O54590 - HALSA - GREMLIN Contacts

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O54590 - Uncharacterized protein

UniProt:	O54590	Sequences: MSNNDATPGVRGLETLLDDRMVSLESPQTQQITRVAVNNLFQFLTENNDVDSVADVDEQDARDWVIHLVKEDDLAANSIRTYFALARATFGWWQRSGEIGQNPLATTTAEEVLPSKSNDVEQQFWTADARERLLNYVDERAHAALENDSSDAARAFRDRSLVYILADTGVRGAEICSVSRDNRRNGLRWTDVDLEAGVMTVLGKSGDQESVSLPGVTSEKLARYRRLVDAPAEWPVIPTGDATSKYRAVRKQLREREYGDEAIEGVLEDCEIDEVLREYEVAPPALTTEGARTLLKRLCGEADVDIDGDYLKPHGGRRGLGDELYGEVAAESAQEVLRHKSIETTHASYRERRAEDLSADIEKVRYSNTDEE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	372 (311)
Sequences:	1937 (1668)
Seq/√Len:	94.6

ECOLI - INTR INTF INTQ XERC XERD INTZ INTD INTA INTB INTS INTE
BACSU - XERC XERD INT YOPP YOMM
HALSA - O54590 Q9HR66 Q9HQV5 Q9HSI7 O52010 O51984
SULSO - Q980D9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
321_G	337_L	5.111	1.00
312_K	315_G	3.956	1.00
56_V	90_F	3.545	1.00
209_E	338_R	3.445	1.00
339_H	345_T	3.228	1.00
56_V	60_D	3.172	1.00
320_L	336_V	3.054	1.00
51_D	60_D	3.025	1.00
42_Q	50_V	2.908	1.00
13_L	37_V	2.894	1.00
161_L	175_I	2.883	1.00
34_R	38_N	2.828	1.00
29_T	33_T	2.804	1.00
125_W	311_L	2.797	1.00
57_D	60_D	2.759	1.00
172_G	314_H	2.754	1.00
165_L	313_P	2.746	1.00
36_A	81_T	2.670	1.00
94_Q	99_I	2.624	1.00
337_L	345_T	2.506	1.00
193_D	196_A	2.389	1.00
13_L	89_T	2.352	1.00
318_R	351_E	2.324	1.00
189_W	225_R	2.299	1.00
165_L	175_I	2.270	1.00
16_L	37_V	2.247	1.00
331_E	334_Q	2.219	1.00
133_L	316_G	2.200	1.00
170_V	201_V	2.118	1.00
128_D	132_R	2.097	1.00
169_G	337_L	2.075	1.00
99_I	103_P	2.075	1.00
65_V	83_F	2.060	1.00
161_L	291_A	2.050	1.00
159_R	163_Y	2.017	1.00
325_Y	333_A	2.015	1.00
334_Q	345_T	2.006	1.00
188_R	191_D	2.005	1.00
40_L	43_F	1.999	1.00
170_V	199_M	1.977	1.00
166_A	319_G	1.964	1.00
35_V	39_N	1.932	1.00
334_Q	342_I	1.815	1.00
74_L	78_S	1.815	1.00
28_Q	31_Q	1.788	1.00
37_V	89_T	1.766	1.00
36_A	85_L	1.759	1.00
64_W	68_L	1.757	1.00
43_F	67_H	1.747	1.00
322_D	352_R	1.743	1.00
126_T	129_A	1.727	1.00
278_E	283_P	1.710	1.00
299_C	311_L	1.709	1.00
77_N	81_T	1.704	1.00
235_P	238_P	1.687	1.00
342_I	345_T	1.676	1.00
232_A	241_D	1.666	1.00
66_I	70_K	1.589	1.00
325_Y	353_R	1.586	1.00
295_L	316_G	1.583	1.00
344_T	348_S	1.560	1.00
279_Y	283_P	1.559	1.00
134_L	163_Y	1.551	1.00
33_T	85_L	1.547	1.00
169_G	320_L	1.528	1.00
295_L	311_L	1.526	1.00
224_Y	228_V	1.487	1.00
197_G	218_S	1.486	1.00
125_W	319_G	1.486	1.00
236_V	241_D	1.435	1.00
138_D	159_R	1.417	0.99
323_E	326_G	1.401	0.99
65_V	69_V	1.397	0.99
172_G	292_R	1.394	0.99
239_T	242_A	1.375	0.99
324_L	333_A	1.367	0.99
90_F	104_L	1.366	0.99
61_A	86_A	1.363	0.99
136_Y	301_E	1.354	0.99
32_I	81_T	1.349	0.99
214_P	217_T	1.346	0.99
76_A	80_R	1.331	0.99
68_L	82_Y	1.330	0.99
12_G	89_T	1.322	0.99
90_F	103_P	1.307	0.99
17_L	30_Q	1.303	0.99
108_T	114_P	1.302	0.99
295_L	313_P	1.297	0.99
235_P	241_D	1.287	0.99
104_L	107_T	1.285	0.99
175_I	291_A	1.284	0.99
234_W	238_P	1.258	0.99
253_L	256_R	1.253	0.99
173_A	177_S	1.252	0.99
318_R	338_R	1.237	0.99
331_E	347_A	1.232	0.99
40_L	44_L	1.228	0.98
197_G	201_V	1.224	0.98
187_L	192_V	1.221	0.98
53_V	90_F	1.218	0.98
130_R	134_L	1.205	0.98
61_A	104_L	1.198	0.98
292_R	313_P	1.194	0.98
169_G	345_T	1.187	0.98
43_F	48_N	1.177	0.98
62_R	66_I	1.173	0.98
337_L	344_T	1.170	0.98
295_L	299_C	1.169	0.98
43_F	64_W	1.167	0.98
321_G	325_Y	1.167	0.98
171_R	314_H	1.166	0.98
84_A	87_R	1.165	0.98
12_G	53_V	1.161	0.98
14_E	42_Q	1.152	0.98
334_Q	344_T	1.148	0.98
245_K	250_R	1.146	0.98
161_L	286_L	1.139	0.97
256_R	260_D	1.135	0.97
21_M	30_Q	1.130	0.97
218_S	222_A	1.129	0.97
133_L	162_V	1.127	0.97
321_G	345_T	1.123	0.97
236_V	239_T	1.117	0.97
163_Y	220_K	1.113	0.97
297_R	301_E	1.113	0.97
239_T	243_T	1.110	0.97
187_L	199_M	1.107	0.97
157_R	160_S	1.107	0.97
38_N	42_Q	1.100	0.97
32_I	36_A	1.100	0.97
60_D	63_D	1.100	0.97
248_A	251_K	1.097	0.97
213_L	218_S	1.095	0.97
74_L	79_I	1.093	0.97
236_V	242_A	1.085	0.97
164_I	199_M	1.083	0.97
137_V	162_V	1.068	0.96
352_R	356_D	1.067	0.96
197_G	215_G	1.065	0.96
232_A	236_V	1.064	0.96
190_T	275_V	1.061	0.96
48_N	56_V	1.052	0.96
64_W	82_Y	1.052	0.96
334_Q	350_R	1.039	0.96
273_D	276_L	1.037	0.96
68_L	79_I	1.036	0.96
247_R	250_R	1.026	0.95
204_K	207_D	1.023	0.95
322_D	351_E	1.019	0.95
160_S	217_T	1.019	0.95
326_G	353_R	1.017	0.95
69_V	79_I	1.015	0.95
234_W	239_T	1.008	0.95
39_N	64_W	1.000	0.95
235_P	239_T	0.991	0.94
129_A	305_D	0.986	0.94
99_I	102_N	0.982	0.94
255_E	260_D	0.977	0.94
341_S	347_A	0.976	0.94
229_D	261_E	0.976	0.94
78_S	82_Y	0.972	0.94
204_K	221_L	0.971	0.94
124_F	322_D	0.960	0.93
56_V	103_P	0.959	0.93
14_E	17_L	0.958	0.93
170_V	175_I	0.957	0.93
128_D	131_E	0.954	0.93
334_Q	339_H	0.949	0.93
130_R	323_E	0.947	0.93
168_T	320_L	0.940	0.93
44_L	48_N	0.938	0.93
331_E	350_R	0.938	0.93
325_Y	350_R	0.937	0.93
200_T	210_S	0.936	0.93
325_Y	334_Q	0.929	0.92
167_D	214_P	0.929	0.92
292_R	295_L	0.927	0.92
204_K	314_H	0.926	0.92
157_R	224_Y	0.926	0.92
91_G	105_A	0.925	0.92
174_E	209_E	0.925	0.92
125_W	133_L	0.912	0.92
335_E	342_I	0.911	0.91
240_G	272_I	0.909	0.91
124_F	315_G	0.908	0.91
209_E	221_L	0.907	0.91
131_E	135_N	0.902	0.91
224_Y	227_L	0.897	0.91
213_L	217_T	0.894	0.91
225_R	228_V	0.894	0.91
288_T	292_R	0.892	0.91
64_W	86_A	0.891	0.91
169_G	321_G	0.891	0.91
37_V	41_F	0.891	0.91
341_S	344_T	0.889	0.90
243_T	246_Y	0.888	0.90
172_G	288_T	0.883	0.90
202_L	208_Q	0.882	0.90
75_A	78_S	0.862	0.89
125_W	129_A	0.858	0.89
16_L	88_A	0.854	0.89
68_L	74_L	0.852	0.89
226_R	230_A	0.851	0.88
103_P	106_T	0.847	0.88
189_W	194_L	0.845	0.88
160_S	164_I	0.844	0.88
272_I	281_V	0.843	0.88
124_F	165_L	0.840	0.88
176_C	291_A	0.834	0.87
89_T	93_W	0.833	0.87
166_A	323_E	0.831	0.87
16_L	20_R	0.830	0.87
102_N	107_T	0.829	0.87
324_L	329_A	0.828	0.87
326_G	355_E	0.825	0.87
95_R	98_E	0.824	0.87
168_T	211_V	0.823	0.87
133_L	299_C	0.818	0.86
124_F	351_E	0.817	0.86
12_G	16_L	0.815	0.86
26_S	340_K	0.814	0.86
315_G	352_R	0.813	0.86
165_L	316_G	0.811	0.86
155_A	159_R	0.810	0.86
335_E	357_L	0.809	0.86
336_V	357_L	0.807	0.86
289_E	293_T	0.803	0.85
275_V	278_E	0.796	0.85
313_P	316_G	0.794	0.85
30_Q	34_R	0.792	0.85
263_I	267_L	0.790	0.84
320_L	337_L	0.789	0.84
336_V	352_R	0.788	0.84
176_C	288_T	0.779	0.84
271_E	274_E	0.775	0.83
167_D	217_T	0.774	0.83
11_R	14_E	0.774	0.83
240_G	243_T	0.774	0.83
19_D	93_W	0.773	0.83
189_W	192_V	0.772	0.83
314_H	351_E	0.771	0.83
25_E	33_T	0.767	0.83
297_R	300_G	0.765	0.83
65_V	79_I	0.764	0.82
318_R	321_G	0.764	0.82
203_G	206_G	0.763	0.82
19_D	23_S	0.759	0.82
67_H	71_E	0.747	0.81
137_V	159_R	0.744	0.81
161_L	176_C	0.740	0.80
125_W	130_R	0.738	0.80
133_L	301_E	0.737	0.80
335_E	351_E	0.737	0.80
329_A	336_V	0.736	0.80
204_K	209_E	0.733	0.80
87_R	91_G	0.731	0.80
273_D	279_Y	0.730	0.79
127_A	131_E	0.727	0.79
331_E	335_E	0.727	0.79
265_G	269_D	0.727	0.79
261_E	264_E	0.726	0.79
133_L	304_V	0.725	0.79
232_A	242_A	0.725	0.79
103_P	107_T	0.724	0.79
277_R	280_E	0.720	0.79
164_I	170_V	0.717	0.78
77_N	108_T	0.714	0.78
164_I	175_I	0.713	0.78
171_R	174_E	0.710	0.78
209_E	325_Y	0.705	0.77
212_S	336_V	0.703	0.77
43_F	63_D	0.702	0.77
317_R	349_Y	0.695	0.76
193_D	324_L	0.694	0.76
299_C	302_A	0.692	0.76
333_A	357_L	0.689	0.75
314_H	334_Q	0.688	0.75
97_G	101_Q	0.687	0.75
329_A	333_A	0.686	0.75
126_T	336_V	0.684	0.75
223_R	226_R	0.682	0.75
43_F	49_D	0.681	0.75
124_F	342_I	0.681	0.75
40_L	82_Y	0.680	0.75
332_S	341_S	0.679	0.74
232_A	235_P	0.676	0.74
94_Q	102_N	0.675	0.74
134_L	159_R	0.675	0.74
253_L	260_D	0.673	0.74
59_Q	96_S	0.672	0.74
247_R	254_R	0.672	0.74
41_F	89_T	0.670	0.73
129_A	304_V	0.669	0.73
271_E	275_V	0.668	0.73
31_Q	102_N	0.668	0.73
334_Q	337_L	0.664	0.73
311_L	315_G	0.657	0.72
127_A	135_N	0.657	0.72
320_L	323_E	0.656	0.72
108_T	113_L	0.652	0.71
321_G	350_R	0.652	0.71
296_K	300_G	0.652	0.71
245_K	256_R	0.651	0.71
255_E	258_Y	0.651	0.71
156_F	159_R	0.651	0.71
330_A	333_A	0.648	0.71
12_G	92_W	0.648	0.71
339_H	349_Y	0.646	0.71
233_E	242_A	0.645	0.71
353_R	356_D	0.644	0.70
92_W	96_S	0.643	0.70
16_L	33_T	0.641	0.70
164_I	217_T	0.640	0.70
254_R	257_E	0.639	0.70
165_L	168_T	0.638	0.70
26_S	32_I	0.636	0.70
170_V	338_R	0.635	0.69
235_P	243_T	0.634	0.69
207_D	340_K	0.634	0.69
280_E	283_P	0.634	0.69
298_L	302_A	0.633	0.69
244_S	282_A	0.630	0.69
162_V	298_L	0.626	0.68
263_I	268_E	0.625	0.68
344_T	350_R	0.623	0.68
211_V	221_L	0.618	0.67
320_L	330_A	0.618	0.67
261_E	265_G	0.618	0.67
330_A	337_L	0.617	0.67
113_L	116_K	0.616	0.67
81_T	84_A	0.616	0.67
194_L	203_G	0.615	0.67
322_D	353_R	0.615	0.67
86_A	103_P	0.613	0.67
59_Q	63_D	0.613	0.67
39_N	42_Q	0.612	0.67
44_L	90_F	0.612	0.67
289_E	292_R	0.611	0.66
228_V	268_E	0.610	0.66
137_V	298_L	0.610	0.66
219_E	223_R	0.610	0.66
63_D	215_G	0.609	0.66
215_G	219_E	0.608	0.66
16_L	93_W	0.606	0.66
125_W	299_C	0.606	0.66
107_T	114_P	0.605	0.66
108_T	138_D	0.605	0.66
130_R	133_L	0.605	0.66
55_D	60_D	0.604	0.66
232_A	237_I	0.602	0.65
30_Q	211_V	0.601	0.65
31_Q	35_V	0.601	0.65
297_R	302_A	0.599	0.65
198_V	201_V	0.599	0.65
58_E	96_S	0.598	0.65
41_F	49_D	0.597	0.65
223_R	230_A	0.596	0.65
127_A	161_L	0.595	0.64
354_A	357_L	0.594	0.64
253_L	263_I	0.594	0.64
275_V	282_A	0.593	0.64
42_Q	201_V	0.592	0.64
245_K	255_E	0.592	0.64
12_G	15_T	0.591	0.64
130_R	166_A	0.588	0.64
15_T	18_D	0.588	0.64
216_V	220_K	0.587	0.63
267_L	276_L	0.586	0.63
238_P	241_D	0.585	0.63
135_N	226_R	0.583	0.63
333_A	345_T	0.583	0.63
161_L	165_L	0.583	0.63
18_D	34_R	0.582	0.63
289_E	313_P	0.582	0.63
322_D	356_D	0.581	0.63
188_R	285_A	0.579	0.62
257_E	260_D	0.579	0.62
237_I	240_G	0.579	0.62
159_R	220_K	0.575	0.62
161_L	164_I	0.574	0.62
125_W	312_K	0.574	0.62
257_E	261_E	0.572	0.61
86_A	97_G	0.572	0.61
242_A	245_K	0.571	0.61
293_T	297_R	0.570	0.61
20_R	329_A	0.570	0.61
292_R	311_L	0.569	0.61
44_L	56_V	0.568	0.61
334_Q	340_K	0.567	0.61
189_W	277_R	0.562	0.60
355_E	358_S	0.562	0.60
191_D	202_L	0.561	0.60
89_T	92_W	0.561	0.60
268_E	271_E	0.560	0.60
14_E	34_R	0.560	0.60
237_I	243_T	0.559	0.60
203_G	209_E	0.559	0.60
217_T	220_K	0.557	0.59
261_E	266_V	0.557	0.59
13_L	16_L	0.556	0.59
43_F	93_W	0.556	0.59
336_V	353_R	0.554	0.59
225_R	261_E	0.553	0.59
331_E	348_S	0.552	0.59
16_L	92_W	0.551	0.59
13_L	134_L	0.551	0.59
12_G	93_W	0.550	0.58
93_W	99_I	0.550	0.58
329_A	332_S	0.550	0.58
277_R	283_P	0.549	0.58
22_V	66_I	0.548	0.58
105_A	108_T	0.547	0.58
36_A	39_N	0.545	0.58
273_D	278_E	0.544	0.58
323_E	331_E	0.542	0.57
316_G	339_H	0.542	0.57
134_L	316_G	0.541	0.57
260_D	268_E	0.541	0.57
131_E	218_S	0.541	0.57
260_D	263_I	0.540	0.57
253_L	257_E	0.540	0.57
172_G	316_G	0.539	0.57
234_W	237_I	0.539	0.57
61_A	98_E	0.539	0.57
74_L	82_Y	0.538	0.57
266_V	269_D	0.537	0.57
331_E	352_R	0.536	0.56
48_N	64_W	0.536	0.56
15_T	19_D	0.536	0.56
325_Y	337_L	0.532	0.56
167_D	319_G	0.532	0.56
57_D	286_L	0.532	0.56
345_T	350_R	0.531	0.56
29_T	170_V	0.531	0.56
138_D	156_F	0.530	0.56
233_E	236_V	0.530	0.56
61_A	97_G	0.529	0.56
334_Q	347_A	0.527	0.55
59_Q	305_D	0.527	0.55
247_R	253_L	0.527	0.55
40_L	48_N	0.525	0.55
200_T	203_G	0.525	0.55
299_C	316_G	0.523	0.55
165_L	323_E	0.522	0.55
122_Q	321_G	0.520	0.54
332_S	336_V	0.517	0.54
20_R	93_W	0.517	0.54
166_A	325_Y	0.516	0.54
277_R	282_A	0.514	0.53
137_V	302_A	0.514	0.53
233_E	237_I	0.513	0.53
197_G	213_L	0.513	0.53
75_A	247_R	0.513	0.53
291_A	298_L	0.509	0.53
97_G	103_P	0.508	0.53
172_G	313_P	0.507	0.52
302_A	305_D	0.505	0.52
255_E	290_G	0.504	0.52
33_T	318_R	0.503	0.52
246_Y	249_V	0.503	0.52
300_G	305_D	0.502	0.52
234_W	241_D	0.502	0.52
219_E	296_K	0.501	0.52
36_A	82_Y	0.501	0.52
177_S	340_K	0.501	0.52
12_G	80_R	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a0pA	1	0.7231	100	0.382	Contact Map
1z1bA	3	0.7634	100	0.399	Contact Map
2a3vA	3	0.8226	100	0.407	Contact Map
1z19A	3	0.7554	100	0.414	Contact Map
4a8eA	2	0.7097	100	0.429	Contact Map
1xo0A	3	0.8011	100	0.431	Contact Map
3nkhA	2	0.5511	100	0.571	Contact Map
1ae9A	4	0.457	99.9	0.624	Contact Map
1aihA	2	0.4543	99.9	0.64	Contact Map
4e0gA	2	0.7258	99.9	0.658	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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