GREMLIN Database
O54562 - Uncharacterized protein
UniProt: O54562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (133)
Sequences: 128 (92)
Seq/√Len: 7.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_P85_E2.6020.78
108_Y131_N2.4940.75
2_V120_E2.4790.75
115_A137_V2.1350.63
6_E33_D2.1200.62
5_P90_T2.0220.58
44_R102_A2.0180.58
32_V138_V2.0070.58
93_T103_K2.0020.57
96_D134_F1.9920.57
104_V133_A1.8820.52
102_A108_Y1.8440.51
110_V125_I1.8050.49
55_T68_A1.8030.49
124_E128_V1.7630.48
97_Q104_V1.7620.48
103_K120_E1.7500.47
126_D136_S1.7350.46
114_G137_V1.7320.46
90_T103_K1.7290.46
15_T116_Q1.7210.46
14_A30_T1.7010.45
96_D132_V1.6550.43
2_V93_T1.6010.41
10_S31_E1.5960.41
123_I129_Q1.5570.39
85_E115_A1.5390.39
37_I74_S1.5240.38
90_T117_P1.5090.38
132_V135_A1.4840.37
56_K119_D1.4630.36
110_V122_T1.4600.36
21_E47_V1.4420.35
16_V58_A1.4400.35
22_T32_V1.4400.35
39_P140_T1.3980.33
105_E128_V1.3780.33
106_R113_P1.3760.33
45_I58_A1.3590.32
123_I137_V1.3460.31
116_Q119_D1.3370.31
115_A138_V1.3320.31
2_V90_T1.3270.31
5_P97_Q1.3270.31
85_E92_E1.2890.30
12_F27_V1.2870.29
130_E134_F1.2820.29
93_T116_Q1.2530.28
103_K119_D1.2430.28
19_R55_T1.2370.28
32_V54_S1.2220.27
21_E37_I1.2180.27
90_T93_T1.2090.27
88_D134_F1.1660.26
37_I139_D1.1510.25
43_Y87_R1.1460.25
14_A77_P1.1340.25
17_E83_E1.1270.24
73_N110_V1.1260.24
69_P126_D1.1230.24
18_K68_A1.1200.24
94_V115_A1.1110.24
23_Y32_V1.1100.24
53_S114_G1.1050.24
91_I137_V1.0930.23
33_D118_G1.0920.23
16_V76_P1.0820.23
10_S121_P1.0820.23
5_P26_E1.0760.23
115_A126_D1.0570.22
87_R105_E1.0530.22
122_T134_F1.0480.22
42_T124_E1.0420.22
96_D135_A1.0330.22
47_V120_E1.0300.22
90_T120_E1.0250.21
57_T69_P1.0140.21
88_D103_K1.0140.21
34_H121_P1.0120.21
6_E126_D0.9950.21
46_G113_P0.9940.21
96_D122_T0.9890.20
90_T130_E0.9760.20
87_R106_R0.9730.20
29_Q47_V0.9710.20
27_V115_A0.9630.20
114_G140_T0.9630.20
25_L52_Q0.9510.19
19_R130_E0.9490.19
52_Q71_E0.9340.19
130_E135_A0.9270.19
85_E128_V0.9230.19
31_E92_E0.9210.19
16_V125_I0.9210.19
30_T131_N0.9160.19
40_G76_P0.9160.19
75_G123_I0.9110.18
21_E138_V0.9070.18
97_Q133_A0.8920.18
36_A77_P0.8920.18
90_T119_D0.8780.18
88_D96_D0.8740.18
79_P131_N0.8700.17
5_P24_T0.8570.17
54_S69_P0.8550.17
24_T27_V0.8540.17
46_G50_Q0.8430.17
20_G123_I0.8370.17
110_V134_F0.8320.17
96_D110_V0.8310.17
40_G53_S0.8250.16
33_D74_S0.8240.16
83_E123_I0.8210.16
20_G40_G0.8150.16
21_E94_V0.8120.16
88_D127_Q0.8060.16
27_V139_D0.8040.16
49_T55_T0.8020.16
7_S103_K0.7880.16
119_D140_T0.7810.15
87_R124_E0.7770.15
88_D132_V0.7750.15
122_T132_V0.7580.15
40_G122_T0.7550.15
14_A85_E0.7490.15
48_L83_E0.7430.15
37_I51_R0.7420.15
68_A71_E0.7380.15
83_E134_F0.7360.15
11_L90_T0.7340.14
12_F124_E0.7330.14
22_T51_R0.7320.14
25_L126_D0.7290.14
74_S139_D0.7290.14
32_V71_E0.7220.14
31_E131_N0.7170.14
67_P124_E0.6930.14
25_L38_S0.6870.14
90_T127_Q0.6830.13
43_Y124_E0.6800.13
19_R72_R0.6760.13
47_V125_I0.6690.13
3_E37_I0.6600.13
58_A68_A0.6590.13
49_T54_S0.6510.13
81_V102_A0.6450.13
78_T132_V0.6440.13
78_T88_D0.6430.13
71_E118_G0.6400.13
110_V132_V0.6400.13
24_T105_E0.6360.13
87_R128_V0.6350.13
26_E57_T0.6330.13
27_V30_T0.6270.12
15_T41_E0.6270.12
24_T57_T0.6220.12
13_S83_E0.6190.12
66_Q69_P0.6180.12
46_G105_E0.6140.12
26_E49_T0.6040.12
39_P131_N0.6030.12
21_E130_E0.5990.12
52_Q115_A0.5980.12
116_Q120_E0.5940.12
68_A85_E0.5920.12
16_V67_P0.5900.12
83_E118_G0.5840.12
82_T91_I0.5760.12
41_E101_I0.5750.12
31_E137_V0.5700.11
10_S103_K0.5690.11
22_T26_E0.5650.11
40_G52_Q0.5630.11
88_D135_A0.5610.11
14_A31_E0.5600.11
40_G51_R0.5570.11
17_E135_A0.5550.11
48_L134_F0.5520.11
52_Q55_T0.5500.11
88_D110_V0.5470.11
2_V103_K0.5420.11
6_E101_I0.5390.11
45_I85_E0.5350.11
13_S133_A0.5350.11
42_T125_I0.5310.11
85_E105_E0.5260.11
115_A121_P0.5240.11
20_G37_I0.5220.11
54_S57_T0.5200.11
33_D116_Q0.5170.11
16_V40_G0.5160.11
34_H93_T0.5150.11
122_T125_I0.5130.11
105_E110_V0.5130.11
3_E90_T0.5100.11
7_S123_I0.5050.10
6_E53_S0.5050.10
54_S77_P0.5020.10
27_V52_Q0.5010.10
115_A127_Q0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yezA 1 0.469 99.2 0.793 Contact Map
1uwvA 1 0.4138 99.2 0.794 Contact Map
1yvcA 1 0.4828 99.1 0.802 Contact Map
2jjqA 1 0.3724 98.8 0.822 Contact Map
3waiA 1 0.4897 11.9 0.957 Contact Map
2wknA 5 0.669 9.4 0.959 Contact Map
3b5nC 1 0.3172 8.3 0.96 Contact Map
2mrnA 2 0.4138 7.2 0.961 Contact Map
3lzkA 2 0.6828 6.4 0.962 Contact Map
3pjyA 1 0.331 6.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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