GREMLIN Database
O54583 - Uncharacterized protein
UniProt: O54583 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 286 (270)
Sequences: 150 (122)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_L218_L3.9680.96
175_Y201_I3.2370.89
154_I216_R3.2030.89
160_G244_Y3.0570.86
93_A157_P2.6030.76
16_L29_L2.5700.75
244_Y248_L2.4940.72
41_D243_S2.4510.71
108_P172_L2.3930.69
6_I172_L2.3790.69
6_I228_V2.3110.66
46_V61_V2.3090.66
243_S251_R2.2160.63
141_R251_R2.2090.63
8_I268_H2.1780.61
115_Y209_Y2.1370.60
16_L45_T2.1310.60
122_V177_Y2.1220.59
71_G273_V2.1090.59
221_E267_G2.0750.57
88_V92_T2.0280.56
73_R223_D1.9700.53
84_I231_L1.9290.52
2_L6_I1.9010.51
200_Q203_S1.8840.50
117_S177_Y1.8710.49
61_V68_E1.8480.49
6_I184_L1.8260.48
233_N267_G1.8230.48
102_N106_L1.8200.47
149_L197_I1.8190.47
112_T209_Y1.8100.47
157_P277_I1.7810.46
14_A26_T1.7440.44
34_T256_V1.7210.44
115_Y176_Y1.7170.43
112_T250_D1.7130.43
76_V181_T1.6890.42
6_I150_I1.6880.42
16_L146_F1.6860.42
141_R222_V1.6790.42
66_Y87_N1.6670.41
116_E121_D1.6640.41
246_M267_G1.6580.41
76_V223_D1.6560.41
114_L183_T1.6110.39
115_Y208_I1.6100.39
16_L256_V1.6030.39
49_D267_G1.5750.38
14_A27_L1.5720.38
67_H104_Q1.5650.38
7_D65_L1.5650.38
20_P47_I1.5300.36
87_N256_V1.5270.36
49_D170_Y1.5140.36
214_L229_A1.5010.35
89_A276_E1.5000.35
218_L252_V1.4920.35
100_G161_T1.4900.35
38_E41_D1.4820.35
226_Y242_P1.4710.34
38_E180_E1.4530.34
8_I228_V1.4100.32
171_D192_E1.4060.32
75_L199_S1.4050.32
111_S157_P1.4020.32
8_I20_P1.3970.32
197_I201_I1.3810.31
48_A226_Y1.3790.31
37_A244_Y1.3740.31
8_I34_T1.3450.30
45_T110_R1.3330.29
79_L198_R1.3320.29
19_P76_V1.3280.29
190_S256_V1.3280.29
142_S174_L1.3180.29
100_G216_R1.2800.28
112_T214_L1.2750.28
126_A205_E1.2740.28
9_A12_M1.2700.27
91_T220_A1.2700.27
116_E196_R1.2590.27
24_A103_E1.2570.27
151_T217_M1.2490.27
75_L271_A1.2430.27
47_I213_S1.2360.26
130_L190_S1.2360.26
16_L247_Y1.2360.26
106_L150_I1.2310.26
150_I256_V1.2270.26
210_G254_G1.2140.26
69_D269_A1.2120.26
23_F255_A1.1870.25
157_P245_K1.1870.25
157_P221_E1.1840.25
6_I20_P1.1820.25
49_D111_S1.1820.25
116_E145_V1.1800.25
34_T245_K1.1790.25
217_M246_M1.1710.24
7_D249_G1.1690.24
19_P255_A1.1550.24
40_S243_S1.1380.23
123_D147_L1.1360.23
33_V73_R1.1340.23
2_L34_T1.1280.23
238_S252_V1.1240.23
14_A177_Y1.1210.23
156_K213_S1.1210.23
76_V261_A1.1190.23
157_P244_Y1.1170.23
107_Q165_L1.1070.23
54_R92_T1.1060.23
119_E177_Y1.0960.22
174_L275_E1.0920.22
12_M29_L1.0910.22
63_K167_Y1.0900.22
156_K189_S1.0880.22
120_S180_E1.0870.22
146_F229_A1.0860.22
154_I166_D1.0860.22
91_T161_T1.0850.22
122_V255_A1.0780.22
22_S27_L1.0760.22
72_W172_L1.0740.22
38_E81_D1.0680.22
58_V126_A1.0590.21
114_L131_D1.0580.21
248_L255_A1.0570.21
8_I260_D1.0530.21
96_D141_R1.0450.21
70_A252_V1.0440.21
118_T132_D1.0430.21
66_Y72_W1.0310.21
111_S215_V1.0240.20
73_R76_V1.0210.20
222_V266_Q1.0120.20
51_D267_G1.0110.20
192_E209_Y1.0100.20
221_E257_R1.0060.20
192_E276_E1.0040.20
121_D204_D0.9960.20
85_E89_A0.9920.20
164_P197_I0.9910.20
37_A76_V0.9900.20
113_R189_S0.9890.20
77_P81_D0.9860.19
76_V186_E0.9820.19
126_A197_I0.9820.19
48_A244_Y0.9820.19
34_T124_L0.9740.19
122_V211_G0.9590.19
62_V73_R0.9570.19
25_F165_L0.9560.19
14_A22_S0.9530.19
207_E276_E0.9520.19
143_D276_E0.9490.19
186_E194_S0.9490.19
54_R76_V0.9410.18
226_Y271_A0.9390.18
94_G222_V0.9360.18
38_E209_Y0.9350.18
172_L184_L0.9340.18
76_V218_L0.9330.18
49_D215_V0.9310.18
34_T273_V0.9280.18
36_P271_A0.9250.18
27_L66_Y0.9190.18
39_D114_L0.9190.18
109_Y251_R0.9150.18
47_I61_V0.9130.18
26_T59_D0.9130.18
64_R110_R0.9110.18
47_I142_S0.9030.17
4_E35_R0.8900.17
5_G230_G0.8900.17
5_G35_R0.8900.17
4_E28_Q0.8900.17
5_G32_R0.8900.17
5_G31_G0.8900.17
5_G28_Q0.8900.17
4_E32_R0.8900.17
4_E230_G0.8900.17
4_E17_H0.8900.17
5_G17_H0.8900.17
35_R230_G0.8900.17
32_R230_G0.8900.17
32_R35_R0.8900.17
31_G230_G0.8900.17
28_Q35_R0.8900.17
31_G35_R0.8900.17
28_Q230_G0.8900.17
28_Q32_R0.8900.17
28_Q31_G0.8900.17
17_H28_Q0.8900.17
17_H31_G0.8900.17
17_H230_G0.8900.17
17_H32_R0.8900.17
4_E31_G0.8900.17
17_H35_R0.8900.17
85_E151_T0.8870.17
45_T218_L0.8850.17
143_D199_S0.8820.17
69_D73_R0.8810.17
88_V185_F0.8800.17
158_T176_Y0.8800.17
87_N91_T0.8780.17
76_V259_T0.8770.17
54_R208_I0.8760.17
29_L76_V0.8710.17
70_A163_T0.8710.17
58_V125_V0.8710.17
49_D273_V0.8640.17
67_H79_L0.8620.17
27_L46_V0.8620.17
3_G228_V0.8590.16
77_P105_D0.8540.16
188_S212_E0.8490.16
176_Y185_F0.8480.16
101_V106_L0.8460.16
150_I158_T0.8420.16
248_L260_D0.8410.16
246_M268_H0.8370.16
91_T231_L0.8350.16
81_D274_D0.8330.16
25_F214_L0.8290.16
85_E116_E0.8220.16
41_D187_A0.8210.16
36_P75_L0.8200.16
116_E182_E0.8190.16
243_S246_M0.8170.16
83_Y189_S0.8080.15
147_L201_I0.8040.15
130_L255_A0.8030.15
16_L97_A0.7990.15
13_V270_V0.7980.15
226_Y266_Q0.7970.15
257_R261_A0.7950.15
185_F269_A0.7940.15
47_I253_E0.7920.15
216_R219_Q0.7880.15
142_S220_A0.7870.15
43_A54_R0.7860.15
156_K202_V0.7860.15
186_E198_R0.7750.15
70_A126_A0.7740.15
33_V271_A0.7720.15
266_Q273_V0.7640.15
23_F90_A0.7640.15
172_L216_R0.7610.14
194_S267_G0.7450.14
84_I205_E0.7440.14
6_I124_L0.7400.14
188_S228_V0.7380.14
126_A144_E0.7370.14
27_L51_D0.7360.14
37_A40_S0.7330.14
13_V151_T0.7320.14
231_L270_V0.7320.14
170_Y215_V0.7280.14
115_Y142_S0.7250.14
20_P76_V0.7230.14
13_V40_S0.7230.14
103_E148_G0.7200.14
191_D223_D0.7190.14
253_E256_V0.7180.14
43_A221_E0.7070.13
109_Y246_M0.7050.13
99_R262_Q0.7050.13
126_A143_D0.7040.13
126_A276_E0.7010.13
61_V244_Y0.7000.13
115_Y192_E0.6990.13
165_L214_L0.6960.13
68_E247_Y0.6950.13
113_R196_R0.6940.13
13_V75_L0.6940.13
119_E256_V0.6860.13
170_Y267_G0.6860.13
138_K165_L0.6860.13
156_K208_I0.6840.13
115_Y206_I0.6810.13
25_F76_V0.6790.13
85_E126_A0.6790.13
97_A115_Y0.6780.13
86_T92_T0.6760.13
23_F33_V0.6740.13
223_D266_Q0.6730.13
93_A223_D0.6730.13
176_Y229_A0.6700.13
41_D160_G0.6670.13
116_E148_G0.6660.13
129_S146_F0.6630.13
105_D248_L0.6630.13
214_L243_S0.6600.13
102_N195_D0.6530.12
18_Q237_P0.6500.12
46_V146_F0.6490.12
29_L44_A0.6470.12
47_I96_D0.6440.12
46_V262_Q0.6420.12
31_G65_L0.6410.12
65_L230_G0.6410.12
4_E65_L0.6410.12
5_G65_L0.6410.12
28_Q65_L0.6410.12
32_R65_L0.6410.12
35_R65_L0.6410.12
17_H65_L0.6410.12
224_I271_A0.6410.12
21_K33_V0.6380.12
15_V186_E0.6370.12
87_N270_V0.6350.12
232_A272_E0.6340.12
264_F267_G0.6320.12
180_E207_E0.6310.12
28_Q249_G0.6290.12
35_R249_G0.6290.12
5_G249_G0.6290.12
4_E249_G0.6290.12
32_R249_G0.6290.12
31_G249_G0.6290.12
230_G249_G0.6290.12
17_H249_G0.6290.12
149_L152_E0.6260.12
226_Y229_A0.6250.12
25_F266_Q0.6250.12
112_T271_A0.6240.12
212_E268_H0.6230.12
118_T179_D0.6230.12
98_L171_D0.6220.12
3_G66_Y0.6210.12
181_T217_M0.6200.12
80_V185_F0.6170.12
45_T62_V0.6160.12
113_R122_V0.6150.12
70_A89_A0.6070.12
63_K219_Q0.6000.12
142_S179_D0.5990.12
112_T141_R0.5990.12
15_V23_F0.5960.12
246_M251_R0.5910.11
16_L270_V0.5890.11
186_E217_M0.5880.11
91_T152_E0.5880.11
108_P174_L0.5850.11
153_K204_D0.5850.11
227_Q267_G0.5850.11
33_V198_R0.5830.11
2_L62_V0.5820.11
21_K153_K0.5790.11
233_N242_P0.5770.11
72_W184_L0.5740.11
70_A237_P0.5740.11
44_A197_I0.5730.11
2_L228_V0.5730.11
120_S205_E0.5730.11
174_L229_A0.5680.11
185_F274_D0.5660.11
88_V257_R0.5660.11
20_P228_V0.5630.11
213_S218_L0.5620.11
70_A108_P0.5580.11
33_V273_V0.5530.11
19_P58_V0.5510.11
23_F174_L0.5500.11
122_V175_Y0.5470.11
8_I245_K0.5470.11
69_D115_Y0.5460.11
8_I246_M0.5460.11
104_Q160_G0.5450.11
4_E9_A0.5440.11
9_A35_R0.5440.11
9_A31_G0.5440.11
9_A230_G0.5440.11
9_A28_Q0.5440.11
9_A32_R0.5440.11
5_G9_A0.5440.11
9_A17_H0.5440.11
39_D115_Y0.5430.11
143_D192_E0.5380.11
124_L200_Q0.5340.11
5_G159_W0.5340.11
4_E159_W0.5340.11
35_R159_W0.5340.11
159_W230_G0.5340.11
28_Q159_W0.5340.11
31_G159_W0.5340.11
17_H159_W0.5340.11
32_R159_W0.5340.11
39_D120_S0.5330.11
219_Q229_A0.5260.10
53_L251_R0.5260.10
150_I257_R0.5250.10
176_Y231_L0.5220.10
106_L179_D0.5180.10
88_V148_G0.5170.10
109_Y187_A0.5080.10
20_P152_E0.5040.10
74_Q118_T0.5030.10
20_P75_L0.5020.10
13_V64_R0.5020.10
9_A29_L0.5010.10
75_L96_D0.5010.10
7_D32_R0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oiyA 1 0.2902 98 0.917 Contact Map
3eaqA 2 0.3811 97.9 0.919 Contact Map
4w7sA 2 0.3252 97.9 0.919 Contact Map
3peyA 1 0.2762 97.9 0.919 Contact Map
2z0mA 1 0.1993 97.8 0.919 Contact Map
3h1tA 1 0.2902 97.7 0.921 Contact Map
3eiqA 1 0.2133 97.7 0.922 Contact Map
2fwrA 1 0.2063 97.6 0.923 Contact Map
1fuuA 2 0.2552 97.6 0.923 Contact Map
2i4iA 1 0.2727 97.6 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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