GREMLIN Database
O54648 - Uncharacterized protein
UniProt: O54648 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (348)
Sequences: 963 (775)
Seq/√Len: 41.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_G162_D4.9691.00
68_G72_Q4.5271.00
198_S285_N4.2851.00
324_T329_V4.2111.00
172_L175_R4.0201.00
178_L299_I3.9611.00
73_R76_P3.7661.00
111_I145_A3.6591.00
69_G72_Q3.6381.00
66_S69_G3.3261.00
140_H183_Y3.2121.00
274_E277_D2.7781.00
74_L332_I2.7701.00
199_F266_F2.7151.00
323_D333_L2.7081.00
38_F41_G2.6801.00
110_M175_R2.6041.00
176_L286_L2.5671.00
192_I197_G2.5321.00
87_E152_R2.5001.00
136_G158_E2.4601.00
86_V338_L2.4601.00
108_D175_R2.4331.00
125_D327_E2.3961.00
179_F201_S2.3841.00
298_Q301_R2.3291.00
308_L311_R2.3171.00
49_T296_L2.1921.00
236_D239_R2.1841.00
362_P365_R2.1831.00
203_L207_A2.0130.99
152_R170_S2.0040.99
161_H164_T2.0010.99
30_Q33_V1.9770.99
306_V310_F1.9460.99
31_I81_Y1.9340.99
311_R315_T1.9250.99
93_V346_D1.9120.99
21_G24_E1.8500.98
189_F201_S1.8450.98
79_A331_K1.8390.98
107_S198_S1.8340.98
362_P367_A1.8260.98
153_I338_L1.8080.98
83_R331_K1.7660.98
281_L285_N1.7400.98
361_F366_W1.7380.98
311_R316_Q1.7250.97
209_P242_I1.7170.97
270_G279_Y1.7090.97
110_M151_E1.7030.97
23_V31_I1.6760.97
89_G342_L1.6660.97
284_T296_L1.6470.97
181_L202_R1.6460.97
141_L310_F1.6350.96
199_F285_N1.6260.96
112_A142_L1.6130.96
156_T160_A1.5950.96
140_H156_T1.5730.95
191_R195_N1.5720.95
182_A204_K1.5700.95
19_E84_D1.5670.95
107_S176_L1.5660.95
155_V331_K1.5570.95
184_F207_A1.5520.95
38_F336_A1.5470.95
186_Y207_A1.5410.95
271_V297_A1.5320.95
267_R304_W1.5250.95
34_F73_R1.5070.94
279_Y285_N1.4890.94
277_D284_T1.4820.94
86_V341_L1.4810.94
286_L291_F1.4780.94
364_E369_T1.4770.94
105_R295_D1.4650.93
83_R87_E1.4520.93
34_F74_L1.4400.93
115_T314_K1.4400.93
13_L16_H1.4350.93
34_F77_T1.4330.93
139_L334_L1.3920.91
345_R348_L1.3760.91
190_A194_E1.3730.91
332_I336_A1.3530.90
181_L201_S1.3460.90
171_W177_V1.3370.90
29_L37_A1.3360.90
162_D182_A1.3320.90
32_P36_W1.3290.89
13_L17_A1.3130.89
143_H335_Y1.3040.89
8_F89_G1.3030.88
10_S14_E1.2870.88
20_L23_V1.2780.87
8_F15_E1.2740.87
50_L71_Y1.2720.87
272_R277_D1.2690.87
24_E27_R1.2650.87
113_D307_E1.2620.87
74_L77_T1.2530.86
127_F309_L1.2520.86
74_L333_L1.2400.86
365_R369_T1.2400.86
116_V138_K1.2400.86
291_F296_L1.2340.86
364_E367_A1.2290.85
82_F332_I1.2280.85
49_T53_F1.2190.85
296_L341_L1.2160.85
180_D307_E1.2030.84
315_T343_V1.1940.84
115_T139_L1.1870.83
176_L200_V1.1860.83
312_E345_R1.1800.83
327_E331_K1.1670.82
77_T332_I1.1650.82
23_V27_R1.1580.82
113_D180_D1.1500.81
372_S377_I1.1480.81
150_I309_L1.1460.81
157_D182_A1.1420.81
193_D285_N1.1330.80
274_E306_V1.1250.80
120_H333_L1.1220.80
73_R106_F1.1210.80
119_L137_A1.1200.79
312_E341_L1.1200.79
10_S32_P1.1190.79
364_E370_F1.1190.79
77_T82_F1.1160.79
67_P326_N1.1140.79
84_D159_K1.1130.79
188_R282_Y1.1000.78
273_D280_H1.0960.78
104_D109_V1.0890.78
141_L150_I1.0870.77
200_V299_I1.0840.77
292_F295_D1.0810.77
310_F372_S1.0800.77
110_M142_L1.0760.77
156_T165_L1.0700.76
74_L324_T1.0690.76
142_L151_E1.0680.76
200_V296_L1.0660.76
307_E314_K1.0640.76
179_F182_A1.0540.75
12_F16_H1.0530.75
79_A328_H1.0510.75
167_K188_R1.0490.75
120_H330_V1.0470.75
169_G341_L1.0360.74
57_Y195_N1.0340.74
171_W197_G1.0280.73
144_N181_L1.0270.73
161_H182_A1.0270.73
201_S283_V1.0270.73
268_V286_L1.0260.73
76_P269_V1.0240.73
34_F134_Q1.0220.73
371_R378_L1.0140.72
179_F282_Y1.0110.72
284_T304_W1.0090.72
39_V336_A1.0050.72
324_T333_L1.0030.71
91_D193_D1.0020.71
86_V169_G0.9940.71
6_T284_T0.9920.71
11_E151_E0.9910.71
271_V280_H0.9870.70
104_D339_L0.9840.70
150_I342_L0.9830.70
135_A333_L0.9820.70
31_I77_T0.9810.70
108_D181_L0.9770.69
193_D199_F0.9750.69
70_F311_R0.9700.69
304_W307_E0.9690.69
4_L18_E0.9670.69
79_A83_R0.9650.68
311_R317_Y0.9620.68
138_K285_N0.9620.68
34_F37_A0.9610.68
8_F189_F0.9590.68
74_L134_Q0.9560.68
161_H347_L0.9530.67
22_V81_Y0.9500.67
27_R77_T0.9480.67
363_P366_W0.9440.67
194_E265_R0.9430.67
173_E299_I0.9410.66
185_K324_T0.9410.66
295_D306_V0.9280.65
68_G118_R0.9270.65
38_F324_T0.9230.65
104_D107_S0.9220.65
126_Q331_K0.9170.64
162_D342_L0.9160.64
113_D304_W0.9140.64
180_D314_K0.9130.64
82_F328_H0.9130.64
173_E196_G0.9090.64
241_Y287_S0.9080.64
358_E361_F0.9070.64
216_R382_G0.9050.63
22_V31_I0.9030.63
211_I240_T0.8960.63
7_L12_F0.8950.63
138_K161_H0.8920.62
62_D109_V0.8890.62
309_L317_Y0.8880.62
50_L53_F0.8830.61
77_T181_L0.8820.61
211_I265_R0.8800.61
25_R332_I0.8790.61
358_E363_P0.8730.61
31_I34_F0.8700.60
239_R242_I0.8700.60
101_V105_R0.8690.60
279_Y283_V0.8690.60
80_E194_E0.8680.60
110_M171_W0.8680.60
113_D202_R0.8670.60
25_R30_Q0.8650.60
29_L70_F0.8640.60
82_F173_E0.8600.59
33_V149_T0.8530.59
144_N147_E0.8530.59
110_M177_V0.8520.59
368_A374_A0.8480.58
180_D304_W0.8480.58
34_F71_Y0.8450.58
35_V336_A0.8440.58
85_L292_F0.8440.58
287_S291_F0.8410.58
360_V365_R0.8400.58
319_L337_A0.8360.57
303_R307_E0.8340.57
127_F312_E0.8330.57
180_D300_Y0.8320.57
359_L362_P0.8300.57
152_R349_D0.8300.57
108_D172_L0.8270.56
141_L341_L0.8230.56
104_D299_I0.8180.56
163_S167_K0.8150.55
90_L342_L0.8130.55
202_R304_W0.8130.55
151_E330_V0.8120.55
35_V39_V0.8110.55
373_H376_L0.8060.55
294_A298_Q0.8040.54
267_R307_E0.8000.54
11_E15_E0.7970.54
73_R77_T0.7960.54
15_E292_F0.7950.53
237_L240_T0.7950.53
122_F135_A0.7890.53
312_E316_Q0.7870.53
214_E217_E0.7860.53
248_V298_Q0.7840.52
270_G281_L0.7820.52
103_I306_V0.7800.52
14_E35_V0.7750.52
302_C305_E0.7740.52
118_R136_G0.7720.51
23_V26_D0.7720.51
135_A332_I0.7710.51
113_D303_R0.7690.51
205_Q330_V0.7680.51
311_R314_K0.7680.51
91_D269_V0.7640.51
278_D298_Q0.7640.51
132_E205_Q0.7620.50
142_L177_V0.7590.50
366_W377_I0.7590.50
116_V204_K0.7590.50
312_E330_V0.7570.50
186_Y258_T0.7570.50
110_M172_L0.7550.50
117_L139_L0.7540.50
322_F360_V0.7530.50
365_R368_A0.7520.49
109_V299_I0.7490.49
163_S204_K0.7430.49
8_F49_T0.7430.49
180_D303_R0.7420.49
18_E43_A0.7400.48
153_I168_T0.7390.48
29_L33_V0.7380.48
379_H382_G0.7370.48
136_G162_D0.7360.48
340_S369_T0.7310.48
203_L206_N0.7300.47
84_D88_H0.7290.47
130_R134_Q0.7290.47
271_V282_Y0.7280.47
14_E85_L0.7220.47
293_P329_V0.7220.47
12_F88_H0.7210.47
365_R374_A0.7190.46
296_L310_F0.7190.46
37_A50_L0.7180.46
10_S13_L0.7170.46
166_F188_R0.7160.46
68_G71_Y0.7140.46
107_S291_F0.7130.46
140_H333_L0.7120.46
16_H88_H0.7100.46
362_P366_W0.7100.46
35_V82_F0.7090.45
301_R328_H0.7080.45
9_P14_E0.7070.45
80_E83_R0.7040.45
116_V166_F0.7040.45
204_K334_L0.7030.45
92_E293_P0.7030.45
49_T208_N0.6990.45
123_L325_S0.6970.44
196_G292_F0.6950.44
209_P268_V0.6940.44
114_G136_G0.6920.44
12_F92_E0.6920.44
361_F370_F0.6900.44
287_S348_L0.6890.44
284_T300_Y0.6890.44
122_F325_S0.6860.43
173_E260_S0.6850.43
128_E167_K0.6850.43
295_D345_R0.6850.43
124_A128_E0.6810.43
202_R307_E0.6810.43
282_Y285_N0.6780.43
330_V356_D0.6770.43
155_V334_L0.6770.43
143_H152_R0.6740.42
121_E135_A0.6740.42
81_Y85_L0.6730.42
187_R338_L0.6730.42
178_L193_D0.6720.42
369_T375_Q0.6710.42
158_E344_S0.6710.42
269_V282_Y0.6710.42
182_A267_R0.6700.42
309_L341_L0.6690.42
141_L334_L0.6680.42
183_Y343_V0.6670.42
284_T307_E0.6670.42
134_Q158_E0.6650.41
111_I332_I0.6610.41
9_P12_F0.6590.41
317_Y344_S0.6580.41
82_F102_D0.6580.41
189_F207_A0.6570.41
138_K158_E0.6570.41
360_V367_A0.6560.41
366_W372_S0.6560.41
134_Q333_L0.6560.41
299_I317_Y0.6550.41
153_I215_L0.6540.40
280_H320_D0.6540.40
290_E294_A0.6530.40
189_F328_H0.6530.40
155_V294_A0.6530.40
146_T302_C0.6520.40
28_K33_V0.6510.40
68_G186_Y0.6490.40
138_K150_I0.6470.40
26_D35_V0.6470.40
160_A173_E0.6450.40
108_D144_N0.6440.40
206_N350_L0.6400.39
126_Q129_A0.6400.39
14_E265_R0.6370.39
75_T326_N0.6360.39
20_L81_Y0.6350.39
293_P297_A0.6340.39
16_H37_A0.6330.39
4_L347_L0.6320.38
73_R329_V0.6290.38
347_L351_V0.6280.38
77_T342_L0.6270.38
47_R109_V0.6270.38
6_T10_S0.6260.38
128_E294_A0.6250.38
140_H162_D0.6240.38
181_L204_K0.6230.38
175_R192_I0.6220.38
14_E155_V0.6220.38
39_V340_S0.6180.37
132_E141_L0.6170.37
182_A203_L0.6150.37
110_M269_V0.6140.37
89_G150_I0.6120.37
55_R64_P0.6120.37
297_A317_Y0.6120.37
175_R351_V0.6100.37
53_F336_A0.6100.37
22_V73_R0.6100.37
362_P368_A0.6090.36
212_T242_I0.6090.36
199_F315_T0.6090.36
91_D249_E0.6080.36
27_R176_L0.6080.36
151_E350_L0.6070.36
101_V109_V0.6060.36
182_A308_L0.6030.36
131_H199_F0.6020.36
274_E281_L0.6010.36
138_K363_P0.5990.36
72_Q286_L0.5990.36
24_E31_I0.5980.36
240_T298_Q0.5950.35
366_W370_F0.5950.35
165_L271_V0.5940.35
112_A166_F0.5940.35
161_H181_L0.5920.35
171_W295_D0.5920.35
110_M162_D0.5870.35
29_L69_G0.5870.35
85_L338_L0.5860.34
5_T36_W0.5850.34
273_D349_D0.5840.34
107_S332_I0.5830.34
189_F199_F0.5820.34
273_D277_D0.5810.34
5_T8_F0.5810.34
82_F336_A0.5800.34
199_F271_V0.5800.34
367_A374_A0.5790.34
182_A344_S0.5750.34
142_L186_Y0.5740.33
88_H212_T0.5730.33
16_H84_D0.5730.33
71_Y329_V0.5730.33
132_E263_T0.5730.33
55_R164_T0.5700.33
22_V34_F0.5670.33
300_Y304_W0.5670.33
128_E133_E0.5670.33
162_D180_D0.5650.33
65_I119_L0.5650.33
179_F192_I0.5650.33
324_T330_V0.5620.32
25_R66_S0.5610.32
33_V36_W0.5600.32
117_L334_L0.5580.32
86_V90_L0.5560.32
204_K242_I0.5560.32
120_H135_A0.5550.32
317_Y371_R0.5550.32
74_L104_D0.5550.32
111_I201_S0.5540.32
66_S192_I0.5540.32
34_F332_I0.5540.32
112_A179_F0.5500.32
15_E18_E0.5470.31
53_F58_N0.5470.31
181_L207_A0.5470.31
68_G340_S0.5460.31
189_F262_D0.5460.31
369_T379_H0.5450.31
150_I185_K0.5420.31
128_E309_L0.5420.31
358_E362_P0.5410.31
173_E249_E0.5400.31
14_E18_E0.5400.31
74_L106_F0.5390.31
8_F35_V0.5390.31
113_D314_K0.5390.31
85_L339_L0.5390.31
12_F248_V0.5370.30
71_Y287_S0.5370.30
153_I335_Y0.5370.30
155_V208_N0.5370.30
117_L311_R0.5360.30
109_V382_G0.5350.30
54_R70_F0.5350.30
325_S333_L0.5330.30
363_P369_T0.5330.30
42_F329_V0.5330.30
41_G70_F0.5330.30
65_I208_N0.5330.30
317_Y367_A0.5320.30
108_D151_E0.5320.30
9_P85_L0.5300.30
138_K325_S0.5300.30
145_A299_I0.5280.30
360_V368_A0.5250.30
61_A212_T0.5250.30
19_E22_V0.5250.30
89_G339_L0.5220.29
206_N271_V0.5220.29
44_A313_L0.5200.29
127_F331_K0.5190.29
357_D360_V0.5190.29
41_G332_I0.5180.29
288_R291_F0.5170.29
201_S328_H0.5160.29
27_R345_R0.5160.29
20_L152_R0.5150.29
149_T346_D0.5140.29
104_D198_S0.5130.29
265_R374_A0.5130.29
174_N197_G0.5120.29
45_G73_R0.5120.29
113_D284_T0.5110.28
39_V296_L0.5110.28
40_F112_A0.5100.28
162_D323_D0.5100.28
115_T248_V0.5090.28
205_Q210_V0.5080.28
115_T182_A0.5060.28
83_R171_W0.5040.28
208_N283_V0.5020.28
73_R185_K0.5010.28
78_L197_G0.5010.28
174_N269_V0.5010.28
183_Y318_D0.5010.28
139_L302_C0.5000.28
49_T68_G0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8137 100 0.707 Contact Map
2kycA 1 0.2476 19.4 0.967 Contact Map
1rroA 1 0.2476 18.8 0.968 Contact Map
1w7jB 1 0.2476 17.2 0.968 Contact Map
3pm8A 2 0.2571 15.1 0.969 Contact Map
4ociA 2 0.2689 15.1 0.969 Contact Map
1m45A 1 0.2524 13.8 0.969 Contact Map
4mvfA 1 0.2594 12.6 0.97 Contact Map
1rwyA 1 0.25 12.4 0.97 Contact Map
1s1eA 1 0.3019 12.3 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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