O54535 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

O54535 - Thioredoxin reductase

UniProt:	O54535	Sequences: MTEDSHDLVIAGSGIAGLSAAVYAARADLEPLVLEGDEPGGQLTLTTDVENYLGFPDGVGGMDLVQRGKEQAEQFGAQFEHGRIEAADLDGQPLELSLSTGDTLYTRSLIVATGASARWVGAENEDELMGAGLSTCATCDGAFHRGDDVLVVGGGDSAMEEALFLAKFADSVTVVHRREELRASEIMADRARDHDDVQFRWNTEL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	205 (176)
Sequences:	46680 (31986)
Seq/√Len:	2411.1

ECOLI - AHPF TRXB RCLA STHA DLDH GSHR HCAD NORW DHNA FADH PRET GLTD NIRB YGFT AEGA YGFK
BACSU - DHNA TRXB DLDH2 DLDH3 DLDH1 FENR1 FENR2 YPDA YUMB CZCO YUTJ YJLD NASB NASD GLTB
HALSA - O54535 P82854 DLDH Q9HSN0 Q9HP48 Q9HR27
SULSO - Q97V69 Q97W27 Q97WE3 Q97VD9 Q97YT2 Q97XZ3 Q97Z19 FENR Q97WG1 Q97Y24 Q97VQ4 Q97VJ3 Q97Z14 Q97U72 Q980U1 Q97UP4 Q97ZB4 Q97UV0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
148_D	171_S	3.743	1.00
36_G	83_R	3.027	1.00
150_L	175_V	2.974	1.00
7_D	107_R	2.899	1.00
8_L	24_A	2.866	1.00
7_D	30_E	2.732	1.00
95_E	103_T	2.714	1.00
20_A	110_I	2.666	1.00
32_L	80_E	2.650	1.00
5_S	105_Y	2.607	1.00
9_V	34_L	2.469	1.00
6_H	32_L	2.417	1.00
34_L	104_L	2.415	1.00
5_S	107_R	2.211	1.00
148_D	173_T	2.210	1.00
148_D	170_D	2.203	1.00
9_V	106_T	2.160	1.00
106_T	109_L	2.137	1.00
97_S	103_T	2.031	1.00
135_T	138_T	1.999	1.00
9_V	96_L	1.895	1.00
9_V	104_L	1.765	1.00
94_L	98_L	1.755	1.00
21_A	33_V	1.721	1.00
60_G	63_D	1.714	1.00
86_A	97_S	1.710	1.00
134_S	138_T	1.681	1.00
95_E	105_Y	1.671	1.00
90_D	94_L	1.617	1.00
8_L	110_I	1.584	1.00
149_V	165_L	1.561	1.00
82_G	100_T	1.531	1.00
23_Y	26_R	1.517	1.00
9_V	32_L	1.510	1.00
8_L	29_L	1.491	1.00
7_D	32_L	1.476	1.00
121_G	125_E	1.463	1.00
71_Q	75_F	1.448	1.00
145_R	170_D	1.419	1.00
149_V	170_D	1.401	1.00
154_G	176_H	1.375	1.00
146_G	170_D	1.367	1.00
66_Q	70_E	1.357	1.00
138_T	141_G	1.345	1.00
98_L	104_L	1.341	1.00
69_K	73_E	1.338	1.00
93_P	105_Y	1.333	1.00
90_D	93_P	1.332	1.00
159_M	174_V	1.327	1.00
55_F	58_G	1.324	1.00
13_S	35_E	1.307	1.00
22_V	26_R	1.298	1.00
65_V	69_K	1.295	1.00
70_E	74_Q	1.293	1.00
166_A	171_S	1.274	1.00
53_L	56_P	1.272	1.00
23_Y	27_A	1.262	1.00
6_H	30_E	1.257	1.00
83_R	99_S	1.256	1.00
169_A	172_V	1.233	1.00
151_V	162_A	1.222	1.00
88_D	95_E	1.205	1.00
98_L	102_D	1.196	1.00
38_E	69_K	1.195	1.00
134_S	142_A	1.195	1.00
34_L	84_I	1.188	1.00
73_E	78_Q	1.173	1.00
162_A	174_V	1.172	1.00
8_L	108_S	1.162	1.00
10_I	17_G	1.144	1.00
85_E	99_S	1.142	1.00
136_C	139_C	1.136	1.00
91_G	94_L	1.120	1.00
32_L	104_L	1.094	1.00
70_E	73_E	1.091	1.00
49_V	58_G	1.087	1.00
87_A	109_L	1.086	1.00
24_A	29_L	1.068	1.00
98_L	101_G	1.042	1.00
89_L	94_L	1.039	1.00
21_A	31_P	1.035	1.00
30_E	78_Q	1.031	1.00
88_D	97_S	1.031	1.00
71_Q	74_Q	1.025	1.00
6_H	9_V	1.020	1.00
82_G	85_E	1.016	1.00
44_T	47_T	1.006	1.00
135_T	139_C	0.994	1.00
80_E	104_L	0.988	1.00
131_A	135_T	0.983	1.00
135_T	140_D	0.982	1.00
34_L	80_E	0.980	1.00
25_A	31_P	0.976	1.00
136_C	141_G	0.965	1.00
63_D	66_Q	0.963	1.00
134_S	137_A	0.961	1.00
7_D	29_L	0.959	1.00
39_P	81_H	0.958	1.00
68_G	71_Q	0.953	1.00
132_G	138_T	0.949	1.00
158_A	176_H	0.947	1.00
176_H	183_A	0.942	1.00
5_S	30_E	0.934	1.00
82_G	98_L	0.929	1.00
54_G	58_G	0.928	1.00
6_H	108_S	0.926	1.00
10_I	21_A	0.925	1.00
11_A	111_V	0.917	1.00
124_N	127_E	0.915	1.00
25_A	77_A	0.909	1.00
72_A	75_F	0.908	1.00
19_S	23_Y	0.904	1.00
45_L	48_D	0.899	1.00
61_G	65_V	0.897	1.00
134_S	139_C	0.894	1.00
85_E	97_S	0.878	1.00
63_D	67_R	0.877	1.00
60_G	64_L	0.876	1.00
130_G	135_T	0.876	1.00
32_L	106_T	0.871	1.00
19_S	22_V	0.858	1.00
154_G	181_L	0.858	1.00
120_V	125_E	0.854	1.00
43_L	46_T	0.848	1.00
119_W	126_D	0.846	1.00
83_R	86_A	0.837	1.00
66_Q	69_K	0.833	1.00
136_C	140_D	0.829	1.00
68_G	72_A	0.826	1.00
163_L	167_K	0.823	1.00
34_L	82_G	0.823	1.00
130_G	138_T	0.821	1.00
59_V	63_D	0.817	1.00
180_E	185_E	0.812	1.00
42_Q	45_L	0.812	1.00
150_L	173_T	0.806	1.00
132_G	135_T	0.805	1.00
131_A	134_S	0.803	1.00
147_D	170_D	0.800	1.00
16_A	112_A	0.790	1.00
137_A	140_D	0.790	1.00
82_G	99_S	0.775	1.00
138_T	142_A	0.774	1.00
139_C	142_A	0.772	1.00
90_D	98_L	0.771	1.00
24_A	31_P	0.766	1.00
10_I	20_A	0.762	1.00
7_D	104_L	0.760	1.00
145_R	168_F	0.758	1.00
46_T	137_A	0.757	1.00
82_G	86_A	0.756	1.00
119_W	125_E	0.753	1.00
164_F	168_F	0.747	1.00
161_E	164_F	0.745	1.00
122_A	125_E	0.740	1.00
133_L	136_C	0.731	1.00
137_A	141_G	0.728	1.00
13_S	33_V	0.717	1.00
99_S	102_D	0.716	1.00
176_H	182_R	0.711	1.00
164_F	167_K	0.710	1.00
22_V	75_F	0.710	1.00
119_W	135_T	0.709	1.00
131_A	138_T	0.708	1.00
21_A	77_A	0.706	1.00
90_D	95_E	0.704	1.00
32_L	78_Q	0.702	1.00
118_R	121_G	0.699	1.00
86_A	89_L	0.699	1.00
39_P	69_K	0.699	1.00
121_G	126_D	0.698	1.00
84_I	96_L	0.698	1.00
5_S	93_P	0.697	1.00
81_H	84_I	0.695	1.00
60_G	67_R	0.691	1.00
176_H	181_L	0.689	1.00
147_D	171_S	0.688	1.00
34_L	98_L	0.678	1.00
13_S	39_P	0.676	1.00
144_H	147_D	0.676	1.00
91_G	95_E	0.675	1.00
29_L	107_R	0.672	1.00
131_A	137_A	0.668	1.00
42_Q	46_T	0.668	1.00
131_A	139_C	0.667	1.00
43_L	48_D	0.665	1.00
16_A	110_I	0.664	1.00
72_A	77_A	0.654	1.00
6_H	107_R	0.649	1.00
62_M	66_Q	0.648	1.00
165_L	169_A	0.645	1.00
80_E	102_D	0.643	1.00
49_V	54_G	0.643	1.00
20_A	24_A	0.642	1.00
88_D	91_G	0.641	1.00
136_C	142_A	0.637	1.00
176_H	179_E	0.636	1.00
135_T	141_G	0.629	1.00
35_E	38_E	0.628	1.00
61_G	68_G	0.625	1.00
43_L	49_V	0.625	1.00
84_I	87_A	0.623	1.00
67_R	70_E	0.622	1.00
15_I	19_S	0.621	1.00
67_R	71_Q	0.620	1.00
82_G	102_D	0.619	1.00
25_A	76_G	0.616	1.00
134_S	141_G	0.612	1.00
46_T	49_V	0.603	1.00
10_I	112_A	0.603	1.00
157_S	161_E	0.602	1.00
72_A	79_F	0.601	1.00
93_P	103_T	0.598	1.00
35_E	81_H	0.598	1.00
131_A	142_A	0.594	1.00
131_A	136_C	0.589	1.00
22_V	71_Q	0.588	1.00
7_D	105_Y	0.580	1.00
34_L	106_T	0.579	1.00
47_T	140_D	0.577	1.00
159_M	181_L	0.575	1.00
92_Q	95_E	0.573	1.00
44_T	48_D	0.572	1.00
17_G	21_A	0.572	1.00
10_I	33_V	0.566	1.00
90_D	96_L	0.565	1.00
180_E	183_A	0.559	1.00
132_G	137_A	0.558	1.00
53_L	58_G	0.556	1.00
176_H	180_E	0.554	1.00
139_C	165_L	0.553	1.00
41_G	44_T	0.553	1.00
133_L	139_C	0.551	1.00
49_V	55_F	0.550	1.00
33_V	79_F	0.550	1.00
10_I	31_P	0.548	1.00
162_A	172_V	0.548	1.00
17_G	112_A	0.545	1.00
158_A	174_V	0.542	1.00
151_V	158_A	0.542	1.00
39_P	79_F	0.541	1.00
65_V	68_G	0.539	1.00
93_P	98_L	0.537	1.00
143_F	146_G	0.536	1.00
179_E	182_R	0.532	1.00
134_S	140_D	0.524	1.00
132_G	136_C	0.524	1.00
130_G	134_S	0.523	1.00
37_D	46_T	0.519	1.00
64_L	67_R	0.518	1.00
7_D	106_T	0.516	1.00
178_R	183_A	0.516	1.00
128_L	131_A	0.515	1.00
80_E	86_A	0.513	1.00
62_M	65_V	0.510	1.00
135_T	161_E	0.510	1.00
42_Q	115_A	0.507	1.00
149_V	169_A	0.507	1.00
72_A	78_Q	0.507	1.00
15_I	156_D	0.506	1.00
29_L	108_S	0.506	1.00
127_E	131_A	0.504	1.00
158_A	177_R	0.502	1.00
9_V	109_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a87A	2	1	100	0.236	Contact Map
2q7vA	2	0.9902	100	0.24	Contact Map
4jnqA	2	1	100	0.245	Contact Map
3f8dA	2	0.9902	100	0.249	Contact Map
2q0lA	2	0.9756	100	0.25	Contact Map
4up3A	2	0.9854	100	0.252	Contact Map
3r9uA	2	0.9854	100	0.259	Contact Map
1vdcA	2	0.9951	100	0.264	Contact Map
1fl2A	2	0.9707	100	0.276	Contact Map
3ctyA	2	0.9805	100	0.278	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.