GREMLIN Database
O54559 - Uncharacterized protein
UniProt: O54559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 163 (133)
Sequences: 1682 (1197)
Seq/√Len: 103.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_V139_I3.9981.00
114_I118_V3.1951.00
44_A76_F3.0751.00
29_V128_V2.9951.00
52_S73_R2.9161.00
131_V142_V2.8441.00
146_L150_I2.6091.00
53_T74_L2.3721.00
24_I27_L2.1701.00
43_S129_C2.1431.00
144_A148_V2.1381.00
19_I22_Y1.9571.00
46_A80_I1.9021.00
141_G145_F1.8711.00
102_P106_L1.8461.00
49_F72_W1.8351.00
154_Q158_A1.8191.00
20_S24_I1.7971.00
35_V39_G1.7961.00
82_L85_A1.7581.00
36_I72_W1.7451.00
147_T151_V1.7161.00
126_H138_S1.6831.00
69_S72_W1.6501.00
139_I143_L1.6381.00
140_V144_A1.5821.00
51_E117_R1.5611.00
26_G30_G1.5291.00
132_G136_K1.4701.00
34_T38_L1.4621.00
47_S117_R1.4431.00
52_S69_S1.4331.00
149_A156_V1.4011.00
103_W106_L1.3941.00
113_G145_F1.3701.00
49_F73_R1.3320.99
143_L147_T1.3310.99
131_V144_A1.2610.99
102_P105_L1.2540.99
48_T133_S1.2460.99
43_S48_T1.2440.99
97_T101_Q1.2350.99
75_V83_G1.2280.99
34_T37_Y1.2180.99
67_V70_R1.2010.99
114_I117_R1.2010.99
101_Q104_R1.1880.99
144_A149_A1.1860.99
83_G91_Y1.1800.99
88_A92_Q1.1730.98
36_I40_T1.1650.98
133_S137_T1.1600.98
87_Y90_V1.1490.98
27_L88_A1.1330.98
30_G127_G1.1240.98
153_A157_A1.1050.98
100_V104_R1.1040.98
46_A116_T1.0980.98
27_L31_L1.0940.98
70_R74_L1.0880.98
99_D102_P1.0880.98
87_Y91_Y1.0780.97
23_A27_L1.0710.97
97_T100_V1.0650.97
47_S149_A1.0600.97
81_V85_A1.0530.97
116_T129_C1.0380.97
69_S73_R1.0210.96
97_T102_P0.9890.96
46_A76_F0.9860.96
100_V108_G0.9850.96
28_L31_L0.9850.96
85_A106_L0.9600.95
83_G92_Q0.9520.95
144_A152_T0.9500.95
55_S83_G0.9380.94
26_G149_A0.9380.94
151_V154_Q0.9320.94
127_G142_V0.9240.94
112_V145_F0.9170.93
30_G153_A0.9000.93
115_G126_H0.8980.93
126_H130_G0.8880.92
152_T155_V0.8760.92
33_V148_V0.8740.92
41_G113_G0.8670.91
146_L153_A0.8580.91
29_V142_V0.8570.91
18_G22_Y0.8550.91
103_W107_V0.8550.91
39_G107_V0.8530.91
27_L95_A0.8490.91
107_V156_V0.8430.90
84_A120_K0.8400.90
21_R83_G0.8370.90
33_V146_L0.8310.90
150_I158_A0.8300.90
77_T147_T0.8270.89
43_S137_T0.8190.89
87_Y119_G0.8180.89
84_A98_T0.8170.89
20_S87_Y0.8130.89
18_G21_R0.8090.88
26_G127_G0.8070.88
52_S55_S0.8070.88
85_A88_A0.8040.88
92_Q96_W0.7990.88
70_R82_L0.7890.87
33_V145_F0.7840.87
130_G138_S0.7670.86
34_T40_T0.7650.85
104_R108_G0.7640.85
33_V129_C0.7640.85
106_L113_G0.7600.85
38_L82_L0.7520.84
68_S136_K0.7500.84
75_V79_G0.7480.84
126_H137_T0.7460.84
78_L83_G0.7450.84
44_A128_V0.7400.83
77_T116_T0.7330.83
126_H141_G0.7270.82
138_S145_F0.7260.82
36_I44_A0.7250.82
50_L81_V0.7220.82
32_G76_F0.7070.81
47_S126_H0.7000.80
98_T148_V0.6970.80
43_S133_S0.6930.79
48_T76_F0.6800.78
120_K137_T0.6790.78
93_G103_W0.6770.78
98_T105_L0.6690.77
24_I31_L0.6670.77
46_A111_F0.6650.76
83_G87_Y0.6640.76
43_S76_F0.6630.76
71_D82_L0.6560.75
30_G157_A0.6530.75
73_R129_C0.6410.74
90_V93_G0.6370.73
70_R110_V0.6360.73
44_A80_I0.6190.71
22_Y128_V0.6190.71
119_G136_K0.6140.71
127_G146_L0.6120.70
36_I49_F0.6120.70
31_L90_V0.6110.70
25_G112_V0.6100.70
32_G105_L0.6090.70
27_L118_V0.6070.70
98_T101_Q0.6050.69
49_F77_T0.6010.69
89_V107_V0.6010.69
110_V113_G0.5980.69
29_V66_Y0.5960.68
29_V141_G0.5960.68
19_I120_K0.5890.67
114_I140_V0.5880.67
46_A77_T0.5880.67
32_G35_V0.5870.67
71_D78_L0.5870.67
99_D107_V0.5840.67
20_S23_A0.5790.66
86_V100_V0.5760.66
140_V152_T0.5750.66
93_G147_T0.5730.65
136_K139_I0.5720.65
37_Y40_T0.5690.65
118_V150_I0.5640.64
39_G85_A0.5640.64
56_Y108_G0.5600.64
129_C158_A0.5500.62
107_V147_T0.5500.62
100_V103_W0.5490.62
51_E56_Y0.5480.62
68_S74_L0.5460.62
72_W145_F0.5450.61
90_V140_V0.5440.61
79_G134_A0.5440.61
66_Y86_V0.5430.61
25_G133_S0.5390.61
55_S117_R0.5390.61
129_C146_L0.5370.60
136_K156_V0.5370.60
56_Y67_V0.5360.60
128_V153_A0.5350.60
30_G76_F0.5300.59
56_Y70_R0.5280.59
93_G151_V0.5260.59
55_S68_S0.5250.59
40_T120_K0.5240.58
72_W75_V0.5220.58
46_A131_V0.5200.58
87_Y140_V0.5170.57
131_V136_K0.5160.57
55_S96_W0.5130.57
120_K136_K0.5090.56
50_L77_T0.5030.55
37_Y47_S0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3llqA 3 0.5337 5.2 0.951 Contact Map
2f2bA 4 0.5337 4.3 0.953 Contact Map
3b5dA 2 0.5215 3.6 0.954 Contact Map
4p6vB 1 0.3681 3.3 0.955 Contact Map
2ls4A 1 0.1472 2.9 0.957 Contact Map
2o9gA 3 0.5337 2.6 0.958 Contact Map
3cn5A 3 0.5828 2.4 0.958 Contact Map
3gd8A 4 0.5276 2.4 0.958 Contact Map
4l6vF 1 0.2577 1.7 0.961 Contact Map
2wssS 1 0.1963 1.6 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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