GREMLIN Database
O52041 - Uncharacterized protein
UniProt: O52041 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 153 (139)
Sequences: 558 (381)
Seq/√Len: 32.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_L55_A6.7621.00
73_T138_I4.7081.00
103_I127_L3.5821.00
36_V68_I3.2551.00
29_V67_C3.1601.00
90_C139_L3.1111.00
14_I17_A2.1620.99
30_E67_C2.1600.99
42_V55_A2.0680.98
91_W144_Q2.0420.98
98_R121_D2.0180.98
30_E33_D1.7370.95
70_Q87_Y1.7020.94
85_A138_I1.6430.93
43_L52_A1.6420.93
27_R33_D1.6070.92
74_E78_E1.5960.92
114_H118_T1.5780.91
73_T83_V1.5580.91
104_L127_L1.5180.90
23_G119_P1.5090.89
52_A72_V1.5080.89
66_T89_N1.4830.88
33_D99_T1.4510.87
26_P66_T1.4500.87
130_Y133_P1.4370.87
98_R116_Q1.4220.86
114_H117_S1.3820.85
17_A45_P1.3730.84
42_V47_T1.3660.84
62_G141_E1.3640.84
116_Q122_E1.3470.83
74_E136_V1.3360.83
116_Q119_P1.3020.81
122_E126_R1.2930.80
97_F123_L1.2920.80
94_Y98_R1.2700.79
113_I127_L1.2590.79
42_V45_P1.2480.78
69_S86_T1.2290.77
114_H145_L1.2230.76
67_C91_W1.2220.76
36_V71_F1.1950.75
35_E40_S1.1860.74
43_L72_V1.1850.74
14_I101_Y1.1750.74
97_F118_T1.1680.73
60_P91_W1.1530.72
96_R100_L1.1440.71
33_D52_A1.1430.71
31_H128_Q1.1380.71
39_L69_S1.1210.70
31_H146_E1.1160.70
42_V53_D1.0980.68
46_I80_V1.0930.68
90_C145_L1.0920.68
20_L26_P1.0880.68
79_E136_V1.0650.66
75_R78_E1.0500.65
33_D131_D1.0460.64
61_S71_F1.0420.64
47_T145_L1.0420.64
54_T94_Y1.0220.63
33_D125_D1.0190.62
63_T118_T1.0170.62
88_V139_L1.0150.62
20_L97_F1.0120.62
13_M77_R1.0090.62
10_P15_R1.0020.61
15_R27_R0.9980.61
16_D103_I0.9950.61
46_I54_T0.9930.60
118_T131_D0.9900.60
36_V61_S0.9900.60
64_G140_D0.9890.60
88_V102_Q0.9890.60
14_I40_S0.9690.58
38_H102_Q0.9620.58
84_E135_T0.9620.58
21_R135_T0.9480.57
14_I142_V0.9480.57
67_C141_E0.9410.56
11_N16_D0.9410.56
35_E42_V0.9390.56
127_L130_Y0.9350.56
41_S124_I0.9230.55
30_E99_T0.9140.54
30_E63_T0.9130.54
14_I49_G0.9080.54
19_V66_T0.9070.53
71_F99_T0.8970.53
32_R65_K0.8970.53
27_R109_E0.8960.53
77_R84_E0.8890.52
45_P94_Y0.8870.52
17_A50_E0.8810.51
10_P37_N0.8800.51
63_T89_N0.8760.51
57_V87_Y0.8740.51
71_F76_L0.8740.51
20_L62_G0.8690.50
52_A61_S0.8690.50
60_P123_L0.8660.50
20_L100_L0.8510.49
70_Q78_E0.8470.49
142_V145_L0.8430.48
19_V24_F0.8350.48
40_S70_Q0.8340.47
77_R80_V0.8290.47
55_A107_F0.8260.47
20_L103_I0.8200.46
39_L105_D0.8170.46
89_N145_L0.8090.45
103_I110_T0.8000.45
25_V42_V0.7990.45
89_N97_F0.7950.44
12_F41_S0.7940.44
69_S138_I0.7890.44
21_R107_F0.7860.44
92_R95_T0.7780.43
119_P123_L0.7710.42
87_Y121_D0.7700.42
109_E127_L0.7660.42
95_T98_R0.7570.41
45_P75_R0.7570.41
102_Q122_E0.7570.41
38_H46_I0.7340.39
13_M131_D0.7330.39
31_H63_T0.7330.39
127_L131_D0.7320.39
50_E129_Q0.7260.39
32_R64_G0.7250.39
32_R59_G0.7240.39
36_V72_V0.7240.39
59_G65_K0.7240.39
73_T85_A0.7170.38
33_D132_G0.7140.38
110_T141_E0.7120.38
12_F21_R0.7060.37
88_V136_V0.7050.37
14_I46_I0.7020.37
33_D117_S0.6920.36
66_T84_E0.6890.36
138_I141_E0.6850.36
37_N82_N0.6820.35
48_N85_A0.6750.35
77_R85_A0.6720.35
11_N145_L0.6650.34
68_I72_V0.6640.34
84_E107_F0.6580.34
85_A145_L0.6500.33
39_L68_I0.6410.32
86_T109_E0.6380.32
104_L141_E0.6320.32
35_E118_T0.6240.31
20_L67_C0.6240.31
103_I137_I0.6230.31
129_Q138_I0.6060.30
75_R109_E0.6050.30
47_T105_D0.6040.30
13_M78_E0.6030.30
106_D125_D0.6010.30
97_F116_Q0.5980.29
46_I100_L0.5970.29
100_L128_Q0.5940.29
29_V39_L0.5910.29
109_E133_P0.5880.29
103_I113_I0.5860.28
49_G83_V0.5840.28
66_T140_D0.5820.28
126_R129_Q0.5720.28
15_R78_E0.5710.27
87_Y92_R0.5690.27
33_D51_P0.5680.27
106_D132_G0.5630.27
48_N51_P0.5600.27
108_G111_I0.5600.27
101_Y113_I0.5570.27
35_E133_P0.5560.27
25_V51_P0.5500.26
13_M24_F0.5480.26
59_G64_G0.5460.26
54_T58_T0.5440.26
93_N99_T0.5400.25
20_L141_E0.5380.25
17_A53_D0.5320.25
118_T136_V0.5310.25
31_H39_L0.5290.25
16_D19_V0.5280.25
51_P137_I0.5270.25
95_T104_L0.5250.25
46_I83_V0.5250.25
74_E99_T0.5170.24
31_H124_I0.5170.24
56_I130_Y0.5160.24
23_G89_N0.5160.24
23_G83_V0.5120.24
58_T143_D0.5110.24
22_A30_E0.5090.24
34_A37_N0.5080.24
44_E53_D0.5080.24
140_D143_D0.5070.23
88_V106_D0.5060.23
28_E34_A0.5060.23
38_H106_D0.5050.23
99_T104_L0.5050.23
34_A135_T0.5040.23
100_L148_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w5sA 1 0.915 99.9 0.487 Contact Map
2v1uA 1 0.9346 99.9 0.492 Contact Map
2qbyA 1 0.9085 99.9 0.495 Contact Map
2qbyB 1 0.8954 99.9 0.509 Contact Map
4xgcA 1 0.6928 99.9 0.517 Contact Map
1fnnA 1 0.902 99.9 0.523 Contact Map
4xgcE 1 0.8758 99.8 0.606 Contact Map
3te6A 1 0.9085 99.8 0.612 Contact Map
2fnaA 1 0.8235 99.5 0.683 Contact Map
4xgcD 1 0.9281 99.5 0.683 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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