GREMLIN Database
O54654 - Uncharacterized protein
UniProt: O54654 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (250)
Sequences: 1559 (1341)
Seq/√Len: 84.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
233_Q251_D4.7951.00
188_Y256_R3.7111.00
168_F187_L3.6311.00
249_L252_T3.1031.00
24_N53_K2.9731.00
50_A167_I2.9411.00
173_R177_Q2.7801.00
192_E256_R2.6621.00
204_L208_E2.5331.00
8_R11_A2.4671.00
162_Y170_E2.4531.00
175_I187_L2.4091.00
230_E234_R2.4081.00
82_R86_D2.3971.00
46_K170_E2.3701.00
69_G135_M2.3521.00
45_F64_E2.3361.00
81_L84_V2.3341.00
54_L161_A2.3321.00
50_A161_A2.2161.00
206_A210_K2.2151.00
138_E173_R2.1751.00
29_W32_W2.1441.00
10_L21_A2.1041.00
255_K258_D2.0271.00
49_T63_S2.0221.00
202_V206_A1.9851.00
174_A178_R1.9801.00
23_K64_E1.9531.00
235_Q239_S1.9221.00
52_S66_L1.9071.00
49_T64_E1.8881.00
203_V207_F1.8511.00
191_L260_A1.8321.00
85_L88_V1.8321.00
24_N64_E1.8121.00
230_E233_Q1.7931.00
80_D83_D1.7831.00
255_K259_E1.7771.00
82_R85_L1.7761.00
172_L207_F1.7261.00
30_I85_L1.6991.00
210_K214_D1.6981.00
83_D87_T1.6681.00
226_G229_R1.6601.00
7_L124_L1.6571.00
52_S59_S1.6461.00
32_W36_T1.6411.00
85_L89_T1.6311.00
232_I235_Q1.5961.00
236_W239_S1.5241.00
219_D222_T1.5151.00
81_L85_L1.5141.00
24_N27_N1.5050.99
10_L14_L1.4970.99
144_S163_S1.4910.99
166_E178_R1.4780.99
165_E199_E1.4700.99
84_V88_V1.4500.99
27_N66_L1.4490.99
150_S153_D1.4480.99
46_K135_M1.4360.99
249_L258_D1.4180.99
199_E202_V1.4150.99
173_R210_K1.4090.99
50_A63_S1.4010.99
45_F49_T1.3910.99
48_G51_L1.3880.99
234_R237_E1.3540.99
32_W155_P1.3390.99
180_A183_D1.3290.99
51_L64_E1.3270.99
63_S182_R1.3090.99
24_N63_S1.3070.99
23_K27_N1.2790.98
234_R238_T1.2790.98
187_L260_A1.2710.98
167_I170_E1.2620.98
147_H158_E1.2520.98
44_M71_E1.2480.98
256_R259_E1.2450.98
232_I236_W1.2410.98
81_L88_V1.2380.98
25_Y184_Y1.2370.98
137_D162_Y1.2350.98
128_N185_Y1.2320.98
166_E210_K1.2270.98
187_L191_L1.2150.98
18_Q182_R1.2070.98
203_V210_K1.2070.98
26_V128_N1.2050.97
209_A214_D1.1760.97
145_V158_E1.1710.97
96_F99_S1.1560.97
82_R88_V1.1430.97
248_P251_D1.1250.96
178_R182_R1.1240.96
49_T182_R1.1160.96
79_D83_D1.1160.96
233_Q237_E1.1060.96
201_D204_L1.0960.96
64_E182_R1.0900.95
33_G92_S1.0880.95
24_N49_T1.0870.95
170_E173_R1.0780.95
247_P255_K1.0630.95
182_R211_C1.0610.95
22_E120_Y1.0420.94
27_N55_Y1.0400.94
169_A178_R1.0280.94
252_T255_K1.0270.94
237_E241_P1.0260.94
94_I124_L1.0260.94
24_N28_S1.0230.94
133_D236_W1.0220.94
203_V206_A1.0110.93
95_E234_R1.0070.93
5_N9_V1.0060.93
237_E240_L0.9970.93
45_F53_K0.9970.93
111_T114_V0.9830.92
221_T225_P0.9800.92
206_A213_H0.9790.92
141_A209_A0.9780.92
167_I183_D0.9760.92
66_L183_D0.9730.92
29_W33_G0.9720.92
51_L55_Y0.9600.91
113_Y116_M0.9590.91
69_G140_V0.9580.91
27_N52_S0.9550.91
85_L118_I0.9420.91
5_N8_R0.9400.90
21_A184_Y0.9380.90
45_F51_L0.9370.90
174_A184_Y0.9360.90
140_V162_Y0.9350.90
237_E247_P0.9340.90
181_A235_Q0.9320.90
174_A180_A0.9300.90
202_V205_P0.9290.90
252_T256_R0.9240.90
141_A166_E0.9230.90
221_T224_L0.9190.89
69_G210_K0.9150.89
70_V134_V0.9120.89
207_F211_C0.9090.89
172_L187_L0.9090.89
21_A148_T0.9070.89
173_R203_V0.9060.89
102_H105_R0.9030.89
116_M120_Y0.9020.89
22_E166_E0.8980.88
26_V183_D0.8920.88
86_D89_T0.8880.88
138_E162_Y0.8830.87
70_V136_V0.8820.87
83_D86_D0.8760.87
23_K51_L0.8700.87
69_G182_R0.8650.86
135_M170_E0.8620.86
52_S58_Q0.8610.86
232_I239_S0.8490.85
29_W130_T0.8490.85
79_D217_D0.8450.85
27_N64_E0.8440.85
28_S183_D0.8390.85
166_E173_R0.8380.85
46_K142_F0.8370.85
201_D205_P0.8360.84
44_M169_A0.8350.84
83_D90_E0.8340.84
168_F190_L0.8270.84
142_F166_E0.8160.83
45_F62_F0.8160.83
166_E169_A0.8150.83
34_I139_Y0.8130.83
220_L223_G0.8110.83
46_K162_Y0.8090.82
90_E252_T0.8090.82
23_K62_F0.8080.82
28_S53_K0.8060.82
9_V13_E0.8040.82
81_L89_T0.8020.82
80_D84_V0.7990.82
24_N62_F0.7980.82
205_P208_E0.7970.82
174_A177_Q0.7960.81
254_W258_D0.7890.81
69_G170_E0.7890.81
83_D201_D0.7880.81
46_K69_G0.7860.81
10_L13_E0.7840.80
81_L132_L0.7840.80
30_I89_T0.7810.80
179_G203_V0.7780.80
44_M144_S0.7780.80
169_A184_Y0.7740.80
200_F203_V0.7690.79
228_Q231_D0.7680.79
46_K239_S0.7680.79
34_I150_S0.7640.79
50_A166_E0.7620.79
226_G230_E0.7610.78
79_D86_D0.7590.78
87_T123_V0.7580.78
102_H119_Q0.7570.78
249_L255_K0.7570.78
99_S103_E0.7550.78
49_T62_F0.7520.78
203_V214_D0.7510.78
162_Y214_D0.7500.77
38_D87_T0.7490.77
162_Y180_A0.7470.77
24_N45_F0.7470.77
29_W134_V0.7460.77
177_Q210_K0.7430.77
52_S170_E0.7420.77
111_T130_T0.7350.76
16_V23_K0.7330.76
226_G240_L0.7330.76
51_L54_L0.7320.76
7_L152_E0.7320.76
40_G158_E0.7310.76
135_M210_K0.7270.75
246_D258_D0.7270.75
249_L259_E0.7260.75
8_R18_Q0.7260.75
25_Y152_E0.7240.75
117_S131_S0.7230.75
39_F43_L0.7220.75
113_Y120_Y0.7180.74
70_V174_A0.7120.74
7_L11_A0.7110.74
89_T96_F0.7110.74
240_L243_L0.7060.73
109_Y115_D0.7020.73
82_R89_T0.7000.72
7_L182_R0.6980.72
115_D179_G0.6980.72
7_L21_A0.6970.72
52_S64_E0.6920.72
79_D89_T0.6880.71
164_V193_T0.6870.71
115_D133_D0.6810.70
251_D255_K0.6800.70
102_H259_E0.6800.70
48_G61_R0.6790.70
42_N212_D0.6790.70
162_Y166_E0.6780.70
177_Q184_Y0.6770.70
217_D237_E0.6750.70
112_H115_D0.6750.70
51_L220_L0.6720.69
137_D170_E0.6720.69
158_E234_R0.6650.69
46_K236_W0.6640.68
227_D246_D0.6630.68
144_S147_H0.6620.68
137_D214_D0.6610.68
209_A212_D0.6590.68
206_A214_D0.6580.68
231_D238_T0.6540.67
8_R12_R0.6530.67
250_F253_V0.6530.67
69_G178_R0.6530.67
136_V161_A0.6520.67
48_G98_I0.6520.67
121_R127_P0.6520.67
164_V189_Q0.6480.67
29_W92_S0.6450.66
32_W157_F0.6450.66
54_L146_H0.6440.66
145_V201_D0.6390.65
191_L196_V0.6380.65
6_R10_L0.6360.65
200_F204_L0.6330.65
63_S180_A0.6300.64
54_L167_I0.6290.64
210_K213_H0.6200.63
22_E49_T0.6190.63
171_K186_D0.6170.63
30_I133_D0.6160.63
229_R233_Q0.6160.63
87_T90_E0.6160.63
174_A181_A0.6160.63
41_E225_P0.6130.62
173_R183_D0.6130.62
114_V120_Y0.6120.62
188_Y223_G0.6120.62
23_K49_T0.6100.62
15_G201_D0.6090.62
79_D84_V0.6080.62
19_G126_H0.6070.62
173_R211_C0.6010.61
22_E63_S0.6000.61
21_A25_Y0.5980.60
201_D208_E0.5980.60
88_V96_F0.5970.60
227_D258_D0.5970.60
22_E182_R0.5960.60
52_S60_W0.5960.60
63_S133_D0.5940.60
34_I68_F0.5890.59
229_R237_E0.5880.59
7_L242_D0.5870.59
90_E259_E0.5780.58
48_G171_K0.5770.58
60_W245_G0.5770.58
29_W69_G0.5760.58
23_K48_G0.5730.57
49_T120_Y0.5720.57
220_L224_L0.5690.57
165_E168_F0.5680.57
12_R15_G0.5670.56
117_S144_S0.5650.56
161_A178_R0.5630.56
61_R65_D0.5620.56
52_S62_F0.5590.55
45_F50_A0.5590.55
11_A21_A0.5590.55
250_F257_L0.5580.55
76_G87_T0.5580.55
79_D95_E0.5560.55
136_V213_H0.5520.54
59_S68_F0.5480.54
139_Y176_F0.5480.54
45_F63_S0.5480.54
55_Y62_F0.5480.54
135_M138_E0.5470.54
95_E217_D0.5460.54
170_E236_W0.5450.53
190_L202_V0.5450.53
16_V60_W0.5440.53
239_S244_T0.5440.53
19_G122_A0.5430.53
149_H172_L0.5430.53
92_S99_S0.5410.53
230_E237_E0.5390.53
204_L249_L0.5370.52
78_E82_R0.5360.52
61_R67_D0.5360.52
114_V184_Y0.5350.52
83_D98_I0.5330.52
113_Y138_E0.5320.52
137_D206_A0.5310.52
149_H152_E0.5300.51
92_S100_E0.5290.51
23_K130_T0.5290.51
127_P257_L0.5270.51
12_R18_Q0.5260.51
42_N74_Y0.5250.51
66_L148_T0.5230.51
230_E251_D0.5220.50
48_G186_D0.5200.50
55_Y64_E0.5200.50
80_D237_E0.5190.50
81_L201_D0.5190.50
47_G61_R0.5180.50
30_I157_F0.5170.50
103_E215_D0.5170.50
256_R260_A0.5150.49
14_L246_D0.5130.49
208_E259_E0.5130.49
25_Y185_Y0.5120.49
251_D258_D0.5100.49
51_L182_R0.5060.48
169_A183_D0.5060.48
176_F183_D0.5030.48
231_D240_L0.5020.48
24_N66_L0.5020.48
37_S180_A0.5010.48
135_M173_R0.5000.47
141_A202_V0.5000.47
83_D88_V0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o8sA 1 0.8015 100 0.511 Contact Map
4ok0A 1 0.7978 100 0.513 Contact Map
4wh5A 2 0.5918 97.6 0.859 Contact Map
2fclA 1 0.5019 97.2 0.868 Contact Map
4wqkA 1 0.603 96.3 0.883 Contact Map
3trkA 1 0.3933 27.7 0.945 Contact Map
2hwkA 1 0.4419 19.1 0.949 Contact Map
4wb7A 1 0.2996 8.4 0.956 Contact Map
2pihA 2 0.2959 5.8 0.959 Contact Map
1y66A 3 0.1199 4.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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