O54644 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

O54644 - Uncharacterized protein

UniProt:	O54644	Sequences: MADCDDLSYAAFHDWFEPGFVALLREILDDAIENLDTGRADLSGRLERFRDVLIADATIVSLYQDAADVYAATGEDQAELKLHLIESLSTGLPTRFRTTDGTTHERSQLPTGEWVADALILLDLGFYDFWLFDRIDQNGGWFVSRVKDNANFEIVEELRTWRGNSIPLEGESLQAVLDDLQRQEIDVRITLSFERKRGSGASATRTFRLVGLRNEETEEYHLYLTNLGNDDYSAPDIAQLYRARWEVELLFKGGCHRTSSTPKSRVNAEVDESSDPAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	278 (241)
Sequences:	1150 (941)
Seq/√Len:	60.6

ECOLI - INSG INSL1 INSL2 INSL3 YCHG
HALSA - O54644 Q9HI01 O51972 O54648 O51966 O52023 Q9HI34

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_W	226_N	5.001	1.00
266_V	271_D	4.594	1.00
57_A	105_E	4.434	1.00
175_A	178_D	3.731	1.00
121_L	240_L	3.701	1.00
11_A	14_D	3.635	1.00
8_S	11_A	3.392	1.00
10_A	14_D	3.285	1.00
79_E	101_G	3.263	1.00
83_H	126_F	3.197	1.00
54_I	88_L	3.067	1.00
15_W	18_P	2.998	1.00
265_R	275_D	2.948	1.00
142_F	207_F	2.773	1.00
135_I	140_G	2.418	1.00
142_F	226_N	2.410	1.00
83_H	99_T	2.351	1.00
115_V	118_A	2.272	1.00
227_L	232_Y	2.164	1.00
119_L	227_L	2.156	1.00
51_D	118_A	2.131	1.00
249_L	252_K	2.083	1.00
252_K	257_R	2.053	1.00
122_L	144_S	1.964	1.00
212_L	238_A	1.964	1.00
53_L	118_A	1.932	1.00
21_V	273_S	1.907	1.00
239_Q	242_R	1.901	1.00
211_G	220_Y	1.886	1.00
223_Y	237_I	1.863	1.00
53_L	94_T	1.857	1.00
146_V	150_A	1.831	1.00
29_D	95_R	1.805	1.00
252_K	258_T	1.771	0.99
247_V	251_F	1.739	0.99
16_F	274_S	1.738	0.99
25_R	273_S	1.732	0.99
214_N	217_T	1.730	0.99
157_E	160_T	1.692	0.99
59_I	81_K	1.678	0.99
19_G	24_L	1.666	0.99
132_F	144_S	1.664	0.99
50_R	141_W	1.645	0.99
269_E	273_S	1.642	0.99
104_H	107_S	1.636	0.99
136_D	226_N	1.626	0.99
129_F	150_A	1.607	0.99
55_A	85_I	1.605	0.99
25_R	29_D	1.602	0.99
124_L	144_S	1.562	0.99
214_N	221_H	1.525	0.98
99_T	103_T	1.514	0.98
16_F	19_G	1.512	0.98
212_L	221_H	1.477	0.98
233_S	236_D	1.467	0.98
84_L	251_F	1.440	0.98
127_Y	150_A	1.430	0.97
50_R	119_L	1.417	0.97
15_W	19_G	1.414	0.97
110_P	131_L	1.414	0.97
124_L	145_R	1.379	0.97
24_L	270_V	1.362	0.97
143_V	240_L	1.357	0.97
10_A	13_H	1.355	0.97
221_H	238_A	1.344	0.96
172_S	175_A	1.341	0.96
81_K	101_G	1.334	0.96
136_D	142_F	1.305	0.96
179_D	206_T	1.294	0.95
26_E	30_D	1.285	0.95
123_D	248_E	1.278	0.95
119_L	143_V	1.254	0.95
98_T	273_S	1.242	0.94
244_R	248_E	1.226	0.94
28_L	32_I	1.210	0.93
19_G	274_S	1.206	0.93
152_F	178_D	1.203	0.93
248_E	251_F	1.199	0.93
153_E	179_D	1.194	0.93
22_A	25_R	1.185	0.93
248_E	256_H	1.183	0.93
144_S	224_L	1.177	0.93
211_G	222_L	1.168	0.92
171_E	176_V	1.167	0.92
95_R	113_E	1.164	0.92
215_E	247_V	1.155	0.92
52_V	240_L	1.151	0.92
24_L	274_S	1.132	0.91
125_G	147_K	1.128	0.91
73_T	272_E	1.119	0.90
177_L	206_T	1.108	0.90
253_G	258_T	1.100	0.90
114_W	236_D	1.100	0.90
109_L	131_L	1.097	0.90
159_R	216_E	1.094	0.89
171_E	174_Q	1.091	0.89
68_D	269_E	1.087	0.89
21_V	270_V	1.069	0.88
58_T	82_L	1.065	0.88
268_A	271_D	1.059	0.88
47_E	52_V	1.053	0.88
99_T	108_Q	1.045	0.87
93_P	250_L	1.040	0.87
251_F	260_S	1.038	0.87
51_D	87_S	1.029	0.86
65_D	78_A	1.027	0.86
23_L	84_L	1.017	0.86
28_L	112_G	1.013	0.86
253_G	272_E	1.011	0.85
53_L	85_I	1.011	0.85
21_V	25_R	1.007	0.85
183_Q	198_G	1.003	0.85
266_V	275_D	0.994	0.84
232_Y	237_I	0.985	0.84
28_L	109_L	0.979	0.84
116_A	139_G	0.976	0.83
146_V	149_N	0.971	0.83
134_R	138_N	0.969	0.83
51_D	115_V	0.965	0.83
208_R	245_W	0.963	0.82
174_Q	178_D	0.956	0.82
245_W	248_E	0.949	0.82
48_R	236_D	0.949	0.82
114_W	120_I	0.948	0.81
117_D	139_G	0.937	0.81
122_L	135_I	0.935	0.81
8_S	14_D	0.921	0.80
132_F	150_A	0.919	0.79
84_L	93_P	0.912	0.79
53_L	120_I	0.908	0.79
82_L	276_P	0.891	0.77
268_A	277_A	0.890	0.77
77_Q	101_G	0.888	0.77
105_E	125_G	0.887	0.77
172_S	176_V	0.887	0.77
133_D	137_Q	0.883	0.77
64_Q	78_A	0.881	0.76
22_A	137_Q	0.880	0.76
82_L	98_T	0.874	0.76
81_K	104_H	0.866	0.75
85_I	94_T	0.859	0.75
78_A	275_D	0.858	0.75
65_D	73_T	0.857	0.74
97_R	111_T	0.854	0.74
137_Q	206_T	0.851	0.74
154_I	176_V	0.849	0.74
178_D	209_L	0.846	0.74
175_A	180_L	0.844	0.73
7_L	11_A	0.843	0.73
14_D	19_G	0.841	0.73
68_D	73_T	0.841	0.73
10_A	61_S	0.830	0.72
85_I	120_I	0.825	0.72
23_L	71_A	0.824	0.72
74_G	272_E	0.823	0.71
76_D	97_R	0.821	0.71
123_D	256_H	0.815	0.71
106_R	147_K	0.814	0.71
210_V	237_I	0.811	0.70
265_R	274_S	0.810	0.70
62_L	80_L	0.809	0.70
32_I	92_L	0.808	0.70
98_T	216_E	0.803	0.70
114_W	140_G	0.802	0.69
243_A	246_E	0.801	0.69
143_V	237_I	0.801	0.69
74_G	104_H	0.801	0.69
249_L	253_G	0.797	0.69
132_F	142_F	0.790	0.68
145_R	245_W	0.787	0.68
12_F	211_G	0.787	0.68
138_N	153_E	0.783	0.68
241_Y	244_R	0.777	0.67
33_E	136_D	0.776	0.67
9_Y	14_D	0.775	0.67
58_T	256_H	0.773	0.67
24_L	276_P	0.771	0.66
53_L	115_V	0.769	0.66
117_D	141_W	0.768	0.66
209_L	222_L	0.766	0.66
106_R	110_P	0.765	0.66
174_Q	177_L	0.764	0.66
51_D	124_L	0.762	0.66
176_V	209_L	0.761	0.65
264_S	267_N	0.760	0.65
123_D	241_Y	0.759	0.65
15_W	49_F	0.757	0.65
36_D	45_R	0.756	0.65
155_V	179_D	0.756	0.65
87_S	145_R	0.749	0.64
21_V	277_A	0.748	0.64
47_E	240_L	0.747	0.64
246_E	249_L	0.745	0.64
57_A	102_T	0.741	0.63
122_L	125_G	0.737	0.63
176_V	222_L	0.736	0.63
139_G	154_I	0.735	0.63
120_I	140_G	0.734	0.63
79_E	105_E	0.728	0.62
249_L	258_T	0.726	0.62
93_P	259_S	0.721	0.61
61_S	79_E	0.719	0.61
97_R	206_T	0.719	0.61
220_Y	272_E	0.718	0.61
65_D	137_Q	0.714	0.60
119_L	231_D	0.712	0.60
208_R	214_N	0.704	0.59
44_G	52_V	0.701	0.59
148_D	272_E	0.697	0.59
14_D	227_L	0.697	0.59
100_D	103_T	0.696	0.59
124_L	147_K	0.694	0.58
62_L	264_S	0.693	0.58
30_D	33_E	0.691	0.58
13_H	271_D	0.689	0.58
87_S	90_T	0.689	0.58
252_K	256_H	0.682	0.57
170_G	173_L	0.678	0.57
139_G	233_S	0.676	0.56
34_N	38_G	0.676	0.56
228_G	232_Y	0.676	0.56
151_N	215_E	0.674	0.56
124_L	150_A	0.672	0.56
264_S	271_D	0.671	0.56
242_R	270_V	0.668	0.55
35_L	92_L	0.667	0.55
47_E	50_R	0.666	0.55
63_Y	275_D	0.663	0.55
174_Q	211_G	0.662	0.55
91_G	243_A	0.662	0.55
85_I	131_L	0.661	0.55
143_V	210_V	0.661	0.55
274_S	277_A	0.659	0.54
155_V	206_T	0.657	0.54
14_D	80_L	0.656	0.54
143_V	268_A	0.654	0.54
258_T	275_D	0.654	0.54
133_D	181_Q	0.652	0.54
179_D	182_R	0.647	0.53
55_A	122_L	0.644	0.53
170_G	175_A	0.643	0.53
38_G	156_E	0.642	0.52
148_D	153_E	0.641	0.52
83_H	251_F	0.639	0.52
99_T	272_E	0.636	0.52
207_F	210_V	0.636	0.52
116_A	240_L	0.633	0.51
131_L	223_Y	0.629	0.51
50_R	232_Y	0.628	0.51
19_G	28_L	0.628	0.51
105_E	109_L	0.627	0.51
207_F	259_S	0.626	0.51
173_L	238_A	0.626	0.51
83_H	275_D	0.625	0.51
119_L	146_V	0.624	0.50
9_Y	15_W	0.622	0.50
121_L	153_E	0.620	0.50
11_A	15_W	0.620	0.50
72_A	273_S	0.619	0.50
54_I	96_F	0.618	0.50
176_V	179_D	0.616	0.50
266_V	272_E	0.615	0.49
271_D	275_D	0.614	0.49
16_F	77_Q	0.614	0.49
212_L	216_E	0.613	0.49
53_L	105_E	0.613	0.49
27_I	204_T	0.612	0.49
39_R	121_L	0.611	0.49
83_H	252_K	0.611	0.49
81_K	226_N	0.609	0.49
80_L	276_P	0.608	0.49
125_G	249_L	0.608	0.49
55_A	109_L	0.606	0.48
46_L	247_V	0.605	0.48
122_L	223_Y	0.605	0.48
73_T	101_G	0.603	0.48
225_T	237_I	0.603	0.48
61_S	74_G	0.598	0.48
237_I	251_F	0.595	0.47
66_A	267_N	0.595	0.47
117_D	210_V	0.594	0.47
252_K	271_D	0.593	0.47
82_L	243_A	0.591	0.47
174_Q	198_G	0.590	0.47
88_L	240_L	0.588	0.46
118_A	135_I	0.585	0.46
33_E	113_E	0.584	0.46
100_D	125_G	0.582	0.46
71_A	175_A	0.582	0.46
19_G	124_L	0.581	0.46
212_L	223_Y	0.580	0.46
92_L	114_W	0.580	0.46
170_G	176_V	0.576	0.45
146_V	224_L	0.575	0.45
257_R	271_D	0.574	0.45
10_A	250_L	0.573	0.45
267_N	272_E	0.567	0.44
178_D	181_Q	0.567	0.44
24_L	45_R	0.567	0.44
20_F	140_G	0.565	0.44
125_G	146_V	0.565	0.44
60_V	276_P	0.563	0.44
104_H	124_L	0.563	0.44
66_A	79_E	0.563	0.44
10_A	125_G	0.561	0.43
96_F	158_L	0.561	0.43
117_D	140_G	0.561	0.43
238_A	242_R	0.560	0.43
115_V	140_G	0.559	0.43
8_S	117_D	0.559	0.43
11_A	274_S	0.557	0.43
12_F	273_S	0.557	0.43
241_Y	248_E	0.552	0.42
12_F	252_K	0.550	0.42
129_F	205_R	0.550	0.42
38_G	239_Q	0.546	0.42
13_H	228_G	0.545	0.42
31_A	93_P	0.545	0.42
234_A	240_L	0.544	0.42
112_G	259_S	0.544	0.42
177_L	181_Q	0.543	0.41
13_H	17_E	0.541	0.41
235_P	239_Q	0.540	0.41
261_T	266_V	0.539	0.41
24_L	35_L	0.538	0.41
11_A	16_F	0.538	0.41
8_S	15_W	0.537	0.41
52_V	206_T	0.535	0.41
59_I	79_E	0.534	0.40
70_Y	257_R	0.533	0.40
139_G	215_E	0.532	0.40
125_G	221_H	0.532	0.40
32_I	52_V	0.529	0.40
93_P	128_D	0.529	0.40
267_N	275_D	0.525	0.39
106_R	131_L	0.525	0.39
250_L	253_G	0.523	0.39
15_W	258_T	0.523	0.39
109_L	120_I	0.522	0.39
170_G	179_D	0.517	0.39
87_S	94_T	0.516	0.38
250_L	255_C	0.516	0.38
33_E	210_V	0.515	0.38
11_A	19_G	0.515	0.38
127_Y	223_Y	0.515	0.38
156_E	239_Q	0.514	0.38
18_P	78_A	0.512	0.38
133_D	205_R	0.512	0.38
58_T	125_G	0.511	0.38
119_L	172_S	0.510	0.38
14_D	247_V	0.508	0.38
100_D	199_S	0.508	0.38
226_N	271_D	0.508	0.38
103_T	116_A	0.506	0.37
252_K	259_S	0.506	0.37
72_A	100_D	0.506	0.37
23_L	27_I	0.504	0.37
138_N	204_T	0.502	0.37
87_S	124_L	0.501	0.37
62_L	226_N	0.500	0.37
260_S	276_P	0.500	0.37
72_A	108_Q	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.9532	100	0.568	Contact Map
4mzmA	2	0.1403	5.2	0.964	Contact Map
4u7bA	2	0.7698	4.7	0.964	Contact Map
3dlmA	1	0.7266	4.6	0.965	Contact Map
3qweA	2	0.2626	4.5	0.965	Contact Map
2krcA	1	0.3273	3.8	0.966	Contact Map
3oq4A	1	0.3597	3.3	0.967	Contact Map
3smzA	1	0.2806	3.3	0.967	Contact Map
3dt5A	1	0.2266	2.8	0.968	Contact Map
3j65n	1	0.3165	2.7	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.