GREMLIN Database
O54647 - Uncharacterized protein
UniProt: O54647 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (359)
Sequences: 438 (284)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_I81_V6.1541.00
88_G107_H5.1581.00
171_A178_L4.8841.00
182_L252_Y4.2061.00
325_A329_E4.1941.00
157_I260_A4.0631.00
42_Y54_S3.4080.99
93_F97_T3.3840.99
242_T251_S3.3780.99
182_L230_F3.3610.99
226_D239_A3.3300.99
326_P329_E2.9210.97
149_Y176_V2.9010.97
180_Y206_I2.8880.97
302_D328_G2.8070.97
268_E312_S2.7790.96
110_D114_G2.7390.96
42_Y47_I2.6520.95
133_L148_L2.6470.95
312_S335_D2.5710.95
346_D350_S2.5580.94
148_L157_I2.5160.94
287_R341_E2.4590.93
82_T88_G2.3800.92
318_A322_T2.3250.91
60_F89_G2.2240.89
132_T174_L2.2220.89
88_G92_E2.1760.88
22_K139_P2.1040.86
249_M271_A2.0910.85
147_L178_L2.0500.84
156_I171_A2.0130.83
373_D376_E1.9970.83
168_L200_E1.9630.82
229_T236_T1.9330.80
251_S264_G1.9150.80
242_T292_S1.9130.80
16_V88_G1.9110.80
84_L108_L1.8800.79
194_V205_V1.8550.78
187_H190_H1.8500.77
22_K26_D1.8140.76
178_L230_F1.8080.76
60_F63_L1.7790.74
133_L260_A1.7680.74
330_L337_L1.7440.73
160_L167_Y1.7240.72
89_G94_V1.6850.70
16_V107_H1.6730.70
273_P362_I1.6570.69
33_L49_G1.6560.69
299_T343_A1.6530.69
41_D76_P1.6490.69
18_P88_G1.6480.69
82_T107_H1.6450.68
155_A182_L1.6220.67
140_S162_A1.6140.67
291_E341_E1.6010.66
22_K25_I1.5890.66
88_G103_Y1.5850.65
183_D187_H1.5800.65
89_G113_N1.5780.65
181_A239_A1.5610.64
116_A141_S1.5450.63
339_M347_L1.5240.62
47_I84_L1.5150.62
153_E179_Q1.5140.62
239_A250_T1.5120.62
73_D254_V1.5100.62
382_L389_A1.5090.61
249_M264_G1.4920.61
59_Y63_L1.4860.60
82_T108_L1.4790.60
165_D295_E1.4630.59
81_V103_Y1.4620.59
136_Y170_D1.4600.59
39_T43_E1.4520.58
191_I338_T1.4460.58
81_V329_E1.4300.57
224_A239_A1.4270.57
59_Y64_E1.4240.57
318_A325_A1.4160.56
141_S271_A1.4160.56
16_V30_D1.4110.56
208_E250_T1.3810.54
38_M59_Y1.3610.53
41_D107_H1.3560.53
204_G222_T1.3550.53
86_A90_A1.3530.53
268_E335_D1.3490.53
133_L174_L1.3420.52
92_E107_H1.3390.52
123_E126_G1.3350.52
183_D190_H1.3250.51
165_D231_D1.3240.51
112_M142_G1.3160.51
41_D54_S1.3120.51
142_G381_E1.3000.50
53_T79_R1.2980.50
156_I159_P1.2720.48
197_L325_A1.2630.48
60_F94_V1.2530.47
88_G109_E1.2520.47
184_T359_Y1.2520.47
101_R348_V1.2500.47
45_W112_M1.2470.47
208_E363_I1.2420.47
157_I252_Y1.2370.46
361_D376_E1.2320.46
42_Y46_H1.2200.45
30_D256_D1.2080.45
25_I31_V1.2010.44
24_R29_E1.2000.44
286_A345_V1.1960.44
84_L165_D1.1910.44
71_V75_I1.1900.44
28_G103_Y1.1900.44
208_E353_P1.1770.43
30_D104_D1.1700.43
383_G387_C1.1670.43
24_R80_E1.1630.42
325_A333_E1.1600.42
242_T264_G1.1560.42
175_G256_D1.1530.42
41_D237_I1.1490.42
283_P286_A1.1470.41
224_A307_G1.1470.41
175_G191_I1.1460.41
140_S249_M1.1460.41
247_T284_D1.1410.41
325_A335_D1.1390.41
264_G271_A1.1370.41
112_M143_C1.1310.41
22_K120_D1.1270.40
17_D109_E1.1200.40
157_I182_L1.1120.40
82_T106_D1.1090.39
59_Y89_G1.1060.39
202_I329_E1.1040.39
208_E211_V1.1030.39
300_L304_T1.1000.39
91_S110_D1.0990.39
276_E285_A1.0900.38
29_E373_D1.0900.38
57_V376_E1.0860.38
214_G364_A1.0850.38
284_D365_T1.0840.38
160_L197_L1.0820.38
202_I371_A1.0820.38
181_A260_A1.0780.38
134_L170_D1.0780.38
164_T200_E1.0770.38
207_P212_D1.0750.38
21_L95_A1.0720.37
140_S145_G1.0680.37
175_G220_D1.0650.37
157_I254_V1.0640.37
246_T274_D1.0600.37
104_D231_D1.0560.37
140_S224_A1.0510.36
168_L201_D1.0490.36
249_M289_L1.0440.36
229_T239_A1.0430.36
381_E384_P1.0420.36
20_S133_L1.0410.36
164_T235_A1.0320.35
59_Y248_G1.0270.35
82_T341_E1.0240.35
205_V307_G1.0240.35
148_L240_V1.0230.35
160_L325_A1.0180.35
103_Y107_H1.0080.34
269_S293_L1.0070.34
16_V206_I1.0040.34
34_L62_F0.9990.34
23_D286_A0.9970.34
181_A194_V0.9960.34
159_P378_F0.9960.34
16_V82_T0.9900.33
59_Y94_V0.9850.33
26_D278_G0.9830.33
89_G93_F0.9800.33
275_L362_I0.9760.33
56_N64_E0.9760.33
87_K105_V0.9760.33
379_T384_P0.9740.32
214_G369_Q0.9720.32
317_P323_Y0.9680.32
16_V19_E0.9670.32
135_Q138_R0.9660.32
312_S325_A0.9660.32
60_F90_A0.9510.31
228_D234_D0.9510.31
148_L236_T0.9500.31
166_R178_L0.9480.31
91_S107_H0.9450.31
211_V363_I0.9420.31
267_I335_D0.9420.31
41_D80_E0.9360.31
298_L337_L0.9350.31
28_G55_I0.9270.30
165_D178_L0.9260.30
156_I197_L0.9260.30
99_A105_V0.9250.30
173_N199_E0.9210.30
318_A335_D0.9150.30
175_G332_D0.9150.30
182_L237_I0.9140.30
43_E229_T0.9140.30
76_P248_G0.9130.30
150_D328_G0.9110.29
21_L82_T0.9110.29
237_I309_A0.9110.29
39_T165_D0.9090.29
143_C187_H0.9040.29
27_A33_L0.9040.29
103_Y165_D0.9030.29
277_E285_A0.9010.29
212_D248_G0.8990.29
267_I312_S0.8940.29
297_V380_L0.8860.28
111_G115_W0.8840.28
79_R99_A0.8830.28
31_V82_T0.8800.28
248_G334_M0.8790.28
133_L283_P0.8740.28
53_T157_I0.8720.28
113_N375_E0.8710.28
72_L81_V0.8670.27
30_D222_T0.8640.27
104_D343_A0.8620.27
292_S311_F0.8580.27
232_V291_E0.8560.27
77_D81_V0.8550.27
30_D78_D0.8500.27
25_I254_V0.8480.27
383_G388_A0.8480.27
385_N388_A0.8480.27
246_T273_P0.8480.27
148_L228_D0.8480.27
32_T62_F0.8470.27
56_N78_D0.8460.26
347_L389_A0.8430.26
270_V293_L0.8400.26
239_A326_P0.8380.26
80_E332_D0.8360.26
23_D73_D0.8340.26
200_E361_D0.8320.26
169_D172_D0.8280.26
116_A384_P0.8280.26
276_E357_A0.8270.26
39_T251_S0.8260.26
211_V214_G0.8160.25
93_F99_A0.8130.25
169_D228_D0.8110.25
114_G179_Q0.8090.25
159_P167_Y0.7980.24
133_L155_A0.7960.24
311_F334_M0.7940.24
162_A378_F0.7920.24
17_D74_Q0.7910.24
242_T290_Y0.7900.24
277_E334_M0.7840.24
57_V71_V0.7820.24
94_V202_I0.7800.24
140_S195_R0.7790.24
23_D43_E0.7790.24
252_Y301_P0.7780.24
140_S354_P0.7770.24
200_E230_F0.7770.24
21_L254_V0.7740.23
283_P295_E0.7730.23
34_L104_D0.7710.23
59_Y86_A0.7690.23
222_T296_R0.7690.23
264_G290_Y0.7660.23
135_Q308_G0.7650.23
19_E329_E0.7630.23
45_W143_C0.7590.23
18_P177_D0.7590.23
27_A234_D0.7570.23
169_D197_L0.7570.23
43_E88_G0.7560.23
164_T167_Y0.7540.23
32_T76_P0.7520.23
25_I315_A0.7500.22
186_V363_I0.7490.22
184_T301_P0.7480.22
200_E305_L0.7470.22
188_A272_R0.7430.22
58_P368_G0.7410.22
110_D113_N0.7410.22
293_L337_L0.7400.22
17_D178_L0.7380.22
23_D371_A0.7380.22
262_G266_F0.7370.22
167_Y362_I0.7370.22
250_T354_P0.7370.22
39_T56_N0.7360.22
81_V372_V0.7340.22
177_D374_D0.7340.22
60_F93_F0.7340.22
312_S320_D0.7340.22
28_G373_D0.7340.22
179_Q191_I0.7340.22
154_A176_V0.7330.22
109_E309_A0.7330.22
112_M116_A0.7300.22
155_A228_D0.7240.21
186_V248_G0.7240.21
340_D345_V0.7240.21
240_V335_D0.7220.21
165_D341_E0.7200.21
59_Y62_F0.7190.21
255_D269_S0.7170.21
234_D303_D0.7170.21
189_D310_H0.7150.21
43_E234_D0.7150.21
40_S47_I0.7150.21
269_S363_I0.7140.21
83_V227_G0.7130.21
141_S223_T0.7110.21
88_G187_H0.7100.21
61_E76_P0.7090.21
43_E236_T0.7080.21
56_N334_M0.7080.21
209_A225_A0.7080.21
264_G269_S0.7060.21
82_T92_E0.7040.21
36_A41_D0.7030.21
33_L133_L0.6990.21
16_V103_Y0.6970.20
38_M311_F0.6970.20
286_A358_N0.6950.20
274_D285_A0.6930.20
62_F91_S0.6930.20
74_Q240_V0.6930.20
108_L176_V0.6880.20
46_H335_D0.6810.20
75_I342_Q0.6810.20
254_V260_A0.6770.20
149_Y174_L0.6740.20
285_A334_M0.6710.20
90_A221_M0.6700.20
40_S75_I0.6690.19
267_I318_A0.6670.19
21_L261_T0.6660.19
34_L145_G0.6660.19
18_P164_T0.6660.19
116_A357_A0.6650.19
274_D277_E0.6640.19
254_V261_T0.6620.19
63_L89_G0.6610.19
26_D33_L0.6590.19
142_G154_A0.6590.19
99_A124_V0.6590.19
98_L115_W0.6590.19
145_G271_A0.6580.19
25_I99_A0.6570.19
148_L235_A0.6570.19
138_R308_G0.6560.19
209_A343_A0.6540.19
104_D370_N0.6540.19
113_N240_V0.6520.19
203_E260_A0.6510.19
361_D370_N0.6500.19
179_Q229_T0.6490.19
63_L237_I0.6480.19
93_F376_E0.6480.19
44_E382_L0.6470.19
143_C183_D0.6470.19
86_A89_G0.6460.19
168_L222_T0.6450.19
267_I325_A0.6440.19
98_L102_D0.6440.19
43_E77_D0.6430.19
204_G291_E0.6420.19
39_T89_G0.6420.19
143_C190_H0.6410.19
153_E250_T0.6410.19
228_D256_D0.6400.18
183_D189_D0.6390.18
38_M89_G0.6390.18
156_I178_L0.6380.18
133_L258_L0.6370.18
93_F96_G0.6360.18
112_M187_H0.6340.18
234_D319_A0.6330.18
88_G108_L0.6320.18
140_S355_R0.6290.18
31_V63_L0.6270.18
104_D224_A0.6260.18
175_G333_E0.6260.18
88_G106_D0.6250.18
312_S318_A0.6250.18
147_L176_V0.6250.18
183_D286_A0.6240.18
274_D362_I0.6220.18
45_W142_G0.6190.18
106_D129_G0.6160.18
201_D256_D0.6140.18
381_E387_C0.6110.18
194_V277_E0.6100.17
130_A292_S0.6100.17
87_K193_G0.6100.17
116_A144_L0.6090.17
186_V211_V0.6080.17
57_V99_A0.6060.17
147_L235_A0.6060.17
135_Q275_L0.6060.17
238_E253_L0.6050.17
133_L332_D0.6020.17
75_I80_E0.6000.17
33_L60_F0.5990.17
27_A299_T0.5980.17
45_W154_A0.5970.17
38_M41_D0.5970.17
21_L27_A0.5970.17
27_A257_S0.5960.17
173_N231_D0.5950.17
160_L181_A0.5930.17
169_D220_D0.5910.17
17_D168_L0.5900.17
23_D27_A0.5890.17
196_N374_D0.5890.17
141_S355_R0.5880.17
36_A94_V0.5870.17
87_K90_A0.5860.17
355_R363_I0.5860.17
20_S28_G0.5860.17
265_L276_E0.5860.17
99_A109_E0.5840.17
60_F87_K0.5840.17
28_G172_D0.5840.17
47_I268_E0.5840.17
33_L361_D0.5820.17
223_T326_P0.5820.17
169_D179_Q0.5810.17
35_D111_G0.5790.17
17_D43_E0.5790.17
76_P107_H0.5760.16
271_A307_G0.5760.16
261_T287_R0.5750.16
60_F64_E0.5750.16
125_E133_L0.5750.16
227_G300_L0.5740.16
112_M381_E0.5740.16
30_D55_I0.5740.16
221_M296_R0.5730.16
156_I315_A0.5730.16
18_P82_T0.5720.16
226_D332_D0.5710.16
145_G167_Y0.5700.16
141_S323_Y0.5700.16
144_L190_H0.5700.16
31_V252_Y0.5680.16
43_E104_D0.5630.16
122_V350_S0.5630.16
33_L314_A0.5620.16
276_E386_N0.5600.16
134_L258_L0.5580.16
365_T370_N0.5570.16
56_N59_Y0.5570.16
125_E196_N0.5560.16
55_I230_F0.5560.16
381_E386_N0.5560.16
116_A271_A0.5550.16
145_G307_G0.5550.16
188_A366_N0.5530.16
272_R366_N0.5530.16
55_I74_Q0.5520.16
47_I63_L0.5490.16
48_D58_P0.5480.16
75_I152_G0.5480.16
38_M94_V0.5480.16
357_A362_I0.5480.16
144_L187_H0.5480.16
201_D204_G0.5480.16
271_A323_Y0.5460.16
273_P355_R0.5450.15
73_D173_N0.5440.15
157_I298_L0.5430.15
112_M144_L0.5430.15
183_D192_S0.5420.15
227_G304_T0.5420.15
260_A307_G0.5410.15
173_N342_Q0.5400.15
190_H207_P0.5390.15
242_T249_M0.5380.15
172_D256_D0.5370.15
62_F207_P0.5370.15
72_L76_P0.5370.15
299_T370_N0.5370.15
195_R199_E0.5360.15
331_V357_A0.5350.15
31_V236_T0.5350.15
231_D375_E0.5320.15
17_D343_A0.5320.15
230_F371_A0.5320.15
26_D197_L0.5310.15
273_P344_F0.5310.15
100_E156_I0.5300.15
315_A342_Q0.5290.15
18_P118_I0.5290.15
203_E348_V0.5280.15
75_I309_A0.5280.15
253_L300_L0.5260.15
91_S215_I0.5240.15
16_V77_D0.5240.15
31_V88_G0.5240.15
39_T292_S0.5230.15
73_D76_P0.5220.15
86_A334_M0.5220.15
226_D238_E0.5200.15
38_M93_F0.5190.15
292_S372_V0.5190.15
17_D159_P0.5180.15
88_G114_G0.5180.15
84_L252_Y0.5180.15
172_D260_A0.5180.15
156_I313_D0.5170.15
155_A322_T0.5170.15
87_K221_M0.5130.15
322_T334_M0.5120.15
81_V337_L0.5120.15
116_A323_Y0.5110.15
30_D346_D0.5110.15
145_G170_D0.5080.14
142_G187_H0.5080.14
27_A81_V0.5070.14
17_D299_T0.5060.14
77_D103_Y0.5060.14
165_D169_D0.5050.14
111_G135_Q0.5040.14
110_D172_D0.5040.14
200_E333_E0.5020.14
335_D339_M0.5000.14
212_D353_P0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tp9A 2 0.6725 100 0.696 Contact Map
4efzA 2 0.6348 100 0.713 Contact Map
4yslA 2 0.6398 100 0.721 Contact Map
3r2uA 4 0.6776 100 0.722 Contact Map
4chlA 2 0.5819 100 0.743 Contact Map
4ysbA 2 0.5592 100 0.744 Contact Map
2gcuA 3 0.5819 100 0.75 Contact Map
1qh5A 1 0.5693 100 0.762 Contact Map
2qedA 1 0.5668 100 0.776 Contact Map
1xm8A 1 0.5693 100 0.778 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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