GREMLIN Database
O54535 - Thioredoxin reductase
UniProt: O54535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (176)
Sequences: 46680 (31986)
Seq/√Len: 2411.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_D171_S3.7431.00
36_G83_R3.0271.00
150_L175_V2.9741.00
7_D107_R2.8991.00
8_L24_A2.8661.00
7_D30_E2.7321.00
95_E103_T2.7141.00
20_A110_I2.6661.00
32_L80_E2.6501.00
5_S105_Y2.6071.00
9_V34_L2.4691.00
6_H32_L2.4171.00
34_L104_L2.4151.00
5_S107_R2.2111.00
148_D173_T2.2101.00
148_D170_D2.2031.00
9_V106_T2.1601.00
106_T109_L2.1371.00
97_S103_T2.0311.00
135_T138_T1.9991.00
9_V96_L1.8951.00
9_V104_L1.7651.00
94_L98_L1.7551.00
21_A33_V1.7211.00
60_G63_D1.7141.00
86_A97_S1.7101.00
134_S138_T1.6811.00
95_E105_Y1.6711.00
90_D94_L1.6171.00
8_L110_I1.5841.00
149_V165_L1.5611.00
82_G100_T1.5311.00
23_Y26_R1.5171.00
9_V32_L1.5101.00
8_L29_L1.4911.00
7_D32_L1.4761.00
121_G125_E1.4631.00
71_Q75_F1.4481.00
145_R170_D1.4191.00
149_V170_D1.4011.00
154_G176_H1.3751.00
146_G170_D1.3671.00
66_Q70_E1.3571.00
138_T141_G1.3451.00
98_L104_L1.3411.00
69_K73_E1.3381.00
93_P105_Y1.3331.00
90_D93_P1.3321.00
159_M174_V1.3271.00
55_F58_G1.3241.00
13_S35_E1.3071.00
22_V26_R1.2981.00
65_V69_K1.2951.00
70_E74_Q1.2931.00
166_A171_S1.2741.00
53_L56_P1.2721.00
23_Y27_A1.2621.00
6_H30_E1.2571.00
83_R99_S1.2561.00
169_A172_V1.2331.00
151_V162_A1.2221.00
88_D95_E1.2051.00
98_L102_D1.1961.00
38_E69_K1.1951.00
134_S142_A1.1951.00
34_L84_I1.1881.00
73_E78_Q1.1731.00
162_A174_V1.1721.00
8_L108_S1.1621.00
10_I17_G1.1441.00
85_E99_S1.1421.00
136_C139_C1.1361.00
91_G94_L1.1201.00
32_L104_L1.0941.00
70_E73_E1.0911.00
49_V58_G1.0871.00
87_A109_L1.0861.00
24_A29_L1.0681.00
98_L101_G1.0421.00
89_L94_L1.0391.00
21_A31_P1.0351.00
30_E78_Q1.0311.00
88_D97_S1.0311.00
71_Q74_Q1.0251.00
6_H9_V1.0201.00
82_G85_E1.0161.00
44_T47_T1.0061.00
135_T139_C0.9941.00
80_E104_L0.9881.00
131_A135_T0.9831.00
135_T140_D0.9821.00
34_L80_E0.9801.00
25_A31_P0.9761.00
136_C141_G0.9651.00
63_D66_Q0.9631.00
134_S137_A0.9611.00
7_D29_L0.9591.00
39_P81_H0.9581.00
68_G71_Q0.9531.00
132_G138_T0.9491.00
158_A176_H0.9471.00
176_H183_A0.9421.00
5_S30_E0.9341.00
82_G98_L0.9291.00
54_G58_G0.9281.00
6_H108_S0.9261.00
10_I21_A0.9251.00
11_A111_V0.9171.00
124_N127_E0.9151.00
25_A77_A0.9091.00
72_A75_F0.9081.00
19_S23_Y0.9041.00
45_L48_D0.8991.00
61_G65_V0.8971.00
134_S139_C0.8941.00
85_E97_S0.8781.00
63_D67_R0.8771.00
60_G64_L0.8761.00
130_G135_T0.8761.00
32_L106_T0.8711.00
19_S22_V0.8581.00
154_G181_L0.8581.00
120_V125_E0.8541.00
43_L46_T0.8481.00
119_W126_D0.8461.00
83_R86_A0.8371.00
66_Q69_K0.8331.00
136_C140_D0.8291.00
68_G72_A0.8261.00
163_L167_K0.8231.00
34_L82_G0.8231.00
130_G138_T0.8211.00
59_V63_D0.8171.00
180_E185_E0.8121.00
42_Q45_L0.8121.00
150_L173_T0.8061.00
132_G135_T0.8051.00
131_A134_S0.8031.00
147_D170_D0.8001.00
16_A112_A0.7901.00
137_A140_D0.7901.00
82_G99_S0.7751.00
138_T142_A0.7741.00
139_C142_A0.7721.00
90_D98_L0.7711.00
24_A31_P0.7661.00
10_I20_A0.7621.00
7_D104_L0.7601.00
145_R168_F0.7581.00
46_T137_A0.7571.00
82_G86_A0.7561.00
119_W125_E0.7531.00
164_F168_F0.7471.00
161_E164_F0.7451.00
122_A125_E0.7401.00
133_L136_C0.7311.00
137_A141_G0.7281.00
13_S33_V0.7171.00
99_S102_D0.7161.00
176_H182_R0.7111.00
164_F167_K0.7101.00
22_V75_F0.7101.00
119_W135_T0.7091.00
131_A138_T0.7081.00
21_A77_A0.7061.00
90_D95_E0.7041.00
32_L78_Q0.7021.00
118_R121_G0.6991.00
86_A89_L0.6991.00
39_P69_K0.6991.00
121_G126_D0.6981.00
84_I96_L0.6981.00
5_S93_P0.6971.00
81_H84_I0.6951.00
60_G67_R0.6911.00
176_H181_L0.6891.00
147_D171_S0.6881.00
34_L98_L0.6781.00
13_S39_P0.6761.00
144_H147_D0.6761.00
91_G95_E0.6751.00
29_L107_R0.6721.00
131_A137_A0.6681.00
42_Q46_T0.6681.00
131_A139_C0.6671.00
43_L48_D0.6651.00
16_A110_I0.6641.00
72_A77_A0.6541.00
6_H107_R0.6491.00
62_M66_Q0.6481.00
165_L169_A0.6451.00
80_E102_D0.6431.00
49_V54_G0.6431.00
20_A24_A0.6421.00
88_D91_G0.6411.00
136_C142_A0.6371.00
176_H179_E0.6361.00
135_T141_G0.6291.00
35_E38_E0.6281.00
61_G68_G0.6251.00
43_L49_V0.6251.00
84_I87_A0.6231.00
67_R70_E0.6221.00
15_I19_S0.6211.00
67_R71_Q0.6201.00
82_G102_D0.6191.00
25_A76_G0.6161.00
134_S141_G0.6121.00
46_T49_V0.6031.00
10_I112_A0.6031.00
157_S161_E0.6021.00
72_A79_F0.6011.00
93_P103_T0.5981.00
35_E81_H0.5981.00
131_A142_A0.5941.00
131_A136_C0.5891.00
22_V71_Q0.5881.00
7_D105_Y0.5801.00
34_L106_T0.5791.00
47_T140_D0.5771.00
159_M181_L0.5751.00
92_Q95_E0.5731.00
44_T48_D0.5721.00
17_G21_A0.5721.00
10_I33_V0.5661.00
90_D96_L0.5651.00
180_E183_A0.5591.00
132_G137_A0.5581.00
53_L58_G0.5561.00
176_H180_E0.5541.00
139_C165_L0.5531.00
41_G44_T0.5531.00
133_L139_C0.5511.00
49_V55_F0.5501.00
33_V79_F0.5501.00
10_I31_P0.5481.00
162_A172_V0.5481.00
17_G112_A0.5451.00
158_A174_V0.5421.00
151_V158_A0.5421.00
39_P79_F0.5411.00
65_V68_G0.5391.00
93_P98_L0.5371.00
143_F146_G0.5361.00
179_E182_R0.5321.00
134_S140_D0.5241.00
132_G136_C0.5241.00
130_G134_S0.5231.00
37_D46_T0.5191.00
64_L67_R0.5181.00
7_D106_T0.5161.00
178_R183_A0.5161.00
128_L131_A0.5151.00
80_E86_A0.5131.00
62_M65_V0.5101.00
135_T161_E0.5101.00
42_Q115_A0.5071.00
149_V169_A0.5071.00
72_A78_Q0.5071.00
15_I156_D0.5061.00
29_L108_S0.5061.00
127_E131_A0.5041.00
158_A177_R0.5021.00
9_V109_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a87A 2 1 100 0.236 Contact Map
2q7vA 2 0.9902 100 0.24 Contact Map
4jnqA 2 1 100 0.245 Contact Map
3f8dA 2 0.9902 100 0.249 Contact Map
2q0lA 2 0.9756 100 0.25 Contact Map
4up3A 2 0.9854 100 0.252 Contact Map
3r9uA 2 0.9854 100 0.259 Contact Map
1vdcA 2 0.9951 100 0.264 Contact Map
1fl2A 2 0.9707 100 0.276 Contact Map
3ctyA 2 0.9805 100 0.278 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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