GREMLIN Database
O54596 - CydB
UniProt: O54596 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 331 (308)
Sequences: 3250 (2088)
Seq/√Len: 118.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_M170_I3.7381.00
136_V166_V3.3341.00
318_G321_S3.3011.00
302_G306_L2.8241.00
292_P296_N2.7911.00
53_E188_E2.7741.00
140_L166_V2.7731.00
191_S195_G2.7141.00
33_V259_L2.6511.00
140_L162_G2.6361.00
167_A203_G2.5681.00
170_I196_A2.5151.00
228_V233_A2.4341.00
55_E59_A2.4141.00
311_W314_K2.3671.00
22_G26_F2.3171.00
43_M166_V2.3151.00
100_G141_L2.3031.00
250_R253_A2.2921.00
115_R128_D2.2841.00
175_A193_G2.2601.00
182_D325_E2.2281.00
56_T324_I2.2201.00
235_S238_A2.2081.00
28_L79_L2.2041.00
139_P165_L2.2011.00
26_F30_M2.1631.00
190_R194_V2.1161.00
235_S239_G2.1121.00
300_V304_P2.0731.00
17_P289_V2.0631.00
163_V167_A2.0351.00
144_M162_G2.0271.00
41_I57_F2.0131.00
314_K318_G2.0071.00
132_V136_V1.9991.00
147_G161_T1.9931.00
57_F177_L1.9751.00
209_G213_A1.9751.00
82_A298_V1.9591.00
167_A199_A1.9421.00
139_P169_S1.9221.00
51_E124_K1.9101.00
194_V247_R1.8951.00
134_G138_A1.8881.00
159_V163_V1.8861.00
107_F130_A1.8591.00
19_V299_T1.8481.00
126_Y129_Y1.8391.00
66_D113_E1.8381.00
129_Y133_G1.8191.00
206_V210_T1.7911.00
276_T284_L1.7561.00
174_A193_G1.7241.00
163_V203_G1.7191.00
299_T303_F1.6841.00
186_A251_Y1.6591.00
204_V268_L1.6281.00
150_L273_L1.6231.00
104_A134_G1.6191.00
230_A233_A1.6121.00
234_L238_A1.6011.00
305_V308_L1.5921.00
130_A134_G1.5901.00
58_L112_P1.5801.00
172_T259_L1.5191.00
37_F317_Y1.5181.00
101_F142_L1.5031.00
211_V215_D1.5001.00
204_V265_L1.4861.00
104_A137_F1.4641.00
164_G203_G1.4621.00
148_R158_V1.4521.00
39_F139_P1.4491.00
198_V202_G1.4411.00
24_V78_M1.4401.00
89_R278_Y1.4341.00
53_E326_G1.4311.00
56_T185_L1.4181.00
168_V262_P1.4171.00
206_V209_G1.4141.00
54_R128_D1.3981.00
184_G187_S1.3941.00
41_I61_F1.3901.00
125_R129_Y1.3741.00
178_A186_A1.3671.00
94_N148_R1.3671.00
98_A145_L1.3671.00
141_L144_M1.3591.00
17_P295_L1.3521.00
27_A30_M1.3491.00
179_A252_R1.3381.00
37_F64_V1.3371.00
296_N300_V1.3361.00
99_L103_V1.3331.00
140_L144_M1.3281.00
15_S18_E1.3231.00
94_N97_L1.2981.00
233_A236_I1.2931.00
43_M136_V1.2891.00
42_G135_S1.2781.00
190_R249_G1.2660.99
112_P127_T1.2450.99
44_L174_A1.2330.99
37_F255_L1.2230.99
20_W82_A1.2230.99
46_A132_V1.2220.99
52_H326_G1.2200.99
94_N278_Y1.2150.99
18_E286_R1.2080.99
97_L144_M1.2060.99
245_L257_S1.1940.99
30_M310_L1.1900.99
41_I177_L1.1810.99
192_Y195_G1.1710.99
126_Y130_A1.1490.99
86_V90_L1.1450.99
291_S294_A1.1450.99
76_G91_L1.1400.99
207_L211_V1.1340.99
56_T59_A1.1280.99
122_R126_Y1.1250.99
208_L212_V1.1200.99
221_S225_S1.1170.99
118_R123_W1.1110.99
171_V197_T1.1070.99
292_P295_L1.1050.99
165_L169_S1.0990.99
276_T280_P1.0950.98
48_R57_F1.0910.98
232_V271_V1.0840.98
207_L210_T1.0800.98
79_L86_V1.0790.98
86_V277_V1.0770.98
27_A74_A1.0750.98
50_D53_E1.0740.98
43_M132_V1.0680.98
133_G137_F1.0640.98
168_V265_L1.0630.98
142_L169_S1.0630.98
208_L211_V1.0580.98
210_T215_D1.0540.98
29_G263_T1.0480.98
293_L297_L1.0470.98
29_G266_T1.0450.98
171_V175_A1.0450.98
171_V193_G1.0420.98
244_V247_R1.0390.98
236_I239_G1.0310.98
64_V176_F1.0250.98
116_E124_K1.0150.98
175_A258_A1.0120.97
175_A254_W1.0030.97
293_L296_N1.0030.97
21_F25_V1.0000.97
172_T258_A1.0000.97
26_F77_T0.9950.97
192_Y196_A0.9940.97
50_D326_G0.9780.97
149_W278_Y0.9730.97
184_G188_E0.9720.97
137_F141_L0.9700.97
76_G87_Y0.9700.97
240_L261_L0.9680.97
239_G264_L0.9650.97
67_A316_L0.9610.97
152_A155_T0.9610.97
45_Y132_V0.9540.96
52_H56_T0.9520.96
101_F141_L0.9480.96
186_A190_R0.9460.96
211_V216_A0.9450.96
239_G243_S0.9410.96
164_G204_V0.9390.96
136_V140_L0.9390.96
55_E58_L0.9380.96
210_T214_T0.9360.96
56_T326_G0.9310.96
48_R53_E0.9280.96
167_A200_Y0.9260.96
283_L287_E0.9250.96
233_A237_V0.9230.96
55_E116_E0.9180.96
211_V224_L0.9070.95
104_A138_A0.9060.95
223_V227_P0.9040.95
15_S19_V0.9040.95
211_V214_T0.9030.95
225_S228_V0.8980.95
35_D39_F0.8980.95
228_V232_V0.8960.95
194_V197_T0.8920.95
252_R256_A0.8890.95
20_W298_V0.8870.95
237_V241_G0.8870.95
45_Y58_L0.8820.94
284_L287_E0.8810.94
32_I313_F0.8790.94
191_S194_V0.8740.94
27_A77_T0.8720.94
229_A232_V0.8700.94
28_L75_F0.8660.94
23_A77_T0.8660.94
223_V272_L0.8620.94
232_V235_S0.8600.94
42_G139_P0.8540.93
116_E119_E0.8520.93
290_V294_A0.8490.93
37_F180_K0.8470.93
178_A190_R0.8470.93
26_F306_L0.8450.93
263_T267_L0.8450.93
199_A202_G0.8450.93
129_Y132_V0.8370.93
32_I142_L0.8350.93
304_P308_L0.8350.93
269_V273_L0.8340.93
226_L229_A0.8320.93
91_L98_A0.8320.93
140_L159_V0.8310.93
130_A133_G0.8270.92
80_L87_Y0.8250.92
86_V89_R0.8240.92
139_P142_L0.8180.92
171_V258_A0.8170.92
205_V209_G0.8150.92
179_A255_L0.8140.92
106_V289_V0.8100.92
190_R193_G0.8090.91
122_R125_R0.8080.91
207_L215_D0.8070.91
227_P230_A0.8060.91
92_A95_Y0.8030.91
93_D97_L0.8020.91
23_A26_F0.7960.91
167_A196_A0.7950.91
187_S190_R0.7930.91
228_V231_V0.7930.91
171_V196_A0.7920.91
228_V271_V0.7910.91
232_V236_I0.7890.90
127_T130_A0.7840.90
44_L170_I0.7790.90
109_G112_P0.7750.90
151_F156_L0.7710.89
85_R288_A0.7710.89
196_A199_A0.7690.89
56_T181_T0.7650.89
49_T53_E0.7640.89
136_V139_P0.7610.89
35_D180_K0.7610.89
59_A116_E0.7580.89
146_A269_V0.7570.89
299_T323_P0.7530.88
39_F109_G0.7510.88
187_S191_S0.7460.88
194_V246_A0.7450.88
260_A264_L0.7440.88
144_M159_V0.7430.88
76_G298_V0.7430.88
25_V270_A0.7420.88
193_G246_A0.7420.88
96_L100_G0.7420.88
229_A233_A0.7420.88
223_V233_A0.7400.87
64_V316_L0.7380.87
185_L189_L0.7360.87
157_P210_T0.7350.87
261_L265_L0.7340.87
123_W126_Y0.7290.87
31_Y39_F0.7240.86
77_T306_L0.7230.86
177_L189_L0.7180.86
124_K128_D0.7160.86
297_L301_L0.7160.86
43_M135_S0.7160.86
315_F319_V0.7140.85
283_L288_A0.7130.85
59_A62_G0.7100.85
222_A225_S0.7100.85
176_F321_S0.7090.85
174_A192_Y0.7040.85
38_D41_I0.7000.84
153_G156_L0.6990.84
49_T188_E0.6960.84
235_S242_G0.6960.84
111_G130_A0.6960.84
195_G198_V0.6940.84
53_E184_G0.6930.84
246_A257_S0.6890.83
234_L239_G0.6880.83
187_S249_G0.6820.83
100_G137_F0.6800.83
238_A241_G0.6800.83
134_G139_P0.6800.83
106_V111_G0.6790.83
65_W87_Y0.6750.82
78_M81_A0.6750.82
66_D312_Y0.6740.82
186_A323_P0.6740.82
76_G98_A0.6740.82
24_V301_L0.6740.82
174_A178_A0.6730.82
44_L177_L0.6720.82
240_L264_L0.6710.82
160_L210_T0.6710.82
208_L214_T0.6700.82
190_R251_Y0.6700.82
109_G268_L0.6660.81
181_T323_P0.6660.81
23_A306_L0.6650.81
33_V263_T0.6600.81
299_T302_G0.6580.81
32_I169_S0.6580.81
133_G325_E0.6560.80
60_A176_F0.6540.80
208_L215_D0.6540.80
264_L271_V0.6540.80
29_G33_V0.6540.80
140_L163_V0.6440.79
15_S285_V0.6440.79
313_F316_L0.6430.79
66_D69_E0.6420.79
75_F79_L0.6390.79
32_I266_T0.6370.78
147_G158_V0.6360.78
232_V264_L0.6360.78
151_F155_T0.6320.78
39_F105_L0.6320.78
256_A260_A0.6310.78
31_Y320_F0.6310.78
274_Y295_L0.6300.78
208_L213_A0.6300.78
26_F302_G0.6290.77
17_P292_P0.6280.77
206_V215_D0.6270.77
101_F168_V0.6270.77
177_L181_T0.6250.77
59_A117_Q0.6240.77
60_A325_E0.6240.77
58_L116_E0.6200.76
178_A251_Y0.6200.76
201_L237_V0.6190.76
206_V211_V0.6180.76
51_E116_E0.6170.76
234_L237_V0.6150.76
51_E54_R0.6140.76
31_Y79_L0.6140.76
194_V198_V0.6110.75
314_K321_S0.6110.75
119_E123_W0.6110.75
253_A256_A0.6100.75
51_E128_D0.6090.75
147_G206_V0.6090.75
24_V270_A0.6070.75
121_E124_K0.6070.75
48_R51_E0.6050.75
50_D184_G0.6050.75
24_V86_V0.6050.75
21_F285_V0.6030.74
207_L268_L0.6020.74
119_E126_Y0.6010.74
18_E285_V0.6010.74
231_V235_S0.6000.74
114_L211_V0.6000.74
109_G114_L0.6000.74
275_P285_V0.5990.74
228_V234_L0.5980.74
276_T279_P0.5970.74
281_T287_E0.5960.74
57_F185_L0.5960.74
91_L298_V0.5950.73
100_G103_V0.5950.73
29_G267_L0.5940.73
235_S245_L0.5930.73
24_V192_Y0.5930.73
74_A301_L0.5920.73
131_F135_S0.5900.73
145_L148_R0.5880.73
112_P134_G0.5870.72
29_G259_L0.5860.72
57_F118_R0.5840.72
311_W316_L0.5830.72
267_L271_V0.5810.72
170_I174_A0.5800.72
151_F154_A0.5770.71
168_V261_L0.5760.71
222_A229_A0.5760.71
265_L305_V0.5750.71
27_A298_V0.5730.71
74_A78_M0.5720.71
229_A236_I0.5720.71
121_E125_R0.5720.71
164_G168_V0.5710.70
262_P265_L0.5700.70
53_E56_T0.5690.70
171_V200_Y0.5680.70
46_A129_Y0.5640.70
306_L310_L0.5620.69
61_F112_P0.5590.69
118_R124_K0.5590.69
139_P149_W0.5590.69
23_A302_G0.5580.69
164_G167_A0.5570.69
63_P302_G0.5540.68
97_L104_A0.5530.68
100_G166_V0.5510.68
283_L289_V0.5500.68
239_G242_G0.5500.68
57_F60_A0.5500.68
300_V303_F0.5490.67
47_T192_Y0.5480.67
27_A78_M0.5460.67
98_A262_P0.5450.67
25_V290_V0.5450.67
230_A235_S0.5440.67
188_E191_S0.5430.67
143_G162_G0.5430.67
17_P285_V0.5420.66
117_Q313_F0.5390.66
118_R121_E0.5380.66
139_P166_V0.5370.66
253_A257_S0.5360.66
48_R188_E0.5360.66
89_R93_D0.5340.65
91_L95_Y0.5340.65
182_D186_A0.5310.65
160_L206_V0.5300.65
189_L193_G0.5300.65
287_E293_L0.5300.65
231_V234_L0.5290.65
60_A72_I0.5290.65
103_V321_S0.5260.64
171_V174_A0.5260.64
62_G82_A0.5250.64
54_R115_R0.5250.64
178_A323_P0.5240.64
51_E55_E0.5220.64
306_L311_W0.5210.63
193_G197_T0.5210.63
181_T255_L0.5200.63
220_A225_S0.5160.63
227_P238_A0.5160.63
243_S246_A0.5140.62
81_A161_T0.5140.62
96_L180_K0.5130.62
17_P286_R0.5120.62
163_V198_V0.5120.62
65_W108_R0.5120.62
39_F306_L0.5100.62
202_G244_V0.5100.62
26_F73_V0.5100.62
23_A27_A0.5090.62
159_V162_G0.5080.62
53_E57_F0.5080.62
165_L168_V0.5070.61
112_P268_L0.5040.61
31_Y149_W0.5040.61
43_M104_A0.5030.61
63_P105_L0.5020.61
208_L216_A0.5010.60
167_A170_I0.5000.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mfrA 1 0.1571 19.3 0.968 Contact Map
1qleC 1 0.6103 11 0.972 Contact Map
1fftB 1 0.1571 9.2 0.973 Contact Map
1fftC 1 0.429 7.7 0.974 Contact Map
2m20A 2 0.1208 6.2 0.975 Contact Map
1zzaA 1 0.1541 5.5 0.975 Contact Map
4od4A 1 0.5166 5.4 0.975 Contact Map
1m56C 2 0.6163 3.9 0.977 Contact Map
2l8sA 1 0.1329 3.9 0.977 Contact Map
2yevB 1 0.1571 3.7 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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