GREMLIN Database
O54601 - Uncharacterized protein
UniProt: O54601 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 152 (130)
Sequences: 1353 (950)
Seq/√Len: 83.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_P77_F4.5831.00
104_I112_S3.4771.00
33_V44_G3.4431.00
33_V42_D3.4101.00
71_P74_G3.2991.00
57_G61_F3.1161.00
56_T60_F2.7141.00
61_F64_P2.6381.00
54_A58_V2.4391.00
47_F51_G2.3451.00
24_A29_A2.2761.00
86_R90_I2.2101.00
90_I94_I2.1261.00
71_P76_S2.0731.00
87_N138_R2.0271.00
61_F65_R2.0171.00
134_Q138_R1.9991.00
104_I120_I1.9071.00
123_A127_M1.7931.00
58_V61_F1.7761.00
53_A58_V1.7591.00
74_G78_Q1.7551.00
121_L125_A1.6361.00
110_Y124_L1.6171.00
13_L20_G1.5991.00
88_V92_G1.5711.00
33_V49_M1.5571.00
31_P44_G1.5271.00
23_L53_A1.4740.99
63_A77_F1.4510.99
84_F89_L1.4430.99
22_G28_M1.3310.99
71_P75_D1.3190.99
23_L108_A1.2880.98
20_G24_A1.2790.98
109_A124_L1.2720.98
56_T64_P1.2560.98
113_L124_L1.2360.98
58_V62_V1.1820.97
114_G120_I1.1820.97
119_T122_W1.1710.97
38_L108_A1.1650.97
28_M48_V1.1550.97
11_L14_V1.1500.96
131_A134_Q1.1470.96
126_G129_L1.1460.96
132_Y136_F1.1410.96
118_I121_L1.1370.96
93_A97_V1.1360.96
12_I15_G1.1190.96
128_F131_A1.1130.96
60_F79_R1.1080.96
127_M131_A1.1020.96
49_M53_A1.1000.95
26_S47_F1.0870.95
89_L93_A1.0800.95
74_G77_F1.0730.95
109_A127_M1.0580.94
84_F88_V1.0560.94
13_L24_A1.0440.94
85_D89_L1.0410.94
13_L17_L1.0350.94
23_L38_L1.0210.93
23_L111_A0.9970.92
29_A112_S0.9920.92
116_G131_A0.9910.92
55_V59_T0.9840.92
33_V36_N0.9660.91
85_D92_G0.9660.91
62_V72_L0.9420.90
64_P69_R0.9310.90
102_S123_A0.9160.89
50_F53_A0.9070.88
112_S120_I0.8980.88
80_R85_D0.8940.88
21_F25_Y0.8920.88
11_L133_T0.8920.88
20_G113_L0.8870.87
60_F64_P0.8840.87
38_L111_A0.8830.87
35_L60_F0.8730.86
56_T63_A0.8690.86
63_A68_G0.8690.86
92_G138_R0.8680.86
125_A129_L0.8670.86
60_F63_A0.8610.86
8_F74_G0.8560.85
24_A111_A0.8500.85
68_G77_F0.8480.85
23_L28_M0.8410.84
108_A111_A0.8210.83
29_A111_A0.8210.83
31_P37_F0.7950.81
109_A123_A0.7940.81
9_M12_I0.7880.80
68_G72_L0.7870.80
70_A132_Y0.7860.80
23_L64_P0.7820.80
17_L134_Q0.7760.79
56_T59_T0.7670.78
55_V60_F0.7630.78
87_N102_S0.7600.78
20_G111_A0.7510.77
80_R83_S0.7420.76
110_Y113_L0.7360.75
25_Y62_V0.7150.73
119_T133_T0.7140.73
87_N90_I0.7140.73
87_N134_Q0.7130.73
8_F126_G0.7080.73
113_L120_I0.7060.72
122_W125_A0.7050.72
104_I124_L0.7030.72
10_P76_S0.6900.71
20_G30_R0.6880.70
21_F24_A0.6860.70
89_L137_W0.6850.70
22_G49_M0.6830.70
79_R102_S0.6800.70
10_P136_F0.6770.69
13_L19_F0.6760.69
19_F23_L0.6690.68
132_Y139_S0.6680.68
76_S121_L0.6640.68
30_R49_M0.6630.68
83_S92_G0.6590.67
53_A56_T0.6590.67
16_G20_G0.6530.66
18_I22_G0.6450.66
37_F100_G0.6310.64
48_V51_G0.6290.64
37_F44_G0.6290.64
70_A73_T0.6290.64
114_G118_I0.6250.63
63_A79_R0.6180.62
70_A77_F0.6140.62
81_L84_F0.6130.62
85_D93_A0.6120.61
47_F112_S0.6120.61
73_T94_I0.6120.61
26_S29_A0.6110.61
43_F88_V0.6080.61
13_L59_T0.6060.61
117_N122_W0.6000.60
38_L127_M0.5930.59
10_P61_F0.5890.59
40_F139_S0.5870.58
110_Y119_T0.5840.58
69_R90_I0.5840.58
128_F132_Y0.5830.58
25_Y46_V0.5790.57
14_V86_R0.5780.57
38_L47_F0.5730.56
135_G138_R0.5700.56
60_F92_G0.5700.56
47_F50_F0.5690.56
27_Q36_N0.5660.56
12_I39_Q0.5600.55
36_N41_E0.5580.55
39_Q123_A0.5570.54
22_G45_L0.5560.54
25_Y69_R0.5560.54
30_R44_G0.5550.54
27_Q102_S0.5520.54
20_G56_T0.5500.53
11_L113_L0.5390.52
72_L94_I0.5380.52
15_G38_L0.5360.52
53_A60_F0.5340.51
20_G107_G0.5330.51
29_A35_L0.5300.51
30_R33_V0.5270.50
56_T79_R0.5270.50
81_L139_S0.5220.50
120_I134_Q0.5200.49
29_A32_E0.5190.49
10_P129_L0.5160.49
117_N120_I0.5150.49
24_A27_Q0.5140.49
112_S117_N0.5140.49
29_A49_M0.5140.49
89_L138_R0.5140.49
86_R136_F0.5130.49
27_Q33_V0.5100.48
38_L109_A0.5080.48
48_V107_G0.5070.48
101_L104_I0.5060.48
52_G56_T0.5050.48
10_P13_L0.5040.47
14_V46_V0.5030.47
23_L60_F0.5010.47
57_G94_I0.5010.47
31_P127_M0.5010.47
55_V58_V0.5000.47
73_T132_Y0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldsA 2 0.875 45.6 0.93 Contact Map
3wdoA 1 0.9079 29.8 0.937 Contact Map
4gc0A 1 0.9013 24.7 0.939 Contact Map
4j05A 3 0.8553 20.3 0.942 Contact Map
3o7qA 1 0.8882 18.3 0.943 Contact Map
3j1zP 8 0.9145 16.8 0.944 Contact Map
1pw4A 1 0.8421 9.9 0.949 Contact Map
4w6vA 1 0.8487 9.4 0.95 Contact Map
2l6wA 2 0.2566 9.1 0.95 Contact Map
4zw9A 1 0.8684 8.2 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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