O54661 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

O54661 - Uncharacterized protein

UniProt:	O54661	Sequences: MQELSPAELGEQVQDDDGPLVLDIRHEEDFQEWHIPGSRNVDVYDELTDDPEQAIEPLDDLPSDEQIVTVCAAGVVSQTATAVLRELGYDAVTLTDGMNGWSRVHRHAELPVDVDGTLVQVARPGKGCLSHVLVSDGEAAVFDPSHYLNEYDTVLDEYDAELVGVFDTHAHADHVSGAADLADRHDVPYYLHQKDALAVDATPLEDGQTVTVGRLDIEVIHTPGHSEGSVSFDVEGAALLTGDTLFHDSVGRVELGVEAGIEDADVEGNAATLYESLQRLLDRPDDALVLPAHDPGSPEPPVAATLAEVRERNDDLGRDREAFVEELASDIPDHPPNFERVKRTNVGQESVPEEELAELELGPNNCAAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	369 (354)
Sequences:	444 (284)
Seq/√Len:	15.1

BACSU - YRKH
HALSA - O54661 O54647 Q9HS22

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_L	67_I	6.001	1.00
155_L	162_L	5.076	1.00
304_A	308_E	4.247	1.00
142_F	240_L	4.120	1.00
166_F	232_F	3.964	1.00
166_F	210_V	3.616	0.99
222_T	231_S	3.605	0.99
30_F	38_S	3.461	0.99
206_D	219_V	3.405	0.99
79_T	83_V	3.285	0.99
134_V	160_A	3.201	0.99
30_F	35_I	3.070	0.98
96_D	100_G	3.044	0.98
164_G	190_Y	3.029	0.98
118_L	133_L	2.856	0.97
305_T	308_E	2.826	0.97
271_A	320_R	2.815	0.97
325_E	329_S	2.812	0.97
248_D	295_P	2.805	0.97
285_D	307_A	2.794	0.97
295_P	314_D	2.605	0.95
68_V	74_G	2.587	0.95
117_T	158_Y	2.455	0.93
352_P	355_E	2.365	0.92
74_G	78_Q	2.298	0.91
4_L	74_G	2.242	0.89
133_L	142_F	2.237	0.89
132_V	162_L	2.196	0.88
141_V	155_L	2.186	0.88
178_A	189_Y	2.124	0.87
222_T	276_S	2.057	0.85
309_V	316_L	2.042	0.84
209_T	216_D	2.028	0.84
10_G	13_V	2.020	0.84
6_P	74_G	2.019	0.84
10_G	124_P	2.019	0.84
152_D	184_R	1.994	0.83
162_L	210_V	1.980	0.82
44_Y	75_V	1.927	0.81
75_V	80_A	1.867	0.78
171_H	174_H	1.867	0.78
231_S	244_T	1.842	0.77
118_L	240_L	1.831	0.77
10_G	14_Q	1.830	0.77
21_V	37_G	1.825	0.77
70_V	94_L	1.814	0.76
282_D	322_A	1.807	0.76
27_E	31_Q	1.803	0.76
229_S	251_G	1.759	0.74
29_D	217_I	1.735	0.73
248_D	314_D	1.731	0.73
253_V	341_V	1.688	0.71
301_P	304_A	1.686	0.71
219_V	230_V	1.677	0.70
127_G	360_E	1.656	0.69
145_S	151_Y	1.635	0.68
67_I	89_Y	1.629	0.68
13_V	19_P	1.620	0.67
44_Y	47_L	1.619	0.67
167_D	171_H	1.609	0.67
74_G	89_Y	1.606	0.67
43_V	48_T	1.593	0.66
140_A	166_F	1.589	0.66
121_V	154_V	1.567	0.65
43_V	80_A	1.561	0.64
29_D	38_S	1.558	0.64
138_E	163_V	1.551	0.64
29_D	62_P	1.545	0.64
105_H	109_E	1.538	0.63
109_E	112_V	1.535	0.63
229_S	244_T	1.523	0.63
107_H	111_P	1.510	0.62
75_V	99_N	1.481	0.60
40_N	44_Y	1.435	0.58
85_R	91_A	1.434	0.58
44_Y	48_T	1.428	0.57
118_L	158_Y	1.410	0.56
72_A	76_V	1.401	0.56
74_G	95_T	1.390	0.55
83_V	91_A	1.382	0.55
159_D	175_V	1.379	0.55
90_D	352_P	1.364	0.54
43_V	46_E	1.349	0.53
12_Q	17_D	1.343	0.53
141_V	144_P	1.332	0.52
167_D	174_H	1.322	0.51
105_H	356_L	1.322	0.51
30_F	34_H	1.319	0.51
191_L	196_A	1.318	0.51
256_G	336_P	1.316	0.51
68_V	94_L	1.312	0.51
102_S	126_K	1.299	0.50
40_N	43_V	1.285	0.49
283_R	287_A	1.283	0.49
244_T	251_G	1.282	0.49
133_L	216_D	1.279	0.49
192_H	342_K	1.264	0.48
65_E	85_R	1.239	0.47
46_E	75_V	1.238	0.47
87_L	327_L	1.233	0.46
275_E	320_R	1.231	0.46
181_L	304_A	1.229	0.46
204_L	219_V	1.228	0.46
228_G	313_N	1.227	0.46
4_L	68_V	1.226	0.46
28_E	35_I	1.217	0.46
4_L	190_Y	1.213	0.45
152_D	185_H	1.209	0.45
142_F	232_F	1.209	0.45
188_P	202_T	1.202	0.45
44_Y	80_A	1.198	0.45
222_T	244_T	1.197	0.44
16_D	89_Y	1.188	0.44
77_S	101_W	1.187	0.44
125_G	229_S	1.180	0.44
68_V	320_R	1.177	0.43
125_G	147_Y	1.175	0.43
125_G	204_L	1.168	0.43
157_E	183_D	1.149	0.42
149_N	211_T	1.146	0.42
126_K	251_G	1.146	0.42
216_D	236_G	1.138	0.41
70_V	149_N	1.137	0.41
192_H	332_P	1.133	0.41
148_L	215_L	1.132	0.41
35_I	70_V	1.131	0.41
294_D	313_N	1.127	0.41
43_V	72_A	1.125	0.40
149_N	162_L	1.124	0.40
67_I	308_E	1.119	0.40
98_M	127_G	1.116	0.40
98_M	128_C	1.110	0.40
62_P	228_G	1.102	0.39
254_E	257_V	1.102	0.39
14_Q	265_D	1.099	0.39
165_V	240_L	1.092	0.39
8_E	118_L	1.086	0.38
217_I	292_A	1.083	0.38
159_D	311_E	1.081	0.38
186_D	350_S	1.078	0.38
119_V	154_V	1.076	0.38
18_G	64_D	1.075	0.38
168_T	338_F	1.073	0.38
97_G	101_W	1.071	0.38
175_V	317_G	1.071	0.38
9_L	81_T	1.067	0.37
231_S	251_G	1.065	0.37
59_D	234_V	1.064	0.37
118_L	140_A	1.064	0.37
75_V	79_T	1.059	0.37
145_S	181_L	1.054	0.37
189_Y	290_L	1.052	0.37
254_E	341_V	1.049	0.36
24_I	29_D	1.047	0.36
6_P	91_A	1.047	0.36
204_L	290_L	1.044	0.36
301_P	314_D	1.037	0.36
118_L	267_E	1.028	0.35
257_V	269_N	1.027	0.35
196_A	228_G	1.027	0.35
361_L	368_A	1.026	0.35
222_T	274_Y	1.025	0.35
31_Q	74_G	1.023	0.35
159_D	200_D	1.022	0.35
144_P	151_Y	1.022	0.35
77_S	212_V	1.020	0.35
247_H	295_P	1.019	0.35
125_G	130_S	1.017	0.35
229_S	273_L	1.016	0.35
4_L	18_G	1.015	0.35
247_H	314_D	1.013	0.35
267_E	270_A	1.009	0.34
13_V	234_V	1.008	0.34
4_L	7_A	1.002	0.34
270_A	324_V	0.994	0.34
236_G	267_E	0.990	0.33
66_Q	311_E	0.987	0.33
276_S	351_V	0.979	0.33
43_V	75_V	0.977	0.33
142_F	166_F	0.973	0.33
295_P	304_A	0.972	0.33
145_S	304_A	0.967	0.32
202_T	279_R	0.961	0.32
31_Q	311_E	0.960	0.32
102_S	363_P	0.958	0.32
12_Q	66_Q	0.957	0.32
280_L	289_V	0.954	0.32
79_T	91_A	0.949	0.31
165_V	178_A	0.949	0.31
74_G	94_L	0.948	0.31
165_V	219_V	0.948	0.31
128_C	171_H	0.945	0.31
36_P	184_R	0.945	0.31
31_Q	214_R	0.943	0.31
208_Q	214_R	0.941	0.31
44_Y	73_A	0.939	0.31
4_L	89_Y	0.934	0.31
304_A	312_R	0.934	0.31
5_S	95_T	0.931	0.31
27_E	149_N	0.928	0.30
19_P	68_V	0.923	0.30
13_V	298_P	0.918	0.30
96_D	156_D	0.915	0.30
98_M	360_E	0.914	0.30
170_A	228_G	0.911	0.30
86_E	141_V	0.903	0.29
195_D	342_K	0.903	0.29
209_T	219_V	0.901	0.29
185_H	304_A	0.901	0.29
226_S	254_E	0.898	0.29
31_Q	209_T	0.895	0.29
232_F	284_P	0.894	0.29
133_L	215_L	0.894	0.29
80_A	186_D	0.892	0.29
99_N	354_E	0.889	0.29
226_S	253_V	0.888	0.29
280_L	359_L	0.888	0.29
304_A	314_D	0.886	0.28
48_T	75_V	0.880	0.28
5_S	144_P	0.878	0.28
20_L	62_P	0.876	0.28
26_H	29_D	0.876	0.28
22_L	130_S	0.874	0.28
9_L	68_V	0.871	0.28
11_E	350_S	0.867	0.28
92_V	276_S	0.862	0.27
227_E	268_G	0.862	0.27
27_E	231_S	0.861	0.27
249_S	277_L	0.860	0.27
148_L	184_R	0.860	0.27
147_Y	357_A	0.859	0.27
125_G	179_A	0.850	0.27
53_Q	162_L	0.849	0.27
276_S	294_D	0.849	0.27
153_T	156_D	0.845	0.27
72_A	75_V	0.844	0.27
33_W	37_G	0.837	0.26
63_S	67_I	0.833	0.26
105_H	125_G	0.831	0.26
26_H	43_V	0.831	0.26
150_E	162_L	0.831	0.26
20_L	45_D	0.828	0.26
108_A	247_H	0.826	0.26
175_V	283_R	0.826	0.26
41_V	355_E	0.815	0.25
144_P	357_A	0.815	0.25
184_R	340_R	0.811	0.25
56_E	320_R	0.807	0.25
125_G	333_D	0.806	0.25
16_D	39_R	0.805	0.25
68_V	78_Q	0.803	0.25
142_F	234_V	0.802	0.25
113_D	274_Y	0.801	0.25
21_V	118_L	0.801	0.25
340_R	349_E	0.800	0.25
249_S	344_T	0.795	0.24
11_E	270_A	0.792	0.24
166_F	217_I	0.792	0.24
18_G	202_T	0.791	0.24
153_T	208_Q	0.790	0.24
170_A	195_D	0.784	0.24
37_G	42_D	0.781	0.24
163_V	175_V	0.781	0.24
196_A	332_P	0.780	0.24
133_L	208_Q	0.779	0.24
256_G	269_N	0.778	0.24
151_Y	341_V	0.775	0.24
281_L	316_L	0.774	0.24
120_Q	255_L	0.774	0.24
11_E	31_Q	0.772	0.24
26_H	294_D	0.772	0.24
89_Y	149_N	0.770	0.23
242_G	246_F	0.769	0.23
100_G	104_V	0.767	0.23
167_D	270_A	0.766	0.23
249_S	351_V	0.766	0.23
98_M	171_H	0.758	0.23
24_I	80_A	0.758	0.23
193_Q	205_E	0.757	0.23
29_D	66_Q	0.756	0.23
43_V	76_V	0.755	0.23
153_T	163_V	0.755	0.23
157_E	321_E	0.754	0.23
244_T	274_Y	0.753	0.23
270_A	337_N	0.752	0.23
40_N	48_T	0.752	0.23
178_A	257_V	0.748	0.23
256_G	365_N	0.748	0.23
77_S	83_V	0.747	0.23
249_S	342_K	0.746	0.22
114_V	321_E	0.746	0.22
69_T	207_G	0.745	0.22
21_V	340_R	0.741	0.22
153_T	200_D	0.739	0.22
319_D	324_V	0.739	0.22
187_V	240_L	0.738	0.22
122_A	257_V	0.737	0.22
277_L	316_L	0.736	0.22
334_H	342_K	0.732	0.22
118_L	237_A	0.731	0.22
192_H	230_V	0.728	0.22
186_D	308_E	0.727	0.22
257_V	313_N	0.725	0.22
173_D	293_H	0.722	0.22
139_A	360_E	0.722	0.22
35_I	248_D	0.722	0.22
13_V	85_R	0.721	0.21
76_V	201_A	0.713	0.21
120_Q	123_R	0.711	0.21
27_E	75_V	0.710	0.21
230_V	333_D	0.709	0.21
218_E	233_D	0.708	0.21
139_A	160_A	0.706	0.21
34_H	314_D	0.705	0.21
129_L	174_H	0.704	0.21
39_R	53_Q	0.704	0.21
268_G	344_T	0.701	0.21
92_V	132_V	0.699	0.21
91_A	94_L	0.698	0.21
247_H	304_A	0.697	0.21
159_D	312_R	0.697	0.21
206_D	311_E	0.694	0.20
6_P	12_Q	0.694	0.20
125_G	334_H	0.692	0.20
15_D	21_V	0.688	0.20
96_D	99_N	0.686	0.20
241_T	289_V	0.686	0.20
31_Q	63_S	0.685	0.20
141_V	162_L	0.685	0.20
128_C	167_D	0.684	0.20
179_A	183_D	0.684	0.20
35_I	204_L	0.682	0.20
74_G	171_H	0.680	0.20
26_H	75_V	0.680	0.20
72_A	313_N	0.679	0.20
79_T	85_R	0.678	0.20
128_C	174_H	0.677	0.20
210_V	232_F	0.676	0.20
153_T	181_L	0.673	0.20
184_R	288_L	0.672	0.20
250_V	277_L	0.671	0.20
73_A	177_G	0.671	0.20
120_Q	291_P	0.668	0.20
196_A	299_E	0.668	0.20
195_D	343_R	0.668	0.20
61_L	321_E	0.666	0.19
136_D	214_R	0.666	0.19
83_V	92_V	0.664	0.19
35_I	48_T	0.664	0.19
129_L	171_H	0.663	0.19
123_R	255_L	0.661	0.19
126_K	334_H	0.660	0.19
35_I	38_S	0.659	0.19
59_D	354_E	0.658	0.19
7_A	21_V	0.657	0.19
341_V	364_N	0.656	0.19
341_V	362_G	0.656	0.19
15_D	214_R	0.653	0.19
68_V	211_T	0.652	0.19
257_V	342_K	0.651	0.19
63_S	89_Y	0.651	0.19
100_G	163_V	0.650	0.19
168_T	284_P	0.650	0.19
52_E	56_E	0.650	0.19
212_V	275_E	0.649	0.19
73_A	76_V	0.649	0.19
79_T	355_E	0.648	0.19
32_E	361_L	0.648	0.19
136_D	321_E	0.647	0.19
177_G	363_P	0.646	0.19
95_T	292_A	0.643	0.19
40_N	45_D	0.640	0.19
102_S	336_P	0.639	0.19
188_P	192_H	0.637	0.18
156_D	321_E	0.636	0.18
228_G	294_D	0.633	0.18
167_D	173_D	0.633	0.18
275_E	279_R	0.633	0.18
207_G	283_R	0.631	0.18
124_P	295_P	0.628	0.18
17_D	352_P	0.628	0.18
209_T	214_R	0.627	0.18
138_E	230_V	0.625	0.18
32_E	47_L	0.625	0.18
154_V	334_H	0.624	0.18
337_N	342_K	0.624	0.18
4_L	160_A	0.623	0.18
197_L	201_A	0.621	0.18
148_L	151_Y	0.619	0.18
175_V	330_D	0.616	0.18
95_T	311_E	0.616	0.18
90_D	282_D	0.616	0.18
251_G	302_V	0.616	0.18
194_K	227_E	0.616	0.18
40_N	47_L	0.614	0.18
157_E	211_T	0.613	0.18
105_H	121_V	0.612	0.18
250_V	316_L	0.612	0.18
15_D	282_D	0.611	0.18
103_R	109_E	0.611	0.18
191_L	200_D	0.610	0.18
94_L	101_W	0.610	0.18
208_Q	355_E	0.609	0.18
148_L	180_D	0.607	0.17
5_S	60_D	0.607	0.17
7_A	308_E	0.604	0.17
67_I	351_V	0.603	0.17
127_G	139_A	0.603	0.17
60_D	193_Q	0.602	0.17
167_D	176_S	0.602	0.17
94_L	160_A	0.601	0.17
146_H	242_G	0.600	0.17
342_K	359_L	0.598	0.17
169_H	172_A	0.598	0.17
169_H	252_R	0.598	0.17
172_A	252_R	0.598	0.17
74_G	100_G	0.597	0.17
240_L	290_L	0.596	0.17
21_V	297_S	0.595	0.17
53_Q	56_E	0.594	0.17
186_D	305_T	0.592	0.17
5_S	152_D	0.592	0.17
29_D	69_T	0.591	0.17
337_N	359_L	0.590	0.17
126_K	203_P	0.590	0.17
137_G	212_V	0.590	0.17
84_L	165_V	0.589	0.17
98_M	129_L	0.589	0.17
336_P	365_N	0.588	0.17
173_D	323_F	0.585	0.17
52_E	89_Y	0.583	0.17
5_S	162_L	0.583	0.17
21_V	198_A	0.582	0.17
28_E	61_L	0.582	0.17
170_A	342_K	0.582	0.17
286_D	305_T	0.582	0.17
214_R	349_E	0.581	0.17
198_A	350_S	0.581	0.17
52_E	327_L	0.581	0.17
128_C	360_E	0.580	0.17
132_V	160_A	0.579	0.17
130_S	151_Y	0.578	0.17
143_D	168_T	0.577	0.17
133_L	220_I	0.577	0.17
276_S	280_L	0.576	0.16
21_V	47_L	0.575	0.16
192_H	195_D	0.574	0.16
44_Y	79_T	0.573	0.16
97_G	245_L	0.573	0.16
119_V	238_A	0.572	0.16
121_V	330_D	0.569	0.16
184_R	210_V	0.568	0.16
229_S	342_K	0.568	0.16
126_K	178_A	0.567	0.16
102_S	346_V	0.567	0.16
17_D	104_V	0.567	0.16
233_D	283_R	0.565	0.16
185_H	350_S	0.564	0.16
306_L	367_A	0.563	0.16
40_N	313_N	0.563	0.16
145_S	165_V	0.563	0.16
241_T	271_A	0.563	0.16
140_A	208_Q	0.563	0.16
295_P	301_P	0.562	0.16
26_H	79_T	0.561	0.16
118_L	238_A	0.560	0.16
18_G	39_R	0.559	0.16
26_H	80_A	0.557	0.16
212_V	235_E	0.553	0.16
31_Q	161_E	0.551	0.16
318_R	326_E	0.549	0.16
9_L	265_D	0.548	0.16
81_T	111_P	0.547	0.16
280_L	331_I	0.547	0.16
246_F	293_H	0.546	0.16
14_Q	124_P	0.545	0.16
159_D	322_A	0.545	0.16
244_T	249_S	0.544	0.16
19_P	216_D	0.543	0.15
150_E	153_T	0.542	0.15
220_I	248_D	0.542	0.15
222_T	229_S	0.542	0.15
174_H	191_L	0.542	0.15
14_Q	159_D	0.540	0.15
88_G	246_F	0.539	0.15
6_P	161_E	0.537	0.15
275_E	308_E	0.536	0.15
151_Y	160_A	0.531	0.15
48_T	73_A	0.531	0.15
166_F	350_S	0.529	0.15
141_V	181_L	0.529	0.15
44_Y	76_V	0.528	0.15
44_Y	91_A	0.527	0.15
114_V	209_T	0.527	0.15
126_K	365_N	0.527	0.15
219_V	305_T	0.527	0.15
233_D	237_A	0.527	0.15
230_V	266_V	0.525	0.15
219_V	232_F	0.525	0.15
214_R	286_D	0.524	0.15
16_D	352_P	0.524	0.15
310_R	336_P	0.519	0.15
68_V	91_A	0.518	0.15
331_I	342_K	0.517	0.15
6_P	298_P	0.517	0.15
15_D	157_E	0.517	0.15
151_Y	253_V	0.516	0.15
28_E	350_S	0.515	0.15
237_A	276_S	0.514	0.15
143_D	226_S	0.514	0.15
323_F	364_N	0.514	0.15
323_F	362_G	0.514	0.15
73_A	201_A	0.514	0.15
276_S	327_L	0.513	0.15
134_V	158_Y	0.513	0.15
52_E	55_I	0.512	0.15
7_A	64_D	0.512	0.15
31_Q	236_G	0.511	0.15
21_V	44_Y	0.509	0.15
78_Q	275_E	0.507	0.14
115_D	222_T	0.507	0.14
126_K	129_L	0.506	0.14
85_R	95_T	0.503	0.14
230_V	249_S	0.503	0.14
253_V	269_N	0.502	0.14
24_I	75_V	0.502	0.14
46_E	80_A	0.502	0.14
239_L	306_L	0.502	0.14
171_H	360_E	0.500	0.14
72_A	354_E	0.500	0.14
157_E	279_R	0.500	0.14

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3tp9A	2	0.6883	100	0.678	Contact Map
4efzA	2	0.664	100	0.701	Contact Map
3r2uA	4	0.6992	100	0.703	Contact Map
4yslA	2	0.6694	100	0.706	Contact Map
4ysbA	2	0.5962	100	0.731	Contact Map
4chlA	2	0.6233	100	0.735	Contact Map
2gcuA	3	0.6206	100	0.739	Contact Map
1qh5A	1	0.5989	100	0.755	Contact Map
2p18A	1	0.6775	100	0.757	Contact Map
2qedA	1	0.5989	100	0.759	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.