O54662 - HALSA - GREMLIN Contacts

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O54662 - Uncharacterized protein

UniProt:	O54662	Sequences: MSLLLVSFFAGFGLLIGILFGFFGMGGSFLVTPALLVMGYPSRVAVGSGLAFVFGTSVIGALRHRDHGHVDYKLAVIMTVAMTIGIEAGKRVVDALHAAGNADLVISVAYVGLLATVGIFTLRDARASGTTASVDLSERVQALEIPPMVTLRGDVRVSASIIFGIGLVVGVLSGLLGVGGGFLLMPAMMYGLGVPAAIAIGTDILQITISGAFGAFVYARDGFVAIPVVATLLAGSALGARIGAGVSNIVDEDDIKGYFATMLLAGSVAVAAKRVGTAYDIAVLNTVSIALIFGATVVVSGAILLAAVCQLRDDNADFWCRLSAT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (245)
Sequences:	4410 (3059)
Seq/√Len:	195.4

ECOLI - YFCA
BACSU - YTNM YRKJ YUNE YJNA YDHB
HALSA - O54662
SULSO - Q981D0 Q97WF4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
269_A	273_K	4.335	1.00
92_V	171_V	4.314	1.00
85_G	167_L	3.830	1.00
18_I	246_V	3.378	1.00
10_A	235_G	3.058	1.00
165_I	187_A	3.054	1.00
14_L	238_L	2.904	1.00
55_G	233_L	2.902	1.00
59_I	241_R	2.810	1.00
79_T	209_I	2.739	1.00
6_V	231_T	2.521	1.00
59_I	237_A	2.421	1.00
74_L	194_V	2.371	1.00
88_A	167_L	2.351	1.00
219_A	226_I	2.341	1.00
44_V	47_G	2.327	1.00
119_I	123_R	2.255	1.00
230_A	234_A	2.223	1.00
64_H	247_S	2.172	1.00
264_L	268_V	2.133	1.00
12_F	34_A	2.095	1.00
82_M	210_S	2.031	1.00
90_K	214_G	2.026	1.00
118_G	267_S	1.994	1.00
81_A	163_F	1.955	1.00
14_L	235_G	1.941	1.00
113_L	176_L	1.903	1.00
72_Y	76_V	1.897	1.00
234_A	238_L	1.812	1.00
13_G	232_L	1.796	1.00
51_A	229_V	1.785	1.00
10_A	231_T	1.774	1.00
80_V	84_I	1.773	1.00
76_V	80_V	1.744	1.00
58_V	208_T	1.738	1.00
39_G	45_A	1.711	1.00
48_S	229_V	1.692	1.00
63_R	244_A	1.686	1.00
87_E	217_V	1.685	1.00
14_L	242_I	1.684	1.00
115_A	267_S	1.634	1.00
40_Y	228_V	1.604	1.00
185_M	200_I	1.591	1.00
21_G	60_G	1.588	1.00
253_D	257_G	1.577	1.00
41_P	44_V	1.577	1.00
217_V	221_D	1.573	1.00
241_R	245_G	1.566	1.00
8_F	11_G	1.560	1.00
118_G	260_A	1.551	1.00
75_A	205_L	1.543	1.00
121_T	259_F	1.530	1.00
40_Y	225_A	1.519	1.00
73_K	76_V	1.510	1.00
71_D	74_L	1.498	1.00
254_D	257_G	1.479	1.00
245_G	249_I	1.455	1.00
65_R	72_Y	1.455	1.00
16_I	31_V	1.441	1.00
167_L	171_V	1.441	1.00
162_I	192_L	1.440	1.00
180_G	184_L	1.433	1.00
268_V	272_A	1.424	1.00
227_P	231_T	1.422	1.00
73_K	77_I	1.414	1.00
60_G	204_I	1.397	1.00
112_G	116_T	1.396	1.00
54_F	212_A	1.379	1.00
78_M	188_M	1.377	1.00
76_V	79_T	1.368	1.00
195_P	198_I	1.365	1.00
71_D	198_I	1.357	1.00
261_T	265_A	1.354	1.00
126_R	129_G	1.348	1.00
11_G	15_L	1.338	1.00
225_A	228_V	1.326	1.00
50_L	214_G	1.311	1.00
216_F	220_R	1.306	1.00
7_S	11_G	1.305	1.00
185_M	203_D	1.301	1.00
44_V	225_A	1.291	1.00
257_G	261_T	1.286	1.00
4_L	8_F	1.273	1.00
110_Y	113_L	1.271	1.00
265_A	268_V	1.268	1.00
105_V	109_A	1.252	1.00
70_V	75_A	1.249	1.00
57_S	207_I	1.236	1.00
184_L	206_Q	1.228	1.00
75_A	202_T	1.220	1.00
20_F	173_S	1.203	1.00
35_L	232_L	1.203	1.00
251_D	254_D	1.184	1.00
230_A	233_L	1.183	1.00
46_V	218_Y	1.177	1.00
84_I	88_A	1.176	1.00
4_L	7_S	1.174	1.00
13_G	235_G	1.168	1.00
160_S	164_G	1.158	1.00
50_L	173_S	1.143	1.00
88_A	91_R	1.131	1.00
83_T	213_F	1.130	1.00
63_R	245_G	1.112	1.00
61_A	205_L	1.096	1.00
18_I	242_I	1.089	1.00
197_A	247_S	1.086	1.00
5_L	38_M	1.086	1.00
91_R	95_A	1.074	1.00
78_M	206_Q	1.074	1.00
231_T	235_G	1.072	1.00
169_V	183_L	1.063	1.00
164_G	168_V	1.053	1.00
43_R	47_G	1.044	1.00
177_G	180_G	1.044	1.00
86_I	214_G	1.037	1.00
73_K	159_A	1.028	1.00
16_I	30_L	1.027	1.00
156_R	160_S	1.024	1.00
47_G	224_V	1.020	1.00
74_L	78_M	1.018	1.00
215_A	229_V	1.012	1.00
173_S	180_G	1.008	1.00
87_E	91_R	1.004	1.00
223_F	227_P	1.003	1.00
65_R	70_V	0.998	1.00
122_L	260_A	0.992	1.00
8_F	12_F	0.992	1.00
180_G	186_P	0.988	1.00
67_H	248_N	0.982	0.99
240_A	244_A	0.980	0.99
260_A	264_L	0.978	0.99
88_A	171_V	0.977	0.99
53_V	173_S	0.962	0.99
177_G	210_S	0.962	0.99
50_L	53_V	0.956	0.99
126_R	130_T	0.950	0.99
166_G	184_L	0.950	0.99
164_G	167_L	0.947	0.99
258_Y	262_M	0.946	0.99
243_G	256_K	0.946	0.99
168_V	171_V	0.945	0.99
227_P	230_A	0.943	0.99
63_R	67_H	0.939	0.99
82_M	206_Q	0.937	0.99
169_V	180_G	0.935	0.99
57_S	177_G	0.934	0.99
208_T	212_A	0.933	0.99
40_Y	45_A	0.931	0.99
91_R	94_D	0.928	0.99
59_I	240_A	0.924	0.99
61_A	65_R	0.924	0.99
85_G	89_G	0.923	0.99
180_G	207_I	0.917	0.99
10_A	234_A	0.911	0.99
124_D	127_A	0.910	0.99
118_G	264_L	0.907	0.99
156_R	159_A	0.902	0.99
28_S	179_G	0.901	0.99
63_R	241_R	0.894	0.99
123_R	126_R	0.878	0.99
31_V	49_G	0.866	0.99
32_T	49_G	0.862	0.99
185_M	199_A	0.856	0.99
9_F	232_L	0.852	0.99
50_L	211_G	0.844	0.98
31_V	53_V	0.843	0.98
200_I	203_D	0.842	0.98
20_F	56_T	0.842	0.98
187_A	191_G	0.840	0.98
9_F	228_V	0.837	0.98
214_G	218_Y	0.829	0.98
17_G	27_G	0.828	0.98
90_K	174_G	0.826	0.98
72_Y	75_A	0.821	0.98
29_F	114_L	0.819	0.98
189_M	199_A	0.818	0.98
13_G	35_L	0.816	0.98
96_L	105_V	0.815	0.98
10_A	14_L	0.814	0.98
42_S	45_A	0.811	0.98
88_A	92_V	0.804	0.98
82_M	170_G	0.798	0.98
169_V	184_L	0.792	0.98
219_A	224_V	0.790	0.98
207_I	210_S	0.786	0.98
64_H	69_H	0.785	0.97
108_V	112_G	0.779	0.97
81_A	85_G	0.778	0.97
158_S	161_I	0.777	0.97
96_L	175_L	0.776	0.97
239_G	243_G	0.775	0.97
108_V	111_V	0.774	0.97
177_G	218_Y	0.774	0.97
4_L	11_G	0.772	0.97
247_S	255_I	0.767	0.97
40_Y	44_V	0.766	0.97
57_S	240_A	0.760	0.97
48_S	224_V	0.757	0.97
10_A	238_L	0.754	0.97
22_F	255_I	0.748	0.97
59_I	62_L	0.747	0.97
54_F	215_A	0.747	0.97
99_A	108_V	0.742	0.96
46_V	93_V	0.738	0.96
62_L	66_D	0.733	0.96
9_F	231_T	0.732	0.96
180_G	211_G	0.725	0.96
28_S	178_V	0.724	0.96
64_H	244_A	0.723	0.96
61_A	208_T	0.722	0.96
17_G	236_S	0.722	0.96
50_L	177_G	0.721	0.96
46_V	50_L	0.719	0.96
49_G	53_V	0.719	0.96
26_G	179_G	0.718	0.96
94_D	221_D	0.714	0.96
111_V	271_A	0.713	0.96
54_F	58_V	0.709	0.95
21_G	240_A	0.708	0.95
215_A	219_A	0.704	0.95
20_F	204_I	0.702	0.95
173_S	207_I	0.701	0.95
52_F	236_S	0.700	0.95
157_V	161_I	0.698	0.95
53_V	211_G	0.694	0.95
20_F	57_S	0.693	0.95
218_Y	222_G	0.689	0.95
20_F	180_G	0.689	0.95
56_T	177_G	0.687	0.95
58_V	62_L	0.685	0.95
131_T	198_I	0.685	0.95
23_F	121_T	0.674	0.94
59_I	244_A	0.673	0.94
42_S	98_A	0.673	0.94
83_T	216_F	0.673	0.94
49_G	174_G	0.672	0.94
9_F	13_G	0.671	0.94
65_R	68_G	0.670	0.94
20_F	207_I	0.669	0.94
53_V	180_G	0.669	0.94
165_I	168_V	0.661	0.93
130_T	163_F	0.656	0.93
51_A	226_I	0.655	0.93
205_L	208_T	0.655	0.93
173_S	210_S	0.652	0.93
131_T	195_P	0.652	0.93
24_G	179_G	0.651	0.93
55_G	237_A	0.650	0.93
177_G	203_D	0.647	0.93
188_M	206_Q	0.647	0.93
21_G	244_A	0.646	0.93
123_R	127_A	0.646	0.93
116_T	120_F	0.646	0.93
20_F	53_V	0.645	0.93
84_I	167_L	0.645	0.93
57_S	210_S	0.637	0.92
28_S	174_G	0.631	0.92
162_I	188_M	0.631	0.92
98_A	107_S	0.631	0.92
10_A	13_G	0.628	0.92
56_T	180_G	0.628	0.92
56_T	64_H	0.627	0.92
99_A	105_V	0.625	0.91
31_V	232_L	0.623	0.91
189_M	196_A	0.622	0.91
44_V	48_S	0.622	0.91
236_S	240_A	0.618	0.91
161_I	164_G	0.616	0.91
70_V	202_T	0.614	0.91
70_V	205_L	0.614	0.91
28_S	31_V	0.612	0.91
73_K	219_A	0.611	0.90
32_T	178_V	0.609	0.90
82_M	184_L	0.609	0.90
59_I	63_R	0.605	0.90
28_S	49_G	0.604	0.90
114_L	118_G	0.602	0.90
9_F	38_M	0.602	0.90
64_H	166_G	0.599	0.90
111_V	124_D	0.599	0.90
13_G	31_V	0.599	0.90
268_V	271_A	0.596	0.89
37_V	270_V	0.589	0.89
15_L	18_I	0.588	0.89
82_M	209_I	0.588	0.89
188_M	192_L	0.586	0.89
118_G	121_T	0.585	0.88
130_T	153_G	0.584	0.88
94_D	223_F	0.583	0.88
186_P	190_Y	0.582	0.88
21_G	200_I	0.581	0.88
5_L	8_F	0.579	0.88
114_L	270_V	0.577	0.88
78_M	166_G	0.577	0.88
69_H	217_V	0.576	0.88
84_I	163_F	0.576	0.88
20_F	178_V	0.575	0.88
16_I	52_F	0.573	0.87
28_S	203_D	0.572	0.87
18_I	22_F	0.570	0.87
196_A	259_F	0.570	0.87
22_F	250_V	0.569	0.87
23_F	203_D	0.568	0.87
79_T	205_L	0.568	0.87
31_V	178_V	0.567	0.87
44_V	223_F	0.566	0.87
250_V	255_I	0.564	0.87
51_A	215_A	0.564	0.87
237_A	241_R	0.564	0.87
188_M	229_V	0.560	0.86
124_D	256_K	0.559	0.86
118_G	122_L	0.558	0.86
32_T	110_Y	0.556	0.86
18_I	240_A	0.556	0.86
9_F	174_G	0.556	0.86
28_S	53_V	0.554	0.86
22_F	246_V	0.552	0.85
79_T	83_T	0.552	0.85
124_D	189_M	0.547	0.85
166_G	206_Q	0.546	0.85
28_S	232_L	0.545	0.85
20_F	203_D	0.540	0.84
173_S	178_V	0.537	0.84
116_T	227_P	0.534	0.84
110_Y	114_L	0.533	0.83
61_A	72_Y	0.531	0.83
47_G	179_G	0.531	0.83
53_V	207_I	0.531	0.83
52_F	56_T	0.527	0.83
49_G	203_D	0.527	0.83
155_V	158_S	0.527	0.83
209_I	213_F	0.526	0.83
57_S	211_G	0.525	0.83
204_I	207_I	0.524	0.82
51_A	224_V	0.523	0.82
92_V	95_A	0.523	0.82
99_A	107_S	0.523	0.82
72_Y	205_L	0.522	0.82
226_I	230_A	0.521	0.82
19_L	212_A	0.521	0.82
17_G	210_S	0.520	0.82
237_A	240_A	0.520	0.82
255_I	259_F	0.518	0.82
17_G	182_F	0.517	0.82
218_Y	263_L	0.517	0.82
60_G	177_G	0.517	0.82
77_I	80_V	0.516	0.81
163_F	166_G	0.513	0.81
47_G	215_A	0.512	0.81
184_L	210_S	0.512	0.81
182_F	207_I	0.512	0.81
80_V	163_F	0.512	0.81
81_A	166_G	0.512	0.81
56_T	204_I	0.511	0.81
15_L	223_F	0.509	0.81
192_L	199_A	0.509	0.81
54_F	57_S	0.508	0.80
166_G	170_G	0.507	0.80
16_I	184_L	0.506	0.80
169_V	197_A	0.506	0.80
120_F	125_A	0.505	0.80
13_G	48_S	0.504	0.80
18_I	21_G	0.504	0.80
62_L	112_G	0.504	0.80
57_S	173_S	0.502	0.80
196_A	200_I	0.502	0.80
46_V	203_D	0.501	0.80
90_K	218_Y	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.84	85.9	0.932	Contact Map
1pw4A	1	0.84	79.9	0.936	Contact Map
4j05A	3	0.8308	71.8	0.94	Contact Map
4m64A	1	0.8708	63.5	0.944	Contact Map
4xnjA	1	0.8554	62.1	0.944	Contact Map
4rp9A	2	0.3846	59.2	0.945	Contact Map
2gfpA	2	0.8277	40.4	0.951	Contact Map
3llqA	3	0.5877	36.7	0.952	Contact Map
3o7qA	1	0.4	35.8	0.952	Contact Map
3giaA	1	0.3662	35.7	0.952	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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