GREMLIN Database
O54564 - Uncharacterized protein
UniProt: O54564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 190 (154)
Sequences: 651 (333)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_E169_T4.8681.00
177_A187_Q4.8331.00
54_A82_I4.2161.00
151_Q170_T4.0251.00
63_T174_A3.7701.00
46_S73_V3.3881.00
123_K127_D3.1721.00
62_S143_M3.0631.00
131_A135_E2.6860.99
55_Y121_M2.6310.99
65_A145_V2.4980.99
181_M186_I2.4130.99
138_E142_D2.3000.98
58_L75_H2.0850.97
70_E146_E2.0030.96
41_K70_E1.9230.95
69_Y182_A1.9080.95
118_T121_M1.8750.94
121_M156_L1.8370.93
58_L137_I1.8350.93
72_T148_Q1.8340.93
108_A122_E1.8200.93
58_L73_V1.8060.93
44_I190_V1.8010.93
96_V123_K1.7930.93
46_S57_P1.7420.91
81_E103_V1.7240.91
73_V147_F1.7170.91
111_P118_T1.6860.90
177_A186_I1.6810.90
177_A181_M1.6240.88
62_S140_S1.6220.88
119_K122_E1.5980.87
103_V106_A1.5110.84
154_I164_F1.4990.84
128_N156_L1.4960.84
44_I60_L1.4370.81
43_S177_A1.4200.80
141_L167_G1.4050.79
140_S145_V1.3600.77
42_M69_Y1.3220.75
108_A134_E1.3010.74
45_I60_L1.2820.73
93_L163_D1.2740.72
118_T122_E1.2710.72
59_I136_L1.2560.71
89_K105_N1.2540.71
94_S97_G1.2520.71
40_K69_Y1.2410.70
84_H106_A1.1980.67
146_E180_D1.1590.65
60_L174_A1.1560.65
42_M186_I1.1550.65
49_G111_P1.1180.62
153_T156_L1.0990.61
48_K53_M1.0960.60
45_I95_S1.0880.60
65_A175_A1.0840.60
97_G124_K1.0800.59
107_V122_E1.0480.57
43_S187_Q1.0350.56
173_G176_T1.0170.55
69_Y185_D0.9880.52
83_L165_Y0.9840.52
111_P168_V0.9810.52
40_K127_D0.9740.51
116_V127_D0.9690.51
41_K180_D0.9650.51
100_N190_V0.9620.51
82_I110_L0.9520.50
135_E139_T0.9430.49
57_P60_L0.9410.49
85_E166_D0.9350.48
75_H110_L0.9210.47
86_E142_D0.9130.47
46_S60_L0.9100.47
102_P117_T0.9040.46
88_S105_N0.8860.45
175_A179_Q0.8850.45
135_E185_D0.8780.44
72_T177_A0.8700.44
46_S75_H0.8680.43
124_K127_D0.8580.43
57_P73_V0.8530.42
124_K158_D0.8380.41
51_L122_E0.8350.41
124_K160_D0.8350.41
39_A179_Q0.8220.40
96_V120_M0.8220.40
114_D118_T0.8190.40
53_M78_W0.8140.40
142_D166_D0.8120.39
56_P125_I0.8120.39
130_T156_L0.8120.39
55_Y136_L0.8090.39
50_T99_P0.8080.39
49_G59_I0.8060.39
80_L157_M0.8050.39
78_W157_M0.8030.39
170_T177_A0.7980.38
122_E146_E0.7910.38
83_L159_Y0.7890.38
59_I121_M0.7850.37
112_G118_T0.7850.37
51_L55_Y0.7810.37
132_T135_E0.7790.37
45_I97_G0.7780.37
111_P131_A0.7780.37
40_K185_D0.7770.37
148_Q181_M0.7750.37
51_L130_T0.7730.37
67_F180_D0.7670.36
38_D116_V0.7630.36
51_L68_G0.7590.36
66_A173_G0.7520.35
42_M60_L0.7490.35
37_D138_E0.7470.35
60_L178_L0.7410.34
121_M128_N0.7410.34
107_V134_E0.7340.34
126_D169_T0.7300.34
67_F178_L0.7270.34
123_K145_V0.7240.33
130_T152_M0.7220.33
113_M118_T0.7190.33
148_Q171_G0.7140.33
41_K187_Q0.7120.33
116_V120_M0.7110.32
47_T56_P0.7060.32
129_D159_Y0.7020.32
49_G170_T0.7000.32
97_G160_D0.7000.32
113_M116_V0.7000.32
97_G145_V0.6980.32
132_T136_L0.6980.32
147_F155_D0.6940.31
167_G170_T0.6870.31
152_M173_G0.6790.30
83_L171_G0.6720.30
96_V103_V0.6690.30
112_G156_L0.6680.30
132_T156_L0.6660.30
113_M168_V0.6610.29
60_L137_I0.6600.29
56_P174_A0.6570.29
59_I155_D0.6560.29
106_A109_A0.6560.29
39_A183_E0.6540.29
138_E161_E0.6500.29
129_D152_M0.6460.28
84_H100_N0.6440.28
151_Q155_D0.6440.28
98_N114_D0.6410.28
159_Y164_F0.6400.28
121_M179_Q0.6360.28
36_E39_A0.6350.28
125_I161_E0.6310.27
60_L69_Y0.6280.27
51_L59_I0.6280.27
61_A73_V0.6260.27
121_M148_Q0.6250.27
62_S136_L0.6210.27
50_T114_D0.6150.26
55_Y97_G0.6100.26
86_E161_E0.6080.26
47_T93_L0.6060.26
75_H165_Y0.6060.26
41_K183_E0.6050.26
47_T53_M0.6020.26
151_Q173_G0.6010.26
107_V144_G0.5960.25
135_E181_M0.5960.25
47_T117_T0.5950.25
56_P117_T0.5950.25
129_D151_Q0.5950.25
49_G67_F0.5940.25
154_I171_G0.5910.25
94_S101_M0.5910.25
42_M182_A0.5910.25
114_D135_E0.5900.25
122_E134_E0.5880.25
148_Q178_L0.5840.25
50_T70_E0.5840.25
98_N105_N0.5830.25
136_L147_F0.5830.25
58_L187_Q0.5810.25
128_N131_A0.5800.24
47_T76_T0.5780.24
47_T63_T0.5710.24
60_L63_T0.5690.24
39_A129_D0.5680.24
50_T111_P0.5670.24
63_T78_W0.5620.23
41_K131_A0.5590.23
80_L155_D0.5580.23
80_L149_A0.5550.23
92_K161_E0.5540.23
99_P117_T0.5520.23
104_P155_D0.5490.23
82_I147_F0.5460.23
97_G100_N0.5420.22
58_L170_T0.5400.22
51_L118_T0.5390.22
47_T115_R0.5370.22
178_L189_L0.5370.22
61_A76_T0.5360.22
126_D161_E0.5340.22
136_L183_E0.5340.22
107_V132_T0.5320.22
84_H105_N0.5300.22
44_I142_D0.5300.22
40_K147_F0.5290.22
41_K69_Y0.5270.22
133_I143_M0.5220.21
43_S130_T0.5210.21
110_L113_M0.5210.21
171_G179_Q0.5190.21
38_D183_E0.5180.21
42_M135_E0.5170.21
101_M185_D0.5160.21
118_T137_I0.5160.21
38_D165_Y0.5150.21
65_A186_I0.5140.21
48_K55_Y0.5110.21
46_S130_T0.5110.21
72_T182_A0.5100.21
53_M56_P0.5100.21
45_I50_T0.5070.21
62_S65_A0.5060.21
131_A139_T0.5050.21
72_T180_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pnxA 4 0.8105 100 0.407 Contact Map
2qs7A 3 0.7158 100 0.511 Contact Map
3mc3A 3 0.5579 99.8 0.722 Contact Map
1jx7A 5 0.5947 99.5 0.779 Contact Map
1l1sA 3 0.5579 99.5 0.79 Contact Map
2hy5B 1 0.6 99.5 0.791 Contact Map
2d1pB 1 0.6053 99.1 0.827 Contact Map
2pd2A 3 0.5421 98.9 0.837 Contact Map
2hy5A 2 0.6 98.9 0.838 Contact Map
2d1pA 2 0.6053 98.6 0.855 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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