O54575 - HALSA - GREMLIN Contacts

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O54575 - Uncharacterized protein

UniProt:	O54575	Sequences: MSSTQETQTIRQGLSTRESRLLSHLAAEGHQIISIDDVEATLEVAPNTAREIASRLTEKGWLDRLLPGRYLIIPLAAGEEAVYTTHEYLIASHVAEPMYIGYYSALSHHGLTEQVPRTVYVVTPTRAQSREIHGVPYRVATVTERKFFGYEPTSIEGTVVNVADLAKTLVDCADHPEYCGGIRELATAMVAADDQACSWATVGEYLQRLDNGAATKRIVYLADQLSIDLPTRETLVESFTSGYSLLDPTQSEQGSYDSEYRLRINVDPGTLGPTES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (246)
Sequences:	344 (299)
Seq/√Len:	19.1

HALSA - O54575

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
101_G	122_V	5.827	1.00
163_A	168_T	4.510	1.00
219_V	260_Y	3.803	1.00
101_G	163_A	3.738	1.00
168_T	180_G	3.465	1.00
99_Y	163_A	3.247	1.00
166_A	201_T	3.223	0.99
236_V	259_E	3.175	0.99
223_D	259_E	2.964	0.99
164_D	205_Y	2.871	0.99
33_I	62_L	2.717	0.98
65_L	71_L	2.491	0.97
217_R	265_N	2.441	0.96
206_L	218_I	2.307	0.95
217_R	248_P	2.223	0.94
198_S	201_T	2.130	0.92
112_T	116_P	2.109	0.92
97_P	123_T	2.093	0.92
76_A	186_A	2.015	0.90
232_R	236_V	1.974	0.89
149_G	167_K	1.970	0.89
106_L	188_A	1.968	0.89
217_R	246_L	1.937	0.88
169_L	189_M	1.905	0.87
163_A	180_G	1.899	0.87
98_M	163_A	1.865	0.86
149_G	205_Y	1.860	0.86
98_M	115_V	1.852	0.86
176_P	179_C	1.799	0.84
102_Y	122_V	1.792	0.84
56_L	99_Y	1.758	0.83
140_A	162_V	1.745	0.82
243_Y	256_Y	1.742	0.82
111_L	172_C	1.737	0.82
38_V	121_V	1.716	0.81
102_Y	175_H	1.703	0.80
140_A	178_Y	1.679	0.80
98_M	139_V	1.671	0.79
74_P	89_L	1.654	0.78
186_A	221_L	1.650	0.78
100_I	104_S	1.645	0.78
172_C	179_C	1.598	0.76
62_L	221_L	1.591	0.76
49_A	53_A	1.589	0.76
56_L	123_T	1.588	0.75
150_Y	168_T	1.588	0.75
106_L	184_E	1.588	0.75
166_A	184_E	1.580	0.75
109_H	162_V	1.576	0.75
245_L	265_N	1.521	0.72
35_I	53_A	1.511	0.72
65_L	120_Y	1.504	0.71
256_Y	262_L	1.500	0.71
172_C	184_E	1.497	0.71
133_H	222_A	1.494	0.71
109_H	151_E	1.487	0.70
102_Y	106_L	1.470	0.70
154_S	164_D	1.453	0.69
120_Y	167_K	1.439	0.68
216_K	261_R	1.432	0.67
168_T	181_G	1.417	0.67
66_L	69_R	1.414	0.66
113_E	187_T	1.409	0.66
163_A	191_A	1.405	0.66
244_S	262_L	1.389	0.65
112_T	119_V	1.386	0.65
116_P	265_N	1.383	0.65
122_V	167_K	1.382	0.65
236_V	239_F	1.379	0.64
169_L	197_C	1.377	0.64
134_G	221_L	1.360	0.63
166_A	197_C	1.356	0.63
111_L	165_L	1.351	0.63
38_V	42_L	1.327	0.61
213_A	217_R	1.324	0.61
251_S	265_N	1.320	0.61
106_L	172_C	1.301	0.60
176_P	181_G	1.276	0.58
120_Y	206_L	1.229	0.55
33_I	38_V	1.228	0.55
103_Y	217_R	1.226	0.55
102_Y	244_S	1.218	0.55
234_T	237_E	1.218	0.55
45_A	48_T	1.199	0.53
111_L	192_A	1.198	0.53
102_Y	167_K	1.196	0.53
220_Y	265_N	1.180	0.52
167_K	209_L	1.161	0.51
111_L	188_A	1.159	0.51
176_P	262_L	1.155	0.51
88_Y	115_V	1.153	0.51
74_P	163_A	1.152	0.51
130_R	137_Y	1.148	0.50
174_D	211_N	1.145	0.50
74_P	98_M	1.130	0.49
217_R	221_L	1.127	0.49
172_C	188_A	1.125	0.49
52_I	62_L	1.121	0.49
168_T	171_D	1.115	0.48
186_A	220_Y	1.104	0.47
235_L	262_L	1.101	0.47
112_T	162_V	1.094	0.47
122_V	221_L	1.092	0.47
216_K	247_D	1.089	0.47
54_S	57_T	1.087	0.46
184_E	187_T	1.083	0.46
76_A	139_V	1.082	0.46
257_D	264_I	1.076	0.46
100_I	160_V	1.074	0.46
171_D	260_Y	1.069	0.45
94_V	127_A	1.057	0.45
91_A	98_M	1.047	0.44
206_L	215_T	1.047	0.44
34_S	129_S	1.044	0.44
54_S	197_C	1.026	0.43
254_G	265_N	1.022	0.42
135_V	143_T	1.021	0.42
100_I	108_H	1.018	0.42
125_T	139_V	1.011	0.42
164_D	167_K	1.003	0.41
22_L	170_V	1.002	0.41
137_Y	216_K	1.001	0.41
223_D	260_Y	0.988	0.40
37_D	118_T	0.984	0.40
154_S	159_V	0.983	0.40
152_P	161_N	0.979	0.40
214_A	247_D	0.975	0.39
105_A	260_Y	0.973	0.39
29_G	72_I	0.966	0.39
106_L	122_V	0.964	0.39
72_I	201_T	0.961	0.39
112_T	227_I	0.961	0.39
31_Q	101_G	0.960	0.39
246_L	264_I	0.952	0.38
245_L	248_P	0.947	0.38
104_S	149_G	0.942	0.37
148_F	167_K	0.937	0.37
167_K	192_A	0.927	0.37
150_Y	245_L	0.924	0.36
168_T	172_C	0.919	0.36
36_D	198_S	0.914	0.36
95_A	98_M	0.911	0.36
149_G	202_V	0.911	0.36
103_Y	107_S	0.908	0.35
219_V	222_A	0.905	0.35
113_E	185_L	0.893	0.35
146_K	174_D	0.891	0.34
221_L	261_R	0.877	0.34
208_R	268_P	0.876	0.34
173_A	218_I	0.876	0.34
166_A	202_V	0.875	0.34
70_Y	214_A	0.874	0.34
86_H	156_E	0.870	0.33
55_R	158_T	0.870	0.33
116_P	188_A	0.866	0.33
215_T	235_L	0.866	0.33
102_Y	213_A	0.864	0.33
150_Y	167_K	0.863	0.33
35_I	39_E	0.853	0.32
105_A	219_V	0.847	0.32
33_I	143_T	0.841	0.32
83_Y	133_H	0.840	0.32
221_L	246_L	0.839	0.32
110_G	209_L	0.832	0.31
111_L	216_K	0.830	0.31
119_V	149_G	0.819	0.30
248_P	265_N	0.817	0.30
164_D	168_T	0.815	0.30
100_I	197_C	0.813	0.30
172_C	192_A	0.812	0.30
52_I	56_L	0.812	0.30
38_V	71_L	0.807	0.30
42_L	176_P	0.806	0.30
220_Y	264_I	0.803	0.30
20_R	23_S	0.802	0.30
175_H	178_Y	0.800	0.29
46_P	234_T	0.797	0.29
103_Y	220_Y	0.794	0.29
162_V	261_R	0.792	0.29
69_R	84_T	0.792	0.29
99_Y	103_Y	0.785	0.29
220_Y	256_Y	0.780	0.28
169_L	218_I	0.777	0.28
192_A	216_K	0.772	0.28
86_H	104_S	0.772	0.28
36_D	66_L	0.770	0.28
120_Y	178_Y	0.766	0.28
128_Q	257_D	0.765	0.28
252_E	263_R	0.765	0.28
111_L	158_T	0.764	0.28
57_T	64_R	0.758	0.27
144_E	249_T	0.758	0.27
173_A	219_V	0.757	0.27
171_D	219_V	0.757	0.27
102_Y	174_D	0.755	0.27
52_I	55_R	0.752	0.27
37_D	258_S	0.750	0.27
88_Y	108_H	0.750	0.27
221_L	248_P	0.749	0.27
103_Y	192_A	0.747	0.27
176_P	184_E	0.744	0.27
170_V	209_L	0.744	0.27
217_R	247_D	0.744	0.27
87_E	107_S	0.741	0.26
23_S	73_I	0.740	0.26
60_G	164_D	0.736	0.26
97_P	204_E	0.736	0.26
224_Q	257_D	0.735	0.26
39_E	43_E	0.734	0.26
200_A	207_Q	0.733	0.26
65_L	115_V	0.733	0.26
220_Y	249_T	0.728	0.26
58_E	233_E	0.727	0.26
245_L	263_R	0.721	0.26
193_D	223_D	0.720	0.25
38_V	218_I	0.720	0.25
105_A	168_T	0.717	0.25
169_L	188_A	0.714	0.25
125_T	231_T	0.712	0.25
131_E	195_Q	0.706	0.25
166_A	198_S	0.706	0.25
207_Q	235_L	0.705	0.25
121_V	165_L	0.697	0.24
59_K	138_R	0.695	0.24
167_K	205_Y	0.689	0.24
189_M	200_A	0.685	0.24
176_P	180_G	0.679	0.24
45_A	163_A	0.677	0.23
140_A	179_C	0.676	0.23
40_A	151_E	0.675	0.23
56_L	62_L	0.674	0.23
104_S	262_L	0.673	0.23
112_T	115_V	0.672	0.23
127_A	182_I	0.670	0.23
124_P	162_V	0.669	0.23
156_E	223_D	0.665	0.23
108_H	213_A	0.664	0.23
106_L	113_E	0.663	0.23
114_Q	134_G	0.663	0.23
229_L	237_E	0.663	0.23
120_Y	177_E	0.662	0.23
162_V	269_G	0.658	0.23
233_E	258_S	0.657	0.23
185_L	193_D	0.657	0.23
103_Y	112_T	0.657	0.23
22_L	195_Q	0.654	0.22
84_T	172_C	0.651	0.22
230_P	267_D	0.649	0.22
91_A	113_E	0.649	0.22
178_Y	184_E	0.647	0.22
21_L	52_I	0.646	0.22
109_H	230_P	0.646	0.22
91_A	120_Y	0.645	0.22
37_D	193_D	0.645	0.22
114_Q	121_V	0.643	0.22
25_L	43_E	0.641	0.22
217_R	251_S	0.640	0.22
72_I	253_Q	0.640	0.22
95_A	113_E	0.638	0.22
150_Y	163_A	0.637	0.22
54_S	73_I	0.637	0.22
43_E	48_T	0.635	0.22
111_L	119_V	0.635	0.22
129_S	133_H	0.634	0.22
95_A	109_H	0.633	0.22
83_Y	141_T	0.632	0.21
131_E	230_P	0.632	0.21
142_V	147_F	0.632	0.21
160_V	240_T	0.630	0.21
20_R	24_H	0.629	0.21
104_S	197_C	0.628	0.21
203_G	234_T	0.628	0.21
114_Q	221_L	0.627	0.21
231_T	235_L	0.627	0.21
103_Y	188_A	0.625	0.21
221_L	251_S	0.623	0.21
254_G	257_D	0.621	0.21
58_E	252_E	0.621	0.21
162_V	185_L	0.620	0.21
103_Y	265_N	0.616	0.21
265_N	269_G	0.616	0.21
67_P	250_Q	0.613	0.21
58_E	255_S	0.613	0.21
183_R	187_T	0.613	0.21
70_Y	234_T	0.612	0.21
100_I	164_D	0.611	0.21
34_S	68_G	0.610	0.21
42_L	262_L	0.610	0.21
94_V	145_R	0.606	0.20
177_E	212_G	0.604	0.20
179_C	261_R	0.603	0.20
160_V	197_C	0.600	0.20
37_D	150_Y	0.600	0.20
56_L	253_Q	0.600	0.20
60_G	177_E	0.599	0.20
132_I	154_S	0.598	0.20
61_W	108_H	0.598	0.20
34_S	198_S	0.594	0.20
172_C	193_D	0.593	0.20
101_G	215_T	0.593	0.20
88_Y	189_M	0.591	0.20
188_A	193_D	0.588	0.20
34_S	101_G	0.586	0.20
92_S	235_L	0.585	0.20
210_D	227_I	0.585	0.20
102_Y	142_V	0.584	0.19
37_D	224_Q	0.584	0.19
99_Y	122_V	0.583	0.19
56_L	72_I	0.578	0.19
173_A	214_A	0.574	0.19
60_G	131_E	0.572	0.19
170_V	215_T	0.570	0.19
87_E	119_V	0.569	0.19
202_V	229_L	0.569	0.19
173_A	242_G	0.569	0.19
109_H	129_S	0.568	0.19
243_Y	265_N	0.568	0.19
57_T	97_P	0.566	0.19
166_A	205_Y	0.561	0.19
33_I	243_Y	0.561	0.19
186_A	190_V	0.559	0.19
180_G	217_R	0.559	0.19
86_H	170_V	0.559	0.19
178_Y	211_N	0.558	0.18
27_A	180_G	0.558	0.18
29_G	110_G	0.554	0.18
132_I	217_R	0.554	0.18
58_E	162_V	0.552	0.18
180_G	188_A	0.552	0.18
183_R	265_N	0.552	0.18
35_I	134_G	0.551	0.18
189_M	198_S	0.551	0.18
98_M	217_R	0.550	0.18
39_E	104_S	0.550	0.18
95_A	147_F	0.549	0.18
59_K	220_Y	0.549	0.18
161_N	269_G	0.547	0.18
187_T	191_A	0.547	0.18
105_A	180_G	0.545	0.18
104_S	116_P	0.545	0.18
106_L	192_A	0.543	0.18
55_R	264_I	0.542	0.18
138_R	170_V	0.541	0.18
98_M	128_Q	0.536	0.18
100_I	123_T	0.533	0.18
202_V	218_I	0.530	0.17
237_E	255_S	0.529	0.17
88_Y	135_V	0.528	0.17
195_Q	240_T	0.528	0.17
109_H	242_G	0.528	0.17
28_E	140_A	0.527	0.17
56_L	265_N	0.522	0.17
176_P	247_D	0.520	0.17
241_S	253_Q	0.520	0.17
38_V	206_L	0.520	0.17
198_S	218_I	0.519	0.17
172_C	214_A	0.519	0.17
213_A	218_I	0.515	0.17
84_T	189_M	0.514	0.17
88_Y	201_T	0.510	0.17
48_T	239_F	0.508	0.17
99_Y	114_Q	0.507	0.17
98_M	216_K	0.507	0.17
30_H	170_V	0.505	0.17
38_V	256_Y	0.505	0.17
54_S	127_A	0.503	0.16
148_F	205_Y	0.500	0.16
186_A	201_T	0.500	0.16
96_E	131_E	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zelA	1	0.9638	100	0.282	Contact Map
2dk5A	1	0.2899	93.7	0.921	Contact Map
2lnbA	1	0.279	93.2	0.922	Contact Map
2heoA	1	0.2138	92.6	0.924	Contact Map
3lmmA	1	0.2609	92.6	0.924	Contact Map
2k4bA	1	0.2355	92.3	0.924	Contact Map
4ou0A	1	0.2283	90.9	0.927	Contact Map
2d1hA	2	0.3442	90.8	0.928	Contact Map
1p6rA	1	0.2826	90.6	0.928	Contact Map
1qgpA	1	0.2645	90.4	0.928	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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