O54583 - HALSA - GREMLIN Contacts

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O54583 - Uncharacterized protein

UniProt:	O54583	Sequences: MLGEGIDIADLMVAVLHQPPKSFAFTLQLIGRVTRPAEDSDVAATVIADPDKLREAGVDDVVKRLYHEDAGWRQLVPELVDKYIETNVAATTAGQDALRGVNEQDLQPYRSTRLYESTESDVDLVADVSLDDDTIVYKLPRSDEVFLGLITEKIDKPTWGTRTPLDYRQYDLHLYYYHDETETLFEASSSDELSDRIRSQIVSDEIEIYGGESLVRMLQAEVDIEYQVAGLANALGPSGSLPSYKMYLGDRVEGAVRQTDAQAFAQGHAVAEVDEEIISTSQSIAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	286 (270)
Sequences:	150 (122)
Seq/√Len:	7.4

HALSA - O54583

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
214_L	218_L	3.968	0.96
175_Y	201_I	3.237	0.89
154_I	216_R	3.203	0.89
160_G	244_Y	3.057	0.86
93_A	157_P	2.603	0.76
16_L	29_L	2.570	0.75
244_Y	248_L	2.494	0.72
41_D	243_S	2.451	0.71
108_P	172_L	2.393	0.69
6_I	172_L	2.379	0.69
6_I	228_V	2.311	0.66
46_V	61_V	2.309	0.66
243_S	251_R	2.216	0.63
141_R	251_R	2.209	0.63
8_I	268_H	2.178	0.61
115_Y	209_Y	2.137	0.60
16_L	45_T	2.131	0.60
122_V	177_Y	2.122	0.59
71_G	273_V	2.109	0.59
221_E	267_G	2.075	0.57
88_V	92_T	2.028	0.56
73_R	223_D	1.970	0.53
84_I	231_L	1.929	0.52
2_L	6_I	1.901	0.51
200_Q	203_S	1.884	0.50
117_S	177_Y	1.871	0.49
61_V	68_E	1.848	0.49
6_I	184_L	1.826	0.48
233_N	267_G	1.823	0.48
102_N	106_L	1.820	0.47
149_L	197_I	1.819	0.47
112_T	209_Y	1.810	0.47
157_P	277_I	1.781	0.46
14_A	26_T	1.744	0.44
34_T	256_V	1.721	0.44
115_Y	176_Y	1.717	0.43
112_T	250_D	1.713	0.43
76_V	181_T	1.689	0.42
6_I	150_I	1.688	0.42
16_L	146_F	1.686	0.42
141_R	222_V	1.679	0.42
66_Y	87_N	1.667	0.41
116_E	121_D	1.664	0.41
246_M	267_G	1.658	0.41
76_V	223_D	1.656	0.41
114_L	183_T	1.611	0.39
115_Y	208_I	1.610	0.39
16_L	256_V	1.603	0.39
49_D	267_G	1.575	0.38
14_A	27_L	1.572	0.38
67_H	104_Q	1.565	0.38
7_D	65_L	1.565	0.38
20_P	47_I	1.530	0.36
87_N	256_V	1.527	0.36
49_D	170_Y	1.514	0.36
214_L	229_A	1.501	0.35
89_A	276_E	1.500	0.35
218_L	252_V	1.492	0.35
100_G	161_T	1.490	0.35
38_E	41_D	1.482	0.35
226_Y	242_P	1.471	0.34
38_E	180_E	1.453	0.34
8_I	228_V	1.410	0.32
171_D	192_E	1.406	0.32
75_L	199_S	1.405	0.32
111_S	157_P	1.402	0.32
8_I	20_P	1.397	0.32
197_I	201_I	1.381	0.31
48_A	226_Y	1.379	0.31
37_A	244_Y	1.374	0.31
8_I	34_T	1.345	0.30
45_T	110_R	1.333	0.29
79_L	198_R	1.332	0.29
19_P	76_V	1.328	0.29
190_S	256_V	1.328	0.29
142_S	174_L	1.318	0.29
100_G	216_R	1.280	0.28
112_T	214_L	1.275	0.28
126_A	205_E	1.274	0.28
9_A	12_M	1.270	0.27
91_T	220_A	1.270	0.27
116_E	196_R	1.259	0.27
24_A	103_E	1.257	0.27
151_T	217_M	1.249	0.27
75_L	271_A	1.243	0.27
47_I	213_S	1.236	0.26
130_L	190_S	1.236	0.26
16_L	247_Y	1.236	0.26
106_L	150_I	1.231	0.26
150_I	256_V	1.227	0.26
210_G	254_G	1.214	0.26
69_D	269_A	1.212	0.26
23_F	255_A	1.187	0.25
157_P	245_K	1.187	0.25
157_P	221_E	1.184	0.25
6_I	20_P	1.182	0.25
49_D	111_S	1.182	0.25
116_E	145_V	1.180	0.25
34_T	245_K	1.179	0.25
217_M	246_M	1.171	0.24
7_D	249_G	1.169	0.24
19_P	255_A	1.155	0.24
40_S	243_S	1.138	0.23
123_D	147_L	1.136	0.23
33_V	73_R	1.134	0.23
2_L	34_T	1.128	0.23
238_S	252_V	1.124	0.23
14_A	177_Y	1.121	0.23
156_K	213_S	1.121	0.23
76_V	261_A	1.119	0.23
157_P	244_Y	1.117	0.23
107_Q	165_L	1.107	0.23
54_R	92_T	1.106	0.23
119_E	177_Y	1.096	0.22
174_L	275_E	1.092	0.22
12_M	29_L	1.091	0.22
63_K	167_Y	1.090	0.22
156_K	189_S	1.088	0.22
120_S	180_E	1.087	0.22
146_F	229_A	1.086	0.22
154_I	166_D	1.086	0.22
91_T	161_T	1.085	0.22
122_V	255_A	1.078	0.22
22_S	27_L	1.076	0.22
72_W	172_L	1.074	0.22
38_E	81_D	1.068	0.22
58_V	126_A	1.059	0.21
114_L	131_D	1.058	0.21
248_L	255_A	1.057	0.21
8_I	260_D	1.053	0.21
96_D	141_R	1.045	0.21
70_A	252_V	1.044	0.21
118_T	132_D	1.043	0.21
66_Y	72_W	1.031	0.21
111_S	215_V	1.024	0.20
73_R	76_V	1.021	0.20
222_V	266_Q	1.012	0.20
51_D	267_G	1.011	0.20
192_E	209_Y	1.010	0.20
221_E	257_R	1.006	0.20
192_E	276_E	1.004	0.20
121_D	204_D	0.996	0.20
85_E	89_A	0.992	0.20
164_P	197_I	0.991	0.20
37_A	76_V	0.990	0.20
113_R	189_S	0.989	0.20
77_P	81_D	0.986	0.19
76_V	186_E	0.982	0.19
126_A	197_I	0.982	0.19
48_A	244_Y	0.982	0.19
34_T	124_L	0.974	0.19
122_V	211_G	0.959	0.19
62_V	73_R	0.957	0.19
25_F	165_L	0.956	0.19
14_A	22_S	0.953	0.19
207_E	276_E	0.952	0.19
143_D	276_E	0.949	0.19
186_E	194_S	0.949	0.19
54_R	76_V	0.941	0.18
226_Y	271_A	0.939	0.18
94_G	222_V	0.936	0.18
38_E	209_Y	0.935	0.18
172_L	184_L	0.934	0.18
76_V	218_L	0.933	0.18
49_D	215_V	0.931	0.18
34_T	273_V	0.928	0.18
36_P	271_A	0.925	0.18
27_L	66_Y	0.919	0.18
39_D	114_L	0.919	0.18
109_Y	251_R	0.915	0.18
47_I	61_V	0.913	0.18
26_T	59_D	0.913	0.18
64_R	110_R	0.911	0.18
47_I	142_S	0.903	0.17
4_E	35_R	0.890	0.17
5_G	230_G	0.890	0.17
5_G	35_R	0.890	0.17
4_E	28_Q	0.890	0.17
5_G	32_R	0.890	0.17
5_G	31_G	0.890	0.17
5_G	28_Q	0.890	0.17
4_E	32_R	0.890	0.17
4_E	230_G	0.890	0.17
4_E	17_H	0.890	0.17
5_G	17_H	0.890	0.17
35_R	230_G	0.890	0.17
32_R	230_G	0.890	0.17
32_R	35_R	0.890	0.17
31_G	230_G	0.890	0.17
28_Q	35_R	0.890	0.17
31_G	35_R	0.890	0.17
28_Q	230_G	0.890	0.17
28_Q	32_R	0.890	0.17
28_Q	31_G	0.890	0.17
17_H	28_Q	0.890	0.17
17_H	31_G	0.890	0.17
17_H	230_G	0.890	0.17
17_H	32_R	0.890	0.17
4_E	31_G	0.890	0.17
17_H	35_R	0.890	0.17
85_E	151_T	0.887	0.17
45_T	218_L	0.885	0.17
143_D	199_S	0.882	0.17
69_D	73_R	0.881	0.17
88_V	185_F	0.880	0.17
158_T	176_Y	0.880	0.17
87_N	91_T	0.878	0.17
76_V	259_T	0.877	0.17
54_R	208_I	0.876	0.17
29_L	76_V	0.871	0.17
70_A	163_T	0.871	0.17
58_V	125_V	0.871	0.17
49_D	273_V	0.864	0.17
67_H	79_L	0.862	0.17
27_L	46_V	0.862	0.17
3_G	228_V	0.859	0.16
77_P	105_D	0.854	0.16
188_S	212_E	0.849	0.16
176_Y	185_F	0.848	0.16
101_V	106_L	0.846	0.16
150_I	158_T	0.842	0.16
248_L	260_D	0.841	0.16
246_M	268_H	0.837	0.16
91_T	231_L	0.835	0.16
81_D	274_D	0.833	0.16
25_F	214_L	0.829	0.16
85_E	116_E	0.822	0.16
41_D	187_A	0.821	0.16
36_P	75_L	0.820	0.16
116_E	182_E	0.819	0.16
243_S	246_M	0.817	0.16
83_Y	189_S	0.808	0.15
147_L	201_I	0.804	0.15
130_L	255_A	0.803	0.15
16_L	97_A	0.799	0.15
13_V	270_V	0.798	0.15
226_Y	266_Q	0.797	0.15
257_R	261_A	0.795	0.15
185_F	269_A	0.794	0.15
47_I	253_E	0.792	0.15
216_R	219_Q	0.788	0.15
142_S	220_A	0.787	0.15
43_A	54_R	0.786	0.15
156_K	202_V	0.786	0.15
186_E	198_R	0.775	0.15
70_A	126_A	0.774	0.15
33_V	271_A	0.772	0.15
266_Q	273_V	0.764	0.15
23_F	90_A	0.764	0.15
172_L	216_R	0.761	0.14
194_S	267_G	0.745	0.14
84_I	205_E	0.744	0.14
6_I	124_L	0.740	0.14
188_S	228_V	0.738	0.14
126_A	144_E	0.737	0.14
27_L	51_D	0.736	0.14
37_A	40_S	0.733	0.14
13_V	151_T	0.732	0.14
231_L	270_V	0.732	0.14
170_Y	215_V	0.728	0.14
115_Y	142_S	0.725	0.14
20_P	76_V	0.723	0.14
13_V	40_S	0.723	0.14
103_E	148_G	0.720	0.14
191_D	223_D	0.719	0.14
253_E	256_V	0.718	0.14
43_A	221_E	0.707	0.13
109_Y	246_M	0.705	0.13
99_R	262_Q	0.705	0.13
126_A	143_D	0.704	0.13
126_A	276_E	0.701	0.13
61_V	244_Y	0.700	0.13
115_Y	192_E	0.699	0.13
165_L	214_L	0.696	0.13
68_E	247_Y	0.695	0.13
113_R	196_R	0.694	0.13
13_V	75_L	0.694	0.13
119_E	256_V	0.686	0.13
170_Y	267_G	0.686	0.13
138_K	165_L	0.686	0.13
156_K	208_I	0.684	0.13
115_Y	206_I	0.681	0.13
25_F	76_V	0.679	0.13
85_E	126_A	0.679	0.13
97_A	115_Y	0.678	0.13
86_T	92_T	0.676	0.13
23_F	33_V	0.674	0.13
223_D	266_Q	0.673	0.13
93_A	223_D	0.673	0.13
176_Y	229_A	0.670	0.13
41_D	160_G	0.667	0.13
116_E	148_G	0.666	0.13
129_S	146_F	0.663	0.13
105_D	248_L	0.663	0.13
214_L	243_S	0.660	0.13
102_N	195_D	0.653	0.12
18_Q	237_P	0.650	0.12
46_V	146_F	0.649	0.12
29_L	44_A	0.647	0.12
47_I	96_D	0.644	0.12
46_V	262_Q	0.642	0.12
31_G	65_L	0.641	0.12
65_L	230_G	0.641	0.12
4_E	65_L	0.641	0.12
5_G	65_L	0.641	0.12
28_Q	65_L	0.641	0.12
32_R	65_L	0.641	0.12
35_R	65_L	0.641	0.12
17_H	65_L	0.641	0.12
224_I	271_A	0.641	0.12
21_K	33_V	0.638	0.12
15_V	186_E	0.637	0.12
87_N	270_V	0.635	0.12
232_A	272_E	0.634	0.12
264_F	267_G	0.632	0.12
180_E	207_E	0.631	0.12
28_Q	249_G	0.629	0.12
35_R	249_G	0.629	0.12
5_G	249_G	0.629	0.12
4_E	249_G	0.629	0.12
32_R	249_G	0.629	0.12
31_G	249_G	0.629	0.12
230_G	249_G	0.629	0.12
17_H	249_G	0.629	0.12
149_L	152_E	0.626	0.12
226_Y	229_A	0.625	0.12
25_F	266_Q	0.625	0.12
112_T	271_A	0.624	0.12
212_E	268_H	0.623	0.12
118_T	179_D	0.623	0.12
98_L	171_D	0.622	0.12
3_G	66_Y	0.621	0.12
181_T	217_M	0.620	0.12
80_V	185_F	0.617	0.12
45_T	62_V	0.616	0.12
113_R	122_V	0.615	0.12
70_A	89_A	0.607	0.12
63_K	219_Q	0.600	0.12
142_S	179_D	0.599	0.12
112_T	141_R	0.599	0.12
15_V	23_F	0.596	0.12
246_M	251_R	0.591	0.11
16_L	270_V	0.589	0.11
186_E	217_M	0.588	0.11
91_T	152_E	0.588	0.11
108_P	174_L	0.585	0.11
153_K	204_D	0.585	0.11
227_Q	267_G	0.585	0.11
33_V	198_R	0.583	0.11
2_L	62_V	0.582	0.11
21_K	153_K	0.579	0.11
233_N	242_P	0.577	0.11
72_W	184_L	0.574	0.11
70_A	237_P	0.574	0.11
44_A	197_I	0.573	0.11
2_L	228_V	0.573	0.11
120_S	205_E	0.573	0.11
174_L	229_A	0.568	0.11
185_F	274_D	0.566	0.11
88_V	257_R	0.566	0.11
20_P	228_V	0.563	0.11
213_S	218_L	0.562	0.11
70_A	108_P	0.558	0.11
33_V	273_V	0.553	0.11
19_P	58_V	0.551	0.11
23_F	174_L	0.550	0.11
122_V	175_Y	0.547	0.11
8_I	245_K	0.547	0.11
69_D	115_Y	0.546	0.11
8_I	246_M	0.546	0.11
104_Q	160_G	0.545	0.11
4_E	9_A	0.544	0.11
9_A	35_R	0.544	0.11
9_A	31_G	0.544	0.11
9_A	230_G	0.544	0.11
9_A	28_Q	0.544	0.11
9_A	32_R	0.544	0.11
5_G	9_A	0.544	0.11
9_A	17_H	0.544	0.11
39_D	115_Y	0.543	0.11
143_D	192_E	0.538	0.11
124_L	200_Q	0.534	0.11
5_G	159_W	0.534	0.11
4_E	159_W	0.534	0.11
35_R	159_W	0.534	0.11
159_W	230_G	0.534	0.11
28_Q	159_W	0.534	0.11
31_G	159_W	0.534	0.11
17_H	159_W	0.534	0.11
32_R	159_W	0.534	0.11
39_D	120_S	0.533	0.11
219_Q	229_A	0.526	0.10
53_L	251_R	0.526	0.10
150_I	257_R	0.525	0.10
176_Y	231_L	0.522	0.10
106_L	179_D	0.518	0.10
88_V	148_G	0.517	0.10
109_Y	187_A	0.508	0.10
20_P	152_E	0.504	0.10
74_Q	118_T	0.503	0.10
20_P	75_L	0.502	0.10
13_V	64_R	0.502	0.10
9_A	29_L	0.501	0.10
75_L	96_D	0.501	0.10
7_D	32_R	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3oiyA	1	0.2902	98	0.917	Contact Map
3eaqA	2	0.3811	97.9	0.919	Contact Map
4w7sA	2	0.3252	97.9	0.919	Contact Map
3peyA	1	0.2762	97.9	0.919	Contact Map
2z0mA	1	0.1993	97.8	0.919	Contact Map
3h1tA	1	0.2902	97.7	0.921	Contact Map
3eiqA	1	0.2133	97.7	0.922	Contact Map
2fwrA	1	0.2063	97.6	0.923	Contact Map
1fuuA	2	0.2552	97.6	0.923	Contact Map
2i4iA	1	0.2727	97.6	0.923	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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