GREMLIN Database
O52019 - Uncharacterized protein
UniProt: O52019 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 203 (164)
Sequences: 1496 (1007)
Seq/√Len: 78.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T111_E4.6281.00
101_T113_L3.5401.00
72_R102_D3.3131.00
117_E121_A3.0891.00
40_G144_K2.8621.00
41_T63_A2.7631.00
12_W68_L2.6781.00
12_W43_A2.5651.00
110_S114_S2.4931.00
33_S36_A2.3671.00
94_T98_S2.3191.00
167_D171_A2.2891.00
97_R117_E2.2061.00
113_L117_E2.1681.00
13_F40_G2.1351.00
57_Q61_T2.0271.00
87_I90_S1.9841.00
45_C133_M1.9661.00
46_L61_T1.8851.00
122_R131_K1.8691.00
119_Y130_V1.8661.00
65_I112_L1.8041.00
44_L133_M1.8011.00
45_C63_A1.8001.00
69_G100_V1.7471.00
11_E72_R1.6901.00
23_W145_Y1.6891.00
33_S137_D1.6711.00
137_D141_Q1.6471.00
59_A126_T1.6461.00
118_E124_T1.6061.00
59_A63_A1.5891.00
57_Q60_V1.5620.99
179_T182_G1.5410.99
114_S117_E1.5310.99
53_D125_P1.5070.99
26_R29_D1.4950.99
22_G145_Y1.4920.99
100_V104_V1.4670.99
40_G137_D1.4600.99
9_L44_L1.4340.99
41_T133_M1.4300.99
65_I115_L1.4090.99
38_T41_T1.3930.99
58_K126_T1.3920.99
15_L38_T1.3650.99
15_L34_V1.3600.99
42_A64_L1.3410.98
89_T92_K1.3390.98
80_A88_P1.3220.98
97_R101_T1.3170.98
52_E125_P1.3090.98
91_E95_A1.2900.98
21_T77_A1.2770.98
30_S36_A1.2660.98
63_A130_V1.2640.98
101_T117_E1.2580.98
80_A95_A1.2470.97
180_E184_D1.2430.97
62_M124_T1.2410.97
162_E165_N1.2270.97
11_E14_D1.2170.97
77_A80_A1.2130.97
18_E34_V1.1930.97
56_R60_V1.1860.97
72_R103_L1.1830.96
88_P91_E1.1760.96
55_D58_K1.1730.96
23_W31_P1.1680.96
49_A56_R1.1620.96
122_R127_A1.1540.96
54_V59_A1.1350.96
162_E166_L1.1100.95
115_L118_E1.1050.95
102_D105_G1.1030.95
147_R150_R1.0870.94
45_C59_A1.0780.94
48_Y59_A1.0540.93
173_A177_F1.0520.93
44_L136_V1.0490.93
12_W64_L1.0490.93
54_V129_F1.0430.93
23_W141_Q1.0350.93
4_D7_G1.0340.93
92_K131_K1.0270.92
26_R168_E1.0200.92
36_A137_D1.0110.92
141_Q145_Y0.9970.91
170_F173_A0.9960.91
55_D126_T0.9860.91
5_E9_L0.9710.90
13_F144_K0.9510.89
119_Y131_K0.9510.89
180_E183_Q0.9240.88
132_D179_T0.9180.87
93_E97_R0.9110.87
23_W148_Q0.9080.87
125_P129_F0.9030.87
142_A145_Y0.8960.86
8_S107_F0.8940.86
118_E123_D0.8880.86
166_L169_F0.8750.85
99_A102_D0.8740.85
163_F166_L0.8700.85
46_L60_V0.8690.84
122_R135_L0.8640.84
49_A57_Q0.8600.84
63_A119_Y0.8530.83
110_S113_L0.8420.83
59_A130_V0.8400.82
67_D70_E0.8170.81
96_E103_L0.8130.80
78_T131_K0.8010.79
46_L116_W0.7850.78
166_L173_A0.7840.78
167_D173_A0.7810.78
145_Y148_Q0.7810.78
176_R179_T0.7710.77
25_L141_Q0.7710.77
92_K119_Y0.7690.76
125_P128_Q0.7640.76
38_T42_A0.7580.75
92_K95_A0.7530.75
25_L135_L0.7510.75
62_M126_T0.7450.74
62_M65_I0.7440.74
19_L31_P0.7410.74
54_V125_P0.7370.73
131_K135_L0.7320.73
9_L79_R0.7300.73
14_D17_D0.7240.72
43_A64_L0.7180.71
22_G144_K0.7130.71
61_T65_I0.7120.71
62_M118_E0.7080.70
77_A137_D0.7070.70
22_G141_Q0.7070.70
76_I92_K0.7060.70
46_L112_L0.6990.69
36_A116_W0.6900.68
58_K114_S0.6860.68
58_K118_E0.6850.68
66_H70_E0.6830.68
7_G121_A0.6820.67
86_T89_T0.6820.67
43_A65_I0.6800.67
20_R32_E0.6750.67
43_A61_T0.6720.66
56_R59_A0.6710.66
178_Q182_G0.6710.66
41_T44_L0.6700.66
91_E94_T0.6700.66
17_D33_S0.6680.66
167_D170_F0.6670.66
19_L30_S0.6660.66
6_L144_K0.6640.65
16_K32_E0.6620.65
104_V113_L0.6610.65
19_L23_W0.6550.64
174_A178_Q0.6530.64
22_G78_T0.6470.63
45_C129_F0.6470.63
41_T112_L0.6430.63
121_A175_P0.6410.63
88_P92_K0.6410.63
94_T102_D0.6370.62
87_I91_E0.6350.62
171_A175_P0.6320.62
97_R113_L0.6320.62
18_E33_S0.6320.62
15_L63_A0.6310.61
21_T40_G0.6290.61
15_L22_G0.6280.61
10_L140_L0.6280.61
16_K141_Q0.6270.61
112_L133_M0.6240.61
73_T99_A0.6220.60
65_I68_L0.6190.60
142_A150_R0.6150.60
21_T80_A0.6130.59
177_F182_G0.6100.59
105_G109_D0.6070.59
22_G31_P0.6050.58
69_G73_T0.6040.58
64_L108_N0.6040.58
115_L127_A0.5970.57
93_E122_R0.5960.57
99_A106_P0.5920.57
164_E167_D0.5900.56
9_L12_W0.5880.56
89_T131_K0.5840.56
12_W34_V0.5840.56
135_L143_L0.5810.55
44_L80_A0.5800.55
7_G54_V0.5800.55
95_A98_S0.5790.55
36_A39_W0.5790.55
69_G119_Y0.5790.55
58_K62_M0.5780.55
62_M119_Y0.5760.55
142_A147_R0.5740.54
132_D182_G0.5730.54
38_T67_D0.5710.54
76_I79_R0.5710.54
145_Y149_N0.5700.54
177_F180_E0.5690.54
104_V109_D0.5680.54
101_T110_S0.5640.53
138_N142_A0.5580.52
22_G77_A0.5580.52
13_F71_A0.5540.52
174_A177_F0.5530.52
79_R138_N0.5530.52
44_L137_D0.5470.51
46_L65_I0.5440.51
17_D24_E0.5410.50
90_S93_E0.5410.50
10_L141_Q0.5410.50
62_M127_A0.5380.50
17_D137_D0.5370.50
169_F172_T0.5370.50
38_T59_A0.5370.50
10_L144_K0.5350.49
60_V63_A0.5300.49
21_T24_E0.5300.49
22_G34_V0.5260.48
43_A47_L0.5240.48
116_W120_E0.5210.48
11_E102_D0.5210.48
175_P178_Q0.5200.47
165_N170_F0.5200.47
98_S102_D0.5190.47
121_A125_P0.5190.47
71_A103_L0.5170.47
45_C60_V0.5170.47
10_L44_L0.5170.47
171_A174_A0.5160.47
46_L64_L0.5160.47
5_E108_N0.5150.47
131_K141_Q0.5140.47
72_R99_A0.5140.47
31_P141_Q0.5090.46
62_M96_E0.5080.46
87_I93_E0.5060.46
39_W43_A0.5020.45
29_D115_L0.5000.45
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4l1jA 2 0.9113 100 0.303 Contact Map
1ynbA 5 0.803 100 0.307 Contact Map
3kh1A 2 0.8818 100 0.343 Contact Map
1xx7A 5 0.8227 100 0.352 Contact Map
2cqzA 5 0.8276 100 0.392 Contact Map
3mzoA 5 0.9212 100 0.461 Contact Map
2paqA 5 0.8276 100 0.48 Contact Map
2gz4A 2 0.8128 100 0.518 Contact Map
2qgsA 2 0.8621 98 0.848 Contact Map
3b57A 2 0.7882 98 0.849 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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