GREMLIN Database
ARSM - Putative arsenite methyltransferase
UniProt: O52025 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (314)
Sequences: 154 (144)
Seq/√Len: 8.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
351_A385_R6.3941.00
195_P199_A3.7120.96
196_K200_A3.5260.95
305_V344_L3.4370.94
204_G207_V3.2080.91
217_D279_N3.1230.90
169_S172_L3.0860.89
154_S158_G2.8980.86
179_V182_V2.8800.86
309_D362_E2.8330.85
179_V183_A2.8270.85
207_V221_A2.7760.83
194_N200_A2.7650.83
222_A256_V2.6580.81
212_S218_C2.5640.78
360_S364_I2.5210.77
172_L177_D2.4930.76
179_V184_D2.4820.76
234_V263_I2.4220.74
154_S162_D2.4030.73
207_V229_G2.2770.69
196_K199_A2.2760.69
195_P200_A2.2560.68
217_D306_A2.1510.64
197_A200_A2.1470.64
184_D191_G2.0910.62
167_S171_R2.0390.60
279_N306_A1.9710.57
212_S277_I1.9430.56
340_L362_E1.9200.55
269_A272_S1.8790.53
168_G172_L1.8680.53
217_D360_S1.8370.52
174_Y177_D1.8190.51
206_T230_H1.8130.51
177_D183_A1.7820.49
183_A237_T1.7650.49
162_D165_E1.7560.48
124_P384_A1.7440.48
306_A360_S1.7160.47
194_N199_A1.6850.45
167_S172_L1.6800.45
189_G192_C1.6720.45
317_P358_D1.6520.44
195_P198_F1.6500.44
256_V351_A1.5920.42
272_S298_V1.5880.41
327_L332_A1.5760.41
279_N360_S1.5660.41
162_D170_E1.5630.40
272_S300_R1.5630.40
182_V191_G1.5610.40
267_P308_S1.5520.40
213_G255_N1.5480.40
217_D364_I1.5470.40
170_E193_G1.5360.39
359_E375_E1.5340.39
201_M275_V1.5310.39
217_D255_N1.5090.38
168_G171_R1.5090.38
92_N115_N1.4940.38
171_R177_D1.4890.38
197_A225_V1.4860.37
259_R266_L1.4820.37
222_A255_N1.4800.37
214_A240_M1.4720.37
255_N279_N1.4620.36
177_D184_D1.4580.36
358_D374_G1.4530.36
222_A385_R1.4490.36
268_V273_V1.4440.36
67_S70_R1.4310.35
358_D367_W1.4160.35
182_V185_G1.4080.34
320_V323_D1.3990.34
183_A191_G1.3960.34
189_G193_G1.3940.34
288_K360_S1.3890.34
181_S256_V1.3760.33
240_M254_E1.3740.33
211_G233_G1.3670.33
215_G301_P1.3540.32
212_S237_T1.3440.32
267_P304_R1.3430.32
167_S177_D1.3410.32
306_A364_I1.3400.32
194_N197_A1.3310.32
208_L227_P1.3290.32
159_C162_D1.3240.31
268_V294_D1.3120.31
219_F243_K1.3010.31
179_V191_G1.2940.30
169_S177_D1.2780.30
359_E362_E1.2760.30
341_K345_D1.2710.30
255_N258_F1.2640.29
217_D288_K1.2540.29
153_V156_D1.2510.29
153_V210_L1.2470.29
371_R374_G1.2450.29
128_R132_R1.2410.28
285_A309_D1.2280.28
155_G162_D1.2240.28
209_D233_G1.2230.28
197_A201_M1.2200.28
172_L191_G1.2130.28
205_E229_G1.2100.27
294_D385_R1.2090.27
161_S165_E1.2080.27
169_S191_G1.2070.27
165_E174_Y1.1970.27
217_D241_I1.1910.27
157_G162_D1.1900.27
214_A239_E1.1880.27
188_L191_G1.1620.26
286_P385_R1.1620.26
238_P254_E1.1550.26
264_G308_S1.1550.26
153_V158_G1.1540.26
181_S187_D1.1510.26
217_D304_R1.1420.25
187_D193_G1.1330.25
177_D191_G1.1300.25
278_S291_V1.1290.25
217_D220_L1.1280.25
154_S160_C1.1270.25
212_S239_E1.1140.24
169_S184_D1.1090.24
254_E376_Y1.1050.24
241_I277_I1.1050.24
94_P100_C1.0990.24
218_C277_I1.0930.24
279_N288_K1.0930.24
230_H305_V1.0920.24
349_F387_P1.0810.23
217_D277_I1.0720.23
68_V72_P1.0720.23
241_I364_I1.0670.23
225_V286_P1.0560.23
168_G198_F1.0560.23
179_V185_G1.0550.23
358_D376_Y1.0480.22
305_V384_A1.0470.22
279_N304_R1.0470.22
294_D297_R1.0440.22
127_T346_E1.0420.22
328_T332_A1.0410.22
119_V125_E1.0400.22
196_K381_T1.0390.22
234_V281_V1.0360.22
270_D297_R1.0350.22
218_C287_E1.0340.22
212_S306_A1.0340.22
180_A187_D1.0310.22
274_N301_P1.0290.22
215_G303_G1.0250.22
370_D374_G1.0250.22
334_A339_D1.0110.21
361_T378_V1.0080.21
279_N364_I1.0080.21
64_R68_V1.0070.21
339_D361_T1.0050.21
297_R375_E1.0030.21
319_D323_D1.0010.21
292_F340_L0.9960.21
233_G387_P0.9940.21
232_I355_A0.9900.21
159_C363_F0.9890.21
171_R175_D0.9880.21
153_V157_G0.9880.21
219_F277_I0.9870.21
190_L193_G0.9840.21
222_A351_A0.9820.21
153_V162_D0.9810.21
177_D182_V0.9780.20
220_L311_V0.9770.20
291_V309_D0.9760.20
152_D271_E0.9710.20
297_R300_R0.9670.20
65_A70_R0.9650.20
294_D379_S0.9590.20
253_A276_V0.9580.20
284_L358_D0.9570.20
81_R86_D0.9550.20
223_Q238_P0.9500.20
255_N306_A0.9450.20
216_F229_G0.9400.19
269_A300_R0.9360.19
211_G281_V0.9350.19
101_S114_D0.9330.19
269_A299_L0.9260.19
84_R115_N0.9240.19
92_N99_F0.9200.19
292_F307_I0.9130.19
367_W374_G0.9130.19
304_R385_R0.9120.19
319_D330_C0.9120.19
328_T331_V0.9080.19
329_G332_A0.9060.19
215_G274_N0.9040.19
154_S165_E0.9030.19
223_Q261_G0.9010.18
154_S157_G0.8970.18
269_A352_V0.8960.18
220_L364_I0.8950.18
372_D384_A0.8910.18
214_A223_Q0.8900.18
315_P333_G0.8900.18
211_G301_P0.8890.18
243_K298_V0.8880.18
218_C349_F0.8870.18
225_V361_T0.8820.18
75_T81_R0.8800.18
241_I360_S0.8600.17
169_S179_V0.8570.17
384_A387_P0.8570.17
85_K89_A0.8560.17
165_E169_S0.8540.17
357_K378_V0.8470.17
201_M229_G0.8430.17
123_D126_E0.8390.17
255_N288_K0.8380.17
162_D167_S0.8350.17
85_K90_T0.8320.17
321_Q325_D0.8270.17
183_A212_S0.8210.17
237_T240_M0.8210.17
132_R152_D0.8190.17
292_F385_R0.8190.17
209_D236_M0.8180.17
371_R377_L0.8170.16
172_L189_G0.8120.16
89_A92_N0.8110.16
233_G306_A0.8100.16
134_R140_T0.8080.16
285_A291_V0.8010.16
353_E377_L0.7990.16
90_T115_N0.7990.16
280_C359_E0.7970.16
172_L183_A0.7960.16
235_D255_N0.7940.16
184_D258_F0.7920.16
155_G158_G0.7920.16
294_D298_V0.7910.16
232_I281_V0.7880.16
229_G309_D0.7870.16
232_I259_R0.7840.16
196_K201_M0.7840.16
225_V354_I0.7800.16
219_F298_V0.7780.16
275_V306_A0.7730.16
75_T87_R0.7730.16
208_L299_L0.7720.15
97_P113_N0.7720.15
168_G177_D0.7710.15
221_A290_R0.7670.15
369_A374_G0.7660.15
220_L279_N0.7640.15
208_L256_V0.7610.15
235_D306_A0.7600.15
169_S182_V0.7590.15
258_F304_R0.7570.15
81_R98_K0.7560.15
185_G296_Y0.7560.15
110_T128_R0.7540.15
221_A380_A0.7530.15
241_I279_N0.7510.15
185_G191_G0.7480.15
175_D298_V0.7460.15
165_E172_L0.7450.15
200_A204_G0.7450.15
335_S339_D0.7430.15
79_W353_E0.7400.15
281_V307_I0.7390.15
319_D324_P0.7390.15
172_L184_D0.7380.15
216_F240_M0.7370.15
87_R100_C0.7370.15
151_L256_V0.7360.15
154_S166_A0.7340.15
372_D375_E0.7320.15
309_D340_L0.7310.15
307_I379_S0.7310.15
220_L360_S0.7300.15
327_L331_V0.7220.14
271_E300_R0.7200.14
241_I306_A0.7180.14
215_G348_G0.7170.14
298_V309_D0.7160.14
256_V303_G0.7130.14
175_D183_A0.7110.14
224_E257_E0.7080.14
153_V159_C0.7080.14
157_G172_L0.7060.14
132_R368_D0.7050.14
280_C286_P0.7050.14
97_P101_S0.7020.14
91_T101_S0.7010.14
284_L341_K0.7010.14
227_P279_N0.7000.14
320_V352_V0.6980.14
223_Q360_S0.6970.14
209_D258_F0.6960.14
82_G108_E0.6960.14
167_S175_D0.6950.14
130_M133_E0.6950.14
159_C163_E0.6940.14
320_V324_P0.6920.14
127_T140_T0.6920.14
239_E352_V0.6920.14
78_A309_D0.6900.14
309_D359_E0.6890.14
340_L385_R0.6870.14
66_R69_R0.6840.14
177_D189_G0.6830.14
207_V350_E0.6800.14
191_G240_M0.6790.14
225_V304_R0.6730.13
194_N198_F0.6720.13
272_S297_R0.6720.13
102_K109_A0.6680.13
84_R113_N0.6660.13
209_D215_G0.6650.13
287_E382_I0.6630.13
162_D172_L0.6620.13
101_S106_T0.6610.13
171_R174_Y0.6590.13
96_R99_F0.6580.13
84_R101_S0.6570.13
314_A381_T0.6550.13
83_A342_A0.6540.13
260_L365_S0.6520.13
119_V141_S0.6510.13
204_G269_A0.6450.13
196_K304_R0.6450.13
174_Y184_D0.6450.13
208_L229_G0.6440.13
157_G165_E0.6440.13
308_S363_F0.6430.13
378_V381_T0.6430.13
309_D323_D0.6420.13
243_K362_E0.6420.13
262_E365_S0.6410.13
377_L381_T0.6410.13
322_M327_L0.6370.13
211_G215_G0.6350.13
296_Y317_P0.6350.13
84_R89_A0.6350.13
86_D357_K0.6340.13
91_T99_F0.6340.13
276_V329_G0.6310.13
237_T241_I0.6300.13
273_V292_F0.6290.13
83_A103_R0.6250.13
215_G235_D0.6170.12
348_G387_P0.6170.12
213_G237_T0.6160.12
198_F260_L0.6150.12
73_D77_R0.6150.12
309_D373_L0.6140.12
208_L285_A0.6120.12
157_G169_S0.6120.12
259_R267_P0.6110.12
96_R303_G0.6100.12
102_K112_S0.6080.12
119_V123_D0.6080.12
208_L348_G0.6080.12
362_E373_L0.6070.12
279_N309_D0.6070.12
288_K291_V0.6050.12
368_D376_Y0.6050.12
235_D360_S0.6040.12
64_R69_R0.6040.12
214_A279_N0.6030.12
220_L277_I0.6010.12
269_A294_D0.6010.12
222_A273_V0.6000.12
83_A104_S0.6000.12
280_C340_L0.5980.12
341_K383_E0.5980.12
231_V347_A0.5950.12
192_C222_A0.5950.12
227_P348_G0.5930.12
139_A142_G0.5920.12
162_D177_D0.5920.12
177_D188_L0.5880.12
304_R350_E0.5880.12
281_V344_L0.5880.12
277_I306_A0.5850.12
170_E362_E0.5820.12
292_F313_T0.5810.12
148_D156_D0.5810.12
227_P235_D0.5760.12
115_N131_V0.5750.12
317_P376_Y0.5750.12
370_D373_L0.5730.12
220_L278_S0.5720.12
256_V260_L0.5720.12
215_G258_F0.5710.12
281_V355_A0.5680.12
86_D92_N0.5670.12
175_D184_D0.5660.12
206_T272_S0.5650.12
172_L175_D0.5650.12
221_A256_V0.5630.11
320_V361_T0.5620.11
153_V161_S0.5610.11
375_E379_S0.5610.11
218_C254_E0.5600.11
281_V358_D0.5600.11
268_V307_I0.5570.11
254_E364_I0.5570.11
199_A275_V0.5550.11
349_F386_K0.5550.11
130_M152_D0.5530.11
269_A332_A0.5490.11
217_D275_V0.5470.11
184_D218_C0.5470.11
213_G222_A0.5460.11
272_S381_T0.5450.11
159_C309_D0.5430.11
149_V153_V0.5430.11
187_D239_E0.5430.11
288_K309_D0.5410.11
74_C84_R0.5410.11
107_C115_N0.5400.11
268_V274_N0.5400.11
189_G264_G0.5380.11
180_A184_D0.5380.11
94_P97_P0.5370.11
273_V294_D0.5350.11
319_D322_M0.5340.11
209_D348_G0.5330.11
319_D329_G0.5320.11
279_N362_E0.5310.11
367_W370_D0.5300.11
320_V330_C0.5300.11
162_D267_P0.5290.11
215_G302_G0.5280.11
77_R142_G0.5270.11
107_C110_T0.5270.11
169_S174_Y0.5260.11
93_R98_K0.5250.11
84_R94_P0.5250.11
169_S175_D0.5250.11
171_R236_M0.5240.11
375_E380_A0.5240.11
256_V278_S0.5230.11
64_R70_R0.5230.11
203_P380_A0.5210.11
222_A231_V0.5200.11
229_G304_R0.5190.11
158_G220_L0.5180.11
153_V303_G0.5180.11
119_V130_M0.5180.11
115_N143_Q0.5140.11
89_A299_L0.5120.11
363_F371_R0.5120.11
95_R124_P0.5110.11
214_A218_C0.5110.11
281_V328_T0.5100.11
91_T114_D0.5080.11
282_V355_A0.5070.11
104_S108_E0.5070.11
241_I304_R0.5070.11
80_S104_S0.5070.11
304_R360_S0.5050.11
159_C234_V0.5040.11
212_S386_K0.5030.11
205_E228_D0.5010.10
239_E277_I0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fsdA 1 0.532 100 0.644 Contact Map
3f4kA 2 0.5601 100 0.67 Contact Map
3g5tA 1 0.5601 100 0.683 Contact Map
3gu3A 2 0.5294 100 0.686 Contact Map
2yqzA 1 0.5448 100 0.699 Contact Map
1vl5A 1 0.4987 100 0.702 Contact Map
3egeA 1 0.509 100 0.705 Contact Map
2o57A 2 0.5985 100 0.705 Contact Map
4pneA 2 0.5831 100 0.709 Contact Map
4obxA 2 0.5013 100 0.711 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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