O52019 - HALSA - GREMLIN Contacts

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O52019 - Uncharacterized protein

UniProt:	O52019	Sequences: MMTDELGSLLEWFDLKDELRTGWELRNVDSPESVAAHTWGTAALCLLYADQEDVDRQKAVTMALIHDLGEARTGDIATRAEDGRQTIPTSEKETAERSAVTDLVGPFNDSELLSLWEEYEARDTPTAQFVKDMDLVDNCLQALKYERQNRYDEAETTDHFTEFENLDEFFATAAPRFQTEFGQDLFKQIKSEYESEIGRPCQL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	203 (164)
Sequences:	1496 (1007)
Seq/√Len:	78.6

ECOLI - 5DNU
HALSA - O52019
SULSO - Q97W50

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_T	111_E	4.628	1.00
101_T	113_L	3.540	1.00
72_R	102_D	3.313	1.00
117_E	121_A	3.089	1.00
40_G	144_K	2.862	1.00
41_T	63_A	2.763	1.00
12_W	68_L	2.678	1.00
12_W	43_A	2.565	1.00
110_S	114_S	2.493	1.00
33_S	36_A	2.367	1.00
94_T	98_S	2.319	1.00
167_D	171_A	2.289	1.00
97_R	117_E	2.206	1.00
113_L	117_E	2.168	1.00
13_F	40_G	2.135	1.00
57_Q	61_T	2.027	1.00
87_I	90_S	1.984	1.00
45_C	133_M	1.966	1.00
46_L	61_T	1.885	1.00
122_R	131_K	1.869	1.00
119_Y	130_V	1.866	1.00
65_I	112_L	1.804	1.00
44_L	133_M	1.801	1.00
45_C	63_A	1.800	1.00
69_G	100_V	1.747	1.00
11_E	72_R	1.690	1.00
23_W	145_Y	1.689	1.00
33_S	137_D	1.671	1.00
137_D	141_Q	1.647	1.00
59_A	126_T	1.646	1.00
118_E	124_T	1.606	1.00
59_A	63_A	1.589	1.00
57_Q	60_V	1.562	0.99
179_T	182_G	1.541	0.99
114_S	117_E	1.531	0.99
53_D	125_P	1.507	0.99
26_R	29_D	1.495	0.99
22_G	145_Y	1.492	0.99
100_V	104_V	1.467	0.99
40_G	137_D	1.460	0.99
9_L	44_L	1.434	0.99
41_T	133_M	1.430	0.99
65_I	115_L	1.409	0.99
38_T	41_T	1.393	0.99
58_K	126_T	1.392	0.99
15_L	38_T	1.365	0.99
15_L	34_V	1.360	0.99
42_A	64_L	1.341	0.98
89_T	92_K	1.339	0.98
80_A	88_P	1.322	0.98
97_R	101_T	1.317	0.98
52_E	125_P	1.309	0.98
91_E	95_A	1.290	0.98
21_T	77_A	1.277	0.98
30_S	36_A	1.266	0.98
63_A	130_V	1.264	0.98
101_T	117_E	1.258	0.98
80_A	95_A	1.247	0.97
180_E	184_D	1.243	0.97
62_M	124_T	1.241	0.97
162_E	165_N	1.227	0.97
11_E	14_D	1.217	0.97
77_A	80_A	1.213	0.97
18_E	34_V	1.193	0.97
56_R	60_V	1.186	0.97
72_R	103_L	1.183	0.96
88_P	91_E	1.176	0.96
55_D	58_K	1.173	0.96
23_W	31_P	1.168	0.96
49_A	56_R	1.162	0.96
122_R	127_A	1.154	0.96
54_V	59_A	1.135	0.96
162_E	166_L	1.110	0.95
115_L	118_E	1.105	0.95
102_D	105_G	1.103	0.95
147_R	150_R	1.087	0.94
45_C	59_A	1.078	0.94
48_Y	59_A	1.054	0.93
173_A	177_F	1.052	0.93
44_L	136_V	1.049	0.93
12_W	64_L	1.049	0.93
54_V	129_F	1.043	0.93
23_W	141_Q	1.035	0.93
4_D	7_G	1.034	0.93
92_K	131_K	1.027	0.92
26_R	168_E	1.020	0.92
36_A	137_D	1.011	0.92
141_Q	145_Y	0.997	0.91
170_F	173_A	0.996	0.91
55_D	126_T	0.986	0.91
5_E	9_L	0.971	0.90
13_F	144_K	0.951	0.89
119_Y	131_K	0.951	0.89
180_E	183_Q	0.924	0.88
132_D	179_T	0.918	0.87
93_E	97_R	0.911	0.87
23_W	148_Q	0.908	0.87
125_P	129_F	0.903	0.87
142_A	145_Y	0.896	0.86
8_S	107_F	0.894	0.86
118_E	123_D	0.888	0.86
166_L	169_F	0.875	0.85
99_A	102_D	0.874	0.85
163_F	166_L	0.870	0.85
46_L	60_V	0.869	0.84
122_R	135_L	0.864	0.84
49_A	57_Q	0.860	0.84
63_A	119_Y	0.853	0.83
110_S	113_L	0.842	0.83
59_A	130_V	0.840	0.82
67_D	70_E	0.817	0.81
96_E	103_L	0.813	0.80
78_T	131_K	0.801	0.79
46_L	116_W	0.785	0.78
166_L	173_A	0.784	0.78
167_D	173_A	0.781	0.78
145_Y	148_Q	0.781	0.78
176_R	179_T	0.771	0.77
25_L	141_Q	0.771	0.77
92_K	119_Y	0.769	0.76
125_P	128_Q	0.764	0.76
38_T	42_A	0.758	0.75
92_K	95_A	0.753	0.75
25_L	135_L	0.751	0.75
62_M	126_T	0.745	0.74
62_M	65_I	0.744	0.74
19_L	31_P	0.741	0.74
54_V	125_P	0.737	0.73
131_K	135_L	0.732	0.73
9_L	79_R	0.730	0.73
14_D	17_D	0.724	0.72
43_A	64_L	0.718	0.71
22_G	144_K	0.713	0.71
61_T	65_I	0.712	0.71
62_M	118_E	0.708	0.70
77_A	137_D	0.707	0.70
22_G	141_Q	0.707	0.70
76_I	92_K	0.706	0.70
46_L	112_L	0.699	0.69
36_A	116_W	0.690	0.68
58_K	114_S	0.686	0.68
58_K	118_E	0.685	0.68
66_H	70_E	0.683	0.68
7_G	121_A	0.682	0.67
86_T	89_T	0.682	0.67
43_A	65_I	0.680	0.67
20_R	32_E	0.675	0.67
43_A	61_T	0.672	0.66
56_R	59_A	0.671	0.66
178_Q	182_G	0.671	0.66
41_T	44_L	0.670	0.66
91_E	94_T	0.670	0.66
17_D	33_S	0.668	0.66
167_D	170_F	0.667	0.66
19_L	30_S	0.666	0.66
6_L	144_K	0.664	0.65
16_K	32_E	0.662	0.65
104_V	113_L	0.661	0.65
19_L	23_W	0.655	0.64
174_A	178_Q	0.653	0.64
22_G	78_T	0.647	0.63
45_C	129_F	0.647	0.63
41_T	112_L	0.643	0.63
121_A	175_P	0.641	0.63
88_P	92_K	0.641	0.63
94_T	102_D	0.637	0.62
87_I	91_E	0.635	0.62
171_A	175_P	0.632	0.62
97_R	113_L	0.632	0.62
18_E	33_S	0.632	0.62
15_L	63_A	0.631	0.61
21_T	40_G	0.629	0.61
15_L	22_G	0.628	0.61
10_L	140_L	0.628	0.61
16_K	141_Q	0.627	0.61
112_L	133_M	0.624	0.61
73_T	99_A	0.622	0.60
65_I	68_L	0.619	0.60
142_A	150_R	0.615	0.60
21_T	80_A	0.613	0.59
177_F	182_G	0.610	0.59
105_G	109_D	0.607	0.59
22_G	31_P	0.605	0.58
69_G	73_T	0.604	0.58
64_L	108_N	0.604	0.58
115_L	127_A	0.597	0.57
93_E	122_R	0.596	0.57
99_A	106_P	0.592	0.57
164_E	167_D	0.590	0.56
9_L	12_W	0.588	0.56
89_T	131_K	0.584	0.56
12_W	34_V	0.584	0.56
135_L	143_L	0.581	0.55
44_L	80_A	0.580	0.55
7_G	54_V	0.580	0.55
95_A	98_S	0.579	0.55
36_A	39_W	0.579	0.55
69_G	119_Y	0.579	0.55
58_K	62_M	0.578	0.55
62_M	119_Y	0.576	0.55
142_A	147_R	0.574	0.54
132_D	182_G	0.573	0.54
38_T	67_D	0.571	0.54
76_I	79_R	0.571	0.54
145_Y	149_N	0.570	0.54
177_F	180_E	0.569	0.54
104_V	109_D	0.568	0.54
101_T	110_S	0.564	0.53
138_N	142_A	0.558	0.52
22_G	77_A	0.558	0.52
13_F	71_A	0.554	0.52
174_A	177_F	0.553	0.52
79_R	138_N	0.553	0.52
44_L	137_D	0.547	0.51
46_L	65_I	0.544	0.51
17_D	24_E	0.541	0.50
90_S	93_E	0.541	0.50
10_L	141_Q	0.541	0.50
62_M	127_A	0.538	0.50
17_D	137_D	0.537	0.50
169_F	172_T	0.537	0.50
38_T	59_A	0.537	0.50
10_L	144_K	0.535	0.49
60_V	63_A	0.530	0.49
21_T	24_E	0.530	0.49
22_G	34_V	0.526	0.48
43_A	47_L	0.524	0.48
116_W	120_E	0.521	0.48
11_E	102_D	0.521	0.48
175_P	178_Q	0.520	0.47
165_N	170_F	0.520	0.47
98_S	102_D	0.519	0.47
121_A	125_P	0.519	0.47
71_A	103_L	0.517	0.47
45_C	60_V	0.517	0.47
10_L	44_L	0.517	0.47
171_A	174_A	0.516	0.47
46_L	64_L	0.516	0.47
5_E	108_N	0.515	0.47
131_K	141_Q	0.514	0.47
72_R	99_A	0.514	0.47
31_P	141_Q	0.509	0.46
62_M	96_E	0.508	0.46
87_I	93_E	0.506	0.46
39_W	43_A	0.502	0.45
29_D	115_L	0.500	0.45

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4l1jA	2	0.9113	100	0.303	Contact Map
1ynbA	5	0.803	100	0.307	Contact Map
3kh1A	2	0.8818	100	0.343	Contact Map
1xx7A	5	0.8227	100	0.352	Contact Map
2cqzA	5	0.8276	100	0.392	Contact Map
3mzoA	5	0.9212	100	0.461	Contact Map
2paqA	5	0.8276	100	0.48	Contact Map
2gz4A	2	0.8128	100	0.518	Contact Map
2qgsA	2	0.8621	98	0.848	Contact Map
3b57A	2	0.7882	98	0.849	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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