GREMLIN Database
ARSD - Putative arsenical resistance operon repressor ArsD
UniProt: O52028 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 108 (101)
Sequences: 353 (246)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_E30_S5.3321.00
2_T80_N3.5311.00
69_H86_R3.2521.00
65_L76_I2.7700.99
5_T47_A2.5760.99
73_I87_E2.3880.98
85_A94_E2.3170.98
88_T94_E2.3070.98
32_A92_Y2.2940.98
33_L44_V1.9260.93
29_V95_L1.8380.92
17_V22_P1.7860.90
62_I76_I1.7780.90
16_G19_G1.7760.90
11_M14_S1.7460.89
85_A88_T1.7070.88
60_Q63_A1.6900.88
11_M19_G1.6730.87
64_D68_E1.6010.85
65_L73_I1.5680.83
24_D28_E1.5370.82
32_A95_L1.5280.82
14_S17_V1.5170.81
26_L89_Y1.5040.81
32_A35_Q1.4190.77
61_Q82_E1.4180.77
28_E92_Y1.4100.76
54_E58_E1.3830.75
16_G26_L1.3320.72
66_V78_V1.3080.71
76_I83_I1.2990.70
8_E52_N1.2840.69
16_G89_Y1.2750.69
5_T81_D1.2540.67
19_G26_L1.2530.67
78_V83_I1.1820.63
12_C19_G1.1780.62
8_E51_H1.1740.62
18_C26_L1.1620.61
45_S52_N1.1560.61
35_Q92_Y1.1060.57
6_L29_V1.1040.57
4_L62_I1.0920.56
95_L100_E1.0880.56
55_Q58_E1.0510.53
11_M16_G1.0410.53
7_Y62_I1.0350.52
18_C89_Y0.9780.48
4_L99_F0.9770.48
79_V84_V0.9560.47
10_A15_T0.9420.46
55_Q59_T0.9360.45
30_S54_E0.9350.45
79_V83_I0.9320.45
25_E91_S0.9230.44
22_P53_I0.9060.43
11_M26_L0.8970.42
4_L79_V0.8850.42
49_M66_V0.8850.42
5_T45_S0.8770.41
7_Y68_E0.8650.40
7_Y87_E0.8580.40
61_Q64_D0.8420.39
34_D38_N0.8370.38
9_E22_P0.8350.38
34_D37_E0.8320.38
30_S44_V0.8300.38
69_H73_I0.8270.38
8_E14_S0.8220.37
11_M25_E0.8190.37
41_D59_T0.8080.36
36_L42_V0.8020.36
83_I96_A0.7920.35
57_L95_L0.7790.34
57_L60_Q0.7780.34
47_A52_N0.7750.34
65_L85_A0.7740.34
6_L44_V0.7720.34
73_I76_I0.7690.34
11_M18_C0.7580.33
17_V20_P0.7570.33
20_P99_F0.7440.32
38_N81_D0.7410.32
38_N102_S0.7370.32
57_L66_V0.7330.32
29_V92_Y0.7280.31
62_I87_E0.7260.31
19_G89_Y0.7190.31
65_L69_H0.7120.30
65_L88_T0.7070.30
60_Q64_D0.7020.30
70_G76_I0.6960.29
2_T77_T0.6950.29
60_Q95_L0.6940.29
77_T102_S0.6860.29
4_L98_T0.6750.28
5_T43_D0.6730.28
90_L98_T0.6680.28
76_I93_D0.6580.27
11_M93_D0.6570.27
33_L42_V0.6530.27
47_A98_T0.6510.27
72_S79_V0.6500.27
76_I86_R0.6460.26
8_E66_V0.6400.26
48_N55_Q0.6380.26
19_G23_D0.6380.26
73_I98_T0.6350.26
86_R97_S0.6350.26
33_L85_A0.6350.26
63_A67_E0.6300.26
58_E79_V0.6270.25
48_N84_V0.6200.25
7_Y90_L0.6160.25
14_S29_V0.6130.25
64_D95_L0.6130.25
32_A57_L0.6070.24
21_D56_F0.6060.24
15_T67_E0.6000.24
18_C48_N0.5820.23
29_V32_A0.5770.23
50_Q56_F0.5730.23
39_E44_V0.5690.22
20_P47_A0.5690.22
35_Q96_A0.5660.22
13_C19_G0.5620.22
11_M17_V0.5620.22
30_S41_D0.5550.22
84_V98_T0.5530.22
21_D27_V0.5530.22
47_A96_A0.5480.21
8_E27_V0.5460.21
37_E59_T0.5430.21
34_D79_V0.5390.21
68_E84_V0.5390.21
42_V64_D0.5380.21
73_I85_A0.5360.21
65_L82_E0.5350.21
6_L92_Y0.5320.21
54_E57_L0.5310.21
3_Q91_S0.5290.20
51_H56_F0.5290.20
62_I100_E0.5290.20
25_E29_V0.5260.20
7_Y71_P0.5230.20
88_T91_S0.5190.20
68_E86_R0.5090.20
13_C18_C0.5070.19
20_P39_E0.5040.19
29_V88_T0.5040.19
62_I78_V0.5010.19
50_Q57_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kgkA 2 0.8889 100 0.309 Contact Map
3ktbA 5 0.9537 100 0.325 Contact Map
1iloA 1 0.713 96.5 0.859 Contact Map
3zitA 2 0.7222 96.5 0.859 Contact Map
1fo5A 1 0.7685 93.7 0.882 Contact Map
1t1vA 2 0.787 92.6 0.886 Contact Map
4k8mA 2 0.75 91 0.891 Contact Map
2fgxA 1 0.713 90.5 0.892 Contact Map
1nhoA 1 0.7778 90.3 0.893 Contact Map
3ic4A 1 0.7593 89.4 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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