GREMLIN Database
O54662 - Uncharacterized protein
UniProt: O54662 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 325 (245)
Sequences: 4410 (3059)
Seq/√Len: 195.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
269_A273_K4.3351.00
92_V171_V4.3141.00
85_G167_L3.8301.00
18_I246_V3.3781.00
10_A235_G3.0581.00
165_I187_A3.0541.00
14_L238_L2.9041.00
55_G233_L2.9021.00
59_I241_R2.8101.00
79_T209_I2.7391.00
6_V231_T2.5211.00
59_I237_A2.4211.00
74_L194_V2.3711.00
88_A167_L2.3511.00
219_A226_I2.3411.00
44_V47_G2.3271.00
119_I123_R2.2551.00
230_A234_A2.2231.00
64_H247_S2.1721.00
264_L268_V2.1331.00
12_F34_A2.0951.00
82_M210_S2.0311.00
90_K214_G2.0261.00
118_G267_S1.9941.00
81_A163_F1.9551.00
14_L235_G1.9411.00
113_L176_L1.9031.00
72_Y76_V1.8971.00
234_A238_L1.8121.00
13_G232_L1.7961.00
51_A229_V1.7851.00
10_A231_T1.7741.00
80_V84_I1.7731.00
76_V80_V1.7441.00
58_V208_T1.7381.00
39_G45_A1.7111.00
48_S229_V1.6921.00
63_R244_A1.6861.00
87_E217_V1.6851.00
14_L242_I1.6841.00
115_A267_S1.6341.00
40_Y228_V1.6041.00
185_M200_I1.5911.00
21_G60_G1.5881.00
253_D257_G1.5771.00
41_P44_V1.5771.00
217_V221_D1.5731.00
241_R245_G1.5661.00
8_F11_G1.5601.00
118_G260_A1.5511.00
75_A205_L1.5431.00
121_T259_F1.5301.00
40_Y225_A1.5191.00
73_K76_V1.5101.00
71_D74_L1.4981.00
254_D257_G1.4791.00
245_G249_I1.4551.00
65_R72_Y1.4551.00
16_I31_V1.4411.00
167_L171_V1.4411.00
162_I192_L1.4401.00
180_G184_L1.4331.00
268_V272_A1.4241.00
227_P231_T1.4221.00
73_K77_I1.4141.00
60_G204_I1.3971.00
112_G116_T1.3961.00
54_F212_A1.3791.00
78_M188_M1.3771.00
76_V79_T1.3681.00
195_P198_I1.3651.00
71_D198_I1.3571.00
261_T265_A1.3541.00
126_R129_G1.3481.00
11_G15_L1.3381.00
225_A228_V1.3261.00
50_L214_G1.3111.00
216_F220_R1.3061.00
7_S11_G1.3051.00
185_M203_D1.3011.00
44_V225_A1.2911.00
257_G261_T1.2861.00
4_L8_F1.2731.00
110_Y113_L1.2711.00
265_A268_V1.2681.00
105_V109_A1.2521.00
70_V75_A1.2491.00
57_S207_I1.2361.00
184_L206_Q1.2281.00
75_A202_T1.2201.00
20_F173_S1.2031.00
35_L232_L1.2031.00
251_D254_D1.1841.00
230_A233_L1.1831.00
46_V218_Y1.1771.00
84_I88_A1.1761.00
4_L7_S1.1741.00
13_G235_G1.1681.00
160_S164_G1.1581.00
50_L173_S1.1431.00
88_A91_R1.1311.00
83_T213_F1.1301.00
63_R245_G1.1121.00
61_A205_L1.0961.00
18_I242_I1.0891.00
197_A247_S1.0861.00
5_L38_M1.0861.00
91_R95_A1.0741.00
78_M206_Q1.0741.00
231_T235_G1.0721.00
169_V183_L1.0631.00
164_G168_V1.0531.00
43_R47_G1.0441.00
177_G180_G1.0441.00
86_I214_G1.0371.00
73_K159_A1.0281.00
16_I30_L1.0271.00
156_R160_S1.0241.00
47_G224_V1.0201.00
74_L78_M1.0181.00
215_A229_V1.0121.00
173_S180_G1.0081.00
87_E91_R1.0041.00
223_F227_P1.0031.00
65_R70_V0.9981.00
122_L260_A0.9921.00
8_F12_F0.9921.00
180_G186_P0.9881.00
67_H248_N0.9820.99
240_A244_A0.9800.99
260_A264_L0.9780.99
88_A171_V0.9770.99
53_V173_S0.9620.99
177_G210_S0.9620.99
50_L53_V0.9560.99
126_R130_T0.9500.99
166_G184_L0.9500.99
164_G167_L0.9470.99
258_Y262_M0.9460.99
243_G256_K0.9460.99
168_V171_V0.9450.99
227_P230_A0.9430.99
63_R67_H0.9390.99
82_M206_Q0.9370.99
169_V180_G0.9350.99
57_S177_G0.9340.99
208_T212_A0.9330.99
40_Y45_A0.9310.99
91_R94_D0.9280.99
59_I240_A0.9240.99
61_A65_R0.9240.99
85_G89_G0.9230.99
180_G207_I0.9170.99
10_A234_A0.9110.99
124_D127_A0.9100.99
118_G264_L0.9070.99
156_R159_A0.9020.99
28_S179_G0.9010.99
63_R241_R0.8940.99
123_R126_R0.8780.99
31_V49_G0.8660.99
32_T49_G0.8620.99
185_M199_A0.8560.99
9_F232_L0.8520.99
50_L211_G0.8440.98
31_V53_V0.8430.98
200_I203_D0.8420.98
20_F56_T0.8420.98
187_A191_G0.8400.98
9_F228_V0.8370.98
214_G218_Y0.8290.98
17_G27_G0.8280.98
90_K174_G0.8260.98
72_Y75_A0.8210.98
29_F114_L0.8190.98
189_M199_A0.8180.98
13_G35_L0.8160.98
96_L105_V0.8150.98
10_A14_L0.8140.98
42_S45_A0.8110.98
88_A92_V0.8040.98
82_M170_G0.7980.98
169_V184_L0.7920.98
219_A224_V0.7900.98
207_I210_S0.7860.98
64_H69_H0.7850.97
108_V112_G0.7790.97
81_A85_G0.7780.97
158_S161_I0.7770.97
96_L175_L0.7760.97
239_G243_G0.7750.97
108_V111_V0.7740.97
177_G218_Y0.7740.97
4_L11_G0.7720.97
247_S255_I0.7670.97
40_Y44_V0.7660.97
57_S240_A0.7600.97
48_S224_V0.7570.97
10_A238_L0.7540.97
22_F255_I0.7480.97
59_I62_L0.7470.97
54_F215_A0.7470.97
99_A108_V0.7420.96
46_V93_V0.7380.96
62_L66_D0.7330.96
9_F231_T0.7320.96
180_G211_G0.7250.96
28_S178_V0.7240.96
64_H244_A0.7230.96
61_A208_T0.7220.96
17_G236_S0.7220.96
50_L177_G0.7210.96
46_V50_L0.7190.96
49_G53_V0.7190.96
26_G179_G0.7180.96
94_D221_D0.7140.96
111_V271_A0.7130.96
54_F58_V0.7090.95
21_G240_A0.7080.95
215_A219_A0.7040.95
20_F204_I0.7020.95
173_S207_I0.7010.95
52_F236_S0.7000.95
157_V161_I0.6980.95
53_V211_G0.6940.95
20_F57_S0.6930.95
218_Y222_G0.6890.95
20_F180_G0.6890.95
56_T177_G0.6870.95
58_V62_L0.6850.95
131_T198_I0.6850.95
23_F121_T0.6740.94
59_I244_A0.6730.94
42_S98_A0.6730.94
83_T216_F0.6730.94
49_G174_G0.6720.94
9_F13_G0.6710.94
65_R68_G0.6700.94
20_F207_I0.6690.94
53_V180_G0.6690.94
165_I168_V0.6610.93
130_T163_F0.6560.93
51_A226_I0.6550.93
205_L208_T0.6550.93
173_S210_S0.6520.93
131_T195_P0.6520.93
24_G179_G0.6510.93
55_G237_A0.6500.93
177_G203_D0.6470.93
188_M206_Q0.6470.93
21_G244_A0.6460.93
123_R127_A0.6460.93
116_T120_F0.6460.93
20_F53_V0.6450.93
84_I167_L0.6450.93
57_S210_S0.6370.92
28_S174_G0.6310.92
162_I188_M0.6310.92
98_A107_S0.6310.92
10_A13_G0.6280.92
56_T180_G0.6280.92
56_T64_H0.6270.92
99_A105_V0.6250.91
31_V232_L0.6230.91
189_M196_A0.6220.91
44_V48_S0.6220.91
236_S240_A0.6180.91
161_I164_G0.6160.91
70_V202_T0.6140.91
70_V205_L0.6140.91
28_S31_V0.6120.91
73_K219_A0.6110.90
32_T178_V0.6090.90
82_M184_L0.6090.90
59_I63_R0.6050.90
28_S49_G0.6040.90
114_L118_G0.6020.90
9_F38_M0.6020.90
64_H166_G0.5990.90
111_V124_D0.5990.90
13_G31_V0.5990.90
268_V271_A0.5960.89
37_V270_V0.5890.89
15_L18_I0.5880.89
82_M209_I0.5880.89
188_M192_L0.5860.89
118_G121_T0.5850.88
130_T153_G0.5840.88
94_D223_F0.5830.88
186_P190_Y0.5820.88
21_G200_I0.5810.88
5_L8_F0.5790.88
114_L270_V0.5770.88
78_M166_G0.5770.88
69_H217_V0.5760.88
84_I163_F0.5760.88
20_F178_V0.5750.88
16_I52_F0.5730.87
28_S203_D0.5720.87
18_I22_F0.5700.87
196_A259_F0.5700.87
22_F250_V0.5690.87
23_F203_D0.5680.87
79_T205_L0.5680.87
31_V178_V0.5670.87
44_V223_F0.5660.87
250_V255_I0.5640.87
51_A215_A0.5640.87
237_A241_R0.5640.87
188_M229_V0.5600.86
124_D256_K0.5590.86
118_G122_L0.5580.86
32_T110_Y0.5560.86
18_I240_A0.5560.86
9_F174_G0.5560.86
28_S53_V0.5540.86
22_F246_V0.5520.85
79_T83_T0.5520.85
124_D189_M0.5470.85
166_G206_Q0.5460.85
28_S232_L0.5450.85
20_F203_D0.5400.84
173_S178_V0.5370.84
116_T227_P0.5340.84
110_Y114_L0.5330.83
61_A72_Y0.5310.83
47_G179_G0.5310.83
53_V207_I0.5310.83
52_F56_T0.5270.83
49_G203_D0.5270.83
155_V158_S0.5270.83
209_I213_F0.5260.83
57_S211_G0.5250.83
204_I207_I0.5240.82
51_A224_V0.5230.82
92_V95_A0.5230.82
99_A107_S0.5230.82
72_Y205_L0.5220.82
226_I230_A0.5210.82
19_L212_A0.5210.82
17_G210_S0.5200.82
237_A240_A0.5200.82
255_I259_F0.5180.82
17_G182_F0.5170.82
218_Y263_L0.5170.82
60_G177_G0.5170.82
77_I80_V0.5160.81
163_F166_G0.5130.81
47_G215_A0.5120.81
184_L210_S0.5120.81
182_F207_I0.5120.81
80_V163_F0.5120.81
81_A166_G0.5120.81
56_T204_I0.5110.81
15_L223_F0.5090.81
192_L199_A0.5090.81
54_F57_S0.5080.80
166_G170_G0.5070.80
16_I184_L0.5060.80
169_V197_A0.5060.80
120_F125_A0.5050.80
13_G48_S0.5040.80
18_I21_G0.5040.80
62_L112_G0.5040.80
57_S173_S0.5020.80
196_A200_I0.5020.80
46_V203_D0.5010.80
90_K218_Y0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.84 85.9 0.932 Contact Map
1pw4A 1 0.84 79.9 0.936 Contact Map
4j05A 3 0.8308 71.8 0.94 Contact Map
4m64A 1 0.8708 63.5 0.944 Contact Map
4xnjA 1 0.8554 62.1 0.944 Contact Map
4rp9A 2 0.3846 59.2 0.945 Contact Map
2gfpA 2 0.8277 40.4 0.951 Contact Map
3llqA 3 0.5877 36.7 0.952 Contact Map
3o7qA 1 0.4 35.8 0.952 Contact Map
3giaA 1 0.3662 35.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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