GREMLIN Database
O54610 - CydA
UniProt: O54610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 482 (435)
Sequences: 2847 (1535)
Seq/√Len: 73.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_D191_A6.3761.00
292_K305_L5.3241.00
408_V418_A5.1711.00
219_G386_S4.5621.00
253_A357_I4.5411.00
319_S325_A4.3381.00
279_E331_N4.1081.00
316_F323_F3.9581.00
289_A304_N3.8941.00
144_L148_L3.8661.00
292_K301_R3.7141.00
257_D261_R3.0641.00
354_F358_G2.9471.00
207_N255_H2.9411.00
261_R321_G2.8501.00
176_V179_N2.8271.00
242_V363_G2.8261.00
60_N139_D2.8101.00
257_D321_G2.7941.00
282_S326_E2.7221.00
426_T430_L2.6641.00
215_L245_L2.6271.00
376_T380_K2.5681.00
429_T433_V2.5431.00
366_L378_Y2.5221.00
50_I147_V2.4211.00
302_T331_N2.4191.00
352_L356_F2.3791.00
398_Y402_I2.3501.00
286_H309_S2.3041.00
312_G323_F2.2971.00
286_H343_F2.2511.00
269_Q333_Y2.2341.00
302_T336_N2.2141.00
21_E419_V2.2041.00
335_E414_K2.1691.00
57_V143_V2.1621.00
304_N307_T2.1441.00
377_R380_K2.1291.00
280_T332_E2.1241.00
51_Y55_K2.0591.00
284_D309_S2.0361.00
33_S394_L2.0301.00
176_V185_K2.0241.00
137_V145_S2.0241.00
54_W143_V1.9991.00
239_K367_T1.9901.00
352_L388_F1.9621.00
212_S393_L1.9271.00
36_I205_M1.8971.00
249_A357_I1.8821.00
348_F395_T1.8601.00
24_S428_A1.8581.00
293_S340_A1.8521.00
54_W147_V1.8491.00
174_E187_T1.8361.00
278_Y304_N1.8301.00
341_L402_I1.8201.00
19_S22_I1.8101.00
414_K417_E1.8031.00
358_G362_W1.7971.00
451_K455_R1.7891.00
207_N251_F1.7581.00
363_G378_Y1.7581.00
129_V137_V1.7341.00
405_Q415_T1.6821.00
359_L385_A1.6811.00
211_I249_A1.6691.00
34_V443_I1.6641.00
362_W366_L1.6521.00
62_Q66_R1.6471.00
99_Q102_T1.6401.00
30_W436_V1.6371.00
355_L385_A1.6251.00
20_P24_S1.6210.99
33_S398_Y1.6200.99
63_R236_S1.6170.99
138_A141_T1.6140.99
134_R142_Y1.6120.99
104_A108_I1.6080.99
26_M432_L1.6050.99
253_A354_F1.5970.99
328_I332_E1.5870.99
221_S237_A1.5730.99
359_L381_S1.5690.99
190_V193_F1.5170.99
49_I68_R1.5100.99
366_L375_S1.4970.99
67_L237_A1.4940.99
322_D325_A1.4650.99
226_W376_T1.4640.99
52_F67_L1.4510.99
74_V216_L1.4470.99
316_F321_G1.4420.99
218_A242_V1.4390.99
74_V450_L1.4390.99
351_G355_L1.4390.99
49_I146_S1.4380.99
338_P402_I1.4310.99
69_S134_R1.4310.99
280_T326_E1.4230.99
437_V441_A1.4190.99
173_Y412_E1.4120.99
301_R305_L1.4000.98
169_T197_R1.3960.98
290_F344_W1.3890.98
365_Y368_Y1.3820.98
22_I26_M1.3790.98
274_M399_V1.3780.98
56_D65_A1.3740.98
249_A360_A1.3700.98
103_I184_A1.3640.98
440_I444_L1.3530.98
122_L152_G1.3460.98
224_L229_P1.3450.98
186_L192_A1.3350.98
385_A388_F1.3350.98
380_K384_A1.3320.98
289_A307_T1.3290.98
53_T143_V1.3120.98
162_V198_M1.3070.98
413_L418_A1.3020.98
41_L216_L1.2900.97
312_G324_D1.2880.97
71_W237_A1.2860.97
226_W383_I1.2840.97
42_S78_G1.2650.97
433_V437_V1.2580.97
29_G402_I1.2570.97
157_G206_M1.2520.97
76_A131_L1.2480.97
312_G316_F1.2480.97
55_K58_R1.2470.97
65_A69_S1.2340.97
108_I163_V1.2340.97
215_L359_L1.2340.97
218_A238_L1.2320.97
181_M185_K1.2240.96
20_P425_G1.2210.96
50_I54_W1.2110.96
41_L45_L1.2080.96
55_K61_E1.1980.96
364_G368_Y1.1970.96
239_K243_V1.1960.96
30_W432_L1.1950.96
214_A241_A1.1950.96
293_S338_P1.1910.96
43_I209_S1.1890.96
223_Y227_K1.1870.96
277_H286_H1.1850.96
114_F189_P1.1830.96
129_V145_S1.1830.96
281_G284_D1.1720.95
202_Y206_M1.1720.95
319_S322_D1.1690.95
161_L198_M1.1620.95
48_F240_L1.1550.95
24_S423_L1.1510.95
218_A241_A1.1440.95
47_P150_G1.1440.95
300_P303_E1.1440.95
448_Y452_W1.1430.95
220_V454_I1.1380.95
203_V255_H1.1360.95
147_V151_V1.1300.94
41_L390_Y1.1280.94
271_F327_V1.1250.94
215_L356_F1.1250.94
154_W206_M1.1240.94
214_A245_L1.1220.94
264_E318_A1.1160.94
48_F244_L1.1040.94
430_L434_G1.1000.94
249_A253_A1.1000.94
208_A393_L1.0870.93
226_W380_K1.0800.93
264_E271_F1.0730.93
351_G354_F1.0710.93
238_L382_M1.0660.93
149_V153_A1.0600.92
391_A395_T1.0560.92
286_H289_A1.0500.92
362_W377_R1.0490.92
51_Y240_L1.0480.92
348_F391_A1.0460.92
47_P51_Y1.0370.91
271_F274_M1.0360.91
205_M208_A1.0350.91
235_N239_K1.0340.91
366_L371_R1.0310.91
269_Q330_L1.0260.91
338_P341_L1.0260.91
200_W262_H1.0250.91
130_L146_S1.0230.91
169_T262_H1.0200.91
246_L364_G1.0200.91
359_L388_F1.0150.91
52_F240_L1.0140.91
158_F162_V1.0120.90
245_L360_A1.0100.90
53_T146_S1.0090.90
53_T134_R1.0070.90
361_L365_Y1.0070.90
434_G438_L0.9990.90
277_H327_V0.9990.90
173_Y187_T0.9970.90
213_V389_G0.9930.90
56_D134_R0.9930.90
197_R266_T0.9910.90
65_A134_R0.9880.89
378_Y382_M0.9870.89
68_R134_R0.9860.89
226_W379_L0.9840.89
67_L233_A0.9830.89
318_A327_V0.9800.89
319_S324_D0.9740.89
431_T434_G0.9680.88
371_R374_E0.9680.88
21_E416_S0.9670.88
140_R144_L0.9660.88
141_T144_L0.9640.88
231_A235_N0.9610.88
358_G361_L0.9610.88
215_L382_M0.9560.88
176_V181_M0.9520.88
54_W58_R0.9510.88
199_P203_V0.9500.87
104_A409_I0.9490.87
200_W258_A0.9490.87
355_L358_G0.9450.87
143_V147_V0.9390.87
285_L317_L0.9340.87
262_H266_T0.9310.86
47_P50_I0.9290.86
278_Y331_N0.9270.86
218_A382_M0.9260.86
282_S328_I0.9230.86
223_Y383_I0.9230.86
359_L382_M0.9220.86
222_A379_L0.9200.86
247_V251_F0.9190.86
277_H328_I0.9120.85
62_Q65_A0.9110.85
285_L350_V0.9090.85
26_M30_W0.9070.85
293_S300_P0.8990.84
233_A458_L0.8960.84
290_F306_F0.8920.84
150_G154_W0.8920.84
280_T328_I0.8910.84
32_I89_M0.8910.84
139_D143_V0.8900.84
197_R201_M0.8900.84
278_Y293_S0.8880.84
23_A429_T0.8710.82
248_S252_Q0.8680.82
211_I252_Q0.8670.82
355_L359_L0.8670.82
243_V364_G0.8660.82
68_R72_V0.8660.82
312_G325_A0.8650.82
281_G326_E0.8600.82
148_L152_G0.8580.82
158_F193_F0.8570.81
286_H307_T0.8550.81
203_V207_N0.8550.81
216_L390_Y0.8490.81
77_V453_L0.8480.81
408_V413_L0.8480.81
314_G327_V0.8480.81
169_T196_P0.8460.81
135_E139_D0.8460.81
263_V274_M0.8450.81
280_T329_G0.8450.81
290_F305_L0.8440.80
175_M184_A0.8430.80
281_G309_S0.8410.80
254_V258_A0.8400.80
355_L381_S0.8400.80
151_V155_L0.8380.80
424_T427_E0.8350.80
271_F314_G0.8350.80
98_P421_S0.8310.79
23_A432_L0.8280.79
425_G428_A0.8250.79
363_G382_M0.8240.79
426_T429_T0.8230.79
57_V140_R0.8210.79
206_M210_V0.8200.79
70_F457_E0.8160.78
100_F106_E0.8150.78
210_V248_S0.8090.78
211_I245_L0.8080.77
451_K454_I0.8070.77
423_L428_A0.8040.77
100_F104_A0.8030.77
92_Q97_F0.8020.77
243_V367_T0.8020.77
61_E66_R0.8020.77
277_H281_G0.8020.77
441_A445_T0.8010.77
356_F385_A0.8010.77
341_L398_Y0.8000.77
452_W456_G0.7980.77
62_Q139_D0.7940.76
425_G429_T0.7940.76
249_A353_G0.7920.76
66_R459_R0.7910.76
104_A166_W0.7910.76
246_L361_L0.7880.76
289_A306_F0.7870.76
293_S339_V0.7870.76
292_K303_E0.7860.76
430_L433_V0.7840.75
433_V436_V0.7840.75
162_V400_T0.7830.75
310_L313_I0.7830.75
342_V345_S0.7820.75
61_E232_D0.7820.75
342_V398_Y0.7810.75
345_S399_V0.7800.75
288_L306_F0.7790.75
64_Y67_L0.7780.75
251_F255_H0.7750.75
290_F340_A0.7730.74
342_V399_V0.7710.74
283_A325_A0.7680.74
408_V415_T0.7660.74
64_Y458_L0.7660.74
66_R230_D0.7630.73
423_L427_E0.7620.73
424_T428_A0.7610.73
217_V241_A0.7600.73
228_K376_T0.7600.73
263_V400_T0.7600.73
222_A238_L0.7590.73
107_L186_L0.7570.73
246_L360_A0.7550.73
211_I356_F0.7550.73
174_E185_K0.7540.72
200_W259_Y0.7520.72
364_G367_T0.7520.72
134_R146_S0.7510.72
36_I393_L0.7510.72
57_V139_D0.7510.72
78_G216_L0.7490.72
224_L457_E0.7460.72
48_F217_V0.7460.72
345_S395_T0.7440.71
141_T145_S0.7420.71
40_S108_I0.7420.71
314_G317_L0.7420.71
126_F145_S0.7410.71
331_N336_N0.7390.71
54_W57_V0.7380.71
209_S252_Q0.7380.71
119_A156_S0.7370.71
264_E328_I0.7370.71
93_F112_L0.7360.71
227_K384_A0.7340.70
34_V38_F0.7330.70
333_Y336_N0.7320.70
72_V130_L0.7300.70
47_P154_W0.7270.70
136_R455_R0.7270.70
88_P439_Y0.7240.69
283_A329_G0.7240.69
209_S393_L0.7230.69
312_G322_D0.7210.69
269_Q410_Q0.7200.69
77_V449_V0.7190.69
100_F107_L0.7180.69
165_A201_M0.7180.69
165_A195_T0.7160.69
362_W365_Y0.7160.69
362_W381_S0.7150.68
365_Y369_R0.7140.68
243_V247_V0.7140.68
244_L248_S0.7130.68
271_F318_A0.7110.68
74_V453_L0.7110.68
289_A309_S0.7080.68
419_V428_A0.7080.68
225_V231_A0.7010.67
129_V449_V0.6990.67
43_I154_W0.6980.67
286_H304_N0.6950.66
29_G341_L0.6950.66
326_E332_E0.6950.66
308_V313_I0.6950.66
47_P210_V0.6950.66
279_E326_E0.6920.66
292_K304_N0.6900.66
447_L451_K0.6900.66
357_I361_L0.6890.66
114_F159_W0.6850.65
288_L307_T0.6840.65
301_R307_T0.6830.65
435_F442_L0.6820.65
301_R306_F0.6790.64
242_V364_G0.6780.64
293_S301_R0.6770.64
278_Y336_N0.6770.64
197_R262_H0.6770.64
110_G186_L0.6760.64
114_F118_M0.6730.64
63_R67_L0.6720.64
58_R61_E0.6720.64
235_N373_T0.6710.64
165_A198_M0.6710.64
427_E430_L0.6700.63
328_I333_Y0.6680.63
137_V141_T0.6680.63
119_A155_L0.6680.63
292_K302_T0.6680.63
280_T327_V0.6670.63
55_K64_Y0.6670.63
153_A210_V0.6670.63
51_Y59_T0.6650.63
60_N370_G0.6640.63
230_D457_E0.6630.63
315_S327_V0.6630.63
47_P147_V0.6630.63
354_F362_W0.6610.62
53_T57_V0.6600.62
94_G109_G0.6590.62
356_F388_F0.6580.62
19_S26_M0.6570.62
315_S325_A0.6570.62
440_I443_I0.6570.62
126_F152_G0.6570.62
340_A344_W0.6550.62
338_P342_V0.6520.61
84_V411_G0.6520.61
119_A160_I0.6510.61
303_E306_F0.6500.61
335_E407_W0.6490.61
224_L454_I0.6480.61
381_S385_A0.6470.61
38_F84_V0.6430.60
359_L378_Y0.6420.60
387_P391_A0.6410.60
23_A428_A0.6400.60
134_R457_E0.6390.60
98_P101_A0.6370.60
89_M95_T0.6360.59
46_A162_V0.6360.59
418_A421_S0.6360.59
255_H258_A0.6350.59
313_I354_F0.6350.59
260_G347_R0.6340.59
436_V440_I0.6330.59
122_L148_L0.6320.59
342_V402_I0.6320.59
24_S419_V0.6320.59
413_L417_E0.6310.59
107_L173_Y0.6310.59
224_L234_W0.6290.59
107_L184_A0.6270.58
217_V244_L0.6260.58
215_L352_L0.6250.58
352_L392_A0.6230.58
46_A49_I0.6220.58
89_M92_Q0.6210.58
216_L450_L0.6190.57
172_G192_A0.6170.57
52_F68_R0.6160.57
211_I248_S0.6140.57
106_E181_M0.6130.57
249_A352_L0.6110.56
428_A432_L0.6100.56
316_F322_D0.6090.56
300_P305_L0.6090.56
277_H314_G0.6090.56
174_E186_L0.6070.56
214_A248_S0.6070.56
278_Y307_T0.6050.56
276_A347_R0.6050.56
154_W210_V0.6040.56
53_T65_A0.6030.55
91_F116_A0.6020.55
242_V366_L0.6020.55
378_Y381_S0.6010.55
151_V190_V0.6010.55
318_A321_G0.6010.55
442_L446_A0.6010.55
375_S379_L0.5990.55
350_V392_A0.5990.55
90_S163_V0.5990.55
55_K240_L0.5990.55
431_T454_I0.5980.55
63_R232_D0.5950.54
264_E325_A0.5940.54
73_K456_G0.5940.54
55_K59_T0.5930.54
336_N414_K0.5920.54
208_A252_Q0.5920.54
166_W192_A0.5920.54
78_G90_S0.5920.54
179_N185_K0.5910.54
446_A450_L0.5900.54
287_L310_L0.5850.53
352_L395_T0.5850.53
99_Q413_L0.5840.53
191_A194_L0.5830.53
303_E307_T0.5820.53
130_L142_Y0.5820.53
20_P419_V0.5800.53
101_A104_A0.5800.53
276_A289_A0.5780.52
159_W193_F0.5780.52
211_I214_A0.5780.52
224_L458_L0.5770.52
59_T64_Y0.5770.52
238_L379_L0.5770.52
100_F167_M0.5760.52
61_E64_Y0.5760.52
161_L205_M0.5750.52
59_T68_R0.5750.52
279_E334_E0.5740.52
362_W375_S0.5740.52
196_P262_H0.5720.52
461_L464_Q0.5710.51
453_L456_G0.5710.51
218_A385_A0.5710.51
45_L216_L0.5710.51
250_P357_I0.5700.51
233_A237_A0.5700.51
289_A343_F0.5670.51
367_T370_G0.5670.51
383_I386_S0.5660.51
66_R460_S0.5650.51
111_P192_A0.5640.51
173_Y184_A0.5630.50
276_A330_L0.5630.50
18_L429_T0.5620.50
154_W158_F0.5590.50
246_L250_P0.5590.50
24_S420_S0.5590.50
110_G189_P0.5580.50
284_D307_T0.5580.50
128_G131_L0.5570.50
136_R452_W0.5570.50
24_S75_F0.5570.50
42_S81_M0.5560.50
31_T89_M0.5560.50
39_A108_I0.5540.49
72_V134_R0.5540.49
309_S374_E0.5530.49
50_I146_S0.5530.49
148_L151_V0.5510.49
430_L436_V0.5500.49
259_Y262_H0.5490.49
66_R233_A0.5490.49
282_S319_S0.5480.49
172_G191_A0.5480.49
328_I335_E0.5480.49
245_L356_F0.5470.48
49_I75_F0.5470.48
304_N339_V0.5450.48
343_F347_R0.5450.48
279_E301_R0.5440.48
66_R461_L0.5430.48
19_S429_T0.5420.48
78_G390_Y0.5410.48
429_T434_G0.5410.48
34_V81_M0.5410.48
283_A323_F0.5400.48
448_Y451_K0.5390.47
169_T266_T0.5390.47
34_V85_T0.5390.47
230_D458_L0.5380.47
36_I389_G0.5380.47
376_T379_L0.5380.47
281_G445_T0.5370.47
341_L345_S0.5370.47
273_A339_V0.5350.47
86_G123_E0.5350.47
143_V146_S0.5350.47
419_V450_L0.5350.47
100_F108_I0.5340.47
228_K231_A0.5340.47
311_P346_F0.5340.47
44_G246_L0.5330.47
67_L71_W0.5330.47
380_K383_I0.5320.47
216_L454_I0.5320.47
138_A144_L0.5320.47
350_V354_F0.5310.46
66_R73_K0.5310.46
304_N309_S0.5310.46
69_S139_D0.5300.46
106_E184_A0.5300.46
376_T441_A0.5290.46
247_V363_G0.5290.46
291_P344_W0.5280.46
201_M257_D0.5270.46
124_A393_L0.5260.46
31_T435_F0.5260.46
48_F241_A0.5260.46
189_P343_F0.5260.46
87_I125_V0.5250.46
31_T92_Q0.5250.46
201_M400_T0.5240.46
227_K231_A0.5240.46
82_G401_E0.5240.46
215_L388_F0.5230.45
34_V37_I0.5220.45
234_W237_A0.5220.45
272_A314_G0.5210.45
47_P244_L0.5200.45
309_S318_A0.5190.45
260_G317_L0.5180.45
130_L389_G0.5180.45
77_V446_A0.5170.45
277_H435_F0.5160.45
41_L52_F0.5160.45
196_P266_T0.5140.44
249_A356_F0.5140.44
429_T432_L0.5140.44
407_W458_L0.5130.44
77_V450_L0.5130.44
395_T398_Y0.5110.44
61_E236_S0.5110.44
387_P458_L0.5100.44
224_L227_K0.5090.44
272_A332_E0.5090.44
43_I47_P0.5070.44
412_E416_S0.5060.43
211_I352_L0.5060.43
256_G346_F0.5060.43
158_F198_M0.5060.43
232_D236_S0.5050.43
76_A130_L0.5050.43
278_Y302_T0.5050.43
288_L344_W0.5050.43
158_F202_Y0.5040.43
72_V77_V0.5040.43
118_M155_L0.5040.43
48_F100_F0.5030.43
151_V341_L0.5030.43
92_Q116_A0.5030.43
165_A252_Q0.5020.43
140_R143_V0.5020.43
212_S398_Y0.5020.43
301_R304_N0.5020.43
124_A453_L0.5010.43
91_F94_G0.5010.43
230_D460_S0.5000.43
65_A135_E0.5000.43
106_E185_K0.5000.43
164_N401_E0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mk7A 1 0.4585 44.8 0.977 Contact Map
4xp4A 1 0.4357 33.2 0.979 Contact Map
3ukmA 2 0.444 26.2 0.98 Contact Map
3w4tA 1 0.7718 22 0.981 Contact Map
3s8fA 1 0.9212 21.8 0.981 Contact Map
2a65A 2 0.4295 16.4 0.982 Contact Map
4tphA 2 0.7552 13.1 0.983 Contact Map
2f95B 2 0.11 11 0.983 Contact Map
4ltoA 3 0.249 10.3 0.983 Contact Map
3hzqA 3 0.1494 9.4 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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