O54637 - HALSA - GREMLIN Contacts

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O54637 - Bacterio-opsin activator-like protein

UniProt:	O54637	Sequences: MTGTANYVEFEPTRMGLYEASIRVKHECPYRRISERYPDLTIREWPLSDCQVLEITTETTPTDELLDEINEIGTVLYESADDNGYHVVTQSCLCSLEDSVIDRFEEHNCLYQSPTIYRQGWEHYTVVAFDSEDVRELLDSLRSDREIELLSKTSISETQIPHSMLAPANQLFEDITDRQLAALQLALESGYYEQPRKTSLRDLAERTAVARSTYEEHLRKAENKLLTNAGQFLRLVTATSTTNPLGVESGRRTEQTAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	258 (204)
Sequences:	1716 (1374)
Seq/√Len:	96.2

HALSA - O54637 Q9HSM9 Q9HR58 Q9HSR5 Q9HQD9 DMSR Q9HPS7 Q9HQU9
SULSO - Q97YL7 Q97YT8 Q97WR0 Q97ZB6 Q7LXI8 Q97Y14 Q97X87 Q97UD7 Q97UC0 Q97ZX5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
192_Y	222_E	3.950	1.00
185_L	189_S	3.884	1.00
198_T	203_L	3.862	1.00
182_A	207_T	3.467	1.00
104_F	109_C	3.464	1.00
189_S	203_L	3.403	1.00
109_C	128_A	3.214	1.00
189_S	206_R	3.137	1.00
210_A	213_T	3.016	1.00
213_T	217_H	2.905	1.00
199_S	202_D	2.788	1.00
185_L	203_L	2.758	1.00
178_R	217_H	2.715	1.00
200_L	214_Y	2.626	1.00
34_S	120_G	2.589	1.00
193_E	197_K	2.558	1.00
198_T	202_D	2.330	1.00
187_L	227_T	2.295	1.00
194_Q	215_E	2.285	1.00
23_R	121_W	2.182	1.00
66_L	90_Q	2.140	1.00
178_R	181_A	2.092	1.00
178_R	182_A	2.081	1.00
180_L	184_Q	1.944	1.00
196_R	219_R	1.912	1.00
200_L	215_E	1.886	1.00
112_Q	127_V	1.859	1.00
40_L	44_E	1.826	1.00
55_I	92_C	1.782	1.00
211_R	215_E	1.768	1.00
182_A	217_H	1.671	1.00
20_A	134_V	1.658	1.00
22_I	126_V	1.632	1.00
130_D	133_D	1.632	1.00
61_P	64_E	1.618	1.00
183_L	226_L	1.618	1.00
23_R	148_E	1.610	1.00
217_H	224_K	1.581	1.00
217_H	220_K	1.580	1.00
54_E	57_T	1.559	1.00
226_L	229_A	1.552	1.00
209_V	214_Y	1.545	1.00
202_D	205_E	1.531	1.00
194_Q	216_E	1.527	1.00
79_S	198_T	1.486	1.00
213_T	218_L	1.457	1.00
187_L	230_G	1.429	1.00
127_V	192_Y	1.419	1.00
80_A	90_Q	1.400	0.99
183_L	192_Y	1.388	0.99
189_S	198_T	1.384	0.99
203_L	214_Y	1.377	0.99
80_A	88_V	1.341	0.99
190_G	197_K	1.331	0.99
23_R	150_L	1.325	0.99
33_I	72_I	1.315	0.99
182_A	209_V	1.292	0.99
198_T	206_R	1.288	0.99
194_Q	212_S	1.285	0.99
200_L	217_H	1.270	0.99
62_T	66_L	1.247	0.99
212_S	216_E	1.240	0.99
46_P	53_L	1.232	0.99
46_P	52_V	1.228	0.99
205_E	208_A	1.221	0.98
182_A	221_A	1.201	0.98
77_Y	80_A	1.200	0.98
50_C	53_L	1.200	0.98
204_A	214_Y	1.200	0.98
210_A	219_R	1.177	0.98
136_E	139_D	1.175	0.98
78_E	90_Q	1.165	0.98
75_V	78_E	1.159	0.98
139_D	143_S	1.148	0.98
226_L	230_G	1.134	0.98
192_Y	218_L	1.128	0.97
203_L	207_T	1.124	0.97
182_A	214_Y	1.078	0.97
223_N	227_T	1.068	0.96
109_C	113_S	1.067	0.96
175_I	221_A	1.065	0.96
81_D	89_T	1.053	0.96
191_Y	196_R	1.052	0.96
36_R	230_G	1.051	0.96
216_E	220_K	1.042	0.96
181_A	184_Q	1.042	0.96
105_E	203_L	1.041	0.96
62_T	88_V	1.039	0.96
123_H	150_L	1.032	0.96
22_I	138_L	1.032	0.96
20_A	126_V	1.031	0.96
81_D	86_H	1.022	0.95
28_C	122_E	1.022	0.95
96_L	208_A	1.014	0.95
200_L	221_A	1.010	0.95
57_T	65_L	1.007	0.95
64_E	67_D	1.006	0.95
182_A	203_L	1.006	0.95
201_R	211_R	1.005	0.95
194_Q	217_H	0.997	0.95
47_L	50_C	0.996	0.95
66_L	78_E	0.995	0.95
184_Q	188_E	0.993	0.95
152_K	191_Y	0.989	0.95
191_Y	200_L	0.989	0.95
128_A	148_E	0.989	0.95
225_L	229_A	0.983	0.94
108_N	140_S	0.981	0.94
194_Q	201_R	0.971	0.94
64_E	68_E	0.962	0.94
99_S	102_D	0.952	0.93
29_P	33_I	0.942	0.93
172_F	229_A	0.941	0.93
40_L	43_R	0.940	0.93
57_T	62_T	0.936	0.93
172_F	180_L	0.935	0.93
174_D	228_N	0.934	0.93
218_L	222_E	0.932	0.93
69_I	132_E	0.922	0.92
89_T	93_L	0.916	0.92
62_T	65_L	0.914	0.92
58_E	87_V	0.913	0.92
104_F	126_V	0.906	0.92
194_Q	223_N	0.895	0.91
71_E	86_H	0.889	0.91
133_D	136_E	0.881	0.90
19_E	153_T	0.873	0.90
46_P	49_D	0.872	0.90
121_W	169_N	0.870	0.90
192_Y	200_L	0.867	0.90
207_T	214_Y	0.866	0.90
138_L	147_I	0.865	0.90
200_L	211_R	0.862	0.89
135_R	138_L	0.860	0.89
128_A	192_Y	0.860	0.89
213_T	216_E	0.858	0.89
102_D	106_E	0.857	0.89
111_Y	136_E	0.854	0.89
193_E	223_N	0.852	0.89
111_Y	126_V	0.851	0.89
20_A	23_R	0.839	0.88
213_T	221_A	0.839	0.88
26_H	122_E	0.839	0.88
145_R	213_T	0.834	0.88
157_E	193_E	0.802	0.86
64_E	205_E	0.802	0.86
75_V	154_S	0.793	0.85
101_I	111_Y	0.791	0.85
149_L	152_K	0.787	0.85
206_R	216_E	0.786	0.85
18_Y	126_V	0.783	0.84
49_D	52_V	0.782	0.84
42_I	57_T	0.779	0.84
42_I	220_K	0.778	0.84
116_I	123_H	0.777	0.84
81_D	117_Y	0.773	0.84
26_H	124_Y	0.772	0.84
36_R	143_S	0.770	0.83
63_D	232_F	0.769	0.83
34_S	117_Y	0.768	0.83
220_K	223_N	0.768	0.83
126_V	137_L	0.762	0.83
138_L	213_T	0.758	0.82
20_A	72_I	0.756	0.82
19_E	115_T	0.755	0.82
48_S	231_Q	0.753	0.82
52_V	115_T	0.744	0.81
82_D	207_T	0.732	0.80
137_L	216_E	0.728	0.80
221_A	226_L	0.725	0.80
136_E	197_K	0.724	0.80
194_Q	219_R	0.722	0.79
192_Y	221_A	0.718	0.79
22_I	120_G	0.718	0.79
178_R	216_E	0.716	0.79
25_K	31_R	0.712	0.78
190_G	215_E	0.709	0.78
126_V	130_D	0.702	0.77
67_D	116_I	0.698	0.77
31_R	226_L	0.696	0.77
207_T	215_E	0.694	0.77
45_W	209_V	0.689	0.76
18_Y	65_L	0.687	0.76
21_S	123_H	0.685	0.76
39_D	44_E	0.684	0.76
83_N	93_L	0.674	0.75
32_R	100_V	0.666	0.74
220_K	225_L	0.664	0.73
56_T	89_T	0.661	0.73
214_Y	225_L	0.660	0.73
78_E	81_D	0.659	0.73
109_C	112_Q	0.658	0.73
45_W	231_Q	0.653	0.72
69_I	90_Q	0.651	0.72
213_T	229_A	0.649	0.72
18_Y	21_S	0.646	0.71
178_R	222_E	0.644	0.71
183_L	221_A	0.642	0.71
20_A	131_S	0.641	0.71
187_L	229_A	0.640	0.71
100_V	124_Y	0.640	0.71
76_L	143_S	0.636	0.70
46_P	134_V	0.636	0.70
200_L	213_T	0.634	0.70
46_P	50_C	0.627	0.69
148_E	156_S	0.624	0.69
198_T	214_Y	0.624	0.69
48_S	129_F	0.617	0.68
201_R	205_E	0.617	0.68
174_D	227_T	0.616	0.68
123_H	204_A	0.615	0.68
34_S	121_W	0.613	0.67
101_I	224_K	0.611	0.67
28_C	31_R	0.610	0.67
173_E	229_A	0.605	0.66
115_T	122_E	0.602	0.66
97_E	103_R	0.602	0.66
194_Q	213_T	0.601	0.66
191_Y	218_L	0.599	0.66
19_E	213_T	0.598	0.65
36_R	39_D	0.595	0.65
185_L	214_Y	0.594	0.65
209_V	212_S	0.594	0.65
137_L	211_R	0.593	0.65
181_A	206_R	0.593	0.65
195_P	219_R	0.590	0.64
61_P	119_Q	0.589	0.64
25_K	224_K	0.588	0.64
142_R	209_V	0.587	0.64
30_Y	122_E	0.587	0.64
142_R	197_K	0.582	0.63
107_H	140_S	0.580	0.63
141_L	145_R	0.576	0.63
145_R	200_L	0.574	0.62
171_L	225_L	0.573	0.62
18_Y	128_A	0.572	0.62
181_A	185_L	0.572	0.62
190_G	193_E	0.571	0.62
66_L	69_I	0.566	0.61
28_C	226_L	0.564	0.61
36_R	174_D	0.563	0.61
66_L	83_N	0.561	0.61
36_R	68_E	0.559	0.60
213_T	220_K	0.558	0.60
134_V	151_S	0.555	0.60
32_R	150_L	0.555	0.60
122_E	217_H	0.553	0.59
40_L	189_S	0.553	0.59
87_V	199_S	0.550	0.59
35_E	40_L	0.549	0.59
131_S	210_A	0.549	0.59
118_R	121_W	0.549	0.59
85_Y	89_T	0.548	0.59
112_Q	199_S	0.546	0.59
43_R	227_T	0.544	0.58
132_E	177_D	0.543	0.58
211_R	220_K	0.542	0.58
73_G	140_S	0.542	0.58
32_R	74_T	0.541	0.58
208_A	216_E	0.541	0.58
151_S	203_L	0.539	0.58
54_E	111_Y	0.537	0.57
184_Q	230_G	0.537	0.57
200_L	220_K	0.536	0.57
110_L	127_V	0.535	0.57
72_I	75_V	0.535	0.57
201_R	219_R	0.535	0.57
135_R	213_T	0.535	0.57
126_V	224_K	0.534	0.57
117_Y	122_E	0.533	0.57
79_S	91_S	0.533	0.57
28_C	34_S	0.530	0.56
34_S	119_Q	0.529	0.56
139_D	144_D	0.529	0.56
43_R	143_S	0.527	0.56
134_V	181_A	0.527	0.56
109_C	138_L	0.526	0.56
49_D	57_T	0.525	0.56
28_C	124_Y	0.525	0.56
148_E	223_N	0.525	0.56
86_H	91_S	0.524	0.55
29_P	32_R	0.522	0.55
39_D	61_P	0.522	0.55
169_N	220_K	0.521	0.55
60_T	130_D	0.519	0.55
69_I	220_K	0.516	0.54
180_L	232_F	0.516	0.54
103_R	199_S	0.516	0.54
187_L	226_L	0.515	0.54
98_D	104_F	0.511	0.54
192_Y	226_L	0.510	0.53
58_E	126_V	0.509	0.53
81_D	85_Y	0.507	0.53
101_I	104_F	0.506	0.53
95_S	184_Q	0.506	0.53
70_N	120_G	0.506	0.53
29_P	42_I	0.506	0.53
132_E	149_L	0.504	0.53
19_E	134_V	0.503	0.52
92_C	174_D	0.502	0.52
130_D	141_L	0.502	0.52
27_E	189_S	0.502	0.52
187_L	192_Y	0.502	0.52
77_Y	133_D	0.501	0.52
97_E	139_D	0.501	0.52
22_I	125_T	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ku3A	1	0.2364	97.5	0.866	Contact Map
3hugA	3	0.3101	97.1	0.875	Contact Map
4wszA	2	0.2558	97.1	0.875	Contact Map
2o8xA	7	0.2364	97.1	0.876	Contact Map
3c57A	2	0.1977	97	0.878	Contact Map
1s7oA	3	0.3682	97	0.878	Contact Map
1je8A	2	0.2597	96.9	0.878	Contact Map
1ttyA	1	0.3372	96.9	0.879	Contact Map
4g6dA	1	0.2403	96.8	0.88	Contact Map
3vfzA	2	0.2442	96.7	0.882	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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