GREMLIN Database
O52039 - Uncharacterized protein
UniProt: O52039 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (327)
Sequences: 104 (81)
Seq/√Len: 4.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_F361_D4.4430.92
183_I187_H3.2880.73
356_E371_L3.2440.72
136_P375_Q3.2430.72
136_P142_N2.9140.63
59_S248_W2.8080.60
66_I241_A2.7970.60
71_G83_D2.7120.57
143_I353_S2.6120.54
125_K371_L2.5270.52
301_F364_I2.5030.51
319_A379_P2.4930.51
97_A122_V2.4810.50
96_L376_W2.4720.50
100_R332_V2.4360.49
138_V329_L2.4190.48
240_A337_V2.3830.47
137_P375_Q2.3230.45
276_A279_G2.2940.45
90_R187_H2.2900.44
142_N375_Q2.2480.43
99_G251_F2.2170.42
136_P141_R2.2070.42
125_K368_D2.1670.41
127_G375_Q2.1500.40
125_K375_Q2.1410.40
127_G142_N2.1320.40
102_Q205_S2.0230.37
252_D358_R2.0220.37
64_V209_R1.9420.34
239_V358_R1.9410.34
80_F83_D1.9270.34
118_L303_Y1.8700.32
79_L209_R1.8570.32
217_V316_G1.8230.31
204_S374_V1.8200.31
83_D241_A1.8200.31
79_L305_L1.8050.31
357_Y367_Y1.7570.29
69_L218_A1.7440.29
102_Q195_E1.7410.29
356_E368_D1.7380.29
76_V83_D1.7320.29
61_L225_V1.7120.28
59_S65_A1.7070.28
297_F316_G1.6880.28
125_K356_E1.6570.27
178_P252_D1.6460.27
73_R125_K1.6450.27
64_V266_E1.6290.26
160_A182_I1.6190.26
65_A71_G1.6110.26
95_R241_A1.5990.26
51_C372_N1.5970.26
136_P140_P1.5910.25
365_V376_W1.5790.25
176_A289_K1.5770.25
193_A372_N1.5710.25
194_R248_W1.5690.25
293_R319_A1.5680.25
158_V226_A1.5670.25
183_I227_V1.5670.25
111_P293_R1.5540.25
62_V80_F1.5500.24
69_L358_R1.5410.24
51_C55_F1.4790.23
137_P141_R1.4720.23
51_C252_D1.4670.23
189_V213_S1.4640.23
81_I85_A1.4560.22
64_V124_D1.4510.22
294_Q372_N1.4450.22
95_R175_L1.4400.22
141_R375_Q1.4210.22
198_G358_R1.4170.22
89_I253_C1.4170.22
210_R215_L1.4090.21
76_V241_A1.4070.21
76_V80_F1.3910.21
349_W354_H1.3810.21
127_G137_P1.3810.21
136_P371_L1.3780.21
227_V246_A1.3730.21
293_R364_I1.3700.21
90_R94_E1.3670.21
200_Y204_S1.3640.20
368_D371_L1.3620.20
281_P301_F1.3570.20
129_V343_A1.3470.20
140_P305_L1.3460.20
84_A369_T1.3460.20
165_L193_A1.3430.20
60_H209_R1.3260.20
204_S272_R1.3230.20
201_E318_L1.3190.20
281_P360_Y1.3140.20
170_G203_A1.3140.20
131_V198_G1.3020.19
281_P355_V1.2950.19
90_R183_I1.2910.19
81_I244_V1.2880.19
122_V144_P1.2840.19
68_T352_E1.2730.19
146_V361_D1.2730.19
144_P375_Q1.2600.18
250_L364_I1.2460.18
217_V319_A1.2460.18
101_P175_L1.2460.18
140_P319_A1.2460.18
179_G372_N1.2350.18
101_P182_I1.2280.18
210_R213_S1.2270.18
56_I370_Y1.2230.18
70_S282_Y1.2200.18
220_L343_A1.2170.18
140_P154_Y1.2140.18
67_A327_L1.2110.18
67_A297_F1.1990.17
100_R322_A1.1940.17
154_Y294_Q1.1920.17
127_G135_M1.1910.17
75_T101_P1.1910.17
157_L161_F1.1870.17
63_V95_R1.1850.17
65_A83_D1.1840.17
287_H369_T1.1840.17
77_A293_R1.1790.17
96_L176_A1.1700.17
355_V358_R1.1650.17
321_S330_V1.1620.17
247_P266_E1.1620.17
90_R359_L1.1580.17
53_L64_V1.1560.17
127_G136_P1.1550.17
252_D359_L1.1540.17
192_Q205_S1.1500.17
129_V199_V1.1460.16
58_A258_L1.1400.16
113_N361_D1.1380.16
177_I236_T1.1350.16
324_A336_P1.1330.16
87_T138_V1.1220.16
68_T92_L1.1220.16
84_A287_H1.1210.16
140_P375_Q1.1200.16
138_V181_G1.1180.16
201_E355_V1.1180.16
184_A228_L1.1090.16
275_S370_Y1.1080.16
354_H360_Y1.1050.16
171_T304_A1.0970.16
56_I373_T1.0930.16
91_I366_A1.0900.16
191_I293_R1.0880.16
184_A332_V1.0830.15
86_L178_P1.0820.15
136_P277_P1.0790.15
76_V335_L1.0740.15
76_V79_L1.0650.15
94_E178_P1.0630.15
84_A140_P1.0610.15
75_T261_W1.0590.15
127_G277_P1.0520.15
146_V249_V1.0520.15
190_F220_L1.0410.15
85_A311_V1.0410.15
319_A326_W1.0400.15
285_F308_G1.0400.15
252_D256_A1.0390.15
56_I86_L1.0390.15
177_I195_E1.0370.15
146_V170_G1.0350.15
371_L375_Q1.0320.15
77_A336_P1.0260.15
55_F372_N1.0200.14
224_A316_G1.0200.14
88_M266_E1.0100.14
99_G190_F1.0100.14
82_I266_E1.0070.14
127_G141_R1.0060.14
195_E312_M1.0050.14
52_P86_L1.0040.14
62_V95_R1.0030.14
61_L209_R0.9990.14
240_A321_S0.9960.14
60_H242_M0.9940.14
317_I333_V0.9880.14
81_I86_L0.9810.14
61_L149_S0.9780.14
289_K335_L0.9780.14
135_M375_Q0.9770.14
224_A275_S0.9720.14
82_I190_F0.9700.14
49_R337_V0.9500.13
56_I301_F0.9480.13
328_V351_G0.9470.13
48_D168_P0.9400.13
131_V366_A0.9380.13
53_L180_I0.9370.13
162_P205_S0.9370.13
85_A157_L0.9330.13
56_I325_V0.9330.13
53_L296_A0.9240.13
205_S293_R0.9150.13
54_E205_S0.9140.13
57_F370_Y0.9110.13
95_R350_I0.9100.13
215_L378_A0.9090.13
142_N277_P0.9080.13
76_V253_C0.8900.13
200_Y326_W0.8840.13
63_V337_V0.8790.12
142_N182_I0.8780.12
144_P147_V0.8750.12
76_V370_Y0.8740.12
204_S364_I0.8700.12
222_G225_V0.8670.12
343_A350_I0.8650.12
71_G80_F0.8580.12
59_S63_V0.8570.12
193_A278_R0.8550.12
359_L376_W0.8510.12
60_H328_V0.8500.12
143_I257_G0.8450.12
260_P284_T0.8450.12
220_L333_V0.8450.12
170_G318_L0.8450.12
58_A335_L0.8440.12
94_E359_L0.8430.12
184_A334_L0.8400.12
224_A333_V0.8400.12
340_I348_M0.8340.12
301_F320_I0.8310.12
179_G247_P0.8310.12
166_F355_V0.8290.12
141_R277_P0.8240.12
125_K136_P0.8200.12
63_V122_V0.8180.12
79_L213_S0.8170.12
162_P326_W0.8160.12
77_A178_P0.8150.12
251_F267_G0.8150.12
195_E339_L0.8140.12
223_G235_A0.8140.12
286_A334_L0.8130.12
76_V254_R0.8120.12
140_P278_R0.8110.12
143_I334_L0.8110.12
91_I95_R0.8100.12
59_S71_G0.8070.12
68_T238_M0.8070.12
81_I157_L0.8070.12
178_P186_K0.8060.12
172_L199_V0.8050.11
184_A187_H0.8030.11
178_P253_C0.8030.11
91_I194_R0.8020.11
91_I208_I0.8000.11
164_W293_R0.8000.11
91_I241_A0.7990.11
208_I292_V0.7980.11
102_Q299_G0.7970.11
81_I199_V0.7960.11
53_L72_S0.7950.11
335_L367_Y0.7940.11
65_A248_W0.7880.11
142_N233_T0.7870.11
78_C376_W0.7860.11
100_R200_Y0.7820.11
258_L286_A0.7810.11
183_I270_V0.7800.11
252_D380_V0.7760.11
89_I244_V0.7740.11
342_P349_W0.7710.11
67_A279_G0.7710.11
129_V183_I0.7710.11
120_D183_I0.7710.11
73_R186_K0.7700.11
368_D375_Q0.7680.11
120_D252_D0.7680.11
136_P359_L0.7640.11
129_V244_V0.7630.11
289_K294_Q0.7550.11
69_L276_A0.7460.11
69_L279_G0.7430.11
234_P364_I0.7430.11
181_G240_A0.7420.11
80_F257_G0.7410.11
138_V220_L0.7410.11
213_S296_A0.7410.11
310_S373_T0.7380.11
63_V67_A0.7380.11
102_Q243_A0.7370.11
74_L346_L0.7350.11
212_R226_A0.7350.11
354_H359_L0.7310.11
117_D157_L0.7300.11
156_L328_V0.7290.11
207_R363_G0.7250.11
205_S257_G0.7250.11
74_L316_G0.7230.11
167_S247_P0.7210.10
225_V367_Y0.7150.10
95_R376_W0.7120.10
327_L336_P0.7120.10
88_M147_V0.7100.10
225_V251_F0.7100.10
83_D97_A0.7100.10
196_S320_I0.7090.10
160_A237_T0.7080.10
90_R93_Y0.7070.10
54_E287_H0.7030.10
63_V80_F0.7010.10
226_A291_G0.7000.10
122_V274_V0.6980.10
120_D352_E0.6970.10
102_Q135_M0.6970.10
356_E374_V0.6970.10
330_V342_P0.6940.10
144_P362_N0.6940.10
173_S364_I0.6940.10
253_C314_L0.6930.10
129_V334_L0.6910.10
104_G364_I0.6910.10
71_G248_W0.6890.10
138_V174_V0.6890.10
199_V325_V0.6880.10
212_R215_L0.6870.10
356_E367_Y0.6850.10
369_T372_N0.6830.10
128_R202_T0.6830.10
287_H296_A0.6820.10
370_Y381_E0.6810.10
225_V240_A0.6800.10
210_R214_L0.6800.10
126_R353_S0.6790.10
71_G97_A0.6790.10
215_L374_V0.6780.10
257_G281_P0.6760.10
222_G328_V0.6760.10
275_S285_F0.6740.10
197_A319_A0.6740.10
297_F335_L0.6740.10
134_S360_Y0.6730.10
196_S378_A0.6730.10
64_V334_L0.6710.10
141_R371_L0.6710.10
368_D376_W0.6690.10
110_D329_L0.6690.10
58_A253_C0.6670.10
203_A379_P0.6670.10
102_Q188_F0.6670.10
97_A178_P0.6640.10
141_R368_D0.6640.10
90_R203_A0.6620.10
180_I334_L0.6610.10
180_I211_N0.6590.10
47_M57_F0.6590.10
67_A131_V0.6540.10
280_Q360_Y0.6530.10
71_G241_A0.6530.10
273_P281_P0.6500.10
91_I376_W0.6500.10
168_P325_V0.6490.10
80_F254_R0.6480.10
126_R142_N0.6450.10
246_A327_L0.6430.10
80_F95_R0.6430.10
273_P289_K0.6430.10
284_T354_H0.6410.10
205_S211_N0.6410.10
260_P305_L0.6400.10
195_E227_V0.6390.10
69_L163_V0.6380.10
85_A174_V0.6370.10
69_L162_P0.6360.10
88_M340_I0.6290.09
99_G319_A0.6250.09
70_S172_L0.6250.09
90_R378_A0.6220.09
63_V138_V0.6220.09
128_R304_A0.6160.09
119_H198_G0.6150.09
75_T182_I0.6150.09
293_R379_P0.6140.09
320_I337_V0.6130.09
235_A310_S0.6130.09
296_A327_L0.6100.09
153_L330_V0.6100.09
195_E367_Y0.6080.09
205_S310_S0.6070.09
195_E335_L0.6050.09
254_R263_P0.6030.09
125_K212_R0.6020.09
137_P277_P0.5990.09
170_G260_P0.5990.09
379_P382_A0.5980.09
77_A208_I0.5980.09
110_D173_S0.5970.09
172_L330_V0.5970.09
49_R160_A0.5960.09
211_N215_L0.5950.09
305_L362_N0.5950.09
190_F339_L0.5930.09
83_D95_R0.5930.09
176_A336_P0.5910.09
205_S237_T0.5900.09
93_Y156_L0.5880.09
54_E253_C0.5850.09
70_S248_W0.5840.09
171_T266_E0.5840.09
297_F327_L0.5830.09
48_D333_V0.5820.09
138_V324_A0.5820.09
139_Y164_W0.5820.09
216_L333_V0.5820.09
94_E125_K0.5810.09
52_P70_S0.5790.09
52_P205_S0.5790.09
157_L208_I0.5780.09
62_V241_A0.5760.09
79_L140_P0.5760.09
152_I378_A0.5740.09
69_L240_A0.5730.09
320_I378_A0.5710.09
136_P139_Y0.5710.09
340_I353_S0.5710.09
365_V368_D0.5700.09
79_L290_R0.5700.09
188_F372_N0.5690.09
281_P296_A0.5690.09
318_L382_A0.5680.09
237_T284_T0.5670.09
158_V335_L0.5660.09
125_K254_R0.5660.09
170_G325_V0.5660.09
187_H227_V0.5660.09
143_I175_L0.5640.09
100_R358_R0.5600.09
204_S368_D0.5600.09
48_D321_S0.5580.09
221_S331_M0.5550.09
172_L188_F0.5540.09
56_I272_R0.5500.09
128_R302_A0.5490.09
79_L222_G0.5490.09
56_I300_G0.5470.09
49_R358_R0.5450.09
195_E307_A0.5440.09
188_F243_A0.5420.09
268_D293_R0.5410.09
183_I297_F0.5410.09
76_V91_I0.5410.09
315_S323_R0.5390.09
246_A275_S0.5390.09
182_I374_V0.5370.09
70_S83_D0.5370.09
337_V341_L0.5360.09
221_S301_F0.5350.09
225_V242_M0.5340.09
212_R381_E0.5330.09
164_W321_S0.5290.08
52_P297_F0.5280.08
161_F165_L0.5280.08
165_L347_V0.5280.08
199_V244_V0.5270.08
50_T243_A0.5260.08
62_V71_G0.5240.08
59_S80_F0.5230.08
79_L244_V0.5230.08
213_S217_V0.5230.08
284_T349_W0.5230.08
104_G378_A0.5200.08
67_A249_V0.5190.08
185_A249_V0.5180.08
49_R283_T0.5180.08
122_V178_P0.5180.08
204_S361_D0.5170.08
130_P333_V0.5160.08
313_L327_L0.5160.08
156_L300_G0.5140.08
66_I97_A0.5120.08
203_A377_V0.5090.08
130_P200_Y0.5070.08
69_L77_A0.5050.08
193_A373_T0.5050.08
73_R281_P0.5020.08
112_Y249_V0.5010.08
159_V372_N0.5010.08
292_V375_Q0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yleB 1 0.0259 6.2 0.981 Contact Map
3fymA 1 0.0803 5 0.982 Contact Map
2a6hC 1 0.1554 4.9 0.982 Contact Map
2d2pA 1 0.0699 4.8 0.982 Contact Map
3aaeX 1 0.0751 4.3 0.982 Contact Map
3l39A 3 0.1554 4 0.983 Contact Map
4aybB 1 0.1451 3.9 0.983 Contact Map
3effK 4 0.1244 3.8 0.983 Contact Map
4rd8A 1 0.101 3.4 0.983 Contact Map
1ywiA 1 0.0725 3.3 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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