GREMLIN Database
ARSC - Putative arsenate reductase
UniProt: O52030 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (127)
Sequences: 7752 (5283)
Seq/√Len: 468.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_E132_V3.5151.00
24_T28_E2.8871.00
8_K41_E2.8551.00
61_M68_L2.2491.00
30_E128_E2.2211.00
110_D126_D2.1571.00
128_E132_V2.1421.00
92_C108_A2.0841.00
63_E121_R2.0671.00
115_Q119_Q2.0001.00
14_V94_T1.9821.00
59_E117_M1.9661.00
89_T98_D1.8851.00
64_E128_E1.8541.00
28_E42_I1.8211.00
76_V98_D1.7971.00
22_M57_V1.7621.00
11_F27_A1.7511.00
64_E124_R1.7441.00
10_G45_G1.7041.00
60_V124_R1.6881.00
22_M61_M1.6561.00
117_M121_R1.6411.00
27_A42_I1.6201.00
60_V121_R1.6131.00
122_E126_D1.5571.00
25_A66_F1.5471.00
9_F27_A1.5341.00
60_V63_E1.4781.00
53_V58_V1.4601.00
14_V48_H1.4511.00
26_F64_E1.4051.00
79_D83_S1.3941.00
89_T95_L1.3931.00
116_E119_Q1.3631.00
64_E125_D1.3621.00
119_Q122_E1.3511.00
26_F124_R1.3031.00
43_L74_R1.2971.00
15_Q113_D1.2791.00
43_L84_C1.2721.00
25_A68_L1.2531.00
53_V71_R1.2491.00
26_F131_V1.2481.00
26_F127_I1.2361.00
49_P75_E1.2301.00
59_E63_E1.2211.00
8_K43_L1.2201.00
36_L39_S1.2191.00
133_D136_D1.2001.00
63_E117_M1.1971.00
56_E117_M1.1931.00
41_E83_S1.1761.00
27_A131_V1.1731.00
22_M124_R1.1631.00
101_T106_D1.1581.00
47_T97_L1.1581.00
30_E131_V1.1551.00
10_G84_C1.1481.00
56_E59_E1.1311.00
58_V62_G1.1101.00
57_V120_V1.0961.00
58_V68_L1.0781.00
101_T105_R1.0411.00
11_F131_V1.0381.00
8_K83_S1.0331.00
8_K84_C1.0321.00
52_H58_V1.0291.00
74_R80_E1.0271.00
7_T86_I1.0171.00
60_V64_E1.0151.00
66_F128_E1.0071.00
11_F23_S1.0051.00
101_T104_V1.0031.00
26_F66_F1.0021.00
60_V117_M0.9961.00
121_R125_D0.9941.00
56_E116_E0.9901.00
53_V68_L0.9801.00
45_G76_V0.9701.00
30_E135_F0.9611.00
86_I134_L0.9391.00
54_H120_V0.9331.00
88_A134_L0.9321.00
25_A71_R0.9201.00
107_W130_R0.9191.00
57_V60_V0.9091.00
25_A28_E0.9071.00
45_G74_R0.8981.00
66_F124_R0.8951.00
81_L87_V0.8941.00
55_E59_E0.8941.00
26_F128_E0.8881.00
79_D82_E0.8671.00
23_S90_M0.8501.00
91_G94_T0.8441.00
93_S97_L0.8431.00
110_D122_E0.8251.00
109_L126_D0.8201.00
25_A53_V0.8101.00
81_L84_C0.8081.00
125_D129_Q0.8041.00
68_L71_R0.8011.00
133_D137_E0.7941.00
62_G68_L0.7931.00
119_Q123_I0.7911.00
23_S127_I0.7821.00
14_V93_S0.7771.00
109_L127_I0.7761.00
21_Q53_V0.7711.00
109_L123_I0.7661.00
124_R128_E0.7551.00
61_M66_F0.7541.00
43_L83_S0.7451.00
26_F61_M0.7251.00
10_G87_V0.7131.00
95_L99_A0.7111.00
14_V91_G0.7111.00
77_S80_E0.7041.00
102_V105_R0.7031.00
129_Q133_D0.7011.00
29_R66_F0.7001.00
59_E62_G0.6971.00
11_F90_M0.6951.00
51_D73_P0.6941.00
134_L138_F0.6881.00
90_M109_L0.6851.00
90_M94_T0.6831.00
28_E41_E0.6801.00
27_A40_V0.6711.00
9_F86_I0.6681.00
118_E122_E0.6571.00
92_C96_E0.6551.00
52_H72_T0.6481.00
48_H75_E0.6481.00
102_V106_D0.6461.00
126_D130_R0.6431.00
47_T98_D0.6411.00
123_I127_I0.6391.00
36_L135_F0.6391.00
67_D70_E0.6381.00
26_F30_E0.6321.00
76_V81_L0.6280.99
29_R128_E0.6160.99
47_T94_T0.6090.99
48_H97_L0.5980.99
78_T82_E0.5940.99
22_M123_I0.5920.99
18_G120_V0.5890.99
37_E40_V0.5850.99
97_L100_E0.5820.99
36_L40_V0.5690.99
80_E84_C0.5690.99
50_A73_P0.5660.99
15_Q18_G0.5660.99
81_L104_V0.5640.99
62_G67_D0.5610.99
24_T44_T0.5560.99
114_G119_Q0.5540.99
132_V136_D0.5520.99
23_S131_V0.5480.99
99_A102_V0.5420.98
82_E104_V0.5420.98
127_I131_V0.5400.98
73_P76_V0.5360.98
99_A105_R0.5350.98
11_F88_A0.5330.98
28_E70_E0.5330.98
17_A54_H0.5330.98
15_Q48_H0.5320.98
54_H57_V0.5320.98
19_R111_D0.5310.98
123_I126_D0.5300.98
11_F134_L0.5280.98
62_G69_S0.5250.98
46_G49_P0.5210.98
14_V97_L0.5200.98
12_V87_V0.5180.98
99_A106_D0.5170.98
25_A29_R0.5160.98
54_H113_D0.5140.98
27_A135_F0.5130.98
27_A30_E0.5100.98
22_M60_V0.5090.98
56_E115_Q0.5080.98
110_D119_Q0.5030.98
100_E106_D0.5030.98
103_D106_D0.5010.97
110_D123_I0.5000.97
109_L130_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t38A 2 0.9296 100 0.121 Contact Map
1u2pA 1 0.9507 100 0.138 Contact Map
4lrqA 2 0.9296 100 0.14 Contact Map
2cwdA 1 0.9577 100 0.14 Contact Map
3jviA 1 0.9437 100 0.142 Contact Map
2gi4A 1 0.9507 100 0.15 Contact Map
4etmA 2 0.9789 100 0.15 Contact Map
3rh0A 1 0.8944 100 0.152 Contact Map
1d1qA 1 0.9577 100 0.152 Contact Map
2l17A 1 0.9014 100 0.153 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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