A1.2100.92
24_T28_K1.2100.92
282_L367_H1.2090.92
160_L165_H1.2060.92
226_R407_M1.2050.92
437_S440_M1.2000.92
311_R319_A1.1990.92
250_R272_W1.1930.92
216_V268_I1.1930.92
164_D417_L1.1860.91
109_V151_G1.1830.91
24_T27_R1.1770.91
85_E126_H1.1750.91
201_R408_F1.1750.91
38_K43_T1.1740.91
106_P122_R1.1680.91
252_S277_A1.1660.91
326_S329_E1.1660.91
234_W250_R1.1640.91
20_E24_T1.1580.90
256_A277_A1.1570.90
294_E298_E1.1570.90
24_T298_E1.1560.90
9_E13_E1.1560.90
317_L320_R1.1530.90
49_S54_D1.1480.90
223_G232_W1.1460.90
355_A359_G1.1410.90
27_R31_N1.1410.90
104_V124_N1.1360.90
286_W379_P1.1320.89
244_Y418_A1.1220.89
324_D328_R1.1210.89
22_L26_L1.1180.89
48_T53_E1.1140.89
69_G72_P1.1130.89
364_G367_H1.1080.88
358_L362_E1.1060.88
283_Q370_T1.1030.88
306_I310_L1.0990.88
426_N429_E1.0970.88
236_F259_L1.0890.87
110_E182_L1.0810.87
48_T51_D1.0810.87
387_A418_A1.0730.87
316_A319_A1.0700.87
18_R21_E1.0630.86
26_L30_E1.0620.86
12_L16_D1.0580.86
217_V263_F1.0560.86
286_W338_R1.0540.86
341_L344_L1.0530.86
371_F377_V1.0500.86
113_P119_E1.0490.85
112_I116_Q1.0450.85
194_E409_V1.0440.85
338_R365_L1.0410.85
62_G67_K1.0390.85
419_T423_Q1.0360.85
287_A379_P1.0340.85
322_E378_S1.0310.84
221_E249_S1.0250.84
118_P176_F1.0160.84
111_E119_E1.0120.83
236_F255_P1.0110.83
359_G363_G1.0060.83
430_E434_V1.0050.83
287_A380_T1.0000.83
416_L430_E0.9940.82
312_Q340_E0.9930.82
168_P171_K0.9900.82
157_Q161_S0.9900.82
11_K14_Q0.9860.82
100_E126_H0.9820.81
338_R342_E0.9800.81
235_T387_A0.9800.81
92_P137_T0.9750.81
401_L407_M0.9730.81
216_V378_S0.9710.81
357_L360_K0.9610.80
214_A238_T0.9580.80
224_I398_I0.9580.80
218_H381_N0.9570.80
38_K44_D0.9550.80
19_I26_L0.9550.80
287_A381_N0.9530.79
13_E16_D0.9490.79
338_R371_F0.9430.79
225_K228_G0.9400.78
437_S441_L0.9400.78
144_C199_A0.9390.78
389_R393_V0.9350.78
313_V337_A0.9350.78
70_H74_W0.9350.78
170_R186_G0.9310.78
237_K383_A0.9300.78
352_G355_A0.9290.78
112_I157_Q0.9290.78
125_R138_V0.9280.78
286_W368_W0.9250.77
287_A382_N0.9220.77
325_P329_E0.9220.77
40_R45_E0.9210.77
29_Y32_P0.9190.77
52_D55_D0.9080.76
154_V158_S0.9060.76
44_D47_P0.9030.76
21_E25_R0.9010.75
196_A435_V0.9000.75
162_R169_Y0.8990.75
246_V414_L0.8970.75
224_I401_L0.8940.75
201_R412_T0.8910.75
48_T55_D0.8900.75
91_C98_F0.8900.75
95_G130_C0.8840.74
252_S256_A0.8830.74
127_Y138_V0.8830.74
39_R42_G0.8800.74
232_W249_S0.8800.74
24_T32_P0.8780.74
313_V317_L0.8780.74
271_G284_R0.8780.74
212_Q263_F0.8750.73
204_Y243_L0.8730.73
286_W313_V0.8730.73
187_A191_H0.8730.73
294_E297_A0.8690.73
441_L444_A0.8690.73
244_Y389_R0.8680.73
35_P38_K0.8660.73
72_P76_S0.8630.72
208_R245_A0.8600.72
398_I414_L0.8550.72
216_V240_Q0.8530.71
358_L361_I0.8500.71
163_Y190_W0.8490.71
129_Q136_E0.8480.71
63_T72_P0.8460.71
309_A341_L0.8450.71
94_C98_F0.8380.70
71_D74_W0.8380.70
388_L391_P0.8380.70
255_P258_V0.8350.70
235_T384_A0.8340.70
150_F184_L0.8330.70
406_G409_V0.8320.70
271_G360_K0.8320.70
271_G276_P0.8310.69
237_K242_T0.8280.69
159_A435_V0.8260.69
193_T413_V0.8230.69
244_Y388_L0.8220.69
6_D10_E0.8210.68
17_E21_E0.8210.68
383_A386_N0.8180.68
417_L430_E0.8180.68
350_P355_A0.8180.68
95_G133_C0.8160.68
251_G254_V0.8150.68
246_V407_M0.8150.68
153_N157_Q0.8110.68
271_G368_W0.8110.68
263_F267_V0.8090.67
266_T370_T0.8060.67
342_E369_L0.8060.67
175_R178_Q0.8050.67
161_S165_H0.8030.67
14_Q18_R0.8030.67
398_I410_H0.8020.67
163_Y169_Y0.7960.66
207_I416_L0.7950.66
203_E434_V0.7950.66
84_I123_Y0.7950.66
10_E136_E0.7940.66
104_V126_H0.7940.66
84_I121_T0.7940.66
105_S125_R0.7910.66
35_P39_R0.7890.65
250_R275_Y0.7870.65
61_G66_R0.7830.65
205_E209_R0.7830.65
228_G402_R0.7830.65
49_S52_D0.7780.64
166_R397_I0.7750.64
245_A258_V0.7740.64
31_N37_S0.7740.64
231_A404_D0.7730.64
287_A292_E0.7720.64
331_A335_R0.7720.64
235_T388_L0.7710.64
168_P318_Q0.7700.63
152_V436_S0.7690.63
29_Y35_P0.7690.63
290_L307_Y0.7690.63
24_T294_E0.7680.63
103_G127_Y0.7630.63
174_D421_R0.7630.63
32_P35_P0.7620.63
85_E124_N0.7600.62
279_S282_L0.7590.62
221_E279_S0.7580.62
50_Q55_D0.7570.62
401_L410_H0.7570.62
57_V60_D0.7560.62
11_K15_K0.7540.62
66_R70_H0.7540.62
67_K70_H0.7530.62
310_L314_Y0.7530.62
293_A306_I0.7520.62
39_R43_T0.7500.61
60_D66_R0.7490.61
43_T46_S0.7490.61
226_R248_E0.7480.61
431_L435_V0.7460.61
234_W272_W0.7450.61
276_P282_L0.7430.61
269_C274_A0.7420.61
309_A312_Q0.7410.61
169_Y190_W0.7410.61
99_D386_N0.7400.60
66_R69_G0.7390.60
221_E269_C0.7380.60
129_Q134_G0.7380.60
96_D132_S0.7350.60
125_R140_A0.7340.60
306_I309_A0.7340.60
286_W371_F0.7310.59
218_H268_I0.7300.59
10_E13_E0.7290.59
25_R30_E0.7270.59
109_V123_Y0.7260.59
190_W194_E0.7220.59
211_I217_V0.7210.58
214_A415_S0.7210.58
221_E234_W0.7200.58
317_L334_Q0.7200.58
348_S358_L0.7170.58
405_R408_F0.7170.58
53_E59_T0.7170.58
54_D59_T0.7160.58
36_P40_R0.7150.58
72_P75_R0.7140.58
268_I377_V0.7130.58
216_V377_V0.7130.58
221_E272_W0.7120.57
51_D58_R0.7100.57
112_I118_P0.7100.57
61_G64_P0.7090.57
63_T66_R0.7080.57
351_D356_T0.7070.57
184_L188_S0.7060.57
98_F130_C0.7040.57
92_P96_D0.7040.57
318_Q360_K0.7040.57
269_C279_S0.7020.56
390_E421_R0.7020.56
131_D134_G0.7010.56
109_V121_T0.6980.56
233_I411_E0.6970.56
125_R139_A0.6920.55
434_V439_E0.6900.55
58_R61_G0.6880.55
118_P182_L0.6860.55
72_P81_D0.6850.55
226_R414_L0.6840.54
66_R72_P0.6840.54
102_V136_E0.6830.54
341_L345_I0.6830.54
206_Q210_E0.6820.54
225_K231_A0.6800.54
220_D288_H0.6790.54
55_D60_D0.6740.53
23_E27_R0.6740.53
440_M443_R0.6730.53
394_L414_L0.6720.53
318_Q379_P0.6710.53
334_Q337_A0.6700.53
236_F247_R0.6700.53
50_Q61_G0.6690.53
37_S42_G0.6680.53
166_R393_V0.6680.53
31_N35_P0.6670.53
305_P308_H0.6660.52
92_P95_G0.6660.52
28_K33_H0.6650.52
252_S255_P0.6650.52
14_Q19_I0.6650.52
160_L175_R0.6640.52
434_V437_S0.6630.52
289_I292_E0.6630.52
107_R125_R0.6620.52
246_V404_D0.6610.52
420_W423_Q0.6610.52
56_D60_D0.6610.52
102_V129_Q0.6610.52
197_A204_Y0.6610.52
218_H383_A0.6600.52
218_H237_K0.6590.52
32_P37_S0.6560.51
61_G65_G0.6530.51
36_P39_R0.6530.51
55_D59_T0.6530.51
29_Y39_R0.6520.51
153_N185_S0.6520.51
232_W250_R0.6490.51
63_T67_K0.6490.51
345_I362_E0.6470.50
166_R390_E0.6460.50
383_A387_A0.6450.50
218_H244_Y0.6440.50
162_R394_L0.6440.50
392_V401_L0.6430.50
168_P397_I0.6420.50
346_E359_G0.6370.49
393_V396_K0.6360.49
281_N370_T0.6350.49
255_P274_A0.6350.49
286_W289_I0.6350.49
65_G69_G0.6340.49
389_R426_N0.6330.49
64_P69_G0.6320.49
426_N436_S0.6310.49
174_D177_E0.6310.49
273_T276_P0.6310.49
60_D63_T0.6310.49
346_E365_L0.6310.49
163_Y193_T0.6310.49
290_L318_Q0.6290.48
386_N393_V0.6280.48
50_Q54_D0.6270.48
170_R397_I0.6270.48
7_E10_E0.6270.48
48_T54_D0.6260.48
37_S43_T0.6250.48
243_L258_V0.6240.48
164_D174_D0.6240.48
104_V125_R0.6240.48
60_D65_G0.6240.48
274_A282_L0.6240.48
177_E183_E0.6230.48
307_Y380_T0.6200.47
193_T197_A0.6200.47
360_K400_T0.6200.47
20_E23_E0.6200.47
34_T311_R0.6180.47
218_H378_S0.6170.47
304_E308_H0.6170.47
380_T386_N0.6160.47
351_D355_A0.6160.47
227_D231_A0.6150.47
395_R406_G0.6150.47
186_G190_W0.6150.47
227_D402_R0.6130.47
37_S41_S0.6120.47
249_S274_A0.6120.47
318_Q375_P0.6110.46
189_A345_I0.6110.46
350_P359_G0.6110.46
321_L334_Q0.6110.46
257_E261_E0.6110.46
80_P415_S0.6110.46
283_Q379_P0.6080.46
217_V286_W0.6070.46
170_R174_D0.6030.46
12_L19_I0.6020.46
346_E363_G0.6020.46
193_T345_I0.6020.46
349_V352_G0.6020.46
52_D56_D0.6000.45
221_E247_R0.5990.45
237_K386_N0.5990.45
309_A337_A0.5980.45
226_R404_D0.5950.45
219_I259_L0.5950.45
417_L427_P0.5940.45
290_L357_L0.5930.45
27_R30_E0.5920.44
385_E389_R0.5920.44
160_L164_D0.5910.44
314_Y321_L0.5900.44
32_P38_K0.5900.44
297_A304_E0.5890.44
150_F188_S0.5870.44
62_G69_G0.5860.44
336_V339_R0.5840.44
247_R257_E0.5840.44
48_T52_D0.5830.43
234_W249_S0.5820.43
229_E404_D0.5810.43
138_V151_G0.5810.43
211_I238_T0.5800.43
318_Q357_L0.5800.43
26_L38_K0.5790.43
200_G413_V0.5770.43
216_V239_A0.5770.43
27_R33_H0.5770.43
253_D256_A0.5760.43
244_Y386_N0.5750.43
24_T31_N0.5750.43
7_E205_E0.5740.43
286_W421_R0.5730.42
290_L293_A0.5720.42
154_V192_A0.5720.42
162_R168_P0.5700.42
39_R44_D0.5700.42
51_D67_K0.5690.42
16_D20_E0.5680.42
53_E57_V0.5680.42
289_I345_I0.5680.42
162_R172_I0.5670.42
357_L400_T0.5650.42
105_S127_Y0.5650.42
224_I233_I0.5640.41
111_E123_Y0.5640.41
387_A422_Q0.5620.41
69_G74_W0.5600.41
219_I258_V0.5590.41
54_D60_D0.5590.41
332_D336_V0.5580.41
166_R394_L0.5580.41
50_Q424_G0.5570.41
162_R171_K0.5560.41
310_L313_V0.5560.41
200_G412_T0.5550.41
76_S110_E0.5540.40
121_T406_G0.5540.40
74_W108_L0.5540.40
55_D58_R0.5540.40
56_D59_T0.5530.40
100_E128_Y0.5500.40
220_D270_D0.5490.40
91_C95_G0.5480.40
397_I400_T0.5470.40
232_W251_G0.5470.40
92_P184_L0.5470.40
159_A431_L0.5460.40
290_L360_K0.5450.39
404_D408_F0.5450.39
189_A277_A0.5440.39
318_Q400_T0.5440.39
49_S264_A0.5410.39
292_E357_L0.5410.39
138_V141_H0.5410.39
88_C92_P0.5410.39
79_D86_V0.5400.39
282_L364_G0.5380.39
334_Q338_R0.5380.39
232_W275_Y0.5360.39
287_A295_D0.5360.39
329_E375_P0.5350.38
271_G292_E0.5340.38
314_Y360_K0.5330.38
48_T62_G0.5330.38
391_P410_H0.5330.38
38_K45_E0.5330.38
33_H37_S0.5330.38
68_D72_P0.5320.38
96_D131_D0.5310.38
237_K384_A0.5310.38
34_T38_K0.5310.38
224_I392_V0.5300.38
155_I435_V0.5290.38
409_V433_R0.5290.38
327_P332_D0.5280.38
144_C203_E0.5280.38
112_I119_E0.5270.38
297_A300_Q0.5260.37
395_R399_G0.5260.37
318_Q330_R0.5250.37
123_Y139_A0.5250.37
290_L314_Y0.5240.37
433_R436_S0.5240.37
18_R22_L0.5240.37
211_I221_E0.5230.37
158_S190_W0.5230.37
354_V419_T0.5220.37
170_R399_G0.5220.37
255_P301_A0.5220.37
342_E362_E0.5220.37
270_D288_H0.5210.37
396_K399_G0.5200.37
256_A333_L0.5200.37
330_R336_V0.5190.37
187_A421_R0.5180.37
321_L329_E0.5180.37
249_S272_W0.5170.37
234_W275_Y0.5170.37
262_D266_T0.5160.36
244_Y295_D0.5160.36
288_H291_R0.5160.36
182_L432_R0.5160.36
389_R421_R0.5150.36
256_A261_E0.5150.36
28_K38_K0.5150.36
206_Q242_T0.5150.36
57_V64_P0.5140.36
331_A334_Q0.5120.36
99_D129_Q0.5120.36
60_D64_P0.5120.36
360_K375_P0.5110.36
406_G419_T0.5100.36
358_L363_G0.5090.36
37_S40_R0.5090.36
111_E152_V0.5080.36
319_A322_E0.5060.35
220_D285_C0.5040.35
55_D64_P0.5040.35
407_M410_H0.5030.35
226_R405_R0.5030.35
282_L422_Q0.5020.35
266_T373_G0.5010.35
421_R428_Y0.5010.35
62_G66_R0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iloA 3 0.2753 92.2 0.955 Contact Map
4u7bA 2 0.5463 88.6 0.958 Contact Map
3na7A 1 0.2665 85.9 0.96 Contact Map
2yy0A 6 0.0661 71.3 0.965 Contact Map
4u5tA 2 0.0595 66.9 0.966 Contact Map
3o9xA 2 0.2599 62.3 0.967 Contact Map
1hjbA 2 0.0661 61.9 0.967 Contact Map
2dfsA 2 0.1894 59.7 0.968 Contact Map
1nkpB 1 0.0705 56.2 0.968 Contact Map
1gu4A 2 0.0639 55.4 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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