GREMLIN Database
O54661 - Uncharacterized protein
UniProt: O54661 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 369 (354)
Sequences: 444 (284)
Seq/√Len: 15.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_L67_I6.0011.00
155_L162_L5.0761.00
304_A308_E4.2471.00
142_F240_L4.1201.00
166_F232_F3.9641.00
166_F210_V3.6160.99
222_T231_S3.6050.99
30_F38_S3.4610.99
206_D219_V3.4050.99
79_T83_V3.2850.99
134_V160_A3.2010.99
30_F35_I3.0700.98
96_D100_G3.0440.98
164_G190_Y3.0290.98
118_L133_L2.8560.97
305_T308_E2.8260.97
271_A320_R2.8150.97
325_E329_S2.8120.97
248_D295_P2.8050.97
285_D307_A2.7940.97
295_P314_D2.6050.95
68_V74_G2.5870.95
117_T158_Y2.4550.93
352_P355_E2.3650.92
74_G78_Q2.2980.91
4_L74_G2.2420.89
133_L142_F2.2370.89
132_V162_L2.1960.88
141_V155_L2.1860.88
178_A189_Y2.1240.87
222_T276_S2.0570.85
309_V316_L2.0420.84
209_T216_D2.0280.84
10_G13_V2.0200.84
6_P74_G2.0190.84
10_G124_P2.0190.84
152_D184_R1.9940.83
162_L210_V1.9800.82
44_Y75_V1.9270.81
75_V80_A1.8670.78
171_H174_H1.8670.78
231_S244_T1.8420.77
118_L240_L1.8310.77
10_G14_Q1.8300.77
21_V37_G1.8250.77
70_V94_L1.8140.76
282_D322_A1.8070.76
27_E31_Q1.8030.76
229_S251_G1.7590.74
29_D217_I1.7350.73
248_D314_D1.7310.73
253_V341_V1.6880.71
301_P304_A1.6860.71
219_V230_V1.6770.70
127_G360_E1.6560.69
145_S151_Y1.6350.68
67_I89_Y1.6290.68
13_V19_P1.6200.67
44_Y47_L1.6190.67
167_D171_H1.6090.67
74_G89_Y1.6060.67
43_V48_T1.5930.66
140_A166_F1.5890.66
121_V154_V1.5670.65
43_V80_A1.5610.64
29_D38_S1.5580.64
138_E163_V1.5510.64
29_D62_P1.5450.64
105_H109_E1.5380.63
109_E112_V1.5350.63
229_S244_T1.5230.63
107_H111_P1.5100.62
75_V99_N1.4810.60
40_N44_Y1.4350.58
85_R91_A1.4340.58
44_Y48_T1.4280.57
118_L158_Y1.4100.56
72_A76_V1.4010.56
74_G95_T1.3900.55
83_V91_A1.3820.55
159_D175_V1.3790.55
90_D352_P1.3640.54
43_V46_E1.3490.53
12_Q17_D1.3430.53
141_V144_P1.3320.52
167_D174_H1.3220.51
105_H356_L1.3220.51
30_F34_H1.3190.51
191_L196_A1.3180.51
256_G336_P1.3160.51
68_V94_L1.3120.51
102_S126_K1.2990.50
40_N43_V1.2850.49
283_R287_A1.2830.49
244_T251_G1.2820.49
133_L216_D1.2790.49
192_H342_K1.2640.48
65_E85_R1.2390.47
46_E75_V1.2380.47
87_L327_L1.2330.46
275_E320_R1.2310.46
181_L304_A1.2290.46
204_L219_V1.2280.46
228_G313_N1.2270.46
4_L68_V1.2260.46
28_E35_I1.2170.46
4_L190_Y1.2130.45
152_D185_H1.2090.45
142_F232_F1.2090.45
188_P202_T1.2020.45
44_Y80_A1.1980.45
222_T244_T1.1970.44
16_D89_Y1.1880.44
77_S101_W1.1870.44
125_G229_S1.1800.44
68_V320_R1.1770.43
125_G147_Y1.1750.43
125_G204_L1.1680.43
157_E183_D1.1490.42
149_N211_T1.1460.42
126_K251_G1.1460.42
216_D236_G1.1380.41
70_V149_N1.1370.41
192_H332_P1.1330.41
148_L215_L1.1320.41
35_I70_V1.1310.41
294_D313_N1.1270.41
43_V72_A1.1250.40
149_N162_L1.1240.40
67_I308_E1.1190.40
98_M127_G1.1160.40
98_M128_C1.1100.40
62_P228_G1.1020.39
254_E257_V1.1020.39
14_Q265_D1.0990.39
165_V240_L1.0920.39
8_E118_L1.0860.38
217_I292_A1.0830.38
159_D311_E1.0810.38
186_D350_S1.0780.38
119_V154_V1.0760.38
18_G64_D1.0750.38
168_T338_F1.0730.38
97_G101_W1.0710.38
175_V317_G1.0710.38
9_L81_T1.0670.37
231_S251_G1.0650.37
59_D234_V1.0640.37
118_L140_A1.0640.37
75_V79_T1.0590.37
145_S181_L1.0540.37
189_Y290_L1.0520.37
254_E341_V1.0490.36
24_I29_D1.0470.36
6_P91_A1.0470.36
204_L290_L1.0440.36
301_P314_D1.0370.36
118_L267_E1.0280.35
257_V269_N1.0270.35
196_A228_G1.0270.35
361_L368_A1.0260.35
222_T274_Y1.0250.35
31_Q74_G1.0230.35
159_D200_D1.0220.35
144_P151_Y1.0220.35
77_S212_V1.0200.35
247_H295_P1.0190.35
125_G130_S1.0170.35
229_S273_L1.0160.35
4_L18_G1.0150.35
247_H314_D1.0130.35
267_E270_A1.0090.34
13_V234_V1.0080.34
4_L7_A1.0020.34
270_A324_V0.9940.34
236_G267_E0.9900.33
66_Q311_E0.9870.33
276_S351_V0.9790.33
43_V75_V0.9770.33
142_F166_F0.9730.33
295_P304_A0.9720.33
145_S304_A0.9670.32
202_T279_R0.9610.32
31_Q311_E0.9600.32
102_S363_P0.9580.32
12_Q66_Q0.9570.32
280_L289_V0.9540.32
79_T91_A0.9490.31
165_V178_A0.9490.31
74_G94_L0.9480.31
165_V219_V0.9480.31
128_C171_H0.9450.31
36_P184_R0.9450.31
31_Q214_R0.9430.31
208_Q214_R0.9410.31
44_Y73_A0.9390.31
4_L89_Y0.9340.31
304_A312_R0.9340.31
5_S95_T0.9310.31
27_E149_N0.9280.30
19_P68_V0.9230.30
13_V298_P0.9180.30
96_D156_D0.9150.30
98_M360_E0.9140.30
170_A228_G0.9110.30
86_E141_V0.9030.29
195_D342_K0.9030.29
209_T219_V0.9010.29
185_H304_A0.9010.29
226_S254_E0.8980.29
31_Q209_T0.8950.29
232_F284_P0.8940.29
133_L215_L0.8940.29
80_A186_D0.8920.29
99_N354_E0.8890.29
226_S253_V0.8880.29
280_L359_L0.8880.29
304_A314_D0.8860.28
48_T75_V0.8800.28
5_S144_P0.8780.28
20_L62_P0.8760.28
26_H29_D0.8760.28
22_L130_S0.8740.28
9_L68_V0.8710.28
11_E350_S0.8670.28
92_V276_S0.8620.27
227_E268_G0.8620.27
27_E231_S0.8610.27
249_S277_L0.8600.27
148_L184_R0.8600.27
147_Y357_A0.8590.27
125_G179_A0.8500.27
53_Q162_L0.8490.27
276_S294_D0.8490.27
153_T156_D0.8450.27
72_A75_V0.8440.27
33_W37_G0.8370.26
63_S67_I0.8330.26
105_H125_G0.8310.26
26_H43_V0.8310.26
150_E162_L0.8310.26
20_L45_D0.8280.26
108_A247_H0.8260.26
175_V283_R0.8260.26
41_V355_E0.8150.25
144_P357_A0.8150.25
184_R340_R0.8110.25
56_E320_R0.8070.25
125_G333_D0.8060.25
16_D39_R0.8050.25
68_V78_Q0.8030.25
142_F234_V0.8020.25
113_D274_Y0.8010.25
21_V118_L0.8010.25
340_R349_E0.8000.25
249_S344_T0.7950.24
11_E270_A0.7920.24
166_F217_I0.7920.24
18_G202_T0.7910.24
153_T208_Q0.7900.24
170_A195_D0.7840.24
37_G42_D0.7810.24
163_V175_V0.7810.24
196_A332_P0.7800.24
133_L208_Q0.7790.24
256_G269_N0.7780.24
151_Y341_V0.7750.24
281_L316_L0.7740.24
120_Q255_L0.7740.24
11_E31_Q0.7720.24
26_H294_D0.7720.24
89_Y149_N0.7700.23
242_G246_F0.7690.23
100_G104_V0.7670.23
167_D270_A0.7660.23
249_S351_V0.7660.23
98_M171_H0.7580.23
24_I80_A0.7580.23
193_Q205_E0.7570.23
29_D66_Q0.7560.23
43_V76_V0.7550.23
153_T163_V0.7550.23
157_E321_E0.7540.23
244_T274_Y0.7530.23
270_A337_N0.7520.23
40_N48_T0.7520.23
178_A257_V0.7480.23
256_G365_N0.7480.23
77_S83_V0.7470.23
249_S342_K0.7460.22
114_V321_E0.7460.22
69_T207_G0.7450.22
21_V340_R0.7410.22
153_T200_D0.7390.22
319_D324_V0.7390.22
187_V240_L0.7380.22
122_A257_V0.7370.22
277_L316_L0.7360.22
334_H342_K0.7320.22
118_L237_A0.7310.22
192_H230_V0.7280.22
186_D308_E0.7270.22
257_V313_N0.7250.22
173_D293_H0.7220.22
139_A360_E0.7220.22
35_I248_D0.7220.22
13_V85_R0.7210.21
76_V201_A0.7130.21
120_Q123_R0.7110.21
27_E75_V0.7100.21
230_V333_D0.7090.21
218_E233_D0.7080.21
139_A160_A0.7060.21
34_H314_D0.7050.21
129_L174_H0.7040.21
39_R53_Q0.7040.21
268_G344_T0.7010.21
92_V132_V0.6990.21
91_A94_L0.6980.21
247_H304_A0.6970.21
159_D312_R0.6970.21
206_D311_E0.6940.20
6_P12_Q0.6940.20
125_G334_H0.6920.20
15_D21_V0.6880.20
96_D99_N0.6860.20
241_T289_V0.6860.20
31_Q63_S0.6850.20
141_V162_L0.6850.20
128_C167_D0.6840.20
179_A183_D0.6840.20
35_I204_L0.6820.20
74_G171_H0.6800.20
26_H75_V0.6800.20
72_A313_N0.6790.20
79_T85_R0.6780.20
128_C174_H0.6770.20
210_V232_F0.6760.20
153_T181_L0.6730.20
184_R288_L0.6720.20
250_V277_L0.6710.20
73_A177_G0.6710.20
120_Q291_P0.6680.20
196_A299_E0.6680.20
195_D343_R0.6680.20
61_L321_E0.6660.19
136_D214_R0.6660.19
83_V92_V0.6640.19
35_I48_T0.6640.19
129_L171_H0.6630.19
123_R255_L0.6610.19
126_K334_H0.6600.19
35_I38_S0.6590.19
59_D354_E0.6580.19
7_A21_V0.6570.19
341_V364_N0.6560.19
341_V362_G0.6560.19
15_D214_R0.6530.19
68_V211_T0.6520.19
257_V342_K0.6510.19
63_S89_Y0.6510.19
100_G163_V0.6500.19
168_T284_P0.6500.19
52_E56_E0.6500.19
212_V275_E0.6490.19
73_A76_V0.6490.19
79_T355_E0.6480.19
32_E361_L0.6480.19
136_D321_E0.6470.19
177_G363_P0.6460.19
95_T292_A0.6430.19
40_N45_D0.6400.19
102_S336_P0.6390.19
188_P192_H0.6370.18
156_D321_E0.6360.18
228_G294_D0.6330.18
167_D173_D0.6330.18
275_E279_R0.6330.18
207_G283_R0.6310.18
124_P295_P0.6280.18
17_D352_P0.6280.18
209_T214_R0.6270.18
138_E230_V0.6250.18
32_E47_L0.6250.18
154_V334_H0.6240.18
337_N342_K0.6240.18
4_L160_A0.6230.18
197_L201_A0.6210.18
148_L151_Y0.6190.18
175_V330_D0.6160.18
95_T311_E0.6160.18
90_D282_D0.6160.18
251_G302_V0.6160.18
194_K227_E0.6160.18
40_N47_L0.6140.18
157_E211_T0.6130.18
105_H121_V0.6120.18
250_V316_L0.6120.18
15_D282_D0.6110.18
103_R109_E0.6110.18
191_L200_D0.6100.18
94_L101_W0.6100.18
208_Q355_E0.6090.18
148_L180_D0.6070.17
5_S60_D0.6070.17
7_A308_E0.6040.17
67_I351_V0.6030.17
127_G139_A0.6030.17
60_D193_Q0.6020.17
167_D176_S0.6020.17
94_L160_A0.6010.17
146_H242_G0.6000.17
342_K359_L0.5980.17
169_H172_A0.5980.17
169_H252_R0.5980.17
172_A252_R0.5980.17
74_G100_G0.5970.17
240_L290_L0.5960.17
21_V297_S0.5950.17
53_Q56_E0.5940.17
186_D305_T0.5920.17
5_S152_D0.5920.17
29_D69_T0.5910.17
337_N359_L0.5900.17
126_K203_P0.5900.17
137_G212_V0.5900.17
84_L165_V0.5890.17
98_M129_L0.5890.17
336_P365_N0.5880.17
173_D323_F0.5850.17
52_E89_Y0.5830.17
5_S162_L0.5830.17
21_V198_A0.5820.17
28_E61_L0.5820.17
170_A342_K0.5820.17
286_D305_T0.5820.17
214_R349_E0.5810.17
198_A350_S0.5810.17
52_E327_L0.5810.17
128_C360_E0.5800.17
132_V160_A0.5790.17
130_S151_Y0.5780.17
143_D168_T0.5770.17
133_L220_I0.5770.17
276_S280_L0.5760.16
21_V47_L0.5750.16
192_H195_D0.5740.16
44_Y79_T0.5730.16
97_G245_L0.5730.16
119_V238_A0.5720.16
121_V330_D0.5690.16
184_R210_V0.5680.16
229_S342_K0.5680.16
126_K178_A0.5670.16
102_S346_V0.5670.16
17_D104_V0.5670.16
233_D283_R0.5650.16
185_H350_S0.5640.16
306_L367_A0.5630.16
40_N313_N0.5630.16
145_S165_V0.5630.16
241_T271_A0.5630.16
140_A208_Q0.5630.16
295_P301_P0.5620.16
26_H79_T0.5610.16
118_L238_A0.5600.16
18_G39_R0.5590.16
26_H80_A0.5570.16
212_V235_E0.5530.16
31_Q161_E0.5510.16
318_R326_E0.5490.16
9_L265_D0.5480.16
81_T111_P0.5470.16
280_L331_I0.5470.16
246_F293_H0.5460.16
14_Q124_P0.5450.16
159_D322_A0.5450.16
244_T249_S0.5440.16
19_P216_D0.5430.15
150_E153_T0.5420.15
220_I248_D0.5420.15
222_T229_S0.5420.15
174_H191_L0.5420.15
14_Q159_D0.5400.15
88_G246_F0.5390.15
6_P161_E0.5370.15
275_E308_E0.5360.15
151_Y160_A0.5310.15
48_T73_A0.5310.15
166_F350_S0.5290.15
141_V181_L0.5290.15
44_Y76_V0.5280.15
44_Y91_A0.5270.15
114_V209_T0.5270.15
126_K365_N0.5270.15
219_V305_T0.5270.15
233_D237_A0.5270.15
230_V266_V0.5250.15
219_V232_F0.5250.15
214_R286_D0.5240.15
16_D352_P0.5240.15
310_R336_P0.5190.15
68_V91_A0.5180.15
331_I342_K0.5170.15
6_P298_P0.5170.15
15_D157_E0.5170.15
151_Y253_V0.5160.15
28_E350_S0.5150.15
237_A276_S0.5140.15
143_D226_S0.5140.15
323_F364_N0.5140.15
323_F362_G0.5140.15
73_A201_A0.5140.15
276_S327_L0.5130.15
134_V158_Y0.5130.15
52_E55_I0.5120.15
7_A64_D0.5120.15
31_Q236_G0.5110.15
21_V44_Y0.5090.15
78_Q275_E0.5070.14
115_D222_T0.5070.14
126_K129_L0.5060.14
85_R95_T0.5030.14
230_V249_S0.5030.14
253_V269_N0.5020.14
24_I75_V0.5020.14
46_E80_A0.5020.14
239_L306_L0.5020.14
171_H360_E0.5000.14
72_A354_E0.5000.14
157_E279_R0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.6883 100 0.678 Contact Map
4efzA 2 0.664 100 0.701 Contact Map
3r2uA 4 0.6992 100 0.703 Contact Map
4yslA 2 0.6694 100 0.706 Contact Map
4ysbA 2 0.5962 100 0.731 Contact Map
4chlA 2 0.6233 100 0.735 Contact Map
2gcuA 3 0.6206 100 0.739 Contact Map
1qh5A 1 0.5989 100 0.755 Contact Map
2p18A 1 0.6775 100 0.757 Contact Map
2qedA 1 0.5989 100 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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