GREMLIN Database
O54637 - Bacterio-opsin activator-like protein
UniProt: O54637 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (204)
Sequences: 1716 (1374)
Seq/√Len: 96.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_Y222_E3.9501.00
185_L189_S3.8841.00
198_T203_L3.8621.00
182_A207_T3.4671.00
104_F109_C3.4641.00
189_S203_L3.4031.00
109_C128_A3.2141.00
189_S206_R3.1371.00
210_A213_T3.0161.00
213_T217_H2.9051.00
199_S202_D2.7881.00
185_L203_L2.7581.00
178_R217_H2.7151.00
200_L214_Y2.6261.00
34_S120_G2.5891.00
193_E197_K2.5581.00
198_T202_D2.3301.00
187_L227_T2.2951.00
194_Q215_E2.2851.00
23_R121_W2.1821.00
66_L90_Q2.1401.00
178_R181_A2.0921.00
178_R182_A2.0811.00
180_L184_Q1.9441.00
196_R219_R1.9121.00
200_L215_E1.8861.00
112_Q127_V1.8591.00
40_L44_E1.8261.00
55_I92_C1.7821.00
211_R215_E1.7681.00
182_A217_H1.6711.00
20_A134_V1.6581.00
22_I126_V1.6321.00
130_D133_D1.6321.00
61_P64_E1.6181.00
183_L226_L1.6181.00
23_R148_E1.6101.00
217_H224_K1.5811.00
217_H220_K1.5801.00
54_E57_T1.5591.00
226_L229_A1.5521.00
209_V214_Y1.5451.00
202_D205_E1.5311.00
194_Q216_E1.5271.00
79_S198_T1.4861.00
213_T218_L1.4571.00
187_L230_G1.4291.00
127_V192_Y1.4191.00
80_A90_Q1.4000.99
183_L192_Y1.3880.99
189_S198_T1.3840.99
203_L214_Y1.3770.99
80_A88_V1.3410.99
190_G197_K1.3310.99
23_R150_L1.3250.99
33_I72_I1.3150.99
182_A209_V1.2920.99
198_T206_R1.2880.99
194_Q212_S1.2850.99
200_L217_H1.2700.99
62_T66_L1.2470.99
212_S216_E1.2400.99
46_P53_L1.2320.99
46_P52_V1.2280.99
205_E208_A1.2210.98
182_A221_A1.2010.98
77_Y80_A1.2000.98
50_C53_L1.2000.98
204_A214_Y1.2000.98
210_A219_R1.1770.98
136_E139_D1.1750.98
78_E90_Q1.1650.98
75_V78_E1.1590.98
139_D143_S1.1480.98
226_L230_G1.1340.98
192_Y218_L1.1280.97
203_L207_T1.1240.97
182_A214_Y1.0780.97
223_N227_T1.0680.96
109_C113_S1.0670.96
175_I221_A1.0650.96
81_D89_T1.0530.96
191_Y196_R1.0520.96
36_R230_G1.0510.96
216_E220_K1.0420.96
181_A184_Q1.0420.96
105_E203_L1.0410.96
62_T88_V1.0390.96
123_H150_L1.0320.96
22_I138_L1.0320.96
20_A126_V1.0310.96
81_D86_H1.0220.95
28_C122_E1.0220.95
96_L208_A1.0140.95
200_L221_A1.0100.95
57_T65_L1.0070.95
64_E67_D1.0060.95
182_A203_L1.0060.95
201_R211_R1.0050.95
194_Q217_H0.9970.95
47_L50_C0.9960.95
66_L78_E0.9950.95
184_Q188_E0.9930.95
152_K191_Y0.9890.95
191_Y200_L0.9890.95
128_A148_E0.9890.95
225_L229_A0.9830.94
108_N140_S0.9810.94
194_Q201_R0.9710.94
64_E68_E0.9620.94
99_S102_D0.9520.93
29_P33_I0.9420.93
172_F229_A0.9410.93
40_L43_R0.9400.93
57_T62_T0.9360.93
172_F180_L0.9350.93
174_D228_N0.9340.93
218_L222_E0.9320.93
69_I132_E0.9220.92
89_T93_L0.9160.92
62_T65_L0.9140.92
58_E87_V0.9130.92
104_F126_V0.9060.92
194_Q223_N0.8950.91
71_E86_H0.8890.91
133_D136_E0.8810.90
19_E153_T0.8730.90
46_P49_D0.8720.90
121_W169_N0.8700.90
192_Y200_L0.8670.90
207_T214_Y0.8660.90
138_L147_I0.8650.90
200_L211_R0.8620.89
135_R138_L0.8600.89
128_A192_Y0.8600.89
213_T216_E0.8580.89
102_D106_E0.8570.89
111_Y136_E0.8540.89
193_E223_N0.8520.89
111_Y126_V0.8510.89
20_A23_R0.8390.88
213_T221_A0.8390.88
26_H122_E0.8390.88
145_R213_T0.8340.88
157_E193_E0.8020.86
64_E205_E0.8020.86
75_V154_S0.7930.85
101_I111_Y0.7910.85
149_L152_K0.7870.85
206_R216_E0.7860.85
18_Y126_V0.7830.84
49_D52_V0.7820.84
42_I57_T0.7790.84
42_I220_K0.7780.84
116_I123_H0.7770.84
81_D117_Y0.7730.84
26_H124_Y0.7720.84
36_R143_S0.7700.83
63_D232_F0.7690.83
34_S117_Y0.7680.83
220_K223_N0.7680.83
126_V137_L0.7620.83
138_L213_T0.7580.82
20_A72_I0.7560.82
19_E115_T0.7550.82
48_S231_Q0.7530.82
52_V115_T0.7440.81
82_D207_T0.7320.80
137_L216_E0.7280.80
221_A226_L0.7250.80
136_E197_K0.7240.80
194_Q219_R0.7220.79
192_Y221_A0.7180.79
22_I120_G0.7180.79
178_R216_E0.7160.79
25_K31_R0.7120.78
190_G215_E0.7090.78
126_V130_D0.7020.77
67_D116_I0.6980.77
31_R226_L0.6960.77
207_T215_E0.6940.77
45_W209_V0.6890.76
18_Y65_L0.6870.76
21_S123_H0.6850.76
39_D44_E0.6840.76
83_N93_L0.6740.75
32_R100_V0.6660.74
220_K225_L0.6640.73
56_T89_T0.6610.73
214_Y225_L0.6600.73
78_E81_D0.6590.73
109_C112_Q0.6580.73
45_W231_Q0.6530.72
69_I90_Q0.6510.72
213_T229_A0.6490.72
18_Y21_S0.6460.71
178_R222_E0.6440.71
183_L221_A0.6420.71
20_A131_S0.6410.71
187_L229_A0.6400.71
100_V124_Y0.6400.71
76_L143_S0.6360.70
46_P134_V0.6360.70
200_L213_T0.6340.70
46_P50_C0.6270.69
148_E156_S0.6240.69
198_T214_Y0.6240.69
48_S129_F0.6170.68
201_R205_E0.6170.68
174_D227_T0.6160.68
123_H204_A0.6150.68
34_S121_W0.6130.67
101_I224_K0.6110.67
28_C31_R0.6100.67
173_E229_A0.6050.66
115_T122_E0.6020.66
97_E103_R0.6020.66
194_Q213_T0.6010.66
191_Y218_L0.5990.66
19_E213_T0.5980.65
36_R39_D0.5950.65
185_L214_Y0.5940.65
209_V212_S0.5940.65
137_L211_R0.5930.65
181_A206_R0.5930.65
195_P219_R0.5900.64
61_P119_Q0.5890.64
25_K224_K0.5880.64
142_R209_V0.5870.64
30_Y122_E0.5870.64
142_R197_K0.5820.63
107_H140_S0.5800.63
141_L145_R0.5760.63
145_R200_L0.5740.62
171_L225_L0.5730.62
18_Y128_A0.5720.62
181_A185_L0.5720.62
190_G193_E0.5710.62
66_L69_I0.5660.61
28_C226_L0.5640.61
36_R174_D0.5630.61
66_L83_N0.5610.61
36_R68_E0.5590.60
213_T220_K0.5580.60
134_V151_S0.5550.60
32_R150_L0.5550.60
122_E217_H0.5530.59
40_L189_S0.5530.59
87_V199_S0.5500.59
35_E40_L0.5490.59
131_S210_A0.5490.59
118_R121_W0.5490.59
85_Y89_T0.5480.59
112_Q199_S0.5460.59
43_R227_T0.5440.58
132_E177_D0.5430.58
211_R220_K0.5420.58
73_G140_S0.5420.58
32_R74_T0.5410.58
208_A216_E0.5410.58
151_S203_L0.5390.58
54_E111_Y0.5370.57
184_Q230_G0.5370.57
200_L220_K0.5360.57
110_L127_V0.5350.57
72_I75_V0.5350.57
201_R219_R0.5350.57
135_R213_T0.5350.57
126_V224_K0.5340.57
117_Y122_E0.5330.57
79_S91_S0.5330.57
28_C34_S0.5300.56
34_S119_Q0.5290.56
139_D144_D0.5290.56
43_R143_S0.5270.56
134_V181_A0.5270.56
109_C138_L0.5260.56
49_D57_T0.5250.56
28_C124_Y0.5250.56
148_E223_N0.5250.56
86_H91_S0.5240.55
29_P32_R0.5220.55
39_D61_P0.5220.55
169_N220_K0.5210.55
60_T130_D0.5190.55
69_I220_K0.5160.54
180_L232_F0.5160.54
103_R199_S0.5160.54
187_L226_L0.5150.54
98_D104_F0.5110.54
192_Y226_L0.5100.53
58_E126_V0.5090.53
81_D85_Y0.5070.53
101_I104_F0.5060.53
95_S184_Q0.5060.53
70_N120_G0.5060.53
29_P42_I0.5060.53
132_E149_L0.5040.53
19_E134_V0.5030.52
92_C174_D0.5020.52
130_D141_L0.5020.52
27_E189_S0.5020.52
187_L192_Y0.5020.52
77_Y133_D0.5010.52
97_E139_D0.5010.52
22_I125_T0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ku3A 1 0.2364 97.5 0.866 Contact Map
3hugA 3 0.3101 97.1 0.875 Contact Map
4wszA 2 0.2558 97.1 0.875 Contact Map
2o8xA 7 0.2364 97.1 0.876 Contact Map
3c57A 2 0.1977 97 0.878 Contact Map
1s7oA 3 0.3682 97 0.878 Contact Map
1je8A 2 0.2597 96.9 0.878 Contact Map
1ttyA 1 0.3372 96.9 0.879 Contact Map
4g6dA 1 0.2403 96.8 0.88 Contact Map
3vfzA 2 0.2442 96.7 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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