GREMLIN Database
O54663 - Uncharacterized protein
UniProt: O54663 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (114)
Sequences: 170 (114)
Seq/√Len: 10.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_D53_D3.2730.96
30_K92_D3.1080.95
33_F71_F3.0360.94
63_V76_Q2.8770.92
19_L45_V2.6120.88
29_D85_Y2.3020.80
26_K59_A2.2250.78
16_E73_E2.1090.74
48_L97_T2.0680.73
62_A84_Y2.0530.72
48_L52_V1.9210.67
56_R61_R1.8920.65
63_V78_N1.8710.64
12_D42_P1.8670.64
38_E95_Q1.8240.62
108_Y114_L1.8170.62
36_L45_V1.8000.61
14_E18_L1.7400.59
61_R78_N1.7290.58
16_E102_R1.6430.54
24_G93_P1.6360.54
36_L72_I1.6000.52
50_E98_D1.5630.50
19_L46_D1.5300.49
22_F69_T1.4640.46
12_D68_Q1.4480.45
116_Q120_T1.4480.45
36_L63_V1.4320.44
53_D59_A1.4270.44
48_L61_R1.3890.42
100_M103_M1.3890.42
29_D41_E1.3780.42
102_R121_K1.3610.41
64_Q68_Q1.3080.38
72_I121_K1.2780.37
72_I75_E1.2480.36
24_G111_M1.2300.35
29_D62_A1.2110.34
45_V119_E1.2030.34
15_C86_H1.2010.34
55_E85_Y1.1750.33
87_V105_N1.1660.32
49_A59_A1.1570.32
74_K96_I1.1360.31
20_E46_D1.1160.30
44_T85_Y1.1010.30
59_A121_K1.0970.30
28_L93_P1.0970.30
57_S76_Q1.0940.29
17_G73_E1.0910.29
63_V80_E1.0840.29
72_I96_I1.0800.29
15_C60_Y1.0470.28
27_E50_E1.0320.27
98_D119_E1.0100.26
104_L117_E1.0060.26
84_Y103_M1.0050.26
47_E67_L1.0050.26
8_Q88_Y1.0030.26
36_L84_Y0.9860.25
16_E121_K0.9830.25
11_Q16_E0.9800.25
16_E30_K0.9560.24
57_S82_G0.9530.24
37_V109_A0.9340.24
43_M87_V0.9310.23
20_E23_H0.9270.23
13_M68_Q0.9260.23
19_L70_G0.9240.23
23_H61_R0.9180.23
43_M115_I0.9070.23
84_Y97_T0.8960.22
100_M114_L0.8910.22
13_M77_V0.8880.22
22_F77_V0.8870.22
9_L106_D0.8860.22
80_E101_Q0.8830.22
51_A75_E0.8680.21
100_M115_I0.8600.21
29_D65_R0.8560.21
40_E70_G0.8540.21
8_Q119_E0.8510.21
36_L104_L0.8450.21
9_L114_L0.8430.21
35_A51_A0.8410.20
11_Q89_S0.8270.20
58_T96_I0.8230.20
101_Q112_G0.8210.20
54_R120_T0.8040.19
91_S115_I0.8010.19
55_E107_W0.7790.19
53_D102_R0.7720.18
55_E86_H0.7690.18
24_G52_V0.7660.18
71_F89_S0.7660.18
47_E52_V0.7660.18
67_L70_G0.7610.18
38_E120_T0.7580.18
24_G54_R0.7580.18
32_C44_T0.7500.18
50_E81_Q0.7460.18
41_E71_F0.7450.18
53_D120_T0.7410.18
48_L77_V0.7400.18
65_R74_K0.7390.18
53_D90_P0.7390.18
104_L118_F0.7350.17
32_C74_K0.7310.17
85_Y106_D0.7290.17
64_Q67_L0.7270.17
27_E35_A0.7190.17
50_E67_L0.7150.17
33_F37_V0.6990.16
18_L34_Q0.6970.16
41_E77_V0.6900.16
29_D49_A0.6880.16
7_E12_D0.6830.16
52_V74_K0.6830.16
32_C52_V0.6710.16
33_F92_D0.6650.16
11_Q72_I0.6600.15
41_E47_E0.6590.15
51_A68_Q0.6590.15
26_K58_T0.6560.15
32_C100_M0.6460.15
84_Y110_K0.6410.15
59_A96_I0.6400.15
90_P104_L0.6400.15
8_Q97_T0.6390.15
27_E121_K0.6340.15
45_V69_T0.6240.15
7_E90_P0.6230.15
68_Q121_K0.6220.15
92_D103_M0.6170.14
27_E100_M0.6120.14
47_E77_V0.6100.14
27_E90_P0.6050.14
24_G97_T0.6040.14
98_D106_D0.6030.14
65_R101_Q0.6030.14
53_D92_D0.6000.14
40_E71_F0.5920.14
61_R82_G0.5900.14
31_E43_M0.5890.14
102_R109_A0.5870.14
15_C42_P0.5830.14
55_E79_Y0.5790.14
26_K78_N0.5740.13
31_E35_A0.5710.13
18_L91_S0.5700.13
52_V86_H0.5700.13
24_G91_S0.5600.13
73_E92_D0.5560.13
24_G33_F0.5420.13
46_D118_F0.5410.13
92_D116_Q0.5390.13
20_E30_K0.5390.13
28_L111_M0.5390.13
66_L83_G0.5390.13
50_E121_K0.5320.13
15_C85_Y0.5260.12
59_A103_M0.5240.12
27_E53_D0.5210.12
66_L88_Y0.5160.12
12_D44_T0.5130.12
69_T95_Q0.5110.12
88_Y116_Q0.5040.12
100_M106_D0.5030.12
10_R60_Y0.5030.12
15_C20_E0.5010.12
41_E50_E0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3r0aA 2 0.903 99.6 0.656 Contact Map
3qphA 2 0.791 99.3 0.711 Contact Map
1sfxA 3 0.8134 99 0.75 Contact Map
1q1hA 1 0.6269 99 0.752 Contact Map
2d1hA 2 0.7537 98.9 0.758 Contact Map
1okrA 2 0.8284 98.8 0.768 Contact Map
2g9wA 2 0.6791 98.8 0.771 Contact Map
2oqgA 4 0.8134 98.7 0.779 Contact Map
4nb5A 4 0.9328 98.6 0.78 Contact Map
3cuoA 2 0.7313 98.6 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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