O54573 - HALSA - GREMLIN Contacts

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O54573 - SojC

UniProt:	O54573	Sequences: MAGTNSGNSIDSTNSPNSPYDSVDTAGNSRAVSVCMLKGGVGKSTIAVNLARQLATHDHDVLLIDLDPNGHASVGLGFDDHYHNTDEGIGEVFFDEADPTSVVYDTEYEFDILPSSEDLEQVEREIVVGDVFQPSALLKREVVEPLLGDEYDFIVTDSPAYRSRLTDNALVATSNLVLPLAPGNEAMSGLERTIERQIAPLRKHMDVDVLALVPNMLDGRIDQQTQDRQLLERLNSHNSLQDRIPNFARITDWEAVGSGDISPTPGIRDRTSITKAYGERKPLLDYDANCDQLKNFDELAHIVEAGEVVRHG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	312 (246)
Sequences:	14435 (9123)
Seq/√Len:	581.6

ECOLI - BCSQ MIND MRP
BACSU - YLXH SOJ MIND SALA YWQD YVEL
HALSA - O54573 Q9HHZ7 Q9HHU2 Q9HNF1 O51969 O51991 Q9HHL5 Q9HQY5 Q9HQJ7
SULSO - Q97ZW4 Q981B3 Q97VX7 Q97WA2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
111_D	151_Y	4.269	1.00
245_P	272_S	3.905	1.00
47_A	155_V	3.785	1.00
57_H	278_G	3.332	1.00
59_H	153_F	2.930	1.00
54_L	153_F	2.924	1.00
46_I	273_I	2.908	1.00
33_S	173_T	2.902	1.00
259_G	262_S	2.799	1.00
30_R	175_N	2.557	1.00
62_L	151_Y	2.489	1.00
181_A	216_M	2.462	1.00
216_M	246_N	2.451	1.00
221_I	224_Q	2.412	1.00
63_L	72_A	2.314	1.00
48_V	72_A	2.300	1.00
75_G	185_E	2.240	1.00
47_A	63_L	2.218	1.00
105_D	111_D	2.216	1.00
56_T	274_T	2.129	1.00
34_V	50_L	2.075	1.00
53_Q	261_I	2.060	1.00
53_Q	277_Y	2.045	1.00
213_V	276_A	2.034	1.00
51_A	63_L	2.017	1.00
249_R	252_D	2.010	1.00
46_I	213_V	2.001	1.00
231_L	235_N	1.998	1.00
60_D	152_D	1.892	1.00
218_D	246_N	1.844	1.00
229_Q	233_R	1.843	1.00
74_V	188_S	1.807	1.00
59_H	281_K	1.720	1.00
175_N	210_L	1.691	1.00
214_P	228_R	1.685	1.00
66_L	169_A	1.682	1.00
230_L	234_L	1.653	1.00
55_A	110_F	1.652	1.00
54_L	155_V	1.649	1.00
247_F	269_D	1.649	1.00
228_R	232_E	1.648	1.00
242_D	279_E	1.629	1.00
242_D	276_A	1.621	1.00
100_T	150_E	1.621	1.00
57_H	274_T	1.620	1.00
31_A	156_T	1.614	1.00
51_A	155_V	1.609	1.00
88_G	91_E	1.567	1.00
34_V	177_V	1.565	1.00
48_V	75_G	1.556	1.00
50_L	280_R	1.542	1.00
33_S	158_S	1.523	1.00
98_D	101_S	1.514	1.00
66_L	156_T	1.493	1.00
76_L	110_F	1.488	1.00
59_H	152_D	1.487	1.00
55_A	109_E	1.460	1.00
50_L	277_Y	1.431	1.00
217_L	243_R	1.390	1.00
241_Q	279_E	1.386	1.00
29_S	154_I	1.386	1.00
177_V	213_V	1.367	1.00
66_L	89_I	1.357	1.00
34_V	47_A	1.354	1.00
175_N	208_D	1.348	1.00
78_F	112_I	1.336	1.00
51_A	72_A	1.322	1.00
71_H	189_G	1.318	1.00
166_T	169_A	1.317	1.00
48_V	76_L	1.303	1.00
239_S	283_L	1.293	1.00
57_H	281_K	1.291	1.00
176_L	198_I	1.291	1.00
258_S	263_P	1.290	1.00
182_P	214_P	1.288	1.00
99_P	113_L	1.282	1.00
249_R	264_T	1.280	1.00
244_I	269_D	1.278	1.00
230_L	233_R	1.271	1.00
267_I	270_R	1.259	1.00
223_Q	226_Q	1.258	1.00
35_C	193_T	1.256	1.00
42_G	215_N	1.248	1.00
46_I	215_N	1.234	1.00
139_K	142_V	1.221	1.00
87_E	91_E	1.219	1.00
248_A	252_D	1.201	1.00
117_E	192_R	1.186	1.00
183_G	186_A	1.172	1.00
271_T	274_T	1.162	1.00
30_R	174_S	1.143	1.00
51_A	110_F	1.140	1.00
175_N	211_A	1.136	1.00
53_Q	274_T	1.109	1.00
275_K	279_E	1.103	1.00
250_I	269_D	1.092	1.00
147_L	150_E	1.088	1.00
112_I	117_E	1.086	1.00
153_F	281_K	1.084	1.00
46_I	50_L	1.083	1.00
62_L	103_V	1.083	1.00
228_R	231_L	1.079	1.00
165_L	169_A	1.068	1.00
135_S	139_K	1.065	1.00
247_F	267_I	1.065	1.00
89_I	92_V	1.063	1.00
164_R	169_A	1.061	1.00
70_G	73_S	1.056	1.00
240_L	243_R	1.053	1.00
136_A	140_R	1.051	1.00
44_S	72_A	1.036	1.00
123_E	163_S	1.036	1.00
278_G	282_P	1.031	1.00
268_R	271_T	1.028	1.00
204_H	207_V	1.028	1.00
54_L	61_V	1.025	1.00
215_N	273_I	1.021	1.00
106_T	112_I	1.017	1.00
229_Q	232_E	1.014	1.00
137_L	141_E	1.013	1.00
54_L	277_Y	1.007	1.00
131_V	135_S	0.994	1.00
274_T	278_G	0.993	1.00
185_E	254_E	0.988	1.00
275_K	278_G	0.988	1.00
272_S	275_K	0.986	1.00
35_C	158_S	0.979	1.00
52_R	56_T	0.978	1.00
183_G	251_T	0.977	1.00
34_V	46_I	0.976	1.00
71_H	185_E	0.973	1.00
97_A	102_V	0.973	1.00
60_D	150_E	0.972	1.00
256_V	263_P	0.965	1.00
145_P	148_G	0.964	1.00
258_S	262_S	0.957	1.00
261_I	274_T	0.957	1.00
56_T	262_S	0.954	1.00
158_S	169_A	0.954	1.00
136_A	139_K	0.954	1.00
31_A	154_I	0.952	1.00
87_E	97_A	0.949	1.00
231_L	234_L	0.941	1.00
141_E	145_P	0.937	1.00
76_L	112_I	0.933	1.00
101_S	104_Y	0.931	1.00
111_D	149_D	0.929	1.00
32_V	280_R	0.925	1.00
70_G	115_S	0.919	1.00
244_I	272_S	0.919	1.00
49_N	52_R	0.918	1.00
247_F	268_R	0.918	1.00
44_S	75_G	0.908	1.00
64_I	156_T	0.907	1.00
90_G	125_E	0.907	1.00
102_V	113_L	0.905	1.00
68_P	165_L	0.903	1.00
32_V	153_F	0.903	1.00
103_V	111_D	0.890	1.00
214_P	217_L	0.890	1.00
276_A	280_R	0.889	1.00
232_E	235_N	0.889	1.00
52_R	110_F	0.889	1.00
34_V	155_V	0.888	1.00
219_G	222_D	0.887	1.00
230_L	235_N	0.881	1.00
260_D	270_R	0.872	1.00
92_V	102_V	0.869	1.00
195_E	199_A	0.869	1.00
49_N	261_I	0.865	1.00
97_A	101_S	0.864	1.00
45_T	250_I	0.863	1.00
53_Q	57_H	0.862	1.00
31_A	148_G	0.859	1.00
32_V	175_N	0.857	1.00
56_T	261_I	0.853	1.00
252_D	256_V	0.846	1.00
265_P	270_R	0.844	1.00
210_L	284_L	0.842	1.00
137_L	140_R	0.839	1.00
239_S	279_E	0.829	1.00
179_P	215_N	0.829	1.00
41_V	186_A	0.823	1.00
218_D	227_D	0.815	1.00
64_I	154_I	0.803	1.00
140_R	144_E	0.803	1.00
264_T	267_I	0.797	1.00
62_L	154_I	0.795	1.00
178_L	194_I	0.787	1.00
37_L	197_Q	0.780	1.00
30_R	153_F	0.778	1.00
30_R	210_L	0.778	1.00
131_V	137_L	0.773	1.00
100_T	104_Y	0.771	1.00
104_Y	107_E	0.770	1.00
58_D	109_E	0.769	1.00
133_Q	136_A	0.764	1.00
153_F	284_L	0.761	1.00
122_V	126_I	0.758	1.00
63_L	76_L	0.758	1.00
50_L	276_A	0.758	1.00
268_R	272_S	0.757	1.00
269_D	272_S	0.757	1.00
175_N	284_L	0.756	1.00
52_R	261_I	0.755	1.00
53_Q	273_I	0.751	1.00
228_R	243_R	0.750	1.00
178_L	190_L	0.747	1.00
182_P	217_L	0.743	1.00
107_E	262_S	0.742	1.00
228_R	234_L	0.740	1.00
164_R	171_V	0.739	1.00
229_Q	243_R	0.732	1.00
177_V	280_R	0.732	1.00
35_C	166_T	0.731	1.00
182_P	224_Q	0.726	1.00
66_L	165_L	0.723	1.00
46_I	179_P	0.721	1.00
124_R	127_V	0.716	1.00
38_K	43_K	0.716	1.00
181_A	186_A	0.714	1.00
166_T	170_L	0.713	1.00
211_A	240_L	0.713	1.00
31_A	174_S	0.708	1.00
45_T	254_E	0.707	1.00
43_K	160_A	0.704	1.00
74_V	184_N	0.704	1.00
245_P	268_R	0.703	1.00
224_Q	227_D	0.702	1.00
233_R	236_S	0.697	1.00
214_P	231_L	0.697	1.00
90_G	94_F	0.694	1.00
49_N	273_I	0.689	1.00
49_N	259_G	0.689	1.00
69_N	163_S	0.689	1.00
36_M	41_V	0.687	1.00
73_S	114_P	0.687	1.00
266_G	271_T	0.686	1.00
70_G	116_S	0.686	1.00
164_R	168_N	0.685	1.00
61_V	110_F	0.679	1.00
248_A	251_T	0.679	1.00
92_V	113_L	0.678	1.00
47_A	72_A	0.676	1.00
121_Q	124_R	0.676	1.00
231_L	236_S	0.673	1.00
191_E	234_L	0.671	1.00
261_I	270_R	0.671	1.00
124_R	164_R	0.671	1.00
279_E	283_L	0.669	1.00
100_T	145_P	0.669	1.00
103_V	151_Y	0.668	1.00
60_D	111_D	0.667	1.00
137_L	142_V	0.665	1.00
168_N	171_V	0.664	1.00
134_P	137_L	0.664	1.00
104_Y	114_P	0.663	1.00
130_D	134_P	0.661	1.00
139_K	143_V	0.661	1.00
253_W	260_D	0.660	1.00
271_T	275_K	0.659	1.00
270_R	274_T	0.658	1.00
163_S	166_T	0.655	1.00
111_D	114_P	0.654	1.00
167_D	197_Q	0.650	1.00
180_L	212_L	0.645	1.00
53_Q	270_R	0.643	1.00
52_R	259_G	0.640	1.00
151_Y	154_I	0.637	1.00
232_E	236_S	0.635	1.00
127_V	130_D	0.635	1.00
131_V	134_P	0.633	1.00
73_S	116_S	0.631	1.00
61_V	155_V	0.630	1.00
89_I	113_L	0.628	1.00
253_W	263_P	0.627	1.00
228_R	235_N	0.627	1.00
103_V	113_L	0.626	1.00
174_S	206_D	0.626	1.00
144_E	148_G	0.626	1.00
148_G	174_S	0.623	1.00
220_R	223_Q	0.622	1.00
222_D	225_T	0.622	1.00
61_V	152_D	0.621	1.00
44_S	71_H	0.621	1.00
71_H	188_S	0.620	1.00
52_R	262_S	0.620	1.00
265_P	274_T	0.618	1.00
133_Q	140_R	0.614	1.00
87_E	101_S	0.612	1.00
234_L	237_H	0.604	1.00
166_T	171_V	0.604	1.00
232_E	241_Q	0.601	1.00
100_T	103_V	0.600	1.00
155_V	280_R	0.598	1.00
69_N	160_A	0.596	1.00
29_S	150_E	0.593	1.00
38_K	185_E	0.592	1.00
250_I	254_E	0.591	1.00
92_V	99_P	0.591	1.00
91_E	96_E	0.589	1.00
74_V	185_E	0.588	1.00
244_I	276_A	0.588	1.00
53_Q	56_T	0.586	1.00
252_D	263_P	0.585	1.00
30_R	59_H	0.583	1.00
135_S	138_L	0.583	1.00
184_N	188_S	0.580	1.00
101_S	105_D	0.579	1.00
228_R	236_S	0.576	1.00
71_H	74_V	0.576	1.00
221_I	248_A	0.575	1.00
46_I	244_I	0.575	1.00
61_V	153_F	0.574	1.00
169_A	173_T	0.573	1.00
178_L	209_V	0.572	1.00
229_Q	235_N	0.570	1.00
162_R	166_T	0.570	1.00
47_A	51_A	0.570	1.00
35_C	170_L	0.567	1.00
62_L	111_D	0.566	1.00
38_K	41_V	0.563	0.99
191_E	195_E	0.557	0.99
184_N	255_A	0.556	0.99
31_A	173_T	0.555	0.99
214_P	243_R	0.553	0.99
232_E	243_R	0.551	0.99
29_S	148_G	0.550	0.99
279_E	282_P	0.549	0.99
122_V	125_E	0.549	0.99
111_D	150_E	0.548	0.99
72_A	112_I	0.547	0.99
277_Y	281_K	0.545	0.99
33_S	169_A	0.544	0.99
260_D	269_D	0.542	0.99
164_R	167_D	0.539	0.99
58_D	265_P	0.539	0.99
156_T	169_A	0.539	0.99
52_R	55_A	0.535	0.99
147_L	151_Y	0.534	0.99
88_G	116_S	0.534	0.99
32_V	210_L	0.533	0.99
103_V	147_L	0.533	0.99
60_D	151_Y	0.523	0.99
273_I	276_A	0.519	0.99
183_G	246_N	0.517	0.99
138_L	143_V	0.516	0.99
223_Q	251_T	0.515	0.99
30_R	284_L	0.512	0.99
107_E	111_D	0.512	0.99
195_E	200_P	0.510	0.99
225_T	229_Q	0.510	0.99
158_S	166_T	0.510	0.99
32_V	155_V	0.509	0.99
88_G	92_V	0.509	0.99
211_A	239_S	0.508	0.99
226_Q	229_Q	0.508	0.99
132_F	136_A	0.508	0.99
94_F	97_A	0.507	0.99
186_A	190_L	0.507	0.99
280_R	284_L	0.506	0.99
241_Q	275_K	0.504	0.99
33_S	176_L	0.503	0.99
265_P	271_T	0.503	0.99
49_N	260_D	0.503	0.99
242_D	275_K	0.502	0.99
217_L	228_R	0.501	0.99
212_L	238_N	0.500	0.99
176_L	207_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4pfsA	1	0.7853	100	0.365	Contact Map
3ez9A	2	0.7885	100	0.381	Contact Map
3ez2A	2	0.9199	100	0.385	Contact Map
3pg5A	2	0.7372	100	0.392	Contact Map
1wcv1	2	0.7724	100	0.394	Contact Map
4rz3A	2	0.7628	100	0.399	Contact Map
2ozeA	2	0.8846	100	0.4	Contact Map
1g3qA	1	0.7532	100	0.402	Contact Map
1hyqA	1	0.7404	100	0.404	Contact Map
3ea0A	2	0.7532	100	0.407	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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