GREMLIN Database
O54575 - Uncharacterized protein
UniProt: O54575 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (246)
Sequences: 344 (299)
Seq/√Len: 19.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
101_G122_V5.8271.00
163_A168_T4.5101.00
219_V260_Y3.8031.00
101_G163_A3.7381.00
168_T180_G3.4651.00
99_Y163_A3.2471.00
166_A201_T3.2230.99
236_V259_E3.1750.99
223_D259_E2.9640.99
164_D205_Y2.8710.99
33_I62_L2.7170.98
65_L71_L2.4910.97
217_R265_N2.4410.96
206_L218_I2.3070.95
217_R248_P2.2230.94
198_S201_T2.1300.92
112_T116_P2.1090.92
97_P123_T2.0930.92
76_A186_A2.0150.90
232_R236_V1.9740.89
149_G167_K1.9700.89
106_L188_A1.9680.89
217_R246_L1.9370.88
169_L189_M1.9050.87
163_A180_G1.8990.87
98_M163_A1.8650.86
149_G205_Y1.8600.86
98_M115_V1.8520.86
176_P179_C1.7990.84
102_Y122_V1.7920.84
56_L99_Y1.7580.83
140_A162_V1.7450.82
243_Y256_Y1.7420.82
111_L172_C1.7370.82
38_V121_V1.7160.81
102_Y175_H1.7030.80
140_A178_Y1.6790.80
98_M139_V1.6710.79
74_P89_L1.6540.78
186_A221_L1.6500.78
100_I104_S1.6450.78
172_C179_C1.5980.76
62_L221_L1.5910.76
49_A53_A1.5890.76
56_L123_T1.5880.75
150_Y168_T1.5880.75
106_L184_E1.5880.75
166_A184_E1.5800.75
109_H162_V1.5760.75
245_L265_N1.5210.72
35_I53_A1.5110.72
65_L120_Y1.5040.71
256_Y262_L1.5000.71
172_C184_E1.4970.71
133_H222_A1.4940.71
109_H151_E1.4870.70
102_Y106_L1.4700.70
154_S164_D1.4530.69
120_Y167_K1.4390.68
216_K261_R1.4320.67
168_T181_G1.4170.67
66_L69_R1.4140.66
113_E187_T1.4090.66
163_A191_A1.4050.66
244_S262_L1.3890.65
112_T119_V1.3860.65
116_P265_N1.3830.65
122_V167_K1.3820.65
236_V239_F1.3790.64
169_L197_C1.3770.64
134_G221_L1.3600.63
166_A197_C1.3560.63
111_L165_L1.3510.63
38_V42_L1.3270.61
213_A217_R1.3240.61
251_S265_N1.3200.61
106_L172_C1.3010.60
176_P181_G1.2760.58
120_Y206_L1.2290.55
33_I38_V1.2280.55
103_Y217_R1.2260.55
102_Y244_S1.2180.55
234_T237_E1.2180.55
45_A48_T1.1990.53
111_L192_A1.1980.53
102_Y167_K1.1960.53
220_Y265_N1.1800.52
167_K209_L1.1610.51
111_L188_A1.1590.51
176_P262_L1.1550.51
88_Y115_V1.1530.51
74_P163_A1.1520.51
130_R137_Y1.1480.50
174_D211_N1.1450.50
74_P98_M1.1300.49
217_R221_L1.1270.49
172_C188_A1.1250.49
52_I62_L1.1210.49
168_T171_D1.1150.48
186_A220_Y1.1040.47
235_L262_L1.1010.47
112_T162_V1.0940.47
122_V221_L1.0920.47
216_K247_D1.0890.47
54_S57_T1.0870.46
184_E187_T1.0830.46
76_A139_V1.0820.46
257_D264_I1.0760.46
100_I160_V1.0740.46
171_D260_Y1.0690.45
94_V127_A1.0570.45
91_A98_M1.0470.44
206_L215_T1.0470.44
34_S129_S1.0440.44
54_S197_C1.0260.43
254_G265_N1.0220.42
135_V143_T1.0210.42
100_I108_H1.0180.42
125_T139_V1.0110.42
164_D167_K1.0030.41
22_L170_V1.0020.41
137_Y216_K1.0010.41
223_D260_Y0.9880.40
37_D118_T0.9840.40
154_S159_V0.9830.40
152_P161_N0.9790.40
214_A247_D0.9750.39
105_A260_Y0.9730.39
29_G72_I0.9660.39
106_L122_V0.9640.39
72_I201_T0.9610.39
112_T227_I0.9610.39
31_Q101_G0.9600.39
246_L264_I0.9520.38
245_L248_P0.9470.38
104_S149_G0.9420.37
148_F167_K0.9370.37
167_K192_A0.9270.37
150_Y245_L0.9240.36
168_T172_C0.9190.36
36_D198_S0.9140.36
95_A98_M0.9110.36
149_G202_V0.9110.36
103_Y107_S0.9080.35
219_V222_A0.9050.35
113_E185_L0.8930.35
146_K174_D0.8910.34
221_L261_R0.8770.34
208_R268_P0.8760.34
173_A218_I0.8760.34
166_A202_V0.8750.34
70_Y214_A0.8740.34
86_H156_E0.8700.33
55_R158_T0.8700.33
116_P188_A0.8660.33
215_T235_L0.8660.33
102_Y213_A0.8640.33
150_Y167_K0.8630.33
35_I39_E0.8530.32
105_A219_V0.8470.32
33_I143_T0.8410.32
83_Y133_H0.8400.32
221_L246_L0.8390.32
110_G209_L0.8320.31
111_L216_K0.8300.31
119_V149_G0.8190.30
248_P265_N0.8170.30
164_D168_T0.8150.30
100_I197_C0.8130.30
172_C192_A0.8120.30
52_I56_L0.8120.30
38_V71_L0.8070.30
42_L176_P0.8060.30
220_Y264_I0.8030.30
20_R23_S0.8020.30
175_H178_Y0.8000.29
46_P234_T0.7970.29
103_Y220_Y0.7940.29
162_V261_R0.7920.29
69_R84_T0.7920.29
99_Y103_Y0.7850.29
220_Y256_Y0.7800.28
169_L218_I0.7770.28
192_A216_K0.7720.28
86_H104_S0.7720.28
36_D66_L0.7700.28
120_Y178_Y0.7660.28
128_Q257_D0.7650.28
252_E263_R0.7650.28
111_L158_T0.7640.28
57_T64_R0.7580.27
144_E249_T0.7580.27
173_A219_V0.7570.27
171_D219_V0.7570.27
102_Y174_D0.7550.27
52_I55_R0.7520.27
37_D258_S0.7500.27
88_Y108_H0.7500.27
221_L248_P0.7490.27
103_Y192_A0.7470.27
176_P184_E0.7440.27
170_V209_L0.7440.27
217_R247_D0.7440.27
87_E107_S0.7410.26
23_S73_I0.7400.26
60_G164_D0.7360.26
97_P204_E0.7360.26
224_Q257_D0.7350.26
39_E43_E0.7340.26
200_A207_Q0.7330.26
65_L115_V0.7330.26
220_Y249_T0.7280.26
58_E233_E0.7270.26
245_L263_R0.7210.26
193_D223_D0.7200.25
38_V218_I0.7200.25
105_A168_T0.7170.25
169_L188_A0.7140.25
125_T231_T0.7120.25
131_E195_Q0.7060.25
166_A198_S0.7060.25
207_Q235_L0.7050.25
121_V165_L0.6970.24
59_K138_R0.6950.24
167_K205_Y0.6890.24
189_M200_A0.6850.24
176_P180_G0.6790.24
45_A163_A0.6770.23
140_A179_C0.6760.23
40_A151_E0.6750.23
56_L62_L0.6740.23
104_S262_L0.6730.23
112_T115_V0.6720.23
127_A182_I0.6700.23
124_P162_V0.6690.23
156_E223_D0.6650.23
108_H213_A0.6640.23
106_L113_E0.6630.23
114_Q134_G0.6630.23
229_L237_E0.6630.23
120_Y177_E0.6620.23
162_V269_G0.6580.23
233_E258_S0.6570.23
185_L193_D0.6570.23
103_Y112_T0.6570.23
22_L195_Q0.6540.22
84_T172_C0.6510.22
230_P267_D0.6490.22
91_A113_E0.6490.22
178_Y184_E0.6470.22
21_L52_I0.6460.22
109_H230_P0.6460.22
91_A120_Y0.6450.22
37_D193_D0.6450.22
114_Q121_V0.6430.22
25_L43_E0.6410.22
217_R251_S0.6400.22
72_I253_Q0.6400.22
95_A113_E0.6380.22
150_Y163_A0.6370.22
54_S73_I0.6370.22
43_E48_T0.6350.22
111_L119_V0.6350.22
129_S133_H0.6340.22
95_A109_H0.6330.22
83_Y141_T0.6320.21
131_E230_P0.6320.21
142_V147_F0.6320.21
160_V240_T0.6300.21
20_R24_H0.6290.21
104_S197_C0.6280.21
203_G234_T0.6280.21
114_Q221_L0.6270.21
231_T235_L0.6270.21
103_Y188_A0.6250.21
221_L251_S0.6230.21
254_G257_D0.6210.21
58_E252_E0.6210.21
162_V185_L0.6200.21
103_Y265_N0.6160.21
265_N269_G0.6160.21
67_P250_Q0.6130.21
58_E255_S0.6130.21
183_R187_T0.6130.21
70_Y234_T0.6120.21
100_I164_D0.6110.21
34_S68_G0.6100.21
42_L262_L0.6100.21
94_V145_R0.6060.20
177_E212_G0.6040.20
179_C261_R0.6030.20
160_V197_C0.6000.20
37_D150_Y0.6000.20
56_L253_Q0.6000.20
60_G177_E0.5990.20
132_I154_S0.5980.20
61_W108_H0.5980.20
34_S198_S0.5940.20
172_C193_D0.5930.20
101_G215_T0.5930.20
88_Y189_M0.5910.20
188_A193_D0.5880.20
34_S101_G0.5860.20
92_S235_L0.5850.20
210_D227_I0.5850.20
102_Y142_V0.5840.19
37_D224_Q0.5840.19
99_Y122_V0.5830.19
56_L72_I0.5780.19
173_A214_A0.5740.19
60_G131_E0.5720.19
170_V215_T0.5700.19
87_E119_V0.5690.19
202_V229_L0.5690.19
173_A242_G0.5690.19
109_H129_S0.5680.19
243_Y265_N0.5680.19
57_T97_P0.5660.19
166_A205_Y0.5610.19
33_I243_Y0.5610.19
186_A190_V0.5590.19
180_G217_R0.5590.19
86_H170_V0.5590.19
178_Y211_N0.5580.18
27_A180_G0.5580.18
29_G110_G0.5540.18
132_I217_R0.5540.18
58_E162_V0.5520.18
180_G188_A0.5520.18
183_R265_N0.5520.18
35_I134_G0.5510.18
189_M198_S0.5510.18
98_M217_R0.5500.18
39_E104_S0.5500.18
95_A147_F0.5490.18
59_K220_Y0.5490.18
161_N269_G0.5470.18
187_T191_A0.5470.18
105_A180_G0.5450.18
104_S116_P0.5450.18
106_L192_A0.5430.18
55_R264_I0.5420.18
138_R170_V0.5410.18
98_M128_Q0.5360.18
100_I123_T0.5330.18
202_V218_I0.5300.17
237_E255_S0.5290.17
88_Y135_V0.5280.17
195_Q240_T0.5280.17
109_H242_G0.5280.17
28_E140_A0.5270.17
56_L265_N0.5220.17
176_P247_D0.5200.17
241_S253_Q0.5200.17
38_V206_L0.5200.17
198_S218_I0.5190.17
172_C214_A0.5190.17
213_A218_I0.5150.17
84_T189_M0.5140.17
88_Y201_T0.5100.17
48_T239_F0.5080.17
99_Y114_Q0.5070.17
98_M216_K0.5070.17
30_H170_V0.5050.17
38_V256_Y0.5050.17
54_S127_A0.5030.16
148_F205_Y0.5000.16
186_A201_T0.5000.16
96_E131_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zelA 1 0.9638 100 0.282 Contact Map
2dk5A 1 0.2899 93.7 0.921 Contact Map
2lnbA 1 0.279 93.2 0.922 Contact Map
2heoA 1 0.2138 92.6 0.924 Contact Map
3lmmA 1 0.2609 92.6 0.924 Contact Map
2k4bA 1 0.2355 92.3 0.924 Contact Map
4ou0A 1 0.2283 90.9 0.927 Contact Map
2d1hA 2 0.3442 90.8 0.928 Contact Map
1p6rA 1 0.2826 90.6 0.928 Contact Map
1qgpA 1 0.2645 90.4 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.