GREMLIN Database
O54644 - Uncharacterized protein
UniProt: O54644 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 278 (241)
Sequences: 1150 (941)
Seq/√Len: 60.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_W226_N5.0011.00
266_V271_D4.5941.00
57_A105_E4.4341.00
175_A178_D3.7311.00
121_L240_L3.7011.00
11_A14_D3.6351.00
8_S11_A3.3921.00
10_A14_D3.2851.00
79_E101_G3.2631.00
83_H126_F3.1971.00
54_I88_L3.0671.00
15_W18_P2.9981.00
265_R275_D2.9481.00
142_F207_F2.7731.00
135_I140_G2.4181.00
142_F226_N2.4101.00
83_H99_T2.3511.00
115_V118_A2.2721.00
227_L232_Y2.1641.00
119_L227_L2.1561.00
51_D118_A2.1311.00
249_L252_K2.0831.00
252_K257_R2.0531.00
122_L144_S1.9641.00
212_L238_A1.9641.00
53_L118_A1.9321.00
21_V273_S1.9071.00
239_Q242_R1.9011.00
211_G220_Y1.8861.00
223_Y237_I1.8631.00
53_L94_T1.8571.00
146_V150_A1.8311.00
29_D95_R1.8051.00
252_K258_T1.7710.99
247_V251_F1.7390.99
16_F274_S1.7380.99
25_R273_S1.7320.99
214_N217_T1.7300.99
157_E160_T1.6920.99
59_I81_K1.6780.99
19_G24_L1.6660.99
132_F144_S1.6640.99
50_R141_W1.6450.99
269_E273_S1.6420.99
104_H107_S1.6360.99
136_D226_N1.6260.99
129_F150_A1.6070.99
55_A85_I1.6050.99
25_R29_D1.6020.99
124_L144_S1.5620.99
214_N221_H1.5250.98
99_T103_T1.5140.98
16_F19_G1.5120.98
212_L221_H1.4770.98
233_S236_D1.4670.98
84_L251_F1.4400.98
127_Y150_A1.4300.97
50_R119_L1.4170.97
15_W19_G1.4140.97
110_P131_L1.4140.97
124_L145_R1.3790.97
24_L270_V1.3620.97
143_V240_L1.3570.97
10_A13_H1.3550.97
221_H238_A1.3440.96
172_S175_A1.3410.96
81_K101_G1.3340.96
136_D142_F1.3050.96
179_D206_T1.2940.95
26_E30_D1.2850.95
123_D248_E1.2780.95
119_L143_V1.2540.95
98_T273_S1.2420.94
244_R248_E1.2260.94
28_L32_I1.2100.93
19_G274_S1.2060.93
152_F178_D1.2030.93
248_E251_F1.1990.93
153_E179_D1.1940.93
22_A25_R1.1850.93
248_E256_H1.1830.93
144_S224_L1.1770.93
211_G222_L1.1680.92
171_E176_V1.1670.92
95_R113_E1.1640.92
215_E247_V1.1550.92
52_V240_L1.1510.92
24_L274_S1.1320.91
125_G147_K1.1280.91
73_T272_E1.1190.90
177_L206_T1.1080.90
253_G258_T1.1000.90
114_W236_D1.1000.90
109_L131_L1.0970.90
159_R216_E1.0940.89
171_E174_Q1.0910.89
68_D269_E1.0870.89
21_V270_V1.0690.88
58_T82_L1.0650.88
268_A271_D1.0590.88
47_E52_V1.0530.88
99_T108_Q1.0450.87
93_P250_L1.0400.87
251_F260_S1.0380.87
51_D87_S1.0290.86
65_D78_A1.0270.86
23_L84_L1.0170.86
28_L112_G1.0130.86
253_G272_E1.0110.85
53_L85_I1.0110.85
21_V25_R1.0070.85
183_Q198_G1.0030.85
266_V275_D0.9940.84
232_Y237_I0.9850.84
28_L109_L0.9790.84
116_A139_G0.9760.83
146_V149_N0.9710.83
134_R138_N0.9690.83
51_D115_V0.9650.83
208_R245_W0.9630.82
174_Q178_D0.9560.82
245_W248_E0.9490.82
48_R236_D0.9490.82
114_W120_I0.9480.81
117_D139_G0.9370.81
122_L135_I0.9350.81
8_S14_D0.9210.80
132_F150_A0.9190.79
84_L93_P0.9120.79
53_L120_I0.9080.79
82_L276_P0.8910.77
268_A277_A0.8900.77
77_Q101_G0.8880.77
105_E125_G0.8870.77
172_S176_V0.8870.77
133_D137_Q0.8830.77
64_Q78_A0.8810.76
22_A137_Q0.8800.76
82_L98_T0.8740.76
81_K104_H0.8660.75
85_I94_T0.8590.75
78_A275_D0.8580.75
65_D73_T0.8570.74
97_R111_T0.8540.74
137_Q206_T0.8510.74
154_I176_V0.8490.74
178_D209_L0.8460.74
175_A180_L0.8440.73
7_L11_A0.8430.73
14_D19_G0.8410.73
68_D73_T0.8410.73
10_A61_S0.8300.72
85_I120_I0.8250.72
23_L71_A0.8240.72
74_G272_E0.8230.71
76_D97_R0.8210.71
123_D256_H0.8150.71
106_R147_K0.8140.71
210_V237_I0.8110.70
265_R274_S0.8100.70
62_L80_L0.8090.70
32_I92_L0.8080.70
98_T216_E0.8030.70
114_W140_G0.8020.69
243_A246_E0.8010.69
143_V237_I0.8010.69
74_G104_H0.8010.69
249_L253_G0.7970.69
132_F142_F0.7900.68
145_R245_W0.7870.68
12_F211_G0.7870.68
138_N153_E0.7830.68
241_Y244_R0.7770.67
33_E136_D0.7760.67
9_Y14_D0.7750.67
58_T256_H0.7730.67
24_L276_P0.7710.66
53_L115_V0.7690.66
117_D141_W0.7680.66
209_L222_L0.7660.66
106_R110_P0.7650.66
174_Q177_L0.7640.66
51_D124_L0.7620.66
176_V209_L0.7610.65
264_S267_N0.7600.65
123_D241_Y0.7590.65
15_W49_F0.7570.65
36_D45_R0.7560.65
155_V179_D0.7560.65
87_S145_R0.7490.64
21_V277_A0.7480.64
47_E240_L0.7470.64
246_E249_L0.7450.64
57_A102_T0.7410.63
122_L125_G0.7370.63
176_V222_L0.7360.63
139_G154_I0.7350.63
120_I140_G0.7340.63
79_E105_E0.7280.62
249_L258_T0.7260.62
93_P259_S0.7210.61
61_S79_E0.7190.61
97_R206_T0.7190.61
220_Y272_E0.7180.61
65_D137_Q0.7140.60
119_L231_D0.7120.60
208_R214_N0.7040.59
44_G52_V0.7010.59
148_D272_E0.6970.59
14_D227_L0.6970.59
100_D103_T0.6960.59
124_L147_K0.6940.58
62_L264_S0.6930.58
30_D33_E0.6910.58
13_H271_D0.6890.58
87_S90_T0.6890.58
252_K256_H0.6820.57
170_G173_L0.6780.57
139_G233_S0.6760.56
34_N38_G0.6760.56
228_G232_Y0.6760.56
151_N215_E0.6740.56
124_L150_A0.6720.56
264_S271_D0.6710.56
242_R270_V0.6680.55
35_L92_L0.6670.55
47_E50_R0.6660.55
63_Y275_D0.6630.55
174_Q211_G0.6620.55
91_G243_A0.6620.55
85_I131_L0.6610.55
143_V210_V0.6610.55
274_S277_A0.6590.54
155_V206_T0.6570.54
14_D80_L0.6560.54
143_V268_A0.6540.54
258_T275_D0.6540.54
133_D181_Q0.6520.54
179_D182_R0.6470.53
55_A122_L0.6440.53
170_G175_A0.6430.53
38_G156_E0.6420.52
148_D153_E0.6410.52
83_H251_F0.6390.52
99_T272_E0.6360.52
207_F210_V0.6360.52
116_A240_L0.6330.51
131_L223_Y0.6290.51
50_R232_Y0.6280.51
19_G28_L0.6280.51
105_E109_L0.6270.51
207_F259_S0.6260.51
173_L238_A0.6260.51
83_H275_D0.6250.51
119_L146_V0.6240.50
9_Y15_W0.6220.50
121_L153_E0.6200.50
11_A15_W0.6200.50
72_A273_S0.6190.50
54_I96_F0.6180.50
176_V179_D0.6160.50
266_V272_E0.6150.49
271_D275_D0.6140.49
16_F77_Q0.6140.49
212_L216_E0.6130.49
53_L105_E0.6130.49
27_I204_T0.6120.49
39_R121_L0.6110.49
83_H252_K0.6110.49
81_K226_N0.6090.49
80_L276_P0.6080.49
125_G249_L0.6080.49
55_A109_L0.6060.48
46_L247_V0.6050.48
122_L223_Y0.6050.48
73_T101_G0.6030.48
225_T237_I0.6030.48
61_S74_G0.5980.48
237_I251_F0.5950.47
66_A267_N0.5950.47
117_D210_V0.5940.47
252_K271_D0.5930.47
82_L243_A0.5910.47
174_Q198_G0.5900.47
88_L240_L0.5880.46
118_A135_I0.5850.46
33_E113_E0.5840.46
100_D125_G0.5820.46
71_A175_A0.5820.46
19_G124_L0.5810.46
212_L223_Y0.5800.46
92_L114_W0.5800.46
170_G176_V0.5760.45
146_V224_L0.5750.45
257_R271_D0.5740.45
10_A250_L0.5730.45
267_N272_E0.5670.44
178_D181_Q0.5670.44
24_L45_R0.5670.44
20_F140_G0.5650.44
125_G146_V0.5650.44
60_V276_P0.5630.44
104_H124_L0.5630.44
66_A79_E0.5630.44
10_A125_G0.5610.43
96_F158_L0.5610.43
117_D140_G0.5610.43
238_A242_R0.5600.43
115_V140_G0.5590.43
8_S117_D0.5590.43
11_A274_S0.5570.43
12_F273_S0.5570.43
241_Y248_E0.5520.42
12_F252_K0.5500.42
129_F205_R0.5500.42
38_G239_Q0.5460.42
13_H228_G0.5450.42
31_A93_P0.5450.42
234_A240_L0.5440.42
112_G259_S0.5440.42
177_L181_Q0.5430.41
13_H17_E0.5410.41
235_P239_Q0.5400.41
261_T266_V0.5390.41
24_L35_L0.5380.41
11_A16_F0.5380.41
8_S15_W0.5370.41
52_V206_T0.5350.41
59_I79_E0.5340.40
70_Y257_R0.5330.40
139_G215_E0.5320.40
125_G221_H0.5320.40
32_I52_V0.5290.40
93_P128_D0.5290.40
267_N275_D0.5250.39
106_R131_L0.5250.39
250_L253_G0.5230.39
15_W258_T0.5230.39
109_L120_I0.5220.39
170_G179_D0.5170.39
87_S94_T0.5160.38
250_L255_C0.5160.38
33_E210_V0.5150.38
11_A19_G0.5150.38
127_Y223_Y0.5150.38
156_E239_Q0.5140.38
18_P78_A0.5120.38
133_D205_R0.5120.38
58_T125_G0.5110.38
119_L172_S0.5100.38
14_D247_V0.5080.38
100_D199_S0.5080.38
226_N271_D0.5080.38
103_T116_A0.5060.37
252_K259_S0.5060.37
72_A100_D0.5060.37
23_L27_I0.5040.37
138_N204_T0.5020.37
87_S124_L0.5010.37
62_L226_N0.5000.37
260_S276_P0.5000.37
72_A108_Q0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.9532 100 0.568 Contact Map
4mzmA 2 0.1403 5.2 0.964 Contact Map
4u7bA 2 0.7698 4.7 0.964 Contact Map
3dlmA 1 0.7266 4.6 0.965 Contact Map
3qweA 2 0.2626 4.5 0.965 Contact Map
2krcA 1 0.3273 3.8 0.966 Contact Map
3oq4A 1 0.3597 3.3 0.967 Contact Map
3smzA 1 0.2806 3.3 0.967 Contact Map
3dt5A 1 0.2266 2.8 0.968 Contact Map
3j65n 1 0.3165 2.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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