GREMLIN Database
O54590 - Uncharacterized protein
UniProt: O54590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 372 (311)
Sequences: 1937 (1668)
Seq/√Len: 94.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
321_G337_L5.1111.00
312_K315_G3.9561.00
56_V90_F3.5451.00
209_E338_R3.4451.00
339_H345_T3.2281.00
56_V60_D3.1721.00
320_L336_V3.0541.00
51_D60_D3.0251.00
42_Q50_V2.9081.00
13_L37_V2.8941.00
161_L175_I2.8831.00
34_R38_N2.8281.00
29_T33_T2.8041.00
125_W311_L2.7971.00
57_D60_D2.7591.00
172_G314_H2.7541.00
165_L313_P2.7461.00
36_A81_T2.6701.00
94_Q99_I2.6241.00
337_L345_T2.5061.00
193_D196_A2.3891.00
13_L89_T2.3521.00
318_R351_E2.3241.00
189_W225_R2.2991.00
165_L175_I2.2701.00
16_L37_V2.2471.00
331_E334_Q2.2191.00
133_L316_G2.2001.00
170_V201_V2.1181.00
128_D132_R2.0971.00
169_G337_L2.0751.00
99_I103_P2.0751.00
65_V83_F2.0601.00
161_L291_A2.0501.00
159_R163_Y2.0171.00
325_Y333_A2.0151.00
334_Q345_T2.0061.00
188_R191_D2.0051.00
40_L43_F1.9991.00
170_V199_M1.9771.00
166_A319_G1.9641.00
35_V39_N1.9321.00
334_Q342_I1.8151.00
74_L78_S1.8151.00
28_Q31_Q1.7881.00
37_V89_T1.7661.00
36_A85_L1.7591.00
64_W68_L1.7571.00
43_F67_H1.7471.00
322_D352_R1.7431.00
126_T129_A1.7271.00
278_E283_P1.7101.00
299_C311_L1.7091.00
77_N81_T1.7041.00
235_P238_P1.6871.00
342_I345_T1.6761.00
232_A241_D1.6661.00
66_I70_K1.5891.00
325_Y353_R1.5861.00
295_L316_G1.5831.00
344_T348_S1.5601.00
279_Y283_P1.5591.00
134_L163_Y1.5511.00
33_T85_L1.5471.00
169_G320_L1.5281.00
295_L311_L1.5261.00
224_Y228_V1.4871.00
197_G218_S1.4861.00
125_W319_G1.4861.00
236_V241_D1.4351.00
138_D159_R1.4170.99
323_E326_G1.4010.99
65_V69_V1.3970.99
172_G292_R1.3940.99
239_T242_A1.3750.99
324_L333_A1.3670.99
90_F104_L1.3660.99
61_A86_A1.3630.99
136_Y301_E1.3540.99
32_I81_T1.3490.99
214_P217_T1.3460.99
76_A80_R1.3310.99
68_L82_Y1.3300.99
12_G89_T1.3220.99
90_F103_P1.3070.99
17_L30_Q1.3030.99
108_T114_P1.3020.99
295_L313_P1.2970.99
235_P241_D1.2870.99
104_L107_T1.2850.99
175_I291_A1.2840.99
234_W238_P1.2580.99
253_L256_R1.2530.99
173_A177_S1.2520.99
318_R338_R1.2370.99
331_E347_A1.2320.99
40_L44_L1.2280.98
197_G201_V1.2240.98
187_L192_V1.2210.98
53_V90_F1.2180.98
130_R134_L1.2050.98
61_A104_L1.1980.98
292_R313_P1.1940.98
169_G345_T1.1870.98
43_F48_N1.1770.98
62_R66_I1.1730.98
337_L344_T1.1700.98
295_L299_C1.1690.98
43_F64_W1.1670.98
321_G325_Y1.1670.98
171_R314_H1.1660.98
84_A87_R1.1650.98
12_G53_V1.1610.98
14_E42_Q1.1520.98
334_Q344_T1.1480.98
245_K250_R1.1460.98
161_L286_L1.1390.97
256_R260_D1.1350.97
21_M30_Q1.1300.97
218_S222_A1.1290.97
133_L162_V1.1270.97
321_G345_T1.1230.97
236_V239_T1.1170.97
163_Y220_K1.1130.97
297_R301_E1.1130.97
239_T243_T1.1100.97
187_L199_M1.1070.97
157_R160_S1.1070.97
38_N42_Q1.1000.97
32_I36_A1.1000.97
60_D63_D1.1000.97
248_A251_K1.0970.97
213_L218_S1.0950.97
74_L79_I1.0930.97
236_V242_A1.0850.97
164_I199_M1.0830.97
137_V162_V1.0680.96
352_R356_D1.0670.96
197_G215_G1.0650.96
232_A236_V1.0640.96
190_T275_V1.0610.96
48_N56_V1.0520.96
64_W82_Y1.0520.96
334_Q350_R1.0390.96
273_D276_L1.0370.96
68_L79_I1.0360.96
247_R250_R1.0260.95
204_K207_D1.0230.95
322_D351_E1.0190.95
160_S217_T1.0190.95
326_G353_R1.0170.95
69_V79_I1.0150.95
234_W239_T1.0080.95
39_N64_W1.0000.95
235_P239_T0.9910.94
129_A305_D0.9860.94
99_I102_N0.9820.94
255_E260_D0.9770.94
341_S347_A0.9760.94
229_D261_E0.9760.94
78_S82_Y0.9720.94
204_K221_L0.9710.94
124_F322_D0.9600.93
56_V103_P0.9590.93
14_E17_L0.9580.93
170_V175_I0.9570.93
128_D131_E0.9540.93
334_Q339_H0.9490.93
130_R323_E0.9470.93
168_T320_L0.9400.93
44_L48_N0.9380.93
331_E350_R0.9380.93
325_Y350_R0.9370.93
200_T210_S0.9360.93
325_Y334_Q0.9290.92
167_D214_P0.9290.92
292_R295_L0.9270.92
204_K314_H0.9260.92
157_R224_Y0.9260.92
91_G105_A0.9250.92
174_E209_E0.9250.92
125_W133_L0.9120.92
335_E342_I0.9110.91
240_G272_I0.9090.91
124_F315_G0.9080.91
209_E221_L0.9070.91
131_E135_N0.9020.91
224_Y227_L0.8970.91
213_L217_T0.8940.91
225_R228_V0.8940.91
288_T292_R0.8920.91
64_W86_A0.8910.91
169_G321_G0.8910.91
37_V41_F0.8910.91
341_S344_T0.8890.90
243_T246_Y0.8880.90
172_G288_T0.8830.90
202_L208_Q0.8820.90
75_A78_S0.8620.89
125_W129_A0.8580.89
16_L88_A0.8540.89
68_L74_L0.8520.89
226_R230_A0.8510.88
103_P106_T0.8470.88
189_W194_L0.8450.88
160_S164_I0.8440.88
272_I281_V0.8430.88
124_F165_L0.8400.88
176_C291_A0.8340.87
89_T93_W0.8330.87
166_A323_E0.8310.87
16_L20_R0.8300.87
102_N107_T0.8290.87
324_L329_A0.8280.87
326_G355_E0.8250.87
95_R98_E0.8240.87
168_T211_V0.8230.87
133_L299_C0.8180.86
124_F351_E0.8170.86
12_G16_L0.8150.86
26_S340_K0.8140.86
315_G352_R0.8130.86
165_L316_G0.8110.86
155_A159_R0.8100.86
335_E357_L0.8090.86
336_V357_L0.8070.86
289_E293_T0.8030.85
275_V278_E0.7960.85
313_P316_G0.7940.85
30_Q34_R0.7920.85
263_I267_L0.7900.84
320_L337_L0.7890.84
336_V352_R0.7880.84
176_C288_T0.7790.84
271_E274_E0.7750.83
167_D217_T0.7740.83
11_R14_E0.7740.83
240_G243_T0.7740.83
19_D93_W0.7730.83
189_W192_V0.7720.83
314_H351_E0.7710.83
25_E33_T0.7670.83
297_R300_G0.7650.83
65_V79_I0.7640.82
318_R321_G0.7640.82
203_G206_G0.7630.82
19_D23_S0.7590.82
67_H71_E0.7470.81
137_V159_R0.7440.81
161_L176_C0.7400.80
125_W130_R0.7380.80
133_L301_E0.7370.80
335_E351_E0.7370.80
329_A336_V0.7360.80
204_K209_E0.7330.80
87_R91_G0.7310.80
273_D279_Y0.7300.79
127_A131_E0.7270.79
331_E335_E0.7270.79
265_G269_D0.7270.79
261_E264_E0.7260.79
133_L304_V0.7250.79
232_A242_A0.7250.79
103_P107_T0.7240.79
277_R280_E0.7200.79
164_I170_V0.7170.78
77_N108_T0.7140.78
164_I175_I0.7130.78
171_R174_E0.7100.78
209_E325_Y0.7050.77
212_S336_V0.7030.77
43_F63_D0.7020.77
317_R349_Y0.6950.76
193_D324_L0.6940.76
299_C302_A0.6920.76
333_A357_L0.6890.75
314_H334_Q0.6880.75
97_G101_Q0.6870.75
329_A333_A0.6860.75
126_T336_V0.6840.75
223_R226_R0.6820.75
43_F49_D0.6810.75
124_F342_I0.6810.75
40_L82_Y0.6800.75
332_S341_S0.6790.74
232_A235_P0.6760.74
94_Q102_N0.6750.74
134_L159_R0.6750.74
253_L260_D0.6730.74
59_Q96_S0.6720.74
247_R254_R0.6720.74
41_F89_T0.6700.73
129_A304_V0.6690.73
271_E275_V0.6680.73
31_Q102_N0.6680.73
334_Q337_L0.6640.73
311_L315_G0.6570.72
127_A135_N0.6570.72
320_L323_E0.6560.72
108_T113_L0.6520.71
321_G350_R0.6520.71
296_K300_G0.6520.71
245_K256_R0.6510.71
255_E258_Y0.6510.71
156_F159_R0.6510.71
330_A333_A0.6480.71
12_G92_W0.6480.71
339_H349_Y0.6460.71
233_E242_A0.6450.71
353_R356_D0.6440.70
92_W96_S0.6430.70
16_L33_T0.6410.70
164_I217_T0.6400.70
254_R257_E0.6390.70
165_L168_T0.6380.70
26_S32_I0.6360.70
170_V338_R0.6350.69
235_P243_T0.6340.69
207_D340_K0.6340.69
280_E283_P0.6340.69
298_L302_A0.6330.69
244_S282_A0.6300.69
162_V298_L0.6260.68
263_I268_E0.6250.68
344_T350_R0.6230.68
211_V221_L0.6180.67
320_L330_A0.6180.67
261_E265_G0.6180.67
330_A337_L0.6170.67
113_L116_K0.6160.67
81_T84_A0.6160.67
194_L203_G0.6150.67
322_D353_R0.6150.67
86_A103_P0.6130.67
59_Q63_D0.6130.67
39_N42_Q0.6120.67
44_L90_F0.6120.67
289_E292_R0.6110.66
228_V268_E0.6100.66
137_V298_L0.6100.66
219_E223_R0.6100.66
63_D215_G0.6090.66
215_G219_E0.6080.66
16_L93_W0.6060.66
125_W299_C0.6060.66
107_T114_P0.6050.66
108_T138_D0.6050.66
130_R133_L0.6050.66
55_D60_D0.6040.66
232_A237_I0.6020.65
30_Q211_V0.6010.65
31_Q35_V0.6010.65
297_R302_A0.5990.65
198_V201_V0.5990.65
58_E96_S0.5980.65
41_F49_D0.5970.65
223_R230_A0.5960.65
127_A161_L0.5950.64
354_A357_L0.5940.64
253_L263_I0.5940.64
275_V282_A0.5930.64
42_Q201_V0.5920.64
245_K255_E0.5920.64
12_G15_T0.5910.64
130_R166_A0.5880.64
15_T18_D0.5880.64
216_V220_K0.5870.63
267_L276_L0.5860.63
238_P241_D0.5850.63
135_N226_R0.5830.63
333_A345_T0.5830.63
161_L165_L0.5830.63
18_D34_R0.5820.63
289_E313_P0.5820.63
322_D356_D0.5810.63
188_R285_A0.5790.62
257_E260_D0.5790.62
237_I240_G0.5790.62
159_R220_K0.5750.62
161_L164_I0.5740.62
125_W312_K0.5740.62
257_E261_E0.5720.61
86_A97_G0.5720.61
242_A245_K0.5710.61
293_T297_R0.5700.61
20_R329_A0.5700.61
292_R311_L0.5690.61
44_L56_V0.5680.61
334_Q340_K0.5670.61
189_W277_R0.5620.60
355_E358_S0.5620.60
191_D202_L0.5610.60
89_T92_W0.5610.60
268_E271_E0.5600.60
14_E34_R0.5600.60
237_I243_T0.5590.60
203_G209_E0.5590.60
217_T220_K0.5570.59
261_E266_V0.5570.59
13_L16_L0.5560.59
43_F93_W0.5560.59
336_V353_R0.5540.59
225_R261_E0.5530.59
331_E348_S0.5520.59
16_L92_W0.5510.59
13_L134_L0.5510.59
12_G93_W0.5500.58
93_W99_I0.5500.58
329_A332_S0.5500.58
277_R283_P0.5490.58
22_V66_I0.5480.58
105_A108_T0.5470.58
36_A39_N0.5450.58
273_D278_E0.5440.58
323_E331_E0.5420.57
316_G339_H0.5420.57
134_L316_G0.5410.57
260_D268_E0.5410.57
131_E218_S0.5410.57
260_D263_I0.5400.57
253_L257_E0.5400.57
172_G316_G0.5390.57
234_W237_I0.5390.57
61_A98_E0.5390.57
74_L82_Y0.5380.57
266_V269_D0.5370.57
331_E352_R0.5360.56
48_N64_W0.5360.56
15_T19_D0.5360.56
325_Y337_L0.5320.56
167_D319_G0.5320.56
57_D286_L0.5320.56
345_T350_R0.5310.56
29_T170_V0.5310.56
138_D156_F0.5300.56
233_E236_V0.5300.56
61_A97_G0.5290.56
334_Q347_A0.5270.55
59_Q305_D0.5270.55
247_R253_L0.5270.55
40_L48_N0.5250.55
200_T203_G0.5250.55
299_C316_G0.5230.55
165_L323_E0.5220.55
122_Q321_G0.5200.54
332_S336_V0.5170.54
20_R93_W0.5170.54
166_A325_Y0.5160.54
277_R282_A0.5140.53
137_V302_A0.5140.53
233_E237_I0.5130.53
197_G213_L0.5130.53
75_A247_R0.5130.53
291_A298_L0.5090.53
97_G103_P0.5080.53
172_G313_P0.5070.52
302_A305_D0.5050.52
255_E290_G0.5040.52
33_T318_R0.5030.52
246_Y249_V0.5030.52
300_G305_D0.5020.52
234_W241_D0.5020.52
219_E296_K0.5010.52
36_A82_Y0.5010.52
177_S340_K0.5010.52
12_G80_R0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.7231 100 0.382 Contact Map
1z1bA 3 0.7634 100 0.399 Contact Map
2a3vA 3 0.8226 100 0.407 Contact Map
1z19A 3 0.7554 100 0.414 Contact Map
4a8eA 2 0.7097 100 0.429 Contact Map
1xo0A 3 0.8011 100 0.431 Contact Map
3nkhA 2 0.5511 100 0.571 Contact Map
1ae9A 4 0.457 99.9 0.624 Contact Map
1aihA 2 0.4543 99.9 0.64 Contact Map
4e0gA 2 0.7258 99.9 0.658 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.