GREMLIN Database
O52023 - Uncharacterized protein
UniProt: O52023 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 424 (344)
Sequences: 959 (775)
Seq/√Len: 41.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_Y285_N5.4341.00
114_G162_D5.0351.00
68_G72_H4.6051.00
172_L175_R4.0881.00
178_L299_L4.0241.00
69_G72_H3.9181.00
324_T329_V3.8931.00
73_R76_P3.7761.00
111_I145_A3.4821.00
66_S69_G3.3011.00
140_H183_Y3.2481.00
199_F266_F3.0401.00
323_N333_L2.8261.00
86_V338_L2.8001.00
74_L332_I2.7871.00
199_F285_N2.7271.00
38_L41_G2.7081.00
110_M175_R2.5761.00
192_I197_G2.5561.00
308_T311_R2.4521.00
176_L286_L2.4481.00
179_F201_S2.3971.00
136_G158_E2.3661.00
87_E152_R2.3461.00
125_D327_P2.3441.00
108_D175_R2.2971.00
298_T301_R2.2801.00
203_L207_A2.1731.00
49_T296_L2.0800.99
141_L310_F2.0360.99
270_G279_Y2.0260.99
30_Q33_V2.0170.99
31_I81_Y2.0090.99
311_R315_T1.9810.99
271_V297_A1.9750.99
161_H164_T1.9480.99
21_G24_E1.9390.99
79_A331_K1.9300.99
93_V346_E1.9130.99
239_R242_I1.9130.99
152_R170_S1.9000.99
286_L291_F1.8910.99
306_V310_F1.8490.98
83_R331_K1.8090.98
107_R198_Y1.8090.98
191_L195_N1.8030.98
311_R316_Q1.7910.98
140_H156_T1.7840.98
238_S241_Y1.7620.98
23_V31_I1.7520.98
189_F201_S1.7340.98
105_R295_D1.7250.97
112_A142_L1.7110.97
156_T160_T1.7030.97
24_E27_G1.6830.97
110_M151_E1.6630.97
107_R176_L1.6580.97
86_V341_L1.6250.96
247_E250_F1.6220.96
348_L366_W1.5950.96
182_A204_K1.5440.95
282_Y296_L1.5390.95
267_R304_W1.5340.95
162_D182_A1.5190.95
201_S283_I1.4830.94
132_E205_E1.4710.94
364_E371_R1.4700.94
38_L336_A1.4680.94
153_I338_L1.4640.93
186_Y207_A1.4420.93
181_R201_S1.4310.93
13_L16_H1.4260.93
332_I336_A1.4220.92
361_F366_W1.4170.92
110_M172_L1.4110.92
327_P331_K1.4060.92
184_F207_A1.3950.92
181_R202_R1.3850.91
115_T314_K1.3790.91
357_D360_V1.3780.91
34_L73_R1.3740.91
284_T296_L1.3660.91
178_L277_D1.3650.91
34_L77_T1.3410.90
180_D307_E1.3360.90
27_G77_T1.3340.90
273_D277_D1.3310.90
23_V27_G1.3270.90
19_E84_D1.3270.90
29_L37_A1.3190.89
193_D285_N1.3100.89
272_R277_D1.3040.89
22_V81_Y1.3000.89
138_K285_N1.2930.88
115_T139_L1.2810.88
34_L74_L1.2720.87
142_L151_E1.2690.87
180_D300_Y1.2580.87
74_L77_T1.2570.87
291_F296_L1.2550.87
315_T343_V1.2540.87
83_R87_E1.2360.86
120_H333_L1.2250.85
50_L53_F1.2190.85
74_L333_L1.2180.85
345_R348_L1.2170.85
119_L137_A1.2170.85
312_E345_R1.2090.85
13_L17_A1.2070.84
144_N181_R1.2020.84
113_D307_E1.2000.84
32_P36_W1.1990.84
171_W177_V1.1960.84
155_V331_K1.1950.84
356_D360_V1.1940.84
116_V138_K1.1930.84
324_T333_L1.1910.84
49_T53_F1.1910.84
169_G341_L1.1880.84
8_F49_T1.1870.83
57_Y195_N1.1770.83
50_L71_Y1.1680.82
274_S306_V1.1570.82
143_H335_Y1.1500.81
271_V280_H1.1470.81
120_H330_V1.1380.81
156_T165_L1.1370.81
82_L328_D1.1360.81
8_F89_G1.1330.80
367_A371_R1.1310.80
117_L139_L1.1310.80
12_F16_H1.1270.80
190_A194_E1.1240.80
20_L23_V1.1220.80
274_S277_D1.1200.80
167_K188_R1.1190.80
77_T82_L1.1190.80
34_L37_A1.1140.79
108_D181_R1.1040.79
292_F295_D1.0950.78
312_E341_L1.0880.78
214_E217_E1.0810.77
113_D180_D1.0760.77
11_K15_E1.0760.77
77_T332_I1.0710.77
82_L332_I1.0690.76
202_R304_W1.0650.76
31_I77_T1.0640.76
4_L18_E1.0430.75
309_L317_Y1.0430.75
22_V31_I1.0430.75
39_V336_A1.0420.75
49_T208_N1.0390.74
73_R77_T1.0390.74
141_L150_I1.0350.74
150_I309_L1.0240.73
205_E283_I1.0240.73
307_E314_K1.0220.73
10_S14_E1.0190.73
200_V299_L1.0170.73
144_N147_D1.0140.73
79_A328_D1.0070.72
131_H317_Y1.0060.72
34_L134_Q1.0010.72
110_M142_L0.9960.71
194_E265_R0.9960.71
295_D306_V0.9930.71
352_T361_F0.9840.70
89_G342_L0.9840.70
142_L177_V0.9830.70
110_M177_V0.9780.70
73_R106_F0.9720.69
312_E316_Q0.9700.69
74_L134_Q0.9690.69
248_A251_K0.9680.69
176_L200_V0.9650.69
35_V39_V0.9650.69
91_D193_D0.9620.68
187_R338_L0.9610.68
173_Q299_L0.9550.68
193_D199_F0.9540.68
70_F311_R0.9540.68
135_A332_I0.9520.68
296_L341_L0.9480.67
10_S32_P0.9430.67
179_F182_A0.9430.67
75_T326_D0.9420.67
131_H356_D0.9390.67
135_A333_L0.9380.66
14_E35_V0.9360.66
110_M171_W0.9310.66
173_Q196_D0.9280.66
312_E330_V0.9280.66
31_I34_L0.9270.66
104_D107_R0.9260.65
68_G71_Y0.9260.65
122_F135_A0.9230.65
74_L324_T0.9210.65
77_T181_R0.9210.65
368_A371_R0.9190.65
113_D284_T0.9190.65
179_F282_Y0.9180.65
6_T10_S0.9170.65
247_E251_K0.9170.65
67_P326_D0.9160.65
366_W377_I0.9090.64
153_I215_L0.9070.64
33_V149_T0.9050.64
162_D342_L0.9030.63
127_F312_E0.9010.63
271_V282_Y0.8980.63
9_P14_E0.8970.63
157_D182_A0.8880.62
123_L325_S0.8880.62
302_C305_E0.8870.62
11_K151_E0.8870.62
124_S128_Q0.8820.62
104_D109_V0.8810.62
310_F372_S0.8800.61
38_L324_T0.8780.61
127_F136_G0.8780.61
157_D372_S0.8640.60
180_D314_K0.8630.60
171_W295_D0.8630.60
175_R192_I0.8590.60
127_F309_L0.8580.60
113_D304_W0.8560.59
109_V299_L0.8480.59
10_S13_L0.8420.58
150_I342_L0.8410.58
189_F328_D0.8320.57
178_L193_D0.8270.57
25_R30_Q0.8270.57
311_R314_K0.8240.56
304_W307_E0.8220.56
104_D339_L0.8210.56
118_R136_G0.8200.56
113_D202_R0.8170.56
152_R349_D0.8140.55
83_R168_T0.8130.55
162_D180_D0.8130.55
269_V284_T0.8120.55
139_L334_L0.8110.55
15_E18_E0.8100.55
13_L30_Q0.8030.54
68_G118_R0.7990.54
79_A83_R0.7980.54
211_I240_K0.7970.54
85_L292_F0.7950.54
238_S242_I0.7940.54
248_A283_I0.7940.54
300_Y303_R0.7940.54
108_D172_L0.7930.54
77_T342_L0.7840.53
347_L351_V0.7840.53
85_L338_L0.7830.53
84_D88_H0.7790.52
142_L171_W0.7750.52
203_L206_N0.7740.52
55_R164_T0.7690.51
29_L70_F0.7690.51
29_L33_V0.7680.51
181_R207_A0.7660.51
7_L12_F0.7590.50
53_F58_N0.7570.50
366_W372_S0.7560.50
134_Q158_E0.7550.50
369_T375_Q0.7550.50
319_L337_A0.7550.50
182_A203_L0.7540.50
364_E368_A0.7450.49
287_P291_F0.7450.49
12_F88_H0.7430.49
155_V266_F0.7420.49
280_H297_A0.7420.49
49_T68_G0.7400.49
179_F192_I0.7380.48
8_F189_F0.7380.48
9_P12_F0.7350.48
268_V286_L0.7350.48
8_F21_G0.7340.48
5_T15_E0.7340.48
14_E155_V0.7330.48
107_R291_F0.7310.48
357_D368_A0.7310.48
103_I306_V0.7300.48
177_V283_I0.7280.47
138_K158_E0.7250.47
362_P365_R0.7160.46
128_Q309_L0.7120.46
273_D280_H0.7100.46
155_V334_L0.7090.46
113_D303_R0.7070.45
306_V375_Q0.7070.45
206_N350_L0.7050.45
138_K161_H0.7030.45
14_E32_P0.7030.45
303_R307_E0.6970.45
309_L359_I0.6970.45
199_F271_V0.6960.44
90_L342_L0.6950.44
29_L69_G0.6950.44
212_T265_R0.6940.44
209_P242_I0.6940.44
149_T346_E0.6930.44
23_V26_E0.6930.44
80_E83_R0.6920.44
290_E294_E0.6900.44
41_G324_T0.6870.44
52_G368_A0.6870.44
109_V213_E0.6860.44
180_D304_W0.6860.44
18_E21_G0.6860.44
126_E129_A0.6830.43
138_K150_I0.6830.43
14_E18_E0.6820.43
163_S204_K0.6810.43
83_R171_W0.6800.43
35_V82_L0.6800.43
41_G70_F0.6790.43
365_R375_Q0.6760.43
41_G332_I0.6740.42
128_Q157_D0.6740.42
115_T182_A0.6740.42
150_I185_K0.6730.42
359_I362_P0.6720.42
122_F325_S0.6700.42
365_R369_T0.6700.42
111_I332_I0.6680.42
196_D292_F0.6680.42
53_F336_A0.6680.42
157_D160_T0.6660.42
358_E363_P0.6630.41
66_S240_K0.6630.41
293_P329_V0.6610.41
73_R329_V0.6600.41
309_L341_L0.6590.41
146_T302_C0.6590.41
179_F210_L0.6580.41
141_L334_L0.6570.41
128_Q136_G0.6570.41
110_M162_D0.6570.41
107_R285_N0.6550.41
306_V338_L0.6520.40
316_Q364_E0.6490.40
137_A334_L0.6490.40
337_A375_Q0.6470.40
295_D345_R0.6470.40
89_G339_L0.6460.40
161_H181_R0.6460.40
151_E330_V0.6450.40
140_H333_L0.6450.40
205_E330_V0.6440.40
270_G281_L0.6430.40
144_N202_R0.6430.40
185_K324_T0.6410.39
28_K33_V0.6400.39
171_W197_G0.6400.39
366_W370_F0.6380.39
181_R204_K0.6370.39
126_E331_K0.6340.39
311_R317_Y0.6330.39
183_Y343_V0.6320.39
151_E350_L0.6320.39
133_E322_F0.6320.39
155_V297_A0.6310.39
117_L334_L0.6300.38
175_R197_G0.6280.38
74_L81_Y0.6250.38
140_H311_R0.6240.38
129_A334_L0.6230.38
91_D269_V0.6230.38
71_Y329_V0.6220.38
161_H347_L0.6220.38
114_G180_D0.6220.38
182_A344_S0.6210.38
166_F188_R0.6200.38
161_H205_E0.6200.38
138_K325_S0.6200.38
37_A108_D0.6200.38
125_D135_A0.6180.37
166_F177_V0.6170.37
8_F35_V0.6150.37
104_D299_L0.6150.37
141_L208_N0.6140.37
14_E91_D0.6130.37
107_R290_E0.6130.37
288_R291_F0.6120.37
284_T304_W0.6120.37
5_T8_F0.6110.37
12_F92_E0.6100.37
47_S109_V0.6090.37
16_H19_E0.6070.36
34_L71_Y0.6060.36
81_Y128_Q0.6060.36
92_E281_L0.6030.36
15_E292_F0.6030.36
86_V90_L0.6010.36
66_S72_H0.6000.36
162_D166_F0.6000.36
139_L302_C0.6000.36
365_R368_A0.5990.36
141_L341_L0.5970.36
186_Y264_K0.5940.35
14_E85_L0.5930.35
183_Y318_E0.5930.35
113_D314_K0.5910.35
161_H182_A0.5910.35
53_F57_Y0.5870.35
127_F331_K0.5860.35
145_A299_L0.5850.35
202_R307_E0.5850.35
35_V336_A0.5850.35
114_G136_G0.5830.34
180_D303_R0.5830.34
200_V296_L0.5830.34
40_F112_A0.5810.34
26_E35_V0.5810.34
34_L332_I0.5800.34
81_Y85_L0.5800.34
285_N291_F0.5790.34
18_E43_A0.5790.34
72_H137_A0.5770.34
128_Q316_Q0.5760.34
162_D323_N0.5740.34
158_E344_S0.5730.34
25_R332_I0.5730.34
58_N66_S0.5720.33
211_I268_V0.5710.33
4_L237_I0.5710.33
87_E350_L0.5700.33
119_L322_F0.5660.33
300_Y307_E0.5660.33
16_H37_A0.5650.33
360_V364_E0.5650.33
189_F207_A0.5650.33
27_G345_R0.5640.33
173_Q241_Y0.5640.33
15_E133_E0.5640.33
18_E353_E0.5640.33
19_E22_V0.5620.33
24_E31_I0.5610.33
249_E258_T0.5610.33
51_A369_T0.5600.32
196_D277_D0.5590.32
152_R176_L0.5580.32
296_L310_F0.5580.32
19_E91_D0.5580.32
138_K162_D0.5570.32
121_E135_A0.5560.32
204_K334_L0.5560.32
176_L203_L0.5540.32
83_R286_L0.5510.32
86_V333_L0.5500.32
294_E298_T0.5490.32
54_R70_F0.5490.32
116_V204_K0.5490.32
5_T39_V0.5480.31
16_H84_D0.5480.31
200_V337_A0.5480.31
287_P348_L0.5470.31
14_E212_T0.5450.31
193_D264_K0.5440.31
369_T377_I0.5420.31
322_F360_V0.5410.31
78_L197_G0.5410.31
163_S188_R0.5410.31
134_Q333_L0.5380.31
285_N329_V0.5360.31
200_V329_V0.5350.30
153_I168_T0.5350.30
176_L290_E0.5350.30
367_A372_S0.5340.30
39_V340_S0.5340.30
140_H162_D0.5340.30
61_A287_P0.5340.30
33_V36_W0.5340.30
85_L283_I0.5310.30
101_A105_R0.5310.30
363_P367_A0.5300.30
11_K14_E0.5270.30
120_H135_A0.5270.30
82_L281_L0.5270.30
55_R64_T0.5260.30
182_A241_Y0.5260.30
44_A313_L0.5250.30
324_T330_V0.5250.30
210_L214_E0.5240.30
8_F15_E0.5240.30
108_D144_N0.5200.29
74_L104_D0.5200.29
29_L324_T0.5190.29
90_L134_Q0.5190.29
128_Q294_E0.5190.29
20_L81_Y0.5180.29
53_F362_P0.5150.29
37_A157_D0.5150.29
66_S192_I0.5150.29
143_H152_R0.5140.29
99_V102_D0.5130.29
367_A373_H0.5130.29
249_E261_L0.5110.29
364_E369_T0.5100.29
211_I242_I0.5100.29
177_V197_G0.5090.28
14_E265_R0.5080.28
136_G162_D0.5080.28
142_L188_R0.5080.28
143_H165_L0.5060.28
104_D198_Y0.5050.28
82_L336_A0.5050.28
80_E194_E0.5040.28
237_I242_I0.5030.28
10_S186_Y0.5030.28
28_K64_T0.5010.28
299_L317_Y0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1musA 2 0.8491 100 0.703 Contact Map
3pm8A 2 0.2594 18.9 0.967 Contact Map
1w7jB 1 0.2476 18.1 0.967 Contact Map
1rroA 1 0.2476 18 0.967 Contact Map
2kycA 1 0.2476 17.5 0.968 Contact Map
4ociA 2 0.2689 16.4 0.968 Contact Map
1s1eA 1 0.3019 14.2 0.969 Contact Map
1rwyA 1 0.25 13.9 0.969 Contact Map
4mvfA 1 0.2594 13.9 0.969 Contact Map
1m45A 1 0.2524 13.6 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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