O52041 - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

O52041 - Uncharacterized protein

UniProt:	O52041	Sequences: MTCRRITFVPNFMIRDARVLRAGFVPREVEHRDAEVNHLSSVLEPITNGEPADTAIVTGPSGTGKTCISQFVTERLREEVLNVEATYVNCWRNYTRFRTLYQILDDFGETIDIHRQSTPHDELIDRLQQYDGPRTVIILDEVDQLEDPGIIRL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	153 (139)
Sequences:	558 (381)
Seq/√Len:	32.3

HALSA - O52041 CDC6A CDC68 CDC65 CDC62 Q9HNS7 CDC64 CDC66 CDC69 CDC67 CDC61
SULSO - CDC62 CDC61 CDC63

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_L	55_A	6.762	1.00
73_T	138_I	4.708	1.00
103_I	127_L	3.582	1.00
36_V	68_I	3.255	1.00
29_V	67_C	3.160	1.00
90_C	139_L	3.111	1.00
14_I	17_A	2.162	0.99
30_E	67_C	2.160	0.99
42_V	55_A	2.068	0.98
91_W	144_Q	2.042	0.98
98_R	121_D	2.018	0.98
30_E	33_D	1.737	0.95
70_Q	87_Y	1.702	0.94
85_A	138_I	1.643	0.93
43_L	52_A	1.642	0.93
27_R	33_D	1.607	0.92
74_E	78_E	1.596	0.92
114_H	118_T	1.578	0.91
73_T	83_V	1.558	0.91
104_L	127_L	1.518	0.90
23_G	119_P	1.509	0.89
52_A	72_V	1.508	0.89
66_T	89_N	1.483	0.88
33_D	99_T	1.451	0.87
26_P	66_T	1.450	0.87
130_Y	133_P	1.437	0.87
98_R	116_Q	1.422	0.86
114_H	117_S	1.382	0.85
17_A	45_P	1.373	0.84
42_V	47_T	1.366	0.84
62_G	141_E	1.364	0.84
116_Q	122_E	1.347	0.83
74_E	136_V	1.336	0.83
116_Q	119_P	1.302	0.81
122_E	126_R	1.293	0.80
97_F	123_L	1.292	0.80
94_Y	98_R	1.270	0.79
113_I	127_L	1.259	0.79
42_V	45_P	1.248	0.78
69_S	86_T	1.229	0.77
114_H	145_L	1.223	0.76
67_C	91_W	1.222	0.76
36_V	71_F	1.195	0.75
35_E	40_S	1.186	0.74
43_L	72_V	1.185	0.74
14_I	101_Y	1.175	0.74
97_F	118_T	1.168	0.73
60_P	91_W	1.153	0.72
96_R	100_L	1.144	0.71
33_D	52_A	1.143	0.71
31_H	128_Q	1.138	0.71
39_L	69_S	1.121	0.70
31_H	146_E	1.116	0.70
42_V	53_D	1.098	0.68
46_I	80_V	1.093	0.68
90_C	145_L	1.092	0.68
20_L	26_P	1.088	0.68
79_E	136_V	1.065	0.66
75_R	78_E	1.050	0.65
33_D	131_D	1.046	0.64
61_S	71_F	1.042	0.64
47_T	145_L	1.042	0.64
54_T	94_Y	1.022	0.63
33_D	125_D	1.019	0.62
63_T	118_T	1.017	0.62
88_V	139_L	1.015	0.62
20_L	97_F	1.012	0.62
13_M	77_R	1.009	0.62
10_P	15_R	1.002	0.61
15_R	27_R	0.998	0.61
16_D	103_I	0.995	0.61
46_I	54_T	0.993	0.60
118_T	131_D	0.990	0.60
36_V	61_S	0.990	0.60
64_G	140_D	0.989	0.60
88_V	102_Q	0.989	0.60
14_I	40_S	0.969	0.58
38_H	102_Q	0.962	0.58
84_E	135_T	0.962	0.58
21_R	135_T	0.948	0.57
14_I	142_V	0.948	0.57
67_C	141_E	0.941	0.56
11_N	16_D	0.941	0.56
35_E	42_V	0.939	0.56
127_L	130_Y	0.935	0.56
41_S	124_I	0.923	0.55
30_E	99_T	0.914	0.54
30_E	63_T	0.913	0.54
14_I	49_G	0.908	0.54
19_V	66_T	0.907	0.53
71_F	99_T	0.897	0.53
32_R	65_K	0.897	0.53
27_R	109_E	0.896	0.53
77_R	84_E	0.889	0.52
45_P	94_Y	0.887	0.52
17_A	50_E	0.881	0.51
10_P	37_N	0.880	0.51
63_T	89_N	0.876	0.51
57_V	87_Y	0.874	0.51
71_F	76_L	0.874	0.51
20_L	62_G	0.869	0.50
52_A	61_S	0.869	0.50
60_P	123_L	0.866	0.50
20_L	100_L	0.851	0.49
70_Q	78_E	0.847	0.49
142_V	145_L	0.843	0.48
19_V	24_F	0.835	0.48
40_S	70_Q	0.834	0.47
77_R	80_V	0.829	0.47
55_A	107_F	0.826	0.47
20_L	103_I	0.820	0.46
39_L	105_D	0.817	0.46
89_N	145_L	0.809	0.45
103_I	110_T	0.800	0.45
25_V	42_V	0.799	0.45
89_N	97_F	0.795	0.44
12_F	41_S	0.794	0.44
69_S	138_I	0.789	0.44
21_R	107_F	0.786	0.44
92_R	95_T	0.778	0.43
119_P	123_L	0.771	0.42
87_Y	121_D	0.770	0.42
109_E	127_L	0.766	0.42
95_T	98_R	0.757	0.41
45_P	75_R	0.757	0.41
102_Q	122_E	0.757	0.41
38_H	46_I	0.734	0.39
13_M	131_D	0.733	0.39
31_H	63_T	0.733	0.39
127_L	131_D	0.732	0.39
50_E	129_Q	0.726	0.39
32_R	64_G	0.725	0.39
32_R	59_G	0.724	0.39
36_V	72_V	0.724	0.39
59_G	65_K	0.724	0.39
73_T	85_A	0.717	0.38
33_D	132_G	0.714	0.38
110_T	141_E	0.712	0.38
12_F	21_R	0.706	0.37
88_V	136_V	0.705	0.37
14_I	46_I	0.702	0.37
33_D	117_S	0.692	0.36
66_T	84_E	0.689	0.36
138_I	141_E	0.685	0.36
37_N	82_N	0.682	0.35
48_N	85_A	0.675	0.35
77_R	85_A	0.672	0.35
11_N	145_L	0.665	0.34
68_I	72_V	0.664	0.34
84_E	107_F	0.658	0.34
85_A	145_L	0.650	0.33
39_L	68_I	0.641	0.32
86_T	109_E	0.638	0.32
104_L	141_E	0.632	0.32
35_E	118_T	0.624	0.31
20_L	67_C	0.624	0.31
103_I	137_I	0.623	0.31
129_Q	138_I	0.606	0.30
75_R	109_E	0.605	0.30
47_T	105_D	0.604	0.30
13_M	78_E	0.603	0.30
106_D	125_D	0.601	0.30
97_F	116_Q	0.598	0.29
46_I	100_L	0.597	0.29
100_L	128_Q	0.594	0.29
29_V	39_L	0.591	0.29
109_E	133_P	0.588	0.29
103_I	113_I	0.586	0.28
49_G	83_V	0.584	0.28
66_T	140_D	0.582	0.28
126_R	129_Q	0.572	0.28
15_R	78_E	0.571	0.27
87_Y	92_R	0.569	0.27
33_D	51_P	0.568	0.27
106_D	132_G	0.563	0.27
48_N	51_P	0.560	0.27
108_G	111_I	0.560	0.27
101_Y	113_I	0.557	0.27
35_E	133_P	0.556	0.27
25_V	51_P	0.550	0.26
13_M	24_F	0.548	0.26
59_G	64_G	0.546	0.26
54_T	58_T	0.544	0.26
93_N	99_T	0.540	0.25
20_L	141_E	0.538	0.25
17_A	53_D	0.532	0.25
118_T	136_V	0.531	0.25
31_H	39_L	0.529	0.25
16_D	19_V	0.528	0.25
51_P	137_I	0.527	0.25
95_T	104_L	0.525	0.25
46_I	83_V	0.525	0.25
74_E	99_T	0.517	0.24
31_H	124_I	0.517	0.24
56_I	130_Y	0.516	0.24
23_G	89_N	0.516	0.24
23_G	83_V	0.512	0.24
58_T	143_D	0.511	0.24
22_A	30_E	0.509	0.24
34_A	37_N	0.508	0.24
44_E	53_D	0.508	0.24
140_D	143_D	0.507	0.23
88_V	106_D	0.506	0.23
28_E	34_A	0.506	0.23
38_H	106_D	0.505	0.23
99_T	104_L	0.505	0.23
34_A	135_T	0.504	0.23
100_L	148_P	0.500	0.23

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1w5sA	1	0.915	99.9	0.487	Contact Map
2v1uA	1	0.9346	99.9	0.492	Contact Map
2qbyA	1	0.9085	99.9	0.495	Contact Map
2qbyB	1	0.8954	99.9	0.509	Contact Map
4xgcA	1	0.6928	99.9	0.517	Contact Map
1fnnA	1	0.902	99.9	0.523	Contact Map
4xgcE	1	0.8758	99.8	0.606	Contact Map
3te6A	1	0.9085	99.8	0.612	Contact Map
2fnaA	1	0.8235	99.5	0.683	Contact Map
4xgcD	1	0.9281	99.5	0.683	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0068 seconds.