O54654 - HALSA - GREMLIN Contacts

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O54654 - Uncharacterized protein

UniProt:	O54654	Sequences: MISQNRLRVLARELGVRQGYAEKNYVNSWILWGIFTSDFGENLMFKGGTALSKLYFPQSWRFSEDLDFGVEGQYNGSEDDLRDVLDTVTERSGIEFTISEHHESRQQHYPTHYVDMSIQYRAVLDHPNTTSLDVMVDEYVAFDSVHHTHSYEDIPEFELQAYSVEEIFAEKLRAIFQRGAARDYYDLYQLLETESVEIEFDVVLPAFEAKCDHDDLDVDLTTGLPGDQREDIQRQWETSLPDLTGDPPLFDTVWKRLDEAVIDKGTE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	267 (250)
Sequences:	1559 (1341)
Seq/√Len:	84.8

HALSA - O54654

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
233_Q	251_D	4.795	1.00
188_Y	256_R	3.711	1.00
168_F	187_L	3.631	1.00
249_L	252_T	3.103	1.00
24_N	53_K	2.973	1.00
50_A	167_I	2.941	1.00
173_R	177_Q	2.780	1.00
192_E	256_R	2.662	1.00
204_L	208_E	2.533	1.00
8_R	11_A	2.467	1.00
162_Y	170_E	2.453	1.00
175_I	187_L	2.409	1.00
230_E	234_R	2.408	1.00
82_R	86_D	2.397	1.00
46_K	170_E	2.370	1.00
69_G	135_M	2.352	1.00
45_F	64_E	2.336	1.00
81_L	84_V	2.334	1.00
54_L	161_A	2.332	1.00
50_A	161_A	2.216	1.00
206_A	210_K	2.215	1.00
138_E	173_R	2.175	1.00
29_W	32_W	2.144	1.00
10_L	21_A	2.104	1.00
255_K	258_D	2.027	1.00
49_T	63_S	2.022	1.00
202_V	206_A	1.985	1.00
174_A	178_R	1.980	1.00
23_K	64_E	1.953	1.00
235_Q	239_S	1.922	1.00
52_S	66_L	1.907	1.00
49_T	64_E	1.888	1.00
203_V	207_F	1.851	1.00
191_L	260_A	1.832	1.00
85_L	88_V	1.832	1.00
24_N	64_E	1.812	1.00
230_E	233_Q	1.793	1.00
80_D	83_D	1.783	1.00
255_K	259_E	1.777	1.00
82_R	85_L	1.776	1.00
172_L	207_F	1.726	1.00
30_I	85_L	1.699	1.00
210_K	214_D	1.698	1.00
83_D	87_T	1.668	1.00
226_G	229_R	1.660	1.00
7_L	124_L	1.657	1.00
52_S	59_S	1.646	1.00
32_W	36_T	1.641	1.00
85_L	89_T	1.631	1.00
232_I	235_Q	1.596	1.00
236_W	239_S	1.524	1.00
219_D	222_T	1.515	1.00
81_L	85_L	1.514	1.00
24_N	27_N	1.505	0.99
10_L	14_L	1.497	0.99
144_S	163_S	1.491	0.99
166_E	178_R	1.478	0.99
165_E	199_E	1.470	0.99
84_V	88_V	1.450	0.99
27_N	66_L	1.449	0.99
150_S	153_D	1.448	0.99
46_K	135_M	1.436	0.99
249_L	258_D	1.418	0.99
199_E	202_V	1.415	0.99
173_R	210_K	1.409	0.99
50_A	63_S	1.401	0.99
45_F	49_T	1.391	0.99
48_G	51_L	1.388	0.99
234_R	237_E	1.354	0.99
32_W	155_P	1.339	0.99
180_A	183_D	1.329	0.99
51_L	64_E	1.327	0.99
63_S	182_R	1.309	0.99
24_N	63_S	1.307	0.99
23_K	27_N	1.279	0.98
234_R	238_T	1.279	0.98
187_L	260_A	1.271	0.98
167_I	170_E	1.262	0.98
147_H	158_E	1.252	0.98
44_M	71_E	1.248	0.98
256_R	259_E	1.245	0.98
232_I	236_W	1.241	0.98
81_L	88_V	1.238	0.98
25_Y	184_Y	1.237	0.98
137_D	162_Y	1.235	0.98
128_N	185_Y	1.232	0.98
166_E	210_K	1.227	0.98
187_L	191_L	1.215	0.98
18_Q	182_R	1.207	0.98
203_V	210_K	1.207	0.98
26_V	128_N	1.205	0.97
209_A	214_D	1.176	0.97
145_V	158_E	1.171	0.97
96_F	99_S	1.156	0.97
82_R	88_V	1.143	0.97
248_P	251_D	1.125	0.96
178_R	182_R	1.124	0.96
49_T	182_R	1.116	0.96
79_D	83_D	1.116	0.96
233_Q	237_E	1.106	0.96
201_D	204_L	1.096	0.96
64_E	182_R	1.090	0.95
33_G	92_S	1.088	0.95
24_N	49_T	1.087	0.95
170_E	173_R	1.078	0.95
247_P	255_K	1.063	0.95
182_R	211_C	1.061	0.95
22_E	120_Y	1.042	0.94
27_N	55_Y	1.040	0.94
169_A	178_R	1.028	0.94
252_T	255_K	1.027	0.94
237_E	241_P	1.026	0.94
94_I	124_L	1.026	0.94
24_N	28_S	1.023	0.94
133_D	236_W	1.022	0.94
203_V	206_A	1.011	0.93
95_E	234_R	1.007	0.93
5_N	9_V	1.006	0.93
237_E	240_L	0.997	0.93
45_F	53_K	0.997	0.93
111_T	114_V	0.983	0.92
221_T	225_P	0.980	0.92
206_A	213_H	0.979	0.92
141_A	209_A	0.978	0.92
167_I	183_D	0.976	0.92
66_L	183_D	0.973	0.92
29_W	33_G	0.972	0.92
51_L	55_Y	0.960	0.91
113_Y	116_M	0.959	0.91
69_G	140_V	0.958	0.91
27_N	52_S	0.955	0.91
85_L	118_I	0.942	0.91
5_N	8_R	0.940	0.90
21_A	184_Y	0.938	0.90
45_F	51_L	0.937	0.90
174_A	184_Y	0.936	0.90
140_V	162_Y	0.935	0.90
237_E	247_P	0.934	0.90
181_A	235_Q	0.932	0.90
174_A	180_A	0.930	0.90
202_V	205_P	0.929	0.90
252_T	256_R	0.924	0.90
141_A	166_E	0.923	0.90
221_T	224_L	0.919	0.89
69_G	210_K	0.915	0.89
70_V	134_V	0.912	0.89
207_F	211_C	0.909	0.89
172_L	187_L	0.909	0.89
21_A	148_T	0.907	0.89
173_R	203_V	0.906	0.89
102_H	105_R	0.903	0.89
116_M	120_Y	0.902	0.89
22_E	166_E	0.898	0.88
26_V	183_D	0.892	0.88
86_D	89_T	0.888	0.88
138_E	162_Y	0.883	0.87
70_V	136_V	0.882	0.87
83_D	86_D	0.876	0.87
23_K	51_L	0.870	0.87
69_G	182_R	0.865	0.86
135_M	170_E	0.862	0.86
52_S	58_Q	0.861	0.86
232_I	239_S	0.849	0.85
29_W	130_T	0.849	0.85
79_D	217_D	0.845	0.85
27_N	64_E	0.844	0.85
28_S	183_D	0.839	0.85
166_E	173_R	0.838	0.85
46_K	142_F	0.837	0.85
201_D	205_P	0.836	0.84
44_M	169_A	0.835	0.84
83_D	90_E	0.834	0.84
168_F	190_L	0.827	0.84
142_F	166_E	0.816	0.83
45_F	62_F	0.816	0.83
166_E	169_A	0.815	0.83
34_I	139_Y	0.813	0.83
220_L	223_G	0.811	0.83
46_K	162_Y	0.809	0.82
90_E	252_T	0.809	0.82
23_K	62_F	0.808	0.82
28_S	53_K	0.806	0.82
9_V	13_E	0.804	0.82
81_L	89_T	0.802	0.82
80_D	84_V	0.799	0.82
24_N	62_F	0.798	0.82
205_P	208_E	0.797	0.82
174_A	177_Q	0.796	0.81
254_W	258_D	0.789	0.81
69_G	170_E	0.789	0.81
83_D	201_D	0.788	0.81
46_K	69_G	0.786	0.81
10_L	13_E	0.784	0.80
81_L	132_L	0.784	0.80
30_I	89_T	0.781	0.80
179_G	203_V	0.778	0.80
44_M	144_S	0.778	0.80
169_A	184_Y	0.774	0.80
200_F	203_V	0.769	0.79
228_Q	231_D	0.768	0.79
46_K	239_S	0.768	0.79
34_I	150_S	0.764	0.79
50_A	166_E	0.762	0.79
226_G	230_E	0.761	0.78
79_D	86_D	0.759	0.78
87_T	123_V	0.758	0.78
102_H	119_Q	0.757	0.78
249_L	255_K	0.757	0.78
99_S	103_E	0.755	0.78
49_T	62_F	0.752	0.78
203_V	214_D	0.751	0.78
162_Y	214_D	0.750	0.77
38_D	87_T	0.749	0.77
162_Y	180_A	0.747	0.77
24_N	45_F	0.747	0.77
29_W	134_V	0.746	0.77
177_Q	210_K	0.743	0.77
52_S	170_E	0.742	0.77
111_T	130_T	0.735	0.76
16_V	23_K	0.733	0.76
226_G	240_L	0.733	0.76
51_L	54_L	0.732	0.76
7_L	152_E	0.732	0.76
40_G	158_E	0.731	0.76
135_M	210_K	0.727	0.75
246_D	258_D	0.727	0.75
249_L	259_E	0.726	0.75
8_R	18_Q	0.726	0.75
25_Y	152_E	0.724	0.75
117_S	131_S	0.723	0.75
39_F	43_L	0.722	0.75
113_Y	120_Y	0.718	0.74
70_V	174_A	0.712	0.74
7_L	11_A	0.711	0.74
89_T	96_F	0.711	0.74
240_L	243_L	0.706	0.73
109_Y	115_D	0.702	0.73
82_R	89_T	0.700	0.72
7_L	182_R	0.698	0.72
115_D	179_G	0.698	0.72
7_L	21_A	0.697	0.72
52_S	64_E	0.692	0.72
79_D	89_T	0.688	0.71
164_V	193_T	0.687	0.71
115_D	133_D	0.681	0.70
251_D	255_K	0.680	0.70
102_H	259_E	0.680	0.70
48_G	61_R	0.679	0.70
42_N	212_D	0.679	0.70
162_Y	166_E	0.678	0.70
177_Q	184_Y	0.677	0.70
217_D	237_E	0.675	0.70
112_H	115_D	0.675	0.70
51_L	220_L	0.672	0.69
137_D	170_E	0.672	0.69
158_E	234_R	0.665	0.69
46_K	236_W	0.664	0.68
227_D	246_D	0.663	0.68
144_S	147_H	0.662	0.68
137_D	214_D	0.661	0.68
209_A	212_D	0.659	0.68
206_A	214_D	0.658	0.68
231_D	238_T	0.654	0.67
8_R	12_R	0.653	0.67
250_F	253_V	0.653	0.67
69_G	178_R	0.653	0.67
136_V	161_A	0.652	0.67
48_G	98_I	0.652	0.67
121_R	127_P	0.652	0.67
164_V	189_Q	0.648	0.67
29_W	92_S	0.645	0.66
32_W	157_F	0.645	0.66
54_L	146_H	0.644	0.66
145_V	201_D	0.639	0.65
191_L	196_V	0.638	0.65
6_R	10_L	0.636	0.65
200_F	204_L	0.633	0.65
63_S	180_A	0.630	0.64
54_L	167_I	0.629	0.64
210_K	213_H	0.620	0.63
22_E	49_T	0.619	0.63
171_K	186_D	0.617	0.63
30_I	133_D	0.616	0.63
229_R	233_Q	0.616	0.63
87_T	90_E	0.616	0.63
174_A	181_A	0.616	0.63
41_E	225_P	0.613	0.62
173_R	183_D	0.613	0.62
114_V	120_Y	0.612	0.62
188_Y	223_G	0.612	0.62
23_K	49_T	0.610	0.62
15_G	201_D	0.609	0.62
79_D	84_V	0.608	0.62
19_G	126_H	0.607	0.62
173_R	211_C	0.601	0.61
22_E	63_S	0.600	0.61
21_A	25_Y	0.598	0.60
201_D	208_E	0.598	0.60
88_V	96_F	0.597	0.60
227_D	258_D	0.597	0.60
22_E	182_R	0.596	0.60
52_S	60_W	0.596	0.60
63_S	133_D	0.594	0.60
34_I	68_F	0.589	0.59
229_R	237_E	0.588	0.59
7_L	242_D	0.587	0.59
90_E	259_E	0.578	0.58
48_G	171_K	0.577	0.58
60_W	245_G	0.577	0.58
29_W	69_G	0.576	0.58
23_K	48_G	0.573	0.57
49_T	120_Y	0.572	0.57
220_L	224_L	0.569	0.57
165_E	168_F	0.568	0.57
12_R	15_G	0.567	0.56
117_S	144_S	0.565	0.56
161_A	178_R	0.563	0.56
61_R	65_D	0.562	0.56
52_S	62_F	0.559	0.55
45_F	50_A	0.559	0.55
11_A	21_A	0.559	0.55
250_F	257_L	0.558	0.55
76_G	87_T	0.558	0.55
79_D	95_E	0.556	0.55
136_V	213_H	0.552	0.54
59_S	68_F	0.548	0.54
139_Y	176_F	0.548	0.54
45_F	63_S	0.548	0.54
55_Y	62_F	0.548	0.54
135_M	138_E	0.547	0.54
95_E	217_D	0.546	0.54
170_E	236_W	0.545	0.53
190_L	202_V	0.545	0.53
16_V	60_W	0.544	0.53
239_S	244_T	0.544	0.53
19_G	122_A	0.543	0.53
149_H	172_L	0.543	0.53
92_S	99_S	0.541	0.53
230_E	237_E	0.539	0.53
204_L	249_L	0.537	0.52
78_E	82_R	0.536	0.52
61_R	67_D	0.536	0.52
114_V	184_Y	0.535	0.52
83_D	98_I	0.533	0.52
113_Y	138_E	0.532	0.52
137_D	206_A	0.531	0.52
149_H	152_E	0.530	0.51
92_S	100_E	0.529	0.51
23_K	130_T	0.529	0.51
127_P	257_L	0.527	0.51
12_R	18_Q	0.526	0.51
42_N	74_Y	0.525	0.51
66_L	148_T	0.523	0.51
230_E	251_D	0.522	0.50
48_G	186_D	0.520	0.50
55_Y	64_E	0.520	0.50
80_D	237_E	0.519	0.50
81_L	201_D	0.519	0.50
47_G	61_R	0.518	0.50
30_I	157_F	0.517	0.50
103_E	215_D	0.517	0.50
256_R	260_A	0.515	0.49
14_L	246_D	0.513	0.49
208_E	259_E	0.513	0.49
25_Y	185_Y	0.512	0.49
251_D	258_D	0.510	0.49
51_L	182_R	0.506	0.48
169_A	183_D	0.506	0.48
176_F	183_D	0.503	0.48
231_D	240_L	0.502	0.48
24_N	66_L	0.502	0.48
37_S	180_A	0.501	0.48
135_M	173_R	0.500	0.47
141_A	202_V	0.500	0.47
83_D	88_V	0.500	0.47

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o8sA	1	0.8015	100	0.511	Contact Map
4ok0A	1	0.7978	100	0.513	Contact Map
4wh5A	2	0.5918	97.6	0.859	Contact Map
2fclA	1	0.5019	97.2	0.868	Contact Map
4wqkA	1	0.603	96.3	0.883	Contact Map
3trkA	1	0.3933	27.7	0.945	Contact Map
2hwkA	1	0.4419	19.1	0.949	Contact Map
4wb7A	1	0.2996	8.4	0.956	Contact Map
2pihA	2	0.2959	5.8	0.959	Contact Map
1y66A	3	0.1199	4.3	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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