GREMLIN Database
O54523 - Sodium-dependent phosphate transporter
UniProt: O54523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (381)
Sequences: 1284 (753)
Seq/√Len: 38.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L53_I6.1431.00
12_A269_L5.0531.00
21_W295_T4.9051.00
23_I108_T4.1771.00
84_G119_V3.9841.00
337_V342_I3.6001.00
137_A141_L3.4351.00
43_S46_R3.1311.00
60_V283_V3.1261.00
291_V295_T3.1061.00
164_E170_V2.9361.00
300_M303_S2.8011.00
136_A140_V2.7881.00
88_V112_V2.6651.00
172_A182_I2.5011.00
87_L91_L2.4541.00
319_A343_V2.4171.00
225_T229_W2.3771.00
36_A247_G2.3761.00
200_G203_V2.3551.00
172_A176_G2.3521.00
330_A337_V2.2761.00
304_L344_V2.2440.99
40_N306_Q2.2240.99
186_F190_G2.1770.99
208_G216_T2.1310.99
17_L84_G2.1010.99
21_W296_G2.0760.99
55_G254_A1.9950.99
98_I102_T1.9840.99
220_A224_A1.9530.99
206_V210_T1.9510.99
212_A216_T1.9360.98
172_A189_A1.8920.98
213_V217_G1.8900.98
88_V92_G1.8840.98
259_V289_M1.8750.98
381_A385_A1.8460.98
184_F188_G1.8330.98
376_F381_A1.8290.98
70_I113_T1.8150.98
10_A14_L1.8100.98
222_V226_V1.8050.98
218_F222_V1.7860.97
223_V226_V1.7740.97
42_I46_R1.7690.97
174_L182_I1.7680.97
171_L185_S1.7420.97
115_A248_S1.7420.97
171_L176_G1.7210.97
48_A294_W1.6990.96
94_G98_I1.6970.96
19_M92_G1.6910.96
18_F22_V1.6720.96
113_T135_I1.6680.96
117_I132_Y1.6670.96
154_A349_G1.6660.96
180_V208_G1.6630.96
132_Y376_F1.6580.96
176_G182_I1.6450.96
131_K134_Q1.6210.95
45_M49_L1.6140.95
91_L382_L1.6110.95
72_S323_S1.5820.95
225_T228_W1.5650.94
172_A190_G1.5550.94
378_L382_L1.5350.94
156_L160_P1.5320.94
54_F248_S1.5310.94
339_F342_I1.5180.93
162_V232_S1.5120.93
139_W143_P1.5100.93
57_V61_T1.5090.93
281_V286_G1.5040.93
101_T296_G1.4960.93
75_V120_G1.4870.93
20_A25_A1.4650.92
94_G281_V1.4630.92
304_L347_I1.4620.92
204_L207_D1.4550.92
195_T208_G1.4490.92
260_G267_L1.4470.91
363_R366_G1.4460.91
208_G212_A1.4380.91
22_V97_A1.4360.91
171_L174_L1.4300.91
201_Q208_G1.4290.91
153_I318_S1.4270.91
178_V182_I1.4250.91
29_G289_M1.4160.91
133_Q137_A1.4130.90
172_A178_V1.4080.90
20_A262_A1.3920.90
204_L208_G1.3890.90
57_V252_F1.3870.90
259_V285_G1.3730.89
16_S260_G1.3720.89
210_T217_G1.3670.89
171_L175_V1.3650.89
171_L182_I1.3490.88
18_F97_A1.3360.88
8_L82_I1.3340.88
42_I244_L1.3290.88
82_I272_E1.3280.88
17_L288_G1.3230.87
308_Y364_K1.3180.87
368_T377_A1.3110.87
10_A149_I1.3090.87
196_V214_G1.3090.87
182_I185_S1.3070.87
10_A179_L1.2980.86
14_L53_I1.2940.86
151_F353_A1.2940.86
318_S384_Y1.2920.86
8_L86_I1.2910.86
153_I245_A1.2900.86
216_T225_T1.2750.85
270_L281_V1.2720.85
279_F283_V1.2700.85
186_F189_A1.2690.85
201_Q205_A1.2680.85
95_L106_I1.2670.85
171_L186_F1.2660.85
282_L286_G1.2560.84
56_F60_V1.2550.84
263_V285_G1.2370.83
172_A185_S1.2330.83
186_F194_G1.2270.83
85_V116_V1.2180.82
316_S320_L1.2140.82
162_V314_R1.2100.82
36_A320_L1.2070.82
39_A244_L1.1970.81
221_L226_V1.1830.81
152_T156_L1.1820.81
47_A351_G1.1800.80
18_F301_I1.1790.80
158_P163_P1.1760.80
311_L347_I1.1740.80
243_L316_S1.1740.80
140_V144_F1.1730.80
35_P154_A1.1710.80
315_R354_V1.1660.80
233_R236_R1.1660.80
176_G189_A1.1650.80
60_V286_G1.1510.79
385_A389_L1.1460.78
296_G299_R1.1360.78
199_V203_V1.1340.78
74_L264_G1.1320.78
199_V214_G1.1320.78
142_T341_E1.1260.77
173_G176_G1.1170.77
55_G293_S1.1150.76
54_F61_T1.1120.76
35_P319_A1.1110.76
40_N187_L1.1080.76
35_P343_V1.1080.76
88_V93_A1.1010.76
270_L274_G1.0970.75
60_V282_L1.0920.75
123_L387_G1.0870.75
214_G374_G1.0760.74
51_V293_S1.0760.74
10_A213_V1.0760.74
74_L360_V1.0690.73
290_L293_S1.0690.73
110_F341_E1.0680.73
318_S359_A1.0560.72
72_S136_A1.0550.72
213_V279_F1.0550.72
166_Y169_P1.0470.72
223_V227_V1.0460.72
361_D364_K1.0440.72
27_S31_T1.0420.71
44_T301_I1.0410.71
190_G194_G1.0400.71
157_L161_G1.0390.71
91_L383_A1.0370.71
179_L189_A1.0240.70
52_G251_A1.0240.70
172_A179_L1.0210.70
259_V383_A1.0190.70
206_V214_G1.0180.70
385_A388_A1.0150.69
219_A225_T1.0140.69
98_I165_R1.0130.69
202_R206_V1.0120.69
275_M278_T1.0100.69
311_L330_A1.0020.68
281_V288_G0.9970.68
209_L212_A0.9950.68
188_G208_G0.9930.68
243_L249_L0.9920.68
259_V330_A0.9910.68
138_V142_T0.9910.68
244_L276_V0.9890.67
243_L320_L0.9850.67
235_E314_R0.9840.67
139_W265_P0.9820.67
331_V334_G0.9780.66
167_S235_E0.9730.66
75_V385_A0.9730.66
256_G348_I0.9680.66
50_L294_W0.9650.65
54_F286_G0.9640.65
190_G195_T0.9630.65
178_V190_G0.9620.65
309_S359_A0.9570.65
21_W97_A0.9560.65
17_L284_G0.9550.65
39_A80_L0.9510.64
56_F286_G0.9470.64
258_Q261_L0.9420.64
354_V377_A0.9420.64
323_S350_S0.9410.63
70_I264_G0.9400.63
34_A116_V0.9370.63
295_T298_P0.9360.63
203_V208_G0.9330.63
140_V276_V0.9320.63
18_F296_G0.9300.63
208_G222_V0.9300.63
147_G212_A0.9270.62
204_L211_S0.9260.62
217_G221_L0.9260.62
72_S289_M0.9240.62
115_A331_V0.9210.62
56_F290_L0.9190.62
15_A328_Q0.9170.61
176_G186_F0.9150.61
176_G212_A0.9110.61
182_I249_L0.9100.61
60_V279_F0.9070.61
182_I186_F0.9070.61
176_G216_T0.9010.60
75_V390_L0.8990.60
40_N262_A0.8980.60
69_A73_G0.8920.59
176_G180_V0.8910.59
36_A96_M0.8880.59
185_S365_I0.8880.59
171_L179_L0.8880.59
36_A39_A0.8830.58
72_S131_K0.8820.58
159_R173_G0.8810.58
91_L346_A0.8800.58
8_L14_L0.8790.58
39_A96_M0.8790.58
120_G386_A0.8770.58
39_A49_L0.8750.58
203_V206_V0.8730.58
258_Q340_N0.8720.58
141_L335_V0.8670.57
217_G229_W0.8670.57
179_L215_I0.8630.57
319_A347_I0.8590.56
250_V260_G0.8550.56
162_V167_S0.8540.56
71_G111_T0.8530.56
155_S353_A0.8490.55
174_L186_F0.8470.55
31_T258_Q0.8450.55
178_V185_S0.8450.55
108_T260_G0.8450.55
376_F380_F0.8410.55
209_L213_V0.8400.55
180_V216_T0.8400.55
132_Y135_I0.8390.55
117_I128_V0.8370.54
178_V184_F0.8370.54
146_G342_I0.8360.54
210_T214_G0.8340.54
121_L222_V0.8320.54
216_T220_A0.8310.54
380_F386_A0.8310.54
236_R313_P0.8290.54
250_V342_I0.8280.54
14_L245_A0.8270.54
325_L342_I0.8250.53
37_V47_A0.8230.53
99_G293_S0.8230.53
326_I377_A0.8210.53
153_I287_L0.8200.53
355_G359_A0.8170.53
166_Y217_G0.8170.53
189_A246_L0.8150.52
226_V229_W0.8130.52
130_P137_A0.8120.52
75_V158_P0.8090.52
117_I121_L0.8090.52
16_S89_L0.8090.52
176_G184_F0.8080.52
206_V209_L0.8050.52
265_P285_G0.8010.51
300_M371_A0.8010.51
162_V363_R0.7970.51
122_A180_V0.7940.51
162_V287_L0.7920.50
214_G218_F0.7910.50
12_A86_I0.7900.50
150_A322_P0.7880.50
337_V366_G0.7860.50
19_M89_L0.7840.50
110_F114_G0.7830.50
52_G146_G0.7830.50
167_S170_V0.7820.49
144_F169_P0.7800.49
142_T145_V0.7780.49
13_A266_L0.7760.49
137_A333_L0.7700.48
91_L284_G0.7700.48
41_A240_R0.7680.48
236_R353_A0.7640.48
148_G346_A0.7630.48
75_V329_L0.7630.48
59_A253_S0.7620.48
14_L17_L0.7610.48
184_F208_G0.7530.47
70_I116_V0.7530.47
91_L290_L0.7530.47
62_Q243_L0.7490.47
113_T346_A0.7460.46
174_L193_A0.7450.46
107_A239_L0.7450.46
122_A384_Y0.7420.46
150_A346_A0.7410.46
14_L216_T0.7380.46
72_S115_A0.7370.45
322_P346_A0.7370.45
27_S257_S0.7350.45
207_D227_V0.7340.45
145_V335_V0.7330.45
194_G200_G0.7260.44
171_L190_G0.7210.44
134_Q333_L0.7200.44
366_G373_I0.7190.44
12_A19_M0.7190.44
370_G374_G0.7190.44
323_S379_S0.7190.44
116_V175_V0.7180.44
7_A273_V0.7170.44
270_L357_R0.7160.44
9_F273_V0.7140.43
40_N173_G0.7120.43
164_E299_R0.7120.43
120_G124_G0.7110.43
171_L178_V0.7100.43
244_L294_W0.7100.43
241_R250_V0.7100.43
190_G252_F0.7080.43
95_L375_S0.7080.43
67_S267_L0.7060.43
50_L387_G0.7060.43
366_G370_G0.7050.43
153_I325_L0.7050.43
177_A213_V0.7040.43
318_S322_P0.7040.43
29_G37_V0.7040.43
259_V288_G0.7030.42
114_G139_W0.7030.42
308_Y365_I0.7000.42
184_F189_A0.7000.42
196_V220_A0.6970.42
26_G31_T0.6960.42
176_G187_L0.6940.42
169_P213_V0.6920.41
178_V189_A0.6920.41
303_S368_T0.6920.41
146_G329_L0.6910.41
39_A212_A0.6870.41
115_A119_V0.6860.41
74_L291_V0.6860.41
78_I205_A0.6820.41
144_F347_I0.6810.40
220_A225_T0.6800.40
70_I275_M0.6790.40
137_A140_V0.6780.40
33_Y42_I0.6780.40
285_G289_M0.6780.40
317_I368_T0.6780.40
166_Y170_V0.6760.40
55_G305_A0.6750.40
355_G361_D0.6720.40
215_I226_V0.6710.40
206_V213_V0.6700.40
121_L124_G0.6690.39
38_G288_G0.6660.39
14_L363_R0.6630.39
71_G268_P0.6630.39
222_V373_I0.6610.39
199_V207_D0.6610.39
69_A345_S0.6610.39
112_V330_A0.6580.39
33_Y50_L0.6580.39
173_G190_G0.6570.38
56_F365_I0.6560.38
173_G189_A0.6530.38
198_G203_V0.6520.38
185_S189_A0.6520.38
181_N244_L0.6520.38
27_S258_Q0.6500.38
105_P368_T0.6500.38
208_G217_G0.6500.38
96_M379_S0.6490.38
176_G290_L0.6490.38
196_V199_V0.6480.38
245_A366_G0.6480.38
220_A223_V0.6480.38
180_V322_P0.6480.38
39_A121_L0.6450.37
250_V311_L0.6430.37
109_A340_N0.6420.37
95_L378_L0.6420.37
182_I190_G0.6410.37
18_F146_G0.6410.37
254_A258_Q0.6400.37
247_G320_L0.6400.37
155_S159_R0.6390.37
56_F236_R0.6370.37
32_P327_A0.6370.37
148_G213_V0.6360.37
302_K307_D0.6350.37
62_Q241_R0.6330.36
165_R213_V0.6330.36
54_F242_V0.6310.36
33_Y240_R0.6290.36
208_G211_S0.6290.36
43_S98_I0.6290.36
92_G317_I0.6270.36
195_T204_L0.6260.36
161_G239_L0.6260.36
187_L291_V0.6240.36
111_T341_E0.6210.35
108_T298_P0.6210.35
22_V36_A0.6200.35
280_A318_S0.6200.35
186_F193_A0.6190.35
209_L217_G0.6190.35
10_A203_V0.6180.35
234_D299_R0.6170.35
176_G190_G0.6160.35
214_G274_G0.6130.35
72_S161_G0.6120.35
111_T246_L0.6110.35
11_G137_A0.6100.35
249_L320_L0.6090.34
311_L319_A0.6090.34
71_G319_A0.6080.34
231_V234_D0.6070.34
82_I273_V0.6060.34
146_G249_L0.6040.34
200_G217_G0.6030.34
71_G323_S0.6020.34
348_I365_I0.6010.34
73_G264_G0.6010.34
87_L214_G0.6010.34
20_A29_G0.5990.34
374_G378_L0.5980.34
285_G288_G0.5970.33
104_Y147_G0.5970.33
56_F126_S0.5960.33
216_T227_V0.5960.33
244_L337_V0.5960.33
157_L245_A0.5950.33
173_G205_A0.5930.33
383_A387_G0.5870.33
88_V309_S0.5850.33
217_G220_A0.5840.32
132_Y136_A0.5830.32
172_A187_L0.5830.32
64_G332_L0.5820.32
357_R361_D0.5810.32
117_I176_G0.5800.32
259_V265_P0.5800.32
214_G229_W0.5790.32
97_A145_V0.5790.32
331_V341_E0.5780.32
83_A386_A0.5780.32
213_V216_T0.5770.32
98_I385_A0.5770.32
207_D211_S0.5760.32
115_A185_S0.5760.32
37_V66_V0.5750.32
247_G313_P0.5740.32
256_G307_D0.5730.32
72_S134_Q0.5720.31
205_A210_T0.5720.31
223_V228_W0.5710.31
260_G340_N0.5700.31
135_I344_V0.5700.31
138_V340_N0.5690.31
337_V343_V0.5680.31
164_E278_T0.5680.31
360_V365_I0.5670.31
32_P307_D0.5660.31
44_T302_K0.5660.31
74_L88_V0.5640.31
16_S48_A0.5600.31
69_A255_G0.5600.31
130_P291_V0.5580.30
210_T215_I0.5570.30
115_A256_G0.5570.30
212_A374_G0.5560.30
116_V383_A0.5560.30
136_A378_L0.5550.30
121_L381_A0.5540.30
175_V264_G0.5540.30
36_A240_R0.5540.30
386_A390_L0.5540.30
219_A227_V0.5530.30
168_I373_I0.5520.30
33_Y308_Y0.5510.30
8_L147_G0.5500.30
15_A86_I0.5490.30
257_S261_L0.5480.30
322_P337_V0.5460.30
29_G339_F0.5460.30
200_G207_D0.5460.30
330_A376_F0.5430.29
181_N223_V0.5420.29
365_I369_I0.5420.29
38_G41_A0.5410.29
40_N310_S0.5400.29
221_L299_R0.5380.29
144_F274_G0.5380.29
337_V371_A0.5370.29
46_R69_A0.5350.29
135_I295_T0.5350.29
309_S327_A0.5340.29
304_L320_L0.5320.28
214_G226_V0.5310.28
152_T210_T0.5310.28
39_A67_S0.5300.28
124_G146_G0.5290.28
180_V346_A0.5280.28
182_I189_A0.5270.28
285_G293_S0.5260.28
232_S353_A0.5260.28
354_V359_A0.5260.28
300_M344_V0.5250.28
149_I339_F0.5240.28
207_D226_V0.5240.28
153_I339_F0.5230.28
210_T221_L0.5220.28
256_G343_V0.5210.28
281_V383_A0.5200.28
15_A39_A0.5200.28
299_R302_K0.5190.28
140_V239_L0.5170.27
148_G289_M0.5160.27
157_L174_L0.5150.27
270_L280_A0.5140.27
158_P361_D0.5140.27
81_P329_L0.5130.27
150_A299_R0.5120.27
96_M240_R0.5120.27
13_A284_G0.5110.27
364_K367_V0.5100.27
298_P302_K0.5100.27
87_L199_V0.5090.27
64_G349_G0.5090.27
86_I295_T0.5090.27
260_G344_V0.5090.27
359_A362_A0.5080.27
308_Y368_T0.5060.27
17_L119_V0.5060.27
80_L124_G0.5020.26
11_G82_I0.5020.26
250_V343_V0.5020.26
200_G206_V0.5000.26
52_G294_W0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gd8A 4 0.3555 17.9 0.977 Contact Map
2b2hA 3 0.5038 15.8 0.978 Contact Map
4xnjA 1 0.4962 9.4 0.98 Contact Map
4huqS 1 0.3683 9.1 0.98 Contact Map
4qncA 2 0.2097 9 0.98 Contact Map
1u7gA 3 0.4706 7.4 0.981 Contact Map
3iyzA 3 0.3529 6.3 0.981 Contact Map
4x5mA 2 0.2379 6 0.982 Contact Map
2jwaA 2 0.1023 5.7 0.982 Contact Map
3b5dA 2 0.2583 5.5 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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