O52023 - HALSA - GREMLIN Contacts

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O52023 - Uncharacterized protein

UniProt:	O52023	Sequences: MRRLTTLFPSKFLEEHAEELGVVEREGKLQIPVLVWALVFGFAAGESRTLAGFRRCYNSTADETISPGGFYHRLTPTLAEYLRDLVEHGLDEVAVPDTVDADIDRFRDVMIADGTVLRLHEFLSDEFQARHEEQAGAKLHLLHNATDETIERIDVTDEKTHDSTLFKTGSWLQERLVLFDRAYFKYRRFALIDENDGYFVSRLKENANPLITEELREWRGRAIPLEGKQIHDVVDDISRKYIDVEVEAEFKRGQYEGTRSLDTKRFRVVGVRDSDADDYHLYITNLPRDEFFPEDLATLYRCRWEVETLFRELKTQYELDEFNTSDPDVVKILLYAALLSLLVSRELLDLVTEQADDEIVFPPERWAATFRSHAQLILQELGEYLGYSPPPLLERLIEDAQKIHQQRPILQETLATATQPRCES	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	424 (344)
Sequences:	959 (775)
Seq/√Len:	41.8

ECOLI - INSG INSL1 INSL2 INSL3
HALSA - O52023 O51966 O51972 O54648 Q9HI34 Q9HI01 O54644

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
198_Y	285_N	5.434	1.00
114_G	162_D	5.035	1.00
68_G	72_H	4.605	1.00
172_L	175_R	4.088	1.00
178_L	299_L	4.024	1.00
69_G	72_H	3.918	1.00
324_T	329_V	3.893	1.00
73_R	76_P	3.776	1.00
111_I	145_A	3.482	1.00
66_S	69_G	3.301	1.00
140_H	183_Y	3.248	1.00
199_F	266_F	3.040	1.00
323_N	333_L	2.826	1.00
86_V	338_L	2.800	1.00
74_L	332_I	2.787	1.00
199_F	285_N	2.727	1.00
38_L	41_G	2.708	1.00
110_M	175_R	2.576	1.00
192_I	197_G	2.556	1.00
308_T	311_R	2.452	1.00
176_L	286_L	2.448	1.00
179_F	201_S	2.397	1.00
136_G	158_E	2.366	1.00
87_E	152_R	2.346	1.00
125_D	327_P	2.344	1.00
108_D	175_R	2.297	1.00
298_T	301_R	2.280	1.00
203_L	207_A	2.173	1.00
49_T	296_L	2.080	0.99
141_L	310_F	2.036	0.99
270_G	279_Y	2.026	0.99
30_Q	33_V	2.017	0.99
31_I	81_Y	2.009	0.99
311_R	315_T	1.981	0.99
271_V	297_A	1.975	0.99
161_H	164_T	1.948	0.99
21_G	24_E	1.939	0.99
79_A	331_K	1.930	0.99
93_V	346_E	1.913	0.99
239_R	242_I	1.913	0.99
152_R	170_S	1.900	0.99
286_L	291_F	1.891	0.99
306_V	310_F	1.849	0.98
83_R	331_K	1.809	0.98
107_R	198_Y	1.809	0.98
191_L	195_N	1.803	0.98
311_R	316_Q	1.791	0.98
140_H	156_T	1.784	0.98
238_S	241_Y	1.762	0.98
23_V	31_I	1.752	0.98
189_F	201_S	1.734	0.98
105_R	295_D	1.725	0.97
112_A	142_L	1.711	0.97
156_T	160_T	1.703	0.97
24_E	27_G	1.683	0.97
110_M	151_E	1.663	0.97
107_R	176_L	1.658	0.97
86_V	341_L	1.625	0.96
247_E	250_F	1.622	0.96
348_L	366_W	1.595	0.96
182_A	204_K	1.544	0.95
282_Y	296_L	1.539	0.95
267_R	304_W	1.534	0.95
162_D	182_A	1.519	0.95
201_S	283_I	1.483	0.94
132_E	205_E	1.471	0.94
364_E	371_R	1.470	0.94
38_L	336_A	1.468	0.94
153_I	338_L	1.464	0.93
186_Y	207_A	1.442	0.93
181_R	201_S	1.431	0.93
13_L	16_H	1.426	0.93
332_I	336_A	1.422	0.92
361_F	366_W	1.417	0.92
110_M	172_L	1.411	0.92
327_P	331_K	1.406	0.92
184_F	207_A	1.395	0.92
181_R	202_R	1.385	0.91
115_T	314_K	1.379	0.91
357_D	360_V	1.378	0.91
34_L	73_R	1.374	0.91
284_T	296_L	1.366	0.91
178_L	277_D	1.365	0.91
34_L	77_T	1.341	0.90
180_D	307_E	1.336	0.90
27_G	77_T	1.334	0.90
273_D	277_D	1.331	0.90
23_V	27_G	1.327	0.90
19_E	84_D	1.327	0.90
29_L	37_A	1.319	0.89
193_D	285_N	1.310	0.89
272_R	277_D	1.304	0.89
22_V	81_Y	1.300	0.89
138_K	285_N	1.293	0.88
115_T	139_L	1.281	0.88
34_L	74_L	1.272	0.87
142_L	151_E	1.269	0.87
180_D	300_Y	1.258	0.87
74_L	77_T	1.257	0.87
291_F	296_L	1.255	0.87
315_T	343_V	1.254	0.87
83_R	87_E	1.236	0.86
120_H	333_L	1.225	0.85
50_L	53_F	1.219	0.85
74_L	333_L	1.218	0.85
345_R	348_L	1.217	0.85
119_L	137_A	1.217	0.85
312_E	345_R	1.209	0.85
13_L	17_A	1.207	0.84
144_N	181_R	1.202	0.84
113_D	307_E	1.200	0.84
32_P	36_W	1.199	0.84
171_W	177_V	1.196	0.84
155_V	331_K	1.195	0.84
356_D	360_V	1.194	0.84
116_V	138_K	1.193	0.84
324_T	333_L	1.191	0.84
49_T	53_F	1.191	0.84
169_G	341_L	1.188	0.84
8_F	49_T	1.187	0.83
57_Y	195_N	1.177	0.83
50_L	71_Y	1.168	0.82
274_S	306_V	1.157	0.82
143_H	335_Y	1.150	0.81
271_V	280_H	1.147	0.81
120_H	330_V	1.138	0.81
156_T	165_L	1.137	0.81
82_L	328_D	1.136	0.81
8_F	89_G	1.133	0.80
367_A	371_R	1.131	0.80
117_L	139_L	1.131	0.80
12_F	16_H	1.127	0.80
190_A	194_E	1.124	0.80
20_L	23_V	1.122	0.80
274_S	277_D	1.120	0.80
167_K	188_R	1.119	0.80
77_T	82_L	1.119	0.80
34_L	37_A	1.114	0.79
108_D	181_R	1.104	0.79
292_F	295_D	1.095	0.78
312_E	341_L	1.088	0.78
214_E	217_E	1.081	0.77
113_D	180_D	1.076	0.77
11_K	15_E	1.076	0.77
77_T	332_I	1.071	0.77
82_L	332_I	1.069	0.76
202_R	304_W	1.065	0.76
31_I	77_T	1.064	0.76
4_L	18_E	1.043	0.75
309_L	317_Y	1.043	0.75
22_V	31_I	1.043	0.75
39_V	336_A	1.042	0.75
49_T	208_N	1.039	0.74
73_R	77_T	1.039	0.74
141_L	150_I	1.035	0.74
150_I	309_L	1.024	0.73
205_E	283_I	1.024	0.73
307_E	314_K	1.022	0.73
10_S	14_E	1.019	0.73
200_V	299_L	1.017	0.73
144_N	147_D	1.014	0.73
79_A	328_D	1.007	0.72
131_H	317_Y	1.006	0.72
34_L	134_Q	1.001	0.72
110_M	142_L	0.996	0.71
194_E	265_R	0.996	0.71
295_D	306_V	0.993	0.71
352_T	361_F	0.984	0.70
89_G	342_L	0.984	0.70
142_L	177_V	0.983	0.70
110_M	177_V	0.978	0.70
73_R	106_F	0.972	0.69
312_E	316_Q	0.970	0.69
74_L	134_Q	0.969	0.69
248_A	251_K	0.968	0.69
176_L	200_V	0.965	0.69
35_V	39_V	0.965	0.69
91_D	193_D	0.962	0.68
187_R	338_L	0.961	0.68
173_Q	299_L	0.955	0.68
193_D	199_F	0.954	0.68
70_F	311_R	0.954	0.68
135_A	332_I	0.952	0.68
296_L	341_L	0.948	0.67
10_S	32_P	0.943	0.67
179_F	182_A	0.943	0.67
75_T	326_D	0.942	0.67
131_H	356_D	0.939	0.67
135_A	333_L	0.938	0.66
14_E	35_V	0.936	0.66
110_M	171_W	0.931	0.66
173_Q	196_D	0.928	0.66
312_E	330_V	0.928	0.66
31_I	34_L	0.927	0.66
104_D	107_R	0.926	0.65
68_G	71_Y	0.926	0.65
122_F	135_A	0.923	0.65
74_L	324_T	0.921	0.65
77_T	181_R	0.921	0.65
368_A	371_R	0.919	0.65
113_D	284_T	0.919	0.65
179_F	282_Y	0.918	0.65
6_T	10_S	0.917	0.65
247_E	251_K	0.917	0.65
67_P	326_D	0.916	0.65
366_W	377_I	0.909	0.64
153_I	215_L	0.907	0.64
33_V	149_T	0.905	0.64
162_D	342_L	0.903	0.63
127_F	312_E	0.901	0.63
271_V	282_Y	0.898	0.63
9_P	14_E	0.897	0.63
157_D	182_A	0.888	0.62
123_L	325_S	0.888	0.62
302_C	305_E	0.887	0.62
11_K	151_E	0.887	0.62
124_S	128_Q	0.882	0.62
104_D	109_V	0.881	0.62
310_F	372_S	0.880	0.61
38_L	324_T	0.878	0.61
127_F	136_G	0.878	0.61
157_D	372_S	0.864	0.60
180_D	314_K	0.863	0.60
171_W	295_D	0.863	0.60
175_R	192_I	0.859	0.60
127_F	309_L	0.858	0.60
113_D	304_W	0.856	0.59
109_V	299_L	0.848	0.59
10_S	13_L	0.842	0.58
150_I	342_L	0.841	0.58
189_F	328_D	0.832	0.57
178_L	193_D	0.827	0.57
25_R	30_Q	0.827	0.57
311_R	314_K	0.824	0.56
304_W	307_E	0.822	0.56
104_D	339_L	0.821	0.56
118_R	136_G	0.820	0.56
113_D	202_R	0.817	0.56
152_R	349_D	0.814	0.55
83_R	168_T	0.813	0.55
162_D	180_D	0.813	0.55
269_V	284_T	0.812	0.55
139_L	334_L	0.811	0.55
15_E	18_E	0.810	0.55
13_L	30_Q	0.803	0.54
68_G	118_R	0.799	0.54
79_A	83_R	0.798	0.54
211_I	240_K	0.797	0.54
85_L	292_F	0.795	0.54
238_S	242_I	0.794	0.54
248_A	283_I	0.794	0.54
300_Y	303_R	0.794	0.54
108_D	172_L	0.793	0.54
77_T	342_L	0.784	0.53
347_L	351_V	0.784	0.53
85_L	338_L	0.783	0.53
84_D	88_H	0.779	0.52
142_L	171_W	0.775	0.52
203_L	206_N	0.774	0.52
55_R	164_T	0.769	0.51
29_L	70_F	0.769	0.51
29_L	33_V	0.768	0.51
181_R	207_A	0.766	0.51
7_L	12_F	0.759	0.50
53_F	58_N	0.757	0.50
366_W	372_S	0.756	0.50
134_Q	158_E	0.755	0.50
369_T	375_Q	0.755	0.50
319_L	337_A	0.755	0.50
182_A	203_L	0.754	0.50
364_E	368_A	0.745	0.49
287_P	291_F	0.745	0.49
12_F	88_H	0.743	0.49
155_V	266_F	0.742	0.49
280_H	297_A	0.742	0.49
49_T	68_G	0.740	0.49
179_F	192_I	0.738	0.48
8_F	189_F	0.738	0.48
9_P	12_F	0.735	0.48
268_V	286_L	0.735	0.48
8_F	21_G	0.734	0.48
5_T	15_E	0.734	0.48
14_E	155_V	0.733	0.48
107_R	291_F	0.731	0.48
357_D	368_A	0.731	0.48
103_I	306_V	0.730	0.48
177_V	283_I	0.728	0.47
138_K	158_E	0.725	0.47
362_P	365_R	0.716	0.46
128_Q	309_L	0.712	0.46
273_D	280_H	0.710	0.46
155_V	334_L	0.709	0.46
113_D	303_R	0.707	0.45
306_V	375_Q	0.707	0.45
206_N	350_L	0.705	0.45
138_K	161_H	0.703	0.45
14_E	32_P	0.703	0.45
303_R	307_E	0.697	0.45
309_L	359_I	0.697	0.45
199_F	271_V	0.696	0.44
90_L	342_L	0.695	0.44
29_L	69_G	0.695	0.44
212_T	265_R	0.694	0.44
209_P	242_I	0.694	0.44
149_T	346_E	0.693	0.44
23_V	26_E	0.693	0.44
80_E	83_R	0.692	0.44
290_E	294_E	0.690	0.44
41_G	324_T	0.687	0.44
52_G	368_A	0.687	0.44
109_V	213_E	0.686	0.44
180_D	304_W	0.686	0.44
18_E	21_G	0.686	0.44
126_E	129_A	0.683	0.43
138_K	150_I	0.683	0.43
14_E	18_E	0.682	0.43
163_S	204_K	0.681	0.43
83_R	171_W	0.680	0.43
35_V	82_L	0.680	0.43
41_G	70_F	0.679	0.43
365_R	375_Q	0.676	0.43
41_G	332_I	0.674	0.42
128_Q	157_D	0.674	0.42
115_T	182_A	0.674	0.42
150_I	185_K	0.673	0.42
359_I	362_P	0.672	0.42
122_F	325_S	0.670	0.42
365_R	369_T	0.670	0.42
111_I	332_I	0.668	0.42
196_D	292_F	0.668	0.42
53_F	336_A	0.668	0.42
157_D	160_T	0.666	0.42
358_E	363_P	0.663	0.41
66_S	240_K	0.663	0.41
293_P	329_V	0.661	0.41
73_R	329_V	0.660	0.41
309_L	341_L	0.659	0.41
146_T	302_C	0.659	0.41
179_F	210_L	0.658	0.41
141_L	334_L	0.657	0.41
128_Q	136_G	0.657	0.41
110_M	162_D	0.657	0.41
107_R	285_N	0.655	0.41
306_V	338_L	0.652	0.40
316_Q	364_E	0.649	0.40
137_A	334_L	0.649	0.40
337_A	375_Q	0.647	0.40
295_D	345_R	0.647	0.40
89_G	339_L	0.646	0.40
161_H	181_R	0.646	0.40
151_E	330_V	0.645	0.40
140_H	333_L	0.645	0.40
205_E	330_V	0.644	0.40
270_G	281_L	0.643	0.40
144_N	202_R	0.643	0.40
185_K	324_T	0.641	0.39
28_K	33_V	0.640	0.39
171_W	197_G	0.640	0.39
366_W	370_F	0.638	0.39
181_R	204_K	0.637	0.39
126_E	331_K	0.634	0.39
311_R	317_Y	0.633	0.39
183_Y	343_V	0.632	0.39
151_E	350_L	0.632	0.39
133_E	322_F	0.632	0.39
155_V	297_A	0.631	0.39
117_L	334_L	0.630	0.38
175_R	197_G	0.628	0.38
74_L	81_Y	0.625	0.38
140_H	311_R	0.624	0.38
129_A	334_L	0.623	0.38
91_D	269_V	0.623	0.38
71_Y	329_V	0.622	0.38
161_H	347_L	0.622	0.38
114_G	180_D	0.622	0.38
182_A	344_S	0.621	0.38
166_F	188_R	0.620	0.38
161_H	205_E	0.620	0.38
138_K	325_S	0.620	0.38
37_A	108_D	0.620	0.38
125_D	135_A	0.618	0.37
166_F	177_V	0.617	0.37
8_F	35_V	0.615	0.37
104_D	299_L	0.615	0.37
141_L	208_N	0.614	0.37
14_E	91_D	0.613	0.37
107_R	290_E	0.613	0.37
288_R	291_F	0.612	0.37
284_T	304_W	0.612	0.37
5_T	8_F	0.611	0.37
12_F	92_E	0.610	0.37
47_S	109_V	0.609	0.37
16_H	19_E	0.607	0.36
34_L	71_Y	0.606	0.36
81_Y	128_Q	0.606	0.36
92_E	281_L	0.603	0.36
15_E	292_F	0.603	0.36
86_V	90_L	0.601	0.36
66_S	72_H	0.600	0.36
162_D	166_F	0.600	0.36
139_L	302_C	0.600	0.36
365_R	368_A	0.599	0.36
141_L	341_L	0.597	0.36
186_Y	264_K	0.594	0.35
14_E	85_L	0.593	0.35
183_Y	318_E	0.593	0.35
113_D	314_K	0.591	0.35
161_H	182_A	0.591	0.35
53_F	57_Y	0.587	0.35
127_F	331_K	0.586	0.35
145_A	299_L	0.585	0.35
202_R	307_E	0.585	0.35
35_V	336_A	0.585	0.35
114_G	136_G	0.583	0.34
180_D	303_R	0.583	0.34
200_V	296_L	0.583	0.34
40_F	112_A	0.581	0.34
26_E	35_V	0.581	0.34
34_L	332_I	0.580	0.34
81_Y	85_L	0.580	0.34
285_N	291_F	0.579	0.34
18_E	43_A	0.579	0.34
72_H	137_A	0.577	0.34
128_Q	316_Q	0.576	0.34
162_D	323_N	0.574	0.34
158_E	344_S	0.573	0.34
25_R	332_I	0.573	0.34
58_N	66_S	0.572	0.33
211_I	268_V	0.571	0.33
4_L	237_I	0.571	0.33
87_E	350_L	0.570	0.33
119_L	322_F	0.566	0.33
300_Y	307_E	0.566	0.33
16_H	37_A	0.565	0.33
360_V	364_E	0.565	0.33
189_F	207_A	0.565	0.33
27_G	345_R	0.564	0.33
173_Q	241_Y	0.564	0.33
15_E	133_E	0.564	0.33
18_E	353_E	0.564	0.33
19_E	22_V	0.562	0.33
24_E	31_I	0.561	0.33
249_E	258_T	0.561	0.33
51_A	369_T	0.560	0.32
196_D	277_D	0.559	0.32
152_R	176_L	0.558	0.32
296_L	310_F	0.558	0.32
19_E	91_D	0.558	0.32
138_K	162_D	0.557	0.32
121_E	135_A	0.556	0.32
204_K	334_L	0.556	0.32
176_L	203_L	0.554	0.32
83_R	286_L	0.551	0.32
86_V	333_L	0.550	0.32
294_E	298_T	0.549	0.32
54_R	70_F	0.549	0.32
116_V	204_K	0.549	0.32
5_T	39_V	0.548	0.31
16_H	84_D	0.548	0.31
200_V	337_A	0.548	0.31
287_P	348_L	0.547	0.31
14_E	212_T	0.545	0.31
193_D	264_K	0.544	0.31
369_T	377_I	0.542	0.31
322_F	360_V	0.541	0.31
78_L	197_G	0.541	0.31
163_S	188_R	0.541	0.31
134_Q	333_L	0.538	0.31
285_N	329_V	0.536	0.31
200_V	329_V	0.535	0.30
153_I	168_T	0.535	0.30
176_L	290_E	0.535	0.30
367_A	372_S	0.534	0.30
39_V	340_S	0.534	0.30
140_H	162_D	0.534	0.30
61_A	287_P	0.534	0.30
33_V	36_W	0.534	0.30
85_L	283_I	0.531	0.30
101_A	105_R	0.531	0.30
363_P	367_A	0.530	0.30
11_K	14_E	0.527	0.30
120_H	135_A	0.527	0.30
82_L	281_L	0.527	0.30
55_R	64_T	0.526	0.30
182_A	241_Y	0.526	0.30
44_A	313_L	0.525	0.30
324_T	330_V	0.525	0.30
210_L	214_E	0.524	0.30
8_F	15_E	0.524	0.30
108_D	144_N	0.520	0.29
74_L	104_D	0.520	0.29
29_L	324_T	0.519	0.29
90_L	134_Q	0.519	0.29
128_Q	294_E	0.519	0.29
20_L	81_Y	0.518	0.29
53_F	362_P	0.515	0.29
37_A	157_D	0.515	0.29
66_S	192_I	0.515	0.29
143_H	152_R	0.514	0.29
99_V	102_D	0.513	0.29
367_A	373_H	0.513	0.29
249_E	261_L	0.511	0.29
364_E	369_T	0.510	0.29
211_I	242_I	0.510	0.29
177_V	197_G	0.509	0.28
14_E	265_R	0.508	0.28
136_G	162_D	0.508	0.28
142_L	188_R	0.508	0.28
143_H	165_L	0.506	0.28
104_D	198_Y	0.505	0.28
82_L	336_A	0.505	0.28
80_E	194_E	0.504	0.28
237_I	242_I	0.503	0.28
10_S	186_Y	0.503	0.28
28_K	64_T	0.501	0.28
299_L	317_Y	0.500	0.28

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1musA	2	0.8491	100	0.703	Contact Map
3pm8A	2	0.2594	18.9	0.967	Contact Map
1w7jB	1	0.2476	18.1	0.967	Contact Map
1rroA	1	0.2476	18	0.967	Contact Map
2kycA	1	0.2476	17.5	0.968	Contact Map
4ociA	2	0.2689	16.4	0.968	Contact Map
1s1eA	1	0.3019	14.2	0.969	Contact Map
1rwyA	1	0.25	13.9	0.969	Contact Map
4mvfA	1	0.2594	13.9	0.969	Contact Map
1m45A	1	0.2524	13.6	0.969	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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